TY - JOUR A1 - Amorim, Isilda A1 - Spera, Natalia C.M. A1 - Nicoara, Nicoleta A1 - Ramasamy, Devaraj A1 - Alves, Diana F. A1 - Stollenwerk, Manfred A1 - Stadtmüller, Johannes A1 - Döhring, Thorsten A1 - Sadewasser, Sascha A1 - Kolen'ko, Yury V. A1 - Sousa, Juliana P.S. T1 - Overall alkaline water electrolysis over active, stable, low loading iridium catalysts sputtered on nickel foam JF - International Journal of Hydrogen Energy KW - Iridium KW - Katalysator KW - Wasserstoffelektrolyse KW - Wasser KW - Elektrolyse KW - Wasserstofferzeugung Y1 - 2024 U6 - https://doi.org/10.1016/j.ijhydene.2024.10.306 SN - 0360-3199 VL - 92 SP - 852 EP - 864 PB - Elsevier BV ER - TY - JOUR A1 - Dobešová, Lucie A1 - Gier, Theresa A1 - Kopecna, Olga A1 - Pagáčová, Eva A1 - Vičar, Tomáš A1 - Bestvater, Felix A1 - Toufar, Jiří A1 - Bačíková, Alena A1 - Kopel, Pavel A1 - Fedr, Radek A1 - Hildenbrand, Georg A1 - Falková, Iva A1 - Falk, Martin A1 - Hausmann, Michael T1 - Incorporation of Low Concentrations of Gold Nanoparticles: Complex Effects on Radiation Response and Fate of Cancer Cells JF - Pharmaceutics N2 - (1) Background: In oncology research, a long-standing discussion exists about pros and cons of metal nanoparticle-enhanced radiotherapy and real mechanisms behind the tumor cell response to irradiation (IR) in presence of gold nanoparticles (GNPs). A better understanding of this response is, however, necessary to develop more efficient and safety nanoparticle (NP) types designed to disturb specific processes in tumor cells. (2) Aims and Methods: We combined 3D confocal microscopy and super-resolution single molecule localization microscopy (SMLM) to analyze, at the multiscale, the early and late effects of 10 nm-GNPs on DNA double strand break (DSB) induction and repair in tumor cells exposed to different doses of photonic low-LET (linear energy transfer) radiation. The results were correlated to different aspects of short and long-term cell viability. SkBr3 breast cancer cells (selected for the highest incidence of this cancer type among all cancers in women, and because most breast tumors are treated with IR) were incubated with low concentrations of GNPs and irradiated with 60Co γ-rays or 6 MV X-rays. In numerous post-irradiation (PI) times, ranging from 0.5 to 24 h PI, the cells were spatially (3D) fixed and labeled with specific antibodies against γH2AX, 53BP1 and H3K9me3. The extent of DSB induction, multi-parametric micro- and nano-morphology of γH2AX and 53BP1 repair foci, DSB repair kinetics, persistence of unrepaired DSBs, nanoscale clustering of γH2AX and nanoscale (hetero)chromatin re-organization were measured by means of the mentioned microscopy techniques in dependence of radiation dose and GNP concentration. (3) Results: The number of γH2AX/53BP1 signals increased after IR and an additional increase was observed in GNP-treated (GNP(+)) cells compared to untreated controls. However, this phenomenon reflected slight expansion of the G2-phase cell subpopulation in irradiated GNP(+) specimens instead of enhanced DNA damage induction by GNPs. This statement is further supported by some micro- and nano-morphological parameters of γH2AX/53BP1 foci, which slightly differed for cells irradiated in absence or presence of GNPs. At the nanoscale, Ripley’s distance frequency analysis of SMLM signal coordinate matrices also revealed relaxation of heterochromatin (H3K9me3) clusters upon IR. These changes were more prominent in presence of GNPs. The slight expansion of radiosensitive G2 cells correlated with mostly insignificant but systematic decrease in post-irradiation survival of GNP(+) cells. Interestingly, low GNP concentrations accelerated DSB repair kinetics; however, the numbers of persistent γH2AX/53BP1 repair foci were slightly increased in GNP(+) cells. (4) Conclusions: Low concentrations of 10-nm GNPs enhanced the G2/M cell cycle arrest and the proportion of radiosensitive G2 cells, but not the extent of DNA damage induction. GNPs also accelerated DSB repair kinetics and slightly increased presence of unrepaired γH2AX/53BP1 foci at 24 h PI. GNP-mediated cell effects correlated with slight radiosensitization of GNP(+) specimens, significant only for the highest radiation dose tested (4 Gy). KW - Strahlentherapie KW - Krebs, Medizin KW - Tumorzelle KW - Gold KW - Nanopartikel Y1 - 2022 U6 - https://doi.org/https://doi.org/10.3390/pharmaceutics14010166 SN - 1999-4923 VL - 14 IS - 1 PB - MDPI AG ER - TY - JOUR A1 - Rodener, Daniel A1 - Schäfer, Myriam A1 - Hausmann, Michael A1 - Hildenbrand, Georg T1 - Assessing the Potential for Liquid Solvents from X-ray Sources: Considerations on Bodies Orbiting Active Galactic Nuclei JF - Galaxies N2 - We aim to establish a rough first prospect on the potential of certain biorelevant solvents (water, ammonia, and methane) being present in liquid form inside the uppermost few meters of several modeled rocky and icy surfaces of hypothetical bodies orbiting active galactic nuclei (AGNs) and investigate under which constraints this might occur. For this, we adjust and average X-ray spectra from a sample of 20 Type-1 Seyfert galaxies to calculate the mean snowline of the sample used. We then vary the hypothetical body’s orbit between 10% and 100% of the snowline radius and calculate a sub-surface attenuation within four different model surface compositions for each. We then use this as a continuous source term for a thermal model. Example bodies are systematically investigated with sizes between 1/30 and 20 earth radii, with further variations also considered (such as possible bound rotation), to end up with a perspective of solvent phases under a wide slew of different conditions. We find that liquid solvents are possible under a multitude of parameters, with temperature being the main constraint to liquid water whereas body size and pressure are the main constraint to liquid methane and ammonia. KW - Lösungsmittel KW - Röntgenspektrum Y1 - 2022 U6 - https://doi.org/https://doi.org/10.3390/galaxies10050101 SN - 2075-4434 VL - 10 IS - 5 PB - MDPI AG ER - TY - JOUR A1 - Erenpreisa, Jekaterina A1 - Giuliani, Alessandro A1 - Yoshikawa, Kenichi A1 - Falk, Martin A1 - Hildenbrand, Georg A1 - Salmina, Kristine A1 - Freivalds, Talivaldis A1 - Vainshelbaum, Ninel A1 - Weidner, Jonas A1 - Sievers, Aaron A1 - Pilarczyk, Götz A1 - Hausmann, Michael T1 - Spatial-Temporal Genome Regulation in Stress-Response and Cell-Fate Change JF - International Journal of Molecular Sciences N2 - Complex functioning of the genome in the cell nucleus is controlled at different levels: (a) the DNA base sequence containing all relevant inherited information; (b) epigenetic pathways consisting of protein interactions and feedback loops; (c) the genome architecture and organization activating or suppressing genetic interactions between different parts of the genome. Most research so far has shed light on the puzzle pieces at these levels. This article, however, attempts an integrative approach to genome expression regulation incorporating these different layers. Under environmental stress or during cell development, differentiation towards specialized cell types, or to dysfunctional tumor, the cell nucleus seems to react as a whole through coordinated changes at all levels of control. This implies the need for a framework in which biological, chemical, and physical manifestations can serve as a basis for a coherent theory of gene self-organization. An international symposium held at the Biomedical Research and Study Center in Riga, Latvia, on 25 July 2022 addressed novel aspects of the abovementioned topic. The present article reviews the most recent results and conclusions of the state-of-the-art research in this multidisciplinary field of science, which were delivered and discussed by scholars at the Riga symposium. KW - Zellkern KW - Genom Y1 - 2023 U6 - https://doi.org/https://doi.org/10.3390/ijms24032658 SN - 1422-0067 VL - 24 IS - 3 PB - MDPI AG ER - TY - JOUR A1 - Sievers, Aaron A1 - Sauer, Liane A1 - Bisch, Marc A1 - Sprengel, Jan A1 - Hausmann, Michael A1 - Hildenbrand, Georg T1 - Moderation of Structural DNA Properties by Coupled Dinucleotide Contents in Eukaryotes JF - Genes N2 - Dinucleotides are known as determinants for various structural and physiochemical properties of DNA and for binding affinities of proteins to DNA. These properties (e.g., stiffness) and bound proteins (e.g., transcription factors) are known to influence important biological functions, such as transcription regulation and 3D chromatin organization. Accordingly, the question arises of how the considerable variations in dinucleotide contents of eukaryotic chromosomes could still provide consistent DNA properties resulting in similar functions and 3D conformations. In this work, we investigate the hypothesis that coupled dinucleotide contents influence DNA properties in opposite directions to moderate each other’s influences. Analyzing all 2478 chromosomes of 155 eukaryotic species, considering bias from coding sequences and enhancers, we found sets of correlated and anti-correlated dinucleotide contents. Using computational models, we estimated changes of DNA properties resulting from this coupling. We found that especially pure A/T dinucleotides (AA, TT, AT, TA), known to influence histone positioning and AC/GT contents, are relevant moderators and that, e.g., the Roll property, which is known to influence histone affinity of DNA, is preferably moderated. We conclude that dinucleotide contents might indirectly influence transcription and chromatin 3D conformation, via regulation of histone occupancy and/or other mechanisms. KW - Genom Y1 - 2023 U6 - https://doi.org/https://doi.org/10.3390/genes14030755 SN - 2073-4425 VL - 14 IS - 3 PB - MDPI AG ER - TY - JOUR A1 - Henn, Lukas A1 - Sievers, Aaron A1 - Hausmann, Michael A1 - Hildenbrand, Georg T1 - Specific Patterns in Correlations of Super-Short Tandem Repeats (SSTRs) with G+C Content, Genic and Intergenic Regions, and Retrotransposons on All Human Chromosomes JF - Genes N2 - The specific characteristics of k-mer words (2 ≤ k ≤ 11) regarding genomic distribution and evolutionary conservation were recently found. Among them are, in high abundance, words with a tandem repeat structure (repeat unit length of 1 bp to 3 bp). Furthermore, there seems to be a class of extremely short tandem repeats (≤12 bp), so far overlooked, that are non-random-distributed and, therefore, may play a crucial role in the functioning of the genome. In the following article, the positional distributions of these motifs we call super-short tandem repeats (SSTRs) were compared to other functional elements, like genes and retrotransposons. We found length- and sequence-dependent correlations between the local SSTR density and G+C content, and also between the density of SSTRs and genes, as well as correlations with retrotransposon density. In addition to many general interesting relations, we found that SINE Alu has a strong influence on the local SSTR density. Moreover, the observed connection of SSTR patterns to pseudogenes and -exons might imply a special role of SSTRs in gene expression. In summary, our findings support the idea of a special role and the functional relevance of SSTRs in the genome. KW - Genom KW - Genexpression Y1 - 2023 U6 - https://doi.org/https://doi.org/10.3390/genes15010033 SN - 2073-4425 VL - 15 IS - 1 PB - MDPI AG ER - TY - JOUR A1 - Solov’yov, Andrey V. A1 - Verkhovtsev, Alexey V. A1 - Mason, Nigel J. A1 - Amos, Richard A. A1 - Bald, Ilko A1 - Baldacchino, Gérard A1 - Dromey, Brendan A1 - Falk, Martin A1 - Fedor, Juraj A1 - Gerhards, Luca A1 - Hausmann, Michael A1 - Hildenbrand, Georg A1 - Hrabovský, Miloš A1 - Kadlec, Stanislav A1 - Kočišek, Jaroslav A1 - Lépine, Franck A1 - Ming, Siyi A1 - Nisbet, Andrew A1 - Ricketts, Kate A1 - Sala, Leo A1 - Schlathölter, Thomas A1 - Wheatley, Andrew E. H. A1 - Solov’yov, Ilia A. T1 - Condensed Matter Systems Exposed to Radiation: Multiscale Theory, Simulations, and Experiment JF - Chemical Reviews N2 - This roadmap reviews the new, highly interdisciplinary research field studying the behavior of condensed matter systems exposed to radiation. The Review highlights several recent advances in the field and provides a roadmap for the development of the field over the next decade. Condensed matter systems exposed to radiation can be inorganic, organic, or biological, finite or infinite, composed of different molecular species or materials, exist in different phases, and operate under different thermodynamic conditions. Many of the key phenomena related to the behavior of irradiated systems are very similar and can be understood based on the same fundamental theoretical principles and computational approaches. The multiscale nature of such phenomena requires the quantitative description of the radiation-induced effects occurring at different spatial and temporal scales, ranging from the atomic to the macroscopic, and the interlinks between such descriptions. The multiscale nature of the effects and the similarity of their manifestation in systems of different origins necessarily bring together different disciplines, such as physics, chemistry, biology, materials science, nanoscience, and biomedical research, demonstrating the numerous interlinks and commonalities between them. This research field is highly relevant to many novel and emerging technologies and medical applications. KW - Kondensierte Materie KW - Strahlung Y1 - 2024 U6 - https://doi.org/https://doi.org/10.1021/acs.chemrev.3c00902 SN - 0009-2665 VL - 124 IS - 13 SP - 8014 EP - 8129 PB - American Chemical Society (ACS) ER - TY - JOUR A1 - Hikmat, Wisam Mohammed A1 - Sievers, Aaron A1 - Hausmann, Michael A1 - Hildenbrand, Georg T1 - Peculiar k-mer Spectra Are Correlated with 3D Contact Frequencies and Breakpoint Regions in the Human Genome JF - Genes KW - 3D genomics KW - Hi-C KW - k-mer KW - sequence analysis KW - Zellkern KW - Chromatin KW - Genom Y1 - U6 - https://doi.org/10.3390/genes15101247 VL - 15 IS - 10 ER - TY - JOUR A1 - Bischoff, Kay A1 - Esen, Cemal A1 - Hellmann, Ralf T1 - Femtosecond reductive Laser Sintering under multiple focus conditions for rapid production of conductive copper layers JF - Procedia CIRP KW - Femtosekundenlaser KW - Laserstrahlsintern Y1 - 2024 U6 - https://doi.org/http://dx.doi.org/10.1016/j.procir.2024.08.189 SN - 2212-8271 VL - 124 SP - 629 EP - 633 PB - Elsevier BV ER - TY - JOUR A1 - Bischoff, Kay A1 - Mücke, Dominik A1 - Schubert, Andreas A1 - Esen, Cemal A1 - Hellmann, Ralf T1 - Rheological Investigation of Highly Filled Copper(II) Oxide Nanosuspensions to Optimize Precursor Particle Content in Reductive Laser-Sintering JF - Liquids N2 - In this article, the particle concentration of finely dispersed copper(II) oxide nanosuspensions as precursors for reductive laser sintering (RLS) is optimized on the basis of rheological investigations. For this metallization process, a smooth, homogeneous and defect-free precursor layer is a prerequisite for adherent and reproducible copper structures. The knowledge of the rheological properties of an ink is crucial for the selection of a suitable coating technology as well as for the adjustment of the ink formulation. Different dilutions of the nanosuspension were examined for their rheological behavior by recording flow curves. A strong shear thinning behavior was found and the viscosity decreases exponentially with increasing dilution. The viscoelastic behavior was investigated by a simulated doctor blade coating process using three-interval thixotropy tests. An overshoot in viscosity is observed, which decreases with increasing thinning of the precursor. As a comparison to these results, doctor blade coating of planar glass and polymer substrates was performed to prepare precursor layers for reductive laser sintering. Surface morphology measurements of the resulting coatings using laser scanning microscopy and rheological tests show that homogeneous precursor layers with constant thickness can be produced at a particle–solvent ratio of 1.33. A too-high particle content results in an irregular coating layer with deep grooves and a peak-to-valley height Sz of up to 7.8 μm. Precise dilution control allows the fabrication of smooth surfaces with a Sz down to 1.5 μm. KW - Laserstrahlsintern Y1 - 2024 U6 - https://doi.org/http://dx.doi.org/10.3390/liquids4020019 SN - 2673-8015 VL - 4 IS - 2 SP - 382 EP - 392 PB - MDPI AG ER - TY - JOUR A1 - Yang, Yongting A1 - Bischoff, Kay A1 - Mücke, Dominik A1 - Esen, Cemal A1 - Hellmann, Ralf T1 - UV-ultrashort pulsed laser ablation of fused silica JF - Journal of Laser Applications N2 - The authors report on ultraviolet ultrashort pulsed laser ablation of fused silica and compare the achievable micromachining results to those obtained by using the fundamental emission wavelength in infrared. Ablation in ultraviolet reveals a stable efficiency for increasing fluences, whereas using an infrared beam exhibits a decreasing trend of the ablation efficiency at higher and increasing fluences. In addition, a significant improvement in the surface quality is found by using an ultraviolet wavelength in a fluence range up to 20 J/cm2 compared to infrared, e.g., revealing an Ra of down to 0.45 μm on using the ultraviolet wavelength compared to Ra = 0.56 μm on using infrared at fluences up 15 J/cm2. Moreover, taking advantage of the high available pulse energy, the authors compare the achievable ablation efficiency and surface roughness using a conventionally focused ultraviolet beam and a defocused ultraviolet beam, finding that the defocused ultraviolet beam possesses a processing quality comparable to that of the focused beam. Finally, the authors exemplify the potential of ultraviolet ultrashort pulsed laser ablation by using a Tesla mixer for microfluidic integration of fused silica. KW - Laserablation KW - Quarzglas KW - Laserbestrahlung Y1 - 2024 U6 - https://doi.org/http://dx.doi.org/10.2351/7.0001197 SN - 1042-346X VL - 36 IS - 1 PB - Laser Institute of America ER - TY - JOUR A1 - Mahto, Kailash Kumar A1 - Mahato, Bidyut A1 - Chandan, Bikramaditya A1 - Das, Durbanjali A1 - Das, Priyanath A1 - Fotis, Georgios A1 - Vita, Vasiliki A1 - Mann, Michael T1 - A New Symmetrical Source-Based DC/AC Converter with Experimental Verification JF - Electronics N2 - This research paper introduces a new topology for multilevel inverters, emphasizing the reduction of harmonic distortion and the optimization of the component count. The complexity of an inverter is determined by the number of power switches, which is significantly reduced in the presented topology, as fewer switches require fewer driver circuits. In this proposed topology, a new single-phase generalized multilevel inverter is analyzed with an equal magnitude of voltage supply. A 9-level, 11-level, or 13-level symmetrical inverter with RL load is analyzed in MATLAB/Simulink 2019b and then experimentally validated using the dSPACE-1103 controller. The experimental verification of the load voltage and current with different modulation indices is also presented. The analysis of the proposed topology concludes that the total required number of components is lower than that necessary for the classical inverter topologies, as well as for some new proposed multilevel inverters that are also compared with the proposed topology in terms of gate driver circuits, power switches, and DC sources, which thereby enhances the goodness of the proposed topology. Thus, a comparison of this inverter with the other topologies validates its acceptance. KW - Spannungswandler KW - Mehrpunktwechselrichter Y1 - 2024 U6 - https://doi.org/http://dx.doi.org/10.3390/electronics13101975 SN - 2079-9292 VL - 13 IS - 10 PB - MDPI AG ER - TY - JOUR A1 - Das, Durbanjali A1 - Mahato, Bidyut A1 - Chandan, Bikramaditya A1 - Joshi, Hitesh A1 - Mahto, Kailash Kumar A1 - Das, Priyanath A1 - Fotis, Georgios A1 - Vita, Vasiliki A1 - Mann, Michael T1 - A New Cascaded Multilevel Inverter for Modular Structure and Reduced Passive Components JF - Electronics N2 - In high-power applications, achieving adequate power quality in power converter design is accomplished by utilizing multilevel inverters instead of using two-level and three-level inverters. The device generates a sinusoidal output voltage, which results in reduced total harmonic distortion and lower voltage stress on the switches and leads to lower electromagnetic interference, making it suitable for use in renewable energy applications. However, to illustrate the advantages mentioned above, a significant number of switching devices and DC sources are necessary while raising the voltage levels. This article proposes an asymmetrical voltage generation method, which operates in a ratio of 1:5 and generates 25 levels using 11 power switches. The topology is modular in structure, and each module has a lower component count, which significantly reduces the overall cost. The proposed topology is capable of generating negative output voltage levels without the use of an H-bridge configuration, where only three switches are used to generate any voltage levels. The functionality of the developed module is amended by fixing different voltage values in DC sources. This article also presents a comprehensive examination of the circuit and the functioning of various voltage levels. The advantages of the proposed inverter have been demonstrated by comparative research with the currently existing MLI topologies. Ultimately, both the simulation and experimental findings validated the practical capabilities. KW - Mehrpunktwechselrichter Y1 - 2024 U6 - https://doi.org/http://dx.doi.org/10.3390/electronics13173566 SN - 2079-9292 VL - 13 IS - 17 PB - MDPI AG ER - TY - JOUR A1 - Arnold, Jessica A1 - Kotte, Silja T1 - Arbeitgeberattraktivität durch betriebliche Gesundheitsförderung: Eine Strategie für das Employer Branding? JF - Organisationsberatung, Supervision, Coaching N2 - ZusammenfassungAngesichts des Arbeitskräftemangels investieren Unternehmen zunehmend in Employer Branding, um sich als Arbeitgeber auf dem Bewerbermarkt positiv zu positionieren. Gleichzeitig steigt das Bewusstsein für die Bedeutung von Gesundheit bei Einzelnen und Unternehmen. Kann daher Betriebliche Gesundheitsförderung (BGF) und die Kommunikation darüber die Arbeitgeberattraktivität erhöhen? In einer szenario-basierten experimentellen Online-Studie beurteilten die Studienteilnehmenden aus der Bewerber:innen-Rolle die Attraktivität eines Unternehmens auf Basis eines Unternehmensflyers mit vs. ohne Informationen über BGF-Angebote. BGF-Kommunikation hat einen positiven Effekt auf die Arbeitgeberattraktivität, unabhängig von Geschlecht, Bildungsstand und Alter. Die BGF-Kommunikation sollte vor allem authentisch, umfassend und transparent sein und etablierte Online-Kanäle nutzen. KW - Personalmarketing KW - Gesundheitsförderung KW - Unternehmen Y1 - 2024 U6 - https://doi.org/https://doi.org/10.1007/s11613-024-00911-0 SN - 1618-808X PB - Springer Science and Business Media LLC ER - TY - JOUR A1 - Ďuranová, Lenka A1 - Schrödel, Frank A1 - Rösner, Marlene T1 - Spaziergang in die Zukunft der Altenpflege: Wie Robis die Lebensqualität von Oldies verbessern könnten JF - Organisationsberatung, Supervision, Coaching N2 - In der Altenpflege herrscht Fachkräftemangel. Dieser beeinträchtigt Organisationen, Personal, Pflegebedürftige sowie Angehörige und erfordert innovative Lösungen. In der Berufspraxis entstand eine konkrete Forderung: Roboter, die mit den Älteren spazieren gehen. Dieser gehen wir nach. In diesem Beitrag skizzieren wir die Notwendigkeit einer Technologieinnovation in der Altenpflege aus wirtschaftspsychologischer Sicht, danach potenzielle Vorteile des begleitenden Roboters, seine Anwendungsszenarien, Hindernisse bei der Einführung und die notwendigen Entwicklungsschritte. Schließlich appellieren wir an die Praxis, die Technologieentwicklung zu unterstützen. KW - Altenpflege KW - Pflege KW - Digitalisierung KW - Mobiler Roboter Y1 - 2024 U6 - https://doi.org/https://doi.org/10.1007/s11613-024-00896-w SN - 1618-808X VL - 31 IS - 3 SP - 389 EP - 401 PB - Springer Science and Business Media LLC ER - TY - JOUR A1 - Alves, Caroline L. A1 - Rodrigues, Francisco A. A1 - Sallum, Loriz Francisco A1 - Toutain, Thaise A1 - Porto, Joel A1 - Aguiar, Patricia A1 - Thielemann, Christiane A1 - Möckel, Michael T1 - Multiclass classification of Autism Spectrum Disorder, attention deficit hyperactivity disorder, and typically developed individuals using fMRI functional connectivity analysis JF - plos one N2 - Neurodevelopmental conditions, such as Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD), present unique challenges due to overlapping symptoms, making an accurate diagnosis and targeted intervention difficult. Our study employs advanced machine learning techniques to analyze functional magnetic resonance imaging (fMRI) data from individuals with ASD, ADHD, and typically developed (TD) controls, totaling 120 subjects in the study. Leveraging multiclass classification (ML) algorithms, we achieve superior accuracy in distinguishing between ASD, ADHD, and TD groups, surpassing existing benchmarks with an area under the ROC curve near 98%. Our analysis reveals distinct neural signatures associated with ASD and ADHD: individuals with ADHD exhibit altered connectivity patterns of regions involved in attention and impulse control, whereas those with ASD show disruptions in brain regions critical for social and cognitive functions. The observed connectivity patterns, on which the ML c KW - Aufmerksamkeitsdefizit-Syndrom KW - Autismus KW - Funktionelle Kernspintomografie Y1 - 2024 UR - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0305630 U6 - https://doi.org/https://doi.org/10.1371/journal.pone.0305630 VL - 2024 IS - 19(10) SP - 1 EP - 35 ER - TY - JOUR A1 - Sauer, Timm A1 - Zindler, Klaus A1 - Jumar, Ulrich T1 - KI-basierte Regelungskonzepte zur automatischen Spurregelung von Flurförderzeugen JF - at - Automatisierungstechnik N2 - In diesem Beitrag werden zwei KI-basierte Regelungskonzepte zur automatischen Spurführung von Flurförderzeugen (FFZ) einer heterogenen Logistikflotte vorgestellt. Während die modellfreien Verfahren des bestärkenden Lernens für diese Anwendung als Vertreter der direkten neuronalen Regelung vorgestellt werden, lässt sich das zweite Regelungskonzept in die Klasse der indirekten neuronalen Regelungen einordnen. Beide Konzepte zeichnen sich dadurch aus, dass sie dazu in der Lage sind, die Reglerparameter an verschiedene Varianten von FFZ anzupassen sowie vorab bekanntes Wissen bezüglich des Regelstreckenverhaltens beim Entwurf der Regler gezielt zu berücksichtigen. KW - Automatische Spurführung; Künstliche Intelligenz KW - Flurförderer KW - Künstliche Intelligenz KW - Spurführung Y1 - 2024 UR - https://www.degruyter.com/document/doi/10.1515/auto-2023-0155/html U6 - https://doi.org/https://doi.org/10.1515/auto-2023-0155 VL - 72 IS - 4 SP - 336 EP - 353 ER - TY - JOUR A1 - Stieglitz, Veronika A1 - Burwitz, Vadim A1 - Döhring, Thorsten A1 - Hudec, Rene A1 - Vitek, Stanislav T1 - Design and testing of a Kirkpatrick-Baez optics variation JF - EPJ Web of Conferences N2 - Beside Wolter I X-ray optics, which are used at most in currently operating X-ray space telescopes, there exist also other optical designs and their usability for space observations is still the matter of studies. This article covers preliminary testing results of an optical module which is based on a modified Kirkpatrick-Baez optics. This X-ray optics, consisting of four sub-modules, was assembled in Prague and tested at the PANTER test facility of MPE afterward. The sub-modules use different reflective coatings, in part developed by our research group, on complementary flat mirrors, which approximate the shape of a Kirkpatrick-Baez optical design. In this contribution we summarise the design of the optical modules, the details of applied coating layers, and the X-ray characterisation results at the PANTER test facility KW - Kirkpatrick-Baez optics KW - X-ray telescopes KW - Reflective coatings KW - Röntgenoptik KW - Spiegelteleskop Y1 - 2022 UR - https://www.epj-conferences.org/articles/epjconf/abs/2022/10/epjconf_eosam2022_03021/epjconf_eosam2022_03021.html U6 - https://doi.org/10.1051/epjconf/202226603021 VL - 266 (2022) SP - 1 EP - 2 ER - TY - JOUR A1 - Rötzel, Peter T1 - The role of supplier-induced demand on the occurrence of information overload in managerial reporting environments JF - PLOS ONE N2 - This article develops a model showing how information reporters influence information load among decision makers and generate supplier-induced information demand (SID). The intra-corporate information-providing process is an expert market with information asymmetry. I show that information overload occurs as an SID and is the result of informational overconsumption deliberately caused by the supplying reporter. My analysis highlights that the information overload depends on the specificity of information. It also shows that the decision maker may face a hold-up situation in light of switching costs. The more specific the information needed, the higher the threat of information overload. The strategic content of information tempts reporting managers to overload the decision maker for the purpose of increasing their reporting transfer price and to discourage the decision maker from getting the information from another reporting manager. Although the decision maker knows a part of the information demand, information overload involves the cost of using unnecessary inputs, information overload occurs as an SID of information, even if other competing reporting managers exist. My analysis demonstrates that information overload can occur due to uncertainty and opportunism of both the decision maker and reporting managers. KW - Information Overload KW - Controlling KW - Management Reporting KW - Controlling KW - Management KW - Berichterstattung Y1 - 2024 U6 - https://doi.org/https://doi.org/10.1371/journal.pone.0307671 VL - 19 IS - 7 SP - e0307671 EP - e0307671 ER - TY - JOUR A1 - Sallum, Loriz Francisco A1 - Alves, Caroline L. A1 - Thielemann, Christiane A1 - Rodrigues, Francisco A. T1 - Revealing patterns in major depressive disorder with machine learning and networks JF - medrxiv N2 - Major depressive disorder (MDD) is a multifaceted condition that affects millions of people worldwide and is a leading cause of disability. There is an urgent need for an automated and objective method to detect MDD due to the limitations of traditional diagnostic approaches. In this paper, we propose a methodology based on machine and deep learning to classify patients with MDD and identify altered functional connectivity patterns from EEG data. We compare several connectivity metrics and machine learning algorithms. Complex network measures are used to identify structural brain abnormalities in MDD. Using Spearman correlation for network construction and the SVM classifier, we verify that it is possible to identify MDD patients with high accuracy, exceeding literature results. The SHAP (SHAPley Additive Explanations) summary plot highlights the importance of C4-F8 connections and also reveals dysfunction in certain brain areas and hyperconnectivity in others. Despite the lower performance of the complex network measures for the classification problem, assortativity was found to be a promising biomarker. Our findings suggest that understanding and diagnosing MDD may be aided by the use of machine learning methods and complex networks. KW - Depression KW - Elektroencephalographie KW - Maschinelles Lernen Y1 - 2024 U6 - https://doi.org/doi.org/10.1101/2024.06.07.24308619 VL - 2024 IS - 1 SP - 1 EP - 17 ER - TY - JOUR A1 - Szewczyk, Nathaniel J. A1 - Monici, Monica A1 - Thielemann, Christiane T1 - How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems? JF - npj Microgravity N2 - Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, “Biology in Space and Analogue Environments”, focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: “How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?” The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed. KW - Weltraumforschung KW - Biowissenschaften Y1 - 2024 U6 - https://doi.org/DOI: 10.1038/s41526-024-00395-3 VL - 2024 IS - 10 SP - 1 EP - 5 ER - TY - JOUR A1 - Lutz, Christian A1 - Helm, Jonas A1 - Tschirpke, Katrin A1 - Esen, Cemal A1 - Hellmann, Ralf T1 - Drilling Sequence Optimization Using Evolutionary Algorithms to Reduce Heat Accumulation for Femtosecond Laser Drilling with Multi-Spot Beam Profiles JF - MDPI Materials N2 - We report on laser drilling borehole arrays using ultrashort pulsed lasers with a particular focus on reducing the inadvertent heat accumulation across the workpiece by optimizing the drilling sequence. For the optimization, evolutionary algorithms are used and their results are verified by thermal simulation using Comsol and experimentally evaluated using a thermal imaging camera. To enhance process efficiency in terms of boreholes drilled per second, multi-spot approaches are employed using a spatial light modulator. However, as higher temperatures occur across the workpiece when using simultaneous multi-spot drilling as compared to a single-spot process, a subtle spatial distribution and sequence of the multi-spot approach has to be selected in order to limit the resulting local heat input over the processing time. Different optimization approaches based on evolutionary algorithms aid to select those drilling sequences which allow for the combination of a high efficiency of multi-spot profiles, a low-generated process temperature and a high-component quality. In particular, using a 4 x 4 laser spot array allows for the drilling of 40,000 boreholes in less than 76 s (526 boreholes/s) with a reduced temperature increase by about 35%, as compared to a single spot process when employing an optimized drilling sequence. KW - USP laser processing KW - Laser drilling KW - Optimization of heat accumulation KW - Evolutionary Algorithms KW - Thermal simualtions KW - Laserbohren KW - Ultrakurzzeitlaser Y1 - 2023 UR - https://www.mdpi.com/1996-1944/16/17/5775 U6 - https://doi.org/10.3390/ma16175775 VL - 2023 IS - 16/5775 SP - 1 EP - 12 ER - TY - JOUR A1 - Lutz, Christian A1 - Schwarz, Simon A1 - Marx, Jan A1 - Esen, Cemal A1 - Hellmann, Ralf T1 - Multi-Bessel Beams Generated by an Axicon and a Spatial Light Modulator for Drilling Applications JF - MDPI Photonics N2 - We report on an optical setup to generate multi-Bessel beam profiles combining a refractive axicon and a spatial light modulator. Based on their particular beam profile, Bessel beams offer advantageous properties for micro drilling processes and internal volume processing, especially for transparent materials. In addition, the laser power of industrial, ultrashort pulsed lasers has increased significantly over the last few years, offering the possibility for highly efficient processes using multi-spot profiles. Our optical concept combines the dynamic possibilities of beam splitting using a spatial light modulator with the benefits of Bessel beams, which facilitates multi-Bessel beam processing. Beside the simulation and experimental evaluation of the generated multi-Bessel beams, we exemplify the applicability of the developed module for the perforation of thin metal foils by micro drilling. KW - Bessel beam KW - Axicon KW - Optical System KW - Ultrashort pulsed laser KW - Material ablation KW - Bessel-Bündel KW - Ultrakurzzeitlaser Y1 - 2023 UR - https://www.mdpi.com/2304-6732/10/4/413 U6 - https://doi.org/10.3390/photonics10040413 VL - 2023 IS - 10/413 SP - 1 EP - 9 ER - TY - JOUR A1 - Sommer, David A1 - Esen, Cemal A1 - Hellmann, Ralf T1 - Static and Dynamic Mechanical Behaviour of Hybrid-PBF-LB/M-Built and Hot Isostatic Pressed Lattice Structures JF - Mechanical Properties of Polymeric, Metallic, and Composite Materials N2 - We report on a comprehensive study of the mechanical properties of maraging steel body-centred cubic lattice structures fabricated by a hybrid additive manufacturing technology that combines laser powder bed fusion with in situ high-speed milling. As the mechanical properties of additive manufactured components are inferior to, e.g., cast components, surface modifications can improve the mechanical behaviour. Different hybrid additive manufacturing technologies have been designed using additive and subtractive processes, improving process quality. Following this, mechanical testing is performed with respect to static tensile properties and dynamic stress, hardness, and porosity, comparing specimens manufactured by laser powder bed fusion only to those manufactured by the hybrid approach. In addition, the influence of different heat-treatment techniques on the mechanical behaviour of the lattice structures is investigated, namely solution and aging treatment as well as hot isostatic pressing. Thus, the influence of the superior surface quality due to the hybrid approach is evaluated, leading to, e.g., an offset of about 14–16% for the static testing of HIP lattice structures. Furthermore, the dynamic load behaviour can be improved with a finished surface, heading to a shift of the different zones of fatigue behaviour in the testing of hybrid-built specimens. KW - Hybrid additive manufacturing KW - Lattice structures KW - Hot isostatic pressing KW - Fatigue behaviour KW - Isostatisches Heißpressen KW - Selektives Laserschmelzen Y1 - 2023 UR - https://www.mdpi.com/1996-1944/16/9/3556 U6 - https://doi.org/https://doi.org/10.3390/ma16093556 VL - 16 IS - 9 SP - 1 EP - 14 ER - TY - JOUR A1 - Flachs, Dennis A1 - Zhukov, Sergey A1 - Zech, Isabella A1 - Schreck, Timo A1 - Belle, Stefan A1 - Seggern, Heinz von A1 - Kupnik, Mario A1 - Altmann, Alexander Anton A1 - Thielemann, Christiane T1 - Enzymatic Self-Degradable PLA-Based Electrets JF - Journal of Polymers and the Environment N2 - In recent years, the demand for sustainable and degradable materials and electronic devices has increased significantly. Among a range of biodegradable polymers, poly(lactic acid) (PLA) is a good alternative to conventional petrol-based polymers because of its attractive mechanical properties and its easy processability. Recently, PLA has also been described as a promising dielectric material with piezoelectric and electret properties. We expect that PLA—after further optimization— will play an important role as a material for environmentally friendly sensors in the future, where first applications such as air filters and pressure sensors have already been proposed. However, degradation under normal ambient conditions is very slow, and an accelerated and controllable degradation process is highly desirable for any type of PLA-based sensors. Enzymatic hydrolysis with embedded enzymes has been proposed as an approach to accelerate and control degradation. In this work, we investigate the properties of PLA in terms of dielectric and mechanical properties with a focus on its ability to store charges after the enzyme proteinase K (Trit. album) has been incorporated. Results reveal that proteinase K has a positive effect on the charge stability of solvent-cast PLA electrets after complete evaporation of the solvent. Furthermore, we observed a concentration-dependent acceleration of mass loss in a Tris-HCl buffer. A fast degradation within only one day occurred at a concentration of 6 wt% proteinase K. KW - Biologisch abbaubarer Kunststoff Y1 - 2024 U6 - https://doi.org/Journal of https://doi.org/10.1007/s10924-024-03240-6 VL - 2024 IS - 1 SP - 1 EP - 11 ER - TY - JOUR A1 - Balleis, Kristina A1 - Wagner, Stefan T1 - Haftung für Wildschäden in gemeinschaftlichen Jagdbezirken JF - Zeitschrift für Jagdwissenschaft KW - Jagdrecht KW - Forstrecht Y1 - 1998 VL - 44 IS - Juni SP - 85 EP - 93 ER - TY - JOUR A1 - Balleis, Kristina T1 - Keine Heilbarkeit eines Mangels unzureichender interkommunaler Abstimmung im ergänzenden Verfahren nach §215 a BauGB, Urteilsbesprechung JF - Verwaltungsrecht für die Anwaltspraxis KW - Deutschland, Baugesetzbuch KW - Kommunale Zusammenarbeit Y1 - 2000 VL - 2000 IS - 6 SP - 192 EP - 192 ER - TY - JOUR A1 - Balleis, Kristina T1 - Rechtswidrigkeit einer Vorkaufssatzung zur Sicherung städtebaulicher Entwicklung, Urteilsbesprechung JF - Verwaltungsrecht für die Anwaltspraxis KW - Stadtentwicklung KW - Vorkaufsrecht KW - Rechtswidrigkeit Y1 - 2000 VL - 2000 IS - 5 SP - 155 EP - 155 ER - TY - JOUR A1 - Balleis, Kristina T1 - Zulässigkeit und Notwendigkeit einer landesgesetzlichen Verbandsklage im Wasserrecht JF - Recht der Natur / Schnellbrief KW - Verbandsklage KW - Wasserrecht Y1 - 1997 VL - 1997 IS - 47 SP - 18 EP - 19 ER - TY - JOUR A1 - Gvozdovskyy, Igor A1 - Bratova, Daria A1 - Kazantseva, Z. A1 - Malyuta, S. A1 - Lytvyn, Petro A1 - Schwarz, Simon A1 - Hellmann, Ralf T1 - Light-controllable hybrid aligning layer based on LIPSS on sapphire surface and PVCN-F film JF - Journal of Molecular Liquids N2 - The creation of aligning layers for the uniform orientation of liquid crystals is significant for both research and the application of liquid crystals. For all applications, the creation of aligning layers possessing controllable characteristics such as azimuthal and polar anchoring energies, easy-axis of director alignment and pretilt angle, in the same way as it is achieved by using photoaligning layers processed by light, is very important. Here, aligning properties of hybrid aligning layers created on the basis of sapphire surfaces additionally coated by photoaligning layer of PVCN-F are studied. These hybrid layers possess the properties of the nano-structured sapphire layer and the photosensitive PVCN-F layer, and complement each other. The irradiation time dependence of the azimuthal anchoring energy of the hybrid layers is studied. By using certain experimental conditions during irradiation of hybrid layers, e.g., polarization of light and irradiation time, a minimum value of the azimuthal anchoring energy, close to zero, was obtained. Atomic force microscope studies of the irradiated hybrid layers were also carried out. It was found that the behavior of the contact angle of nematic droplets placed on treated sapphire surfaces are in good agreement with properties of hybrid aligning layers and parameters of structuring surface obtained from AFM images. KW - Flüssigkristall KW - Saphir KW - Kristallfläche Y1 - 2023 U6 - https://doi.org/10.1016/j.molliq.2023.122623 VL - 387 IS - keine SP - 122623 EP - 122623 ER - TY - JOUR A1 - Häfner, Tom A1 - Bischoff, Kay A1 - Helm, Jonas A1 - Kunz, Tim A1 - Rung, Stefan A1 - Esen, Cemal A1 - Hellmann, Ralf T1 - Picosecond laser microvia drilling of ABF material using MHz burst mode JF - Materials Research Express N2 - We report on a comprehensive study of laser percussion microvia drilling of Ajinomoto build-up film (ABF) material using an ultrashort pulsed laser in MHz burst mode. After laser processing, microvia drilling quality is being evaluated by the fabricated diameter and taper using laser scanning microscopy and metallography. The influences of the incubation effect, heat accumulation and shielding effects as a result of pulse to pulse interactions are being discussed on the ablation threshold, penetration depth and laser microvia drilling quality. We find that an increasing heat accumulation in MHz burst mode processing is responsible for the void formation and delamination of the insulating ABF layer. Therefore, the parameter clearance is introduced to evaluate these effects on the microvia sidewalls. For a comparable clearance, applying 2 intra-burst pulses achieves an average reduced taper of down to 19.5% compared to single pulse mode. At the same time, a reduced laser drilling time of 16.7% per microvia highlights the enormous potential of the MHz burst mode for laser drilling of ABF material in printed circuit board fabrication. KW - Ultrakurzzeitlaser KW - Pikosekundenbereich Y1 - 2023 VL - 10 IS - 9 SP - 096301 EP - 096311 ER - TY - JOUR A1 - Zettl, Julian A1 - Esen, Cemal A1 - Hellmann, Ralf T1 - Fundamental Considerations and Analysis of the Energy Distribution in Laser Turning with Ultrashort Laser Pulses JF - mdpi Micromachines N2 - This article discusses the process of the laser turning of rotational symmetric, cylindrical components using ultrashort laser pulses with respect to the geometrical conditions and the resulting energy distribution during the laser turning process. As a result, process predictions and potential process optimizations are feasible. Particular attention is drawn to the laser spot formation on the cylindrical surface of the work piece in conjunction with the positioning of the laser beam relative to the rotation axis of the specimen. Based on fundamental calculations and experimental results, an optimum processing strategy is discussed, whereat the use of a trepanning optic in the laser turning process and the forming of a particular surface structure is additionally being issued. KW - ultrashort pulse laser KW - laser turning KW - tangential processing KW - trepanning optic KW - Ultrakurzzeitlaser Y1 - 2023 UR - https://www.mdpi.com/2072-666X/14/10/1838 U6 - https://doi.org/10.3390/mi14101838 VL - 14 IS - 10 SP - 1 EP - 15 ER - TY - JOUR A1 - Dobrovolskij, Dascha A1 - Stark, Hans-Georg T1 - Synthetic demand data generation for individual electricity consumers: Inpainting JF - Energy and AI N2 - In this contribution we deal with the problem of producing “reasonable” data, when considering recorded energy consumption data, which are at certain sections incomplete and/or erroneous. This task is important, when energy providers employ prediction models for expected energy consumption, which are based on past recorded consumption data, which then of course should be reliable and valid. In a related contribution Yilmaz (2022), GAN-based methods for producing such “artificial data” have been investigated. In this contribution, we describe an alternative and complementary method based on signal inpainting, which has been successfully applied to audio processing Lieb and Stark (2018). After giving a short overview of the theory of proximity-based convex optimization, we describe and adapt an iterative inpainting scheme to our problem. The usefulness of this approach is demonstrated by analyzing real-world-data provided by a German energy supplier. KW - Energieverbrauch KW - Energieversorgungsunternehmen Y1 - 2024 VL - 15 IS - Januar 2024 SP - 100312 EP - 100320 ER - TY - JOUR A1 - Lieb, Florian A1 - Knopp, Tobias T1 - A wavelet-based sparse row-action method for image reconstruction in magnetic particle imaging JF - Medical Physics N2 - Purpose Magnetic particle imaging (MPI) is a preclinical imaging technique capable of visualizing the spatio-temporal distribution of magnetic nanoparticles. The image reconstruction of this fast and dynamic process relies on efficiently solving an ill-posed inverse problem. Current approaches to reconstruct the tracer concentration from its measurements are either adapted to image characteristics of MPI but suffer from higher computational complexity and slower convergence or are fast but lack in the image quality of the reconstructed images. Methods In this work we propose a novel MPI reconstruction method to combine the advantages of both approaches into a single algorithm. The underlying sparsity prior is based on an undecimated wavelet transform and is integrated into a fast row-action framework to solve the corresponding MPI minimization problem. Results Its performance is numerically evaluated against a classical FISTA (Fast Iterative Shrinkage-Thresholding Algorithm) approach on simulated and real MPI data. The experimental results show that the proposed method increases image quality with significantly reduced computation times. Conclusions In comparison to state-of-the-art MPI reconstruction methods, our approach shows better reconstruction results and at the same time accelerates the convergence rate of the underlying row-action algorithm. KW - Wavelet KW - Bildgebendes Verfahren KW - Magnetpartikelbildgebung Y1 - 2021 UR - https://doi.org/10.1002/mp.14938 VL - 48 IS - 7 SP - 3893 EP - 3903 ER - TY - JOUR A1 - Bischoff, Kay A1 - Esen, Cemal A1 - Hellmann, Ralf T1 - Preparation of Dispersed Copper(II) Oxide Nanosuspensions as Precursor for Femtosecond Reductive Laser Sintering by High-Energy Ball Milling JF - Nanomaterials N2 - This contribution demonstrates and discusses the preparation of finely dispersed copper(II) oxide nanosuspensions as precursors for reductive laser sintering (RLS). Since the presence of agglomerates interferes with the various RLS sub-processes, fine dispersion is required, and oversized particles must be identified by a measurement methodology. Aside from the established method of scanning electron microscopy for imaging individual dried particles, this work applies the holistic and statistically more significant laser diffraction in combination with dynamic image analysis in wet dispersion. In addition to direct ultrasonic homogenization, high-energy ball milling is introduced for RLS, to produce stable nanosuspensions with a high fine fraction, and, above all, the absence of oversize particles. Whereas ultrasonic dispersion stagnates at particle sizes between 500 nm and 20 μm, even after 8 h, milled suspension contains a high proportion of finest particles with diameters below 100 nm, no agglomerates larger than 1 μm and a trimodal particle size distribution with the median at 50 nm already, after 100 min of milling. The precursor layers produced by doctor blade coating are examined for their quality by laser scanning microscopy. The surface roughness of such a dry film can be reduced from 1.26 μm to 88 nm by milling. Finally, the novel precursor is used for femtosecond RLS, to produce homogeneous, high-quality copper layers with a sheet resistance of 0.28 Ω/sq and a copper mass concentration of 94.2%. KW - Laserstrahlsintern KW - Femtosekundenlaser Y1 - 2023 U6 - https://doi.org/https://doi.org/10.3390/nano13192693 VL - 13 IS - 19 SP - 2693 EP - 2693 ER - TY - JOUR A1 - Bischoff, Kay A1 - Kefer, Stefan A1 - Wienke, Alexander A1 - Overmeyer, Ludger A1 - Kaierle, Stefan A1 - Esen, Cemal A1 - Hellmann, Ralf T1 - Integration of Bragg gratings in aerosol-jetted polymer optical waveguides for strain monitoring capabilities JF - Optics Letters N2 - We demonstrate and discuss the integration of Bragg gratings in aerosol-jetted polymer optical waveguides, produced in the optical assembly and connection technology for component-integrated bus systems (OPTAVER) process. By using a femtosecond laser and adaptive beam shaping, an elliptical focal voxel generates different types of single pulse modification by nonlinear absorption in the waveguide material, which are arranged periodically to form Bragg gratings. Integration of a single grating structure or, alternatively, an array of Bragg grating structures in the multimode waveguide yields a pronounced reflection signal with typical multimodal properties, i.e., a number of reflection peaks with non-Gaussian shapes. However, the main wavelength of reflection, located around 1555 nm, is evaluable by means of an appropriate smoothing algorithm. When loaded by mechanical bending, a pronounced Bragg wavelength shift of this reflected peak up to 160 pm is detected. This demonstrates that the additively manufactured waveguides can be used not only for signal transmission but also as a sensor. KW - Bragg-Reflektor KW - Lichtwellenleiter Y1 - 2023 U6 - https://doi.org/https://doi.org/10.1364/OL.481801 VL - 48 IS - 7 SP - 1778 EP - 1781 ER - TY - JOUR A1 - Bischoff, Kay A1 - Mücke, Dominik A1 - Roth, Gian-Luca A1 - Esen, Cemal A1 - Hellmann, Ralf T1 - UV-Femtosecond-Laser Structuring of Cyclic Olefin Copolymer JF - Polymers N2 - We report on the laser ablation of cyclic olefin copolymer using an amplified ultrashort pulsed laser in the ultraviolet spectral range. In addition to a high ablation depth per laser-structured layer up to 74 μm at a fluence of 22 J cm−2, an excellent mean roughness 𝑅𝑎 of laser-patterned surfaces down to 0.5 μm is demonstrated. Furthermore, with increasing fluence, increasing ablation efficiencies up to 2.5 mm3 W−1 min−1 are determined. Regarding the quality of the ablation, we observed steep ablation flanks and low debris formation, though for fluences above 10.5 J cm−2 the formation of troughs was observed, being attributed to multiple reflections on the ablation flanks. For comparison, laser ablation was performed under identical conditions with an infrared laser wavelength. The results highlight that UV ablation exhibits significant advantages in terms of ablation efficiency, surface roughness and quality. Moreover, our results show that a larger UV focus spot accelerates the ablation process with comparable quality, paving the way for high-power UV ultrashort pulsed lasers towards an efficient and qualitative tool for the laser machining of cyclic olefin copolymer. The production of complex microfluidics further underlines the suitability of this type of laser. KW - Femtosekundenlaser Y1 - 2022 U6 - https://doi.org/https://doi.org/10.3390/polym14142962 VL - 14 IS - 14 SP - 2962 EP - 2962 ER - TY - JOUR A1 - Franz, Daniel A1 - Yang, Yongting A1 - Michel, Luis A1 - Esen, Cemal A1 - Hellmann, Ralf T1 - Evaluation of an ultrashort pulsed laser robot system for flexible and large-area micromachining JF - Journal of Laser Applications N2 - We report for the first time on the realization, characterization and application of an ultrashort pulsed laser robot system for flexible and large-area 2D and 3D laser micromachining with 6 articulated axes. To characterize the dynamic positioning of the laser beam during and after axes movement, CMOS image sensors were integrated into the beam path. A method introduced for the alignment of the optical axes allows a reduction of the deviations in laser beam positioning to less than 141.8 ± 92.9 μm within a 110° rotation range of axis 4. In addition, a high laser beam positioning repeatability of less than 102.2 μm is demonstrated over a total period of 14 h for a movement of axis 5 within a range of 0° to 90°. Initial laser cutting, laser structuring and laser marking applications on automotive dashboards and glass substrates are presented for flexible and large area 2D and 3D manufacturing. By applying a special laser cutting strategy for processing AF 32 eco thin glass, high cutting quality is achieved with a taper of up to 96.3% without the generation of cracks, demonstrating the innovative potential of the high-precision laser robot system. Nonetheless, different identified inherent influences of each axis 1–5 during robot axis movement demand for an innovative beam stabilization concept to achieve high precision in laser beam positioning. KW - Ultrakurzzeitlaser KW - Industrieroboter Y1 - 2023 N1 - Proceedings of the International Congress of Applications of Lasers & Electro-Optics (ICALEO 2023) VL - 35 IS - 4 SP - 042057 EP - 042065 ER - TY - JOUR A1 - Raiyn, Jamal A1 - Weidl, Galia T1 - Predicting Autonomous Driving Behavior through Human Factor Considerations in Safety-Critical Events JF - Smart Cities N2 - This paper investigates the ability of autonomous driving systems to predict outcomes by considering human factors like gender, age, and driving experience, particularly in the context of safety-critical events. The primary objective is to equip autonomous vehicles with the capacity to make plausible deductions, handle conflicting data, and adjust their responses in real-time during safety-critical situations. A foundational dataset, which encompasses various driving scenarios such as lane changes, merging, and navigating complex intersections, is employed to enable vehicles to exhibit appropriate behavior and make sound decisions in critical safety events. The deep learning model incorporates personalized cognitive agents for each driver, considering their distinct preferences, characteristics, and requirements. This personalized approach aims to enhance the safety and efficiency of autonomous driving, contributing to the ongoing development of intelligent transportation systems. The efforts made contribute to advancements in safety, efficiency, and overall performance within autonomous driving systems. To describe the causal relationship between external factors like weather conditions and human factors, and safety-critical driver behaviors, various data mining techniques can be applied. One commonly used method is regression analysis. Additionally, correlation analysis is employed to reveal relationships between different factors, helping to identify the strength and direction of their impact on safety-critical driver behavior. Keywords: car following; decision making; driving behavior; naturalistic driving studies; safety-critical events; cognitive vehicles 1. Introduction Despite the increasing prevalence of vehicle automation, the persistently high number of car crashes remains a concern. Safety-critical events in human-driven scenarios have become more intricate and partially uncontrollable due to unforeseen circumstances. Investigating human driving behavior is imperative to establish traffic baselines for mixed traffic, encompassing traditional, automated, and autonomous vehicles (AVs). Various factors, such as weather conditions affecting visibility in longitudinal car-following (CF) behavior [1,2], influence human driving behavior [3]. Car-following behavior, illustrating how a following vehicle responds to the lead vehicle in the same lane, is a crucial aspect. Existing car-following models often make assumptions about homogeneous drivers, neglecting significant heterogeneity in driving experience, gender, character, emotions, and sociological, psychological, and physiological traits. Failing to account for this heterogeneity hampers a comprehensive understanding of car-following behavior, limiting model accuracy and applicability. In the development of more realistic car-following models for mixed traffic, acknowledging the diversity among drivers is crucial. By including individual variations such as risk-taking tendencies, reaction times, decision-making processes, and driving styles, the modeling of real-world driving complexities can be improved. Simplifying drivers into a few categories overlooks the richness and variety of their characteristics, prompting the need for a more comprehensive approach to capture nuances within different driver profiles. To address these Smart Cities KW - Autonomes Fahrzeug KW - Mensch-Maschine-Kommunikation Y1 - 2024 UR - https://www.mdpi.com/2624-6511/7/1/18 U6 - https://doi.org/https://doi.org/10.3390/ smartcities7010018 VL - 7 IS - 1 SP - 460 EP - 474 ER - TY - JOUR A1 - Kefer, Stefan A1 - Limbach, Tobias A1 - Pape, Natalie A1 - Klamt, Kathrin A1 - Schmauss, Bernhard A1 - Hellmann, Ralf T1 - Birefringence in Injection-Molded Cyclic Olefin Copolymer Substrates and Its Impact on Integrated Photonic Structures JF - Polymers N2 - This contribution quantifies the birefringence within injection-molded cyclic olefin copolymer plates and discusses its impact on the mechanical properties of the plates. It also focuses on the impact of birefringence on integrated waveguides and Bragg gratings and provides fabrication guidelines for such structures. The anisotropy in all three dimensions of the workpiece is examined by means of polarimetry and a prism coupler. It is found that the birefringence is inhomogenously distributed within the workpieces, whereas the maximum birefringence not only varies locally, but also depends on the observation direction. Overall, a maximum birefringence of 10 × 10−4 is found at the plate’s surface near the injection gate. The anisotropy then reduces exponentially towards the center of the workpiece and saturates at 1.8 × 10−4, in a depth of 0.4 mm. Thus, the birefringence strongly affects near-surface photonic structures. It is found that, depending on their orientation and the local birefringence of the substrate, waveguides and Bragg gratings fabricated with comparable parameters behave completely differently in terms of polarization-dependent optical attenuation, cross-sectional intensity distribution and Bragg reflection signal. For example, the support of the TM mode can vary between total loss and an optical attenuation of 0.9 dB × cm−1. In consequence, this study underlines the importance of quantifying the birefringent state of an injection-molded cyclic olefin copolymer workpiece if it is supposed to serve as a substrate for integrated photonic structures. The study furthermore demonstrates that birefringence effects can be omitted by burying the photonic structures deeper into the volume of the thermoplastic. KW - cyclic olefin copolymer KW - birefringence KW - integrated photonics KW - Bragg grating KW - injection molding KW - Bragg-Reflektor KW - Wellenleiter KW - Doppelbrechung Y1 - 2024 UR - https://www.mdpi.com/2073-4360/16/2/168 U6 - https://doi.org/10.3390/polym16020168 VL - 16 IS - 2 SP - 168 EP - 168 ER - TY - JOUR A1 - Trent, Davis A1 - Thielemann, Christiane A1 - Monici, Monica T1 - How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms? JF - npj Microgravity N2 - Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment offers the unique opportunity to carry out experiments without gravity, helping us not only to understand the effects of gravitational alterations on biological systems but also the mechanisms underlying mechanoperception and cell/tissue response to mechanical and gravitational stresses. Despite the progress made so far, for future space exploration programs it is necessary to increase our knowledge on the mechanotransduction processes as well as on the molecular mechanisms underlying microgravity-induced cell and tissue alterations. This white paper reports the suggestions and recommendations of the SciSpacE Science Community for the elaboration of the section of the European Space Agency roadmap “Biology in Space and Analogue Environments” focusing on “How are cells and tissues influenced by gravity and what are the gravity perception mechanisms?” The knowledge gaps that prevent the Science Community from fully answering this question and the activities proposed to fill them are discussed. KW - Zellkultur KW - Schwere KW - Raumfahrtbiologie Y1 - 0024 UR - https://rdcu.be/dyCjL U6 - https://doi.org/10.1038/s41526-024-00357-9 VL - 2014 IS - 10 / 16 SP - 1 EP - 7 ER - TY - JOUR A1 - Voigt, Jorrit A1 - Möckel, Michael T1 - Benchmarking a multi-layer approach and neural network architectures for defect detection in PBF-LB/M JF - Materials Today Communications N2 - The substitution of expensive non-destructive material testing by data-based process monitoring is intensively explored in quality assurance for additive manufactured components. Machine learning show promising results for defect detection but require conceptual adaption to layer wise manufacturing and line scanning patterns in laser powder bed fusion. A multi-layer approach to co-register µ-computer tomography measurements with process monitoring data is developed and a workflow for automatic data set generation is implemented. The objective of this research is to benchmark the volumetric multi-layer approach and specifically selected deep learning methods for defect detection. The volumetric approach shows superior results compared to single slice monitoring. All investigated structured neural network topologies deliver similar performance. KW - Neuronales Netz KW - Maschinelles Lernen KW - Fehlererkennung Y1 - 2022 UR - https://www.sciencedirect.com/science/article/pii/S2352492822017196?via%3Dihub U6 - https://doi.org/https://doi.org/10.1016/j.mtcomm.2022.104878 VL - 2022 IS - 33/104878 SP - * EP - * ER - TY - JOUR A1 - Voigt, Jorrit A1 - Bock, Thomas A1 - Hilpert, Uwe A1 - Hellmann, Ralf A1 - Möckel, Michael T1 - Increased relative density and characteristic melt pool Signals at the edge in PBF-LB/M JF - Additive Manufacturing N2 - Limited process control can cause metallurgical defect formation and inhomogeneous relative density in laser powder bed fusion manufactured parts. This study shows that process monitoring, based on optical melt-pool signal analysis is capable of tracing relative density variations: Unsupervised machine learning, applied to cluster multiple-slice monitoring data, reveals characteristic patterns in this noisy time-series signal, which can be co-registered with geometrical positions in the build part. For cylindrical 15–5 PH stainless steel specimens, manufactured under constant process parameters and post-analyzed by µ-computer tomography, correlations between such patterns and an increased local relative density at the edge have been observed. Finite element method (FEM) modeling of thermal histories at exemplary positions close to the edge suggest pre-heating effects caused by neighboring laser scan trajectories as possible reasons for the increased melt pool intensity at the edge. KW - Maschinelles Lernen KW - Schmelze Y1 - 2022 UR - https://www.sciencedirect.com/science/article/pii/S2214860422001993?via%3Dihub U6 - https://doi.org/https://doi.org/10.1016/j.addma.2022.102798 VL - 2022 IS - 57/102798 SP - * EP - * ER - TY - JOUR A1 - Pineda, Aruane M. A1 - Alves, Caroline L. A1 - Möckel, Michael A1 - de O Toutain, Thaise Graziele L A1 - Moura Porto, Joel Augusto A1 - Rodrigues, Francisco A. T1 - Analysis of quantile graphs in EGC data from elderly and young individuals using machine learning and deep learning JF - Journal of Complex Networks N2 - Heart disease, also known as cardiovascular disease, encompasses a variety of heart conditions that can result in sudden death for many people. Examples include high blood pressure, ischaemia, irregular heartbeats and pericardial effusion. Electrocardiogram (ECG) signal analysis is frequently used to diagnose heart diseases, providing crucial information on how the heart functions. To analyse ECG signals, quantile graphs (QGs) is a method that maps a time series into a network based on the time-series fluctuation proprieties. Here, we demonstrate that the QG methodology can differentiate younger and older patients. Furthermore, we construct networks from the QG method and use machine-learning algorithms to perform the automatic diagnosis, obtaining high accuracy. Indeed, we verify that this method can automatically detect changes in the ECG of elderly and young subjects, with the highest classification performance for the adjacency matrix with a mean area under the receiver operating characteristic curve close to one. The findings reported here confirm the QG method’s utility in deciphering intricate, nonlinear signals like those produced by patient ECGs. Furthermore, we find a more significant, more connected and lower distribution of information networks associated with the networks from ECG data of the elderly compared with younger subjects. Finally, this methodology can be applied to other ECG data related to other diseases, such as ischaemia. KW - Maschinelles Lernen KW - Elektrokardiogramm KW - Älterer Mensch KW - Heranwachsender Y1 - 2023 UR - https://academic.oup.com/comnet/article-abstract/11/5/cnad030/7260365?redirectedFrom=fulltext U6 - https://doi.org/https://doi.org/10.1093/comnet/cnad030 VL - 2023 IS - 11/5 SP - * EP - * ER - TY - JOUR A1 - Stier, Simon P. A1 - Xu, Xukuan A1 - Gold, Lukas A1 - Möckel, Michael T1 - Ontology-Based Battery Production Dataspace and Its Interweaving with Artificial Intelligence-Empowered Data Analytics JF - Energy Technology N2 - Heart disease, also known as cardiovascular disease, encompasses a variety of heart conditions that can result in sudden death for many people. Examples include high blood pressure, ischaemia, irregular heartbeats and pericardial effusion. Electrocardiogram (ECG) signal analysis is frequently used to diagnose heart diseases, providing crucial information on how the heart functions. To analyse ECG signals, quantile graphs (QGs) is a method that maps a time series into a network based on the time-series fluctuation proprieties. Here, we demonstrate that the QG methodology can differentiate younger and older patients. Furthermore, we construct networks from the QG method and use machine-learning algorithms to perform the automatic diagnosis, obtaining high accuracy. Indeed, we verify that this method can automatically detect changes in the ECG of elderly and young subjects, with the highest classification performance for the adjacency matrix with a mean area under the receiver operating characteristic curve close to one. The findings reported here confirm the QG method’s utility in deciphering intricate, nonlinear signals like those produced by patient ECGs. Furthermore, we find a more significant, more connected and lower distribution of information networks associated with the networks from ECG data of the elderly compared with younger subjects. Finally, this methodology can be applied to other ECG data related to other diseases, such as ischaemia. KW - Batterie KW - Künstliche Intelligenz Y1 - 2024 UR - https://onlinelibrary.wiley.com/doi/epdf/10.1002/ente.202301305 U6 - https://doi.org/https://doi.org/10.1002/ente.202301305 VL - 2024 IS - 2301305 SP - 1 EP - 13 ER - TY - JOUR A1 - Zanotto, Franco M. A1 - Zapata Dominguez, Diana A1 - Ayerbe, Elixabete A1 - Boyano, Iker A1 - Burmeister, Christine A1 - Duquesnoy, Marc A1 - Eisentraeger, Marlene A1 - Florez Montaño, Jonathan A1 - Gallo-Bueno,, Alfonso A1 - Gold, Lukas A1 - Hall, Florian A1 - Kaden, Nicolaj A1 - Muerkens, Bernhard A1 - Otaegui, Laida A1 - Reynier, Yvan A1 - Stier, Simon A1 - Thomitzek, Matthias A1 - Turetskyy, Artem A1 - Vallin, Nicolas A1 - Wessel, Jacob A1 - Xu, Xukuan A1 - Abbasov, Jeyhun A1 - Franco, Alejandro A. T1 - Data Specifications for Battery Manufacturing Digitalization: Current Status, Challenges, and Opportunities JF - Chemistry Europe - Batteries & Supercaps N2 - Lithium-ion battery (LIB) manufacturing requires a pilot stage that optimizes its characteristics. However, this process is costly and time-consuming. One way to overcome this is to use a set of computational models that act as a digital twin of the pilot line, exchanging information in real-time that can be compared with measurements to correct parameters. Here we discuss the parameters involved in each step of LIB manufacturing, show available computational modeling approaches, and discuss details about practical implementation in terms of software. Then, we analyze these parameters regarding their criticality for modeling set-up and validation, measurement accuracy, and rapidity. Presenting this in an understandable format allows identifying missing aspects, remaining challenges, and opportunities for the emergence of pilot lines integrating digital twins. Finally, we present the challenges of managing the data produced by these models. As a snapshot of the state-of-the-art, this work is an initial step towards digitalizing battery manufacturing pilot lines, paving the way toward autonomous optimization. KW - Batterie KW - Digitalisierung Y1 - 2022 UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/batt.202200224 U6 - https://doi.org/https://doi.org/10.1002/batt.202200224 VL - 2022 IS - 5/9 SP - 1 EP - 35 ER - TY - JOUR A1 - Alves, Caroline L. A1 - Ciba, Manuel A1 - de O Toutain, Thaise Graziele L A1 - Moura Porto, Joel Augusto A1 - de Sena, Eduardo Pondé A1 - Thielemann, Christiane A1 - Rodrigues, Francisco A. T1 - On the advances in machine learning and complex network measures to an EEG dataset from DMT experiments JF - Journal of Physics: Complexity N2 - There is a growing interest in the medical use of psychedelic substances, as preliminary studies using them for psychiatric disorders have shown positive results. In particular, one of these substances is N, N-dimethyltryptamine (DMT), an agonist serotonergic psychedelic that can induce profound alterations in the state of consciousness. In this work, we use an exploratory tool to reveal DMT-induced changes in brain activity using EEG data and provide new insights into the mechanisms of action of this psychedelic substance. We used a two-class classification based on (A) the connectivity matrix or (B) complex network measures derived from it as input to a support vector machine. We found that both approaches could detect changes in the brain's automatic activity, with case (B) showing the highest AUC (89%), indicating that complex network measurements best capture the brain changes that occur due to DMT use. In the second step, we ranked the features that contributed the most to this result. For case (A), we found that differences in the high alpha, low beta, and delta frequency bands were most important in distinguishing between the state before and after DMT inhalation, which is consistent with the results described in the literature. Further, the connection between the temporal (TP8) and central cortex (C3) and between the precentral gyrus (FC5) and the lateral occipital cortex (P8) contributed most to the classification result. The connection between regions TP8 and C3 has been found in the literature associated with finger movements that might have occurred during DMT consumption. However, the connection between cortical areas FC5 and P8 has not been found in the literature and is presumably related to the volunteers' emotional, visual, sensory, perceptual, and mystical experiences during DMT consumption. For case (B), closeness centrality was the most crucial complex network measure. Furthermore, we discovered larger communities and longer average path lengths when DMT was used and the converse when not, showing that the balance between functional segregation and integration had been disrupted. These findings support the idea that cortical brain activity becomes more entropic under psychedelics. Overall, a robust computational workflow has been developed here with interpretability of how DMT (or other psychedelics) modify brain networks and insights into their mechanism of action. Finally, the same methodology applied here may help interpret EEG time series from patients who consumed other psychedelic drugs. KW - Neuronales Netz KW - Halluzinogen KW - Psychische Störung Y1 - 2024 U6 - https://doi.org/10.1088/2632-072X/ad1c68 VL - 2024 IS - 1 SP - 1 EP - 2 ER - TY - JOUR A1 - Monici, Monica A1 - Thielemann, Christiane T1 - How do gravity alterations affect animal and human systems at a cellular/tissue level? JF - nature npj Microgravity N2 - The present white paper concerns the indications and recommendations of the SciSpacE Science Community to make progress in filling the gaps of knowledge that prevent us from answering the question: “How Do Gravity Alterations Affect Animal and Human Systems at a Cellular/Tissue Level?” This is one of the five major scientific issues of the ESA roadmap “Biology in Space and Analogue Environments”. Despite the many studies conducted so far on spaceflight adaptation mechanisms and related pathophysiological alterations observed in astronauts, we are not yet able to elaborate a synthetic integrated model of the many changes occurring at different system and functional levels. Consequently, it is difficult to develop credible models for predicting long-term consequences of human adaptation to the space environment, as well as to implement medical support plans for long-term missions and a strategy for preventing the possible health risks due to prolonged exposure to spaceflight beyond the low Earth orbit (LEO). The research activities suggested by the scientific community have the aim to overcome these problems by striving to connect biological and physiological aspects in a more holistic view of space adaptation effects. KW - Raumfahrt KW - Schwere KW - Raumfahrtbiologie Y1 - 2023 U6 - https://doi.org/https://doi.org/10.1038/s41526-023-00330-y N1 - Artikel hat 62 Autoren VL - 2023 IS - 9/84 SP - 1 EP - 9 ER - TY - JOUR A1 - Polyakov, Maxim V. A1 - Weidl, Galia T1 - Chiral expansion in the dual (string) model of the Goldstone meson scattering JF - High Energy Physics - Phenomenology N2 - We consider in details the dual models for the Goldstone mesons (pions) scattering in the presence of the explicit chiral symmetry breaking caused by non-zero current quark mass. New method of incorporation of the quark masses into the dual model is suggested. In contrast to the previously considered in the literature methods, the dual amplitude obtained by this method is consistent with all low-energy theorems following from the Effective Chiral Lagrangian (EChL) to the O(p^4) order and simultaneously it does not contain states with negative width. The resonance spectrum of the model and its implications for the fourth and sixth order EChL in large N_c limit are discussed. We argue that the possible relations between large N_c QCD and some underlying string theory can be revealed by studying interactions of hadrons at low-energies. KW - Chiral expansion KW - dual string models KW - Goldstone meson scattering KW - Stringtheorie Y1 - 1996 UR - https://www.researchgate.net/publication/2034505_Chiral_expansion_in_the_dual_string_model_of_the_Goldstone_meson_scattering#fullTextFileContent U6 - https://doi.org/10.48550/arXiv.hep-ph/9612486 VL - 1997 IS - 0/0 SP - 1 EP - 13 ER - TY - JOUR A1 - Weidl, Galia A1 - Madsen, Anders L. A1 - Dahlquist, Erik T1 - Condition Monitoring, Root Cause Analysis and Decision Support on Urgency of Actions JF - Book Series FAIA (Frontiers in Artificial Intelligence and Applications), Soft Computing Systems - Design, Management and Applications N2 - We discuss the use of a hybrid system utilizing Object Oriented Bayesian networks and influence diagrams for probabilistic reasoning under uncertainties in industrial process operations. The Bayesian networks are used for condition monitoring and root cause analysis of process operation. The recommended decision sequence of corrective actions and observations is obtained following the "myopic" approach. The BN inference on most probable root cause is used in an influence diagram for taking decisions on urgency of corrective actions vs. delivery deadline. The build-in chain of causality from root cause to process faults can provide the user with explanation facility and a simulation tool of the effect of intended actions. KW - OOBN KW - Bayesian Networks KW - Prozesssteuerung KW - Prozessanalyse Y1 - 2002 UR - https://www.researchgate.net/publication/228719447_Condition_Monitoring_Root_Cause_Analysis_and_Decision_Support_on_Urgency_of_Actions#fullTextFileContent VL - 2002 IS - 87 SP - 221 EP - 230 ER -