TY - JOUR A1 - Moser, Felipe A1 - Hildenbrand, Georg A1 - Müller, Patrick A1 - Al Saroori, Alexander A1 - Biswas, Abin A1 - Bach, Margund A1 - Wenz, Frederik A1 - Cremer, Christoph A1 - Burger, Nina A1 - Veldwijk, Marlon R. A1 - Hausmann, Michael T1 - Cellular Uptake of Gold Nanoparticles and Their Behavior as Labels for Localization Microscopy JF - Biophysical Journal KW - Krebs, Medizin KW - Strahlentherapie Y1 - 2016 U6 - https://doi.org/https://doi.org/10.1016/j.bpj.2016.01.004 SN - 0006-3495 VL - 110 IS - 4 SP - 947 EP - 953 PB - Elsevier BV ER - TY - JOUR A1 - Bosiek, Katharina A1 - Hausmann, Michael A1 - Hildenbrand, Georg T1 - Perspectives on Comets, Comet-like Asteroids, and Their Predisposition to Provide an Environment That Is Friendly to Life JF - Astrobiology KW - Komet KW - Planetoid Y1 - 2016 U6 - https://doi.org/https://doi.org/10.1089/ast.2015.1354 SN - 1531-1074 VL - 16 IS - 4 SP - 311 EP - 323 PB - Mary Ann Liebert Inc ER - TY - BOOK A1 - Preuß, Norbert A1 - Schöne, Lars Bernhard T1 - Real Estate und Facility Management aus Sicht der Consultingpraxis N2 - Die überarbeitete und deutlich erweiterte 4. Auflage dieses anerkannten Standardwerkes liefert einen umfassenden Einblick in die Grundsäulen des Real Estate und Facility Managements. Von der Projektentwicklung, dem Projektmanagement, über das Transaktions-, Portfolio- und Risikomanagement bis hin zum Asset-, Property- und Facility Management. Alle wesentlichen Leistungen sowie Argumente für ein nachhaltiges Management der Sachwertanlage Immobilie, die hierfür notwendigen Strategien, Methoden sowie Vorgehensweisen werden detailliert dargelegt. Besonders informativ, anregend und aufschlussreich wird der Leser durch den interdisziplinären Ansatz sowie die umfangreichen aktuellen Beispiele, Tabellen und Abbildungen durch den Lebenszyklus der Immobilie geführt. Dieses Werk wendet sich seit nunmehr über 15 Jahren an drei Zielgruppen: Studenten, die sich mit den Grundlagen und den vertiefenden Aspekten der Bau- und Immobilienwirtschaft insgesamt oder mit einzelnen Elementen, wie etwa einer Portfolio-Analyse oder der Due Diligence, gezielt auseinandersetzen wollen; an Praktiker, die die aktuellen Entwicklungen ihres Fachgebiets verfolgen und eine fortwährende Aktualisierung ihres Wissenstandes anstreben sowie Wissenschaftler, die durch die kritische Reflexion der hier beschriebenen Expertisen Impulse für die Weiterentwicklung ihres Forschungsgebietes erhalten können. KW - Facility-Management KW - Consulting Engineering Y1 - 2016 UR - https://link.springer.com/content/pdf/10.1007%2F978-3-662-48291-9.pdf SN - 978-3-662-48290-2 U6 - https://doi.org/10.1007/978-3-662-48291-9 PB - Springer Vieweg CY - Berlin ER - TY - JOUR A1 - Söthje, Dominik A1 - Ischdonat, Nils A1 - Braune, Christian A1 - Setzer, Andreas A1 - Dreyer, Christian T1 - Zweites Leben für Flugzeugkabinen – Chemisches Recycling duromerbasierter faserverstärkter Kunststoffe JF - Kunststoffe KW - Faserverstärkter Kunststoff KW - Recycling KW - Flugzeugkabine Y1 - 2016 VL - 2016 IS - 9 SP - 205 EP - 208 ER - TY - JOUR A1 - Weithmann, Sabrina T1 - Standardization in China: Electric Vehicle Technology as Driver for Change in China’s Automotive Standardization JF - International Journal of Standardization Research (IJSR) N2 - Electric vehicle (EV) development in China emerged with the 863 program (1986) for high technologies and has received support since the 10th Five Year Plan. While standards were of no particular importance in the early years of EV development, standards have increasingly become subject to policies and programs. For instance, the promotion of ‘indigenous' or ‘home-grown' innovation is perceived as means to develop domestic standards and contribute to international standards. Alongside this target, the Chinese government mandated the development of an EV standardization roadmap to serve as a guideline for optimizing standardization work, promoting technical innovation and large-scale industrialization. It was even considered that EV standardization was a novel standard field that has the potential to secure China a forerunner position in technological development as well as international standardization, regardless of standard-setting practices in the conventional automotive sector. Against this background, this paper examines the differences in system set-up and processes of standardization for the traditional automotive and the electric vehicles sector. While conventional automotive standardization is limited to a single sector with the Ministry of Industry of Information Technology and the China Automotive Technology and Research Centre in charge, electric vehicles require the participation of stakeholders from other sectors. Therefore, the negative influence from the conventional decentralized automotive sector on the development of common nationwide standards like the dynamics between national, regional and local actors cannot be deprived. Additionally, this paper also highlights learnings from EV standardization that might set positive impulses for conventional EV standardizations. KW - China KW - Standardization KW - electric vehicles KW - China KW - Elektrofahrzeug KW - Standardisierung Y1 - 2016 VL - 2016 IS - 14 (2) SP - 20 EP - 32 ER - TY - JOUR A1 - Kröhn, Michael A1 - Reuter, Norbert A1 - Hahnle, Michael A1 - Prochus, Tobias A1 - Doll, Konrad T1 - Gestengesteuerte Prozessanalyse JF - atp edition - Automatisierungstechnische Praxis KW - Prozessanalyse Y1 - 2016 VL - 58 IS - 12 SP - 26 EP - 33 ER - TY - CHAP A1 - Krini, Mohammed A1 - Mirza, Zafar Baig A1 - Rodemer, Klaus T1 - A Practical Beamformer-Postfilter System for Microphone Arrays on Seat Belts T2 - 12. ITG Symposium Speech Communication (ITG’16), Paderborn KW - Sicherheitsgurt KW - Mikrofon KW - Array Y1 - 2016 VL - 2016 ER - TY - JOUR A1 - Rajan, Vasudev Kandade A1 - Krini, Mohammed A1 - Schmidt, Gerhard T1 - Signal Processing Techniques for Seat Belt Micro-phone Arrays JF - EURASIP Journal on Advances in Signal Processing KW - Signalverarbeitung KW - Sicherheitsgurt KW - Mikrofon KW - Array Y1 - 2016 VL - 2016 ER - TY - CHAP A1 - Schwarz, Simon A1 - Rung, Stefan A1 - Hellmann, Ralf T1 - Simulation of process parameters towards the generation of low spatial frequency LIPSS on dielectric materials T2 - MultiScience - XXX. microCAD International Multidisciplinary Scientific Conference KW - Laserbestrahlung KW - Quarzglas Y1 - 2016 ER - TY - JOUR A1 - Adelmann, Benedikt A1 - Hellmann, Ralf T1 - SiC absorption of near-infrared laser radiation at high temperatures JF - Applied Physics A KW - Laserbestrahlung KW - NIR Y1 - 2016 VL - 2016 IS - 122 SP - 1 EP - 7 ER - TY - JOUR A1 - Adelmann, Benedikt A1 - Hellmann, Ralf T1 - Numerical and experimental study on flexural strength of laser microstructured alumina JF - Advances in Ceramic Science and Engineering KW - Faserlaser KW - Aluminiumoxide Y1 - 2016 VL - 2016 IS - 5 SP - 28 EP - 34 ER - TY - JOUR A1 - Schwarz, Simon A1 - Rung, Stefan A1 - Hellmann, Ralf T1 - Generation of laser-induced periodic surface structures on transparent material-fused silica JF - Applied Physics Letters KW - Laser KW - Oberflächenstruktur KW - Siliziumdioxid KW - Quarzglas Y1 - 2016 VL - 108 IS - 18 SP - 181607 EP - 181607 ER - TY - JOUR A1 - Roth, Gian-Luca A1 - Rung, Stefan A1 - Hellmann, Ralf T1 - Welding of transparent polymers using femtosecond laser JF - Applied Physics A N2 - Based on nonlinear absorption, we report on laser welding of cycloolefin copolymers without any additional absorption layer employing infrared femtosecond laser. To the best of our knowledge, this is the first report of ultrashort laser welding of this material class, revealing a remarkable high processing speed of 20 mm/s in a single pass mode. Using a 1028 nm laser having a pulse duration of 220 fs at a repetition rate of 571 kHz leads to a welding seam width between 38 and 137 μm, depending on the applied laser average power. The welded joint is characterized by a maximum shear strength of 40 MPa. The experimental results are compared to those reported for femtosecond laser welding of PMMA and to those published for using a Thulium fiber laser. KW - Femtosekundenlaser KW - Laserschweißen Y1 - 2016 VL - 122 IS - 2 SP - 86 EP - 90 ER - TY - JOUR A1 - Samhaber, Robert A1 - Schottdorf, Manuel A1 - El Hady, Ahmed A1 - Bröking, Kai A1 - Daus, Andreas A1 - Thielemann, Christiane A1 - Stühmer, Walter A1 - Wolf, Fred T1 - Growing neuronal islands on multi-electrode arrays using an accurate positioning-μCP device JF - Journal of Neuroscience Methods N2 - Background: Multi-electrode arrays (MEAs) allow non-invasive multi-unit recording in-vitro from cultured neuronal networks. For sufficient neuronal growth and adhesion on such MEAs, substrate preparation is required. Plating of dissociated neurons on a uniformly prepared MEA's surface results in the formation of spatially extended random networks with substantial inter-sample variability. Such cultures are not optimally suited to study the relationship between defined structure and dynamics in neuronal networks. To overcome these shortcomings, neurons can be cultured with pre-defined topology by spatially structured surface modification. Spatially structuring a MEA surface accurately and reproducibly with the equipment of a typical cell-culture laboratory is challenging. New method: In this paper, we present a novel approach utilizing micro-contact printing (μCP) combined with a custom-made device to accurately position patterns on MEAs with high precision. We call this technique AP-μCP (accurate positioning micro-contact printing). Comparison with existing methods: Other approaches presented in the literature using μCP for patterning either relied on facilities or techniques not readily available in a standard cell culture laboratory, or they did not specify means of precise pattern positioning. Conclusion: Here we present a relatively simple device for reproducible and precise patterning in a standard cell-culture laboratory setting. The patterned neuronal islands on MEAs provide a basis for high throughput electrophysiology to study the dynamics of single neurons and neuronal networks. KW - MEA KW - Patterning KW - μCP KW - Mehrfachelektrode KW - Neuronales Netz Y1 - 2016 U6 - https://doi.org/10.1016/j.jneumeth.2015.09.022 VL - 2016 IS - 257 SP - 194 EP - 203 ER - TY - JOUR A1 - Flachs, Dennis A1 - Ciba, Manuel T1 - Cell-based sensor chip for neurotoxicity measurements in drinking water JF - Lékař a technika - Clinician and Technology N2 - Our drinking water contains residues of pharmaceuticals. A sub-group of these contaminants are neuro-active substances, the antiepileptic carbamazepine being one of the most relevant. For assessment of the neurotoxicity of this drug at a sub-therapeutic level, a cell-based sensor chip platform has been realized and characterized. For this purpose, a microelectrode array chip was designed and processed in a clean room and optimized in terms of low processing costs and good recording properties. For characterization of the system neuronal cells were plated on microelectrode array chips and electrical activity was measured as a function of applied carbamazepine concentration. We found that the relative spike rate decreased with increasing drug concentration resulted in IC50 values of around 36 μM. This value is five orders of magnitude higher than the maximal dose found in drinking water. IC50 values for burst rate, burst duration and synchrony were slightly higher, suggesting spike rate being a more sensitive parameter to carbamazepine. KW - Microelectrode array KW - Carbamazepine KW - Neurotoxicity KW - Cell-based biosensor KW - Mikroelektrode KW - Array KW - Biosensor KW - Neurotoxizität Y1 - 2016 VL - 46 IS - 2 SP - 46 EP - 50 ER - TY - JOUR A1 - Oster, Stefan A1 - Daus, Andreas A1 - Erbes, Christian A1 - Goldhammer, Michael A1 - Bochtler, Ulrich A1 - Thielemann, Christiane T1 - Long‐term electromagnetic exposure of developing neuronal networks: A flexible experimental setup JF - Bioelectromagnetics N2 - Neuronal networks in vitro are considered one of the most promising targets of research to assess potential electromagnetic field induced effects on neuronal functionality. A few exposure studies revealed there is currently no evidence of any adverse health effects caused by weak electromagnetic fields. Nevertheless, some published results are inconsistent. Particularly, doubts have been raised regarding possible athermal biological effects in the young brain during neuronal development. Therefore, we developed and characterized a flexible experimental setup based on a transverse electromagnetic waveguide, allowing controlled, reproducible exposure of developing neuronal networks in vitro. Measurement of S‐parameters confirmed very good performance of the Stripline in the band of 800–1000 MHz. Simulations suggested a flexible positioning of cell culture dishes throughout a large exposure area, as specific absorption rate values were quite independent of their position (361.7 ± 11.4 mW/kg) at 1 W, 900 MHz. During exposure, thermal drift inside cellular medium did not exceed 0.1 K. Embryonic rat cortical neurons were cultivated on microelectrode array chips to non‐invasively assess electrophysiological properties of electrogenic networks. Measurements were taken for several weeks, which attest to the experimental setup being a reliable system for long‐term studies on developing neuronal tissue. KW - RF exposure setup KW - mobile communication frequencies KW - SAR dosimetry KW - microelectrode array KW - electrophysiology KW - Neuronales Netz KW - Mikroelektrode KW - Array Y1 - 2016 U6 - https://doi.org/10.1002/bem.21974 VL - 2016 IS - 37 SP - 264 EP - 278 ER - TY - CHAP A1 - Mayer, Margot A1 - Arrizabalaga, Onetsine A1 - Ritter, Sylvia A1 - Thielemann, Christiane T1 - Human Embryonic Stem Cell Derived Neurospheres - A Novel Three Dimensional Model For Neurotoxicological Studies T2 - Frontiers N2 - At present, most neurotoxicological studies in the field of microelectrode array (MEA) technology are based on in vivo or in vitro animal models, particularly in mice or rats. These models contributed much to our knowledge about molecular and cellular mechanisms of neurotoxins affecting the central nervous system. Yet, animal models are not necessarily capable to forecasting the effectiveness of treatment in clinical trials. Therefore the development and characterization of suitable neuronal cell models derived from human cells is emerging in the field of toxicity testing. In this study, we present neurospheres (NS) as a new three dimensional (3D) neuronal cell model based on human embryonic stem cells (hESC), coupled onto microelectrode arrays (MEA). This cell-based assay serves as platform to investigate effects of neuroactive substances on network communication. In order to characterize the neurospheres’ reaction, the well-known GABA receptor antagonist bicuculline and the sodium channel blocker carbamazepine are applied. Preliminary results reveal anticipated and physiologically reasonable alterations in network activity. Thus, we have the first evidence that hESC derived NS are a promising 3D cell model for neurotoxicity testing. In further studies, this model will be used to investigate effects of ionizing radiation on network signaling. KW - human embryonic stem cells KW - neurospheres KW - MEA chips KW - 3D KW - Mikroelektrode KW - Array KW - Embryonale Stammzelle Y1 - 2016 U6 - https://doi.org/10.3389/conf.fnins.2016.93.00081 VL - 2016 IS - MEA Meeting 2016 ER - TY - CHAP A1 - Köhler, Tim A1 - Wölfel, Maximilian A1 - Bochtler, Ulrich A1 - Thielemann, Christiane T1 - TETRA specific long-term exposure of neuronal in vitro networks T2 - BioEM2016 KW - Neuronales Netz Y1 - 2016 ER - TY - CHAP A1 - Körbitzer, Berit Silke A1 - Krauß, Peter A1 - Schneider, Jörg A1 - Thielemann, Christiane T1 - Characterization Of Graphene-Coated Microelectrode Arrays For Recording And Stimulation Of Neuronal Cells T2 - Frontiers KW - Mikroelektrode KW - Array KW - Nervenstimulation Y1 - 2016 U6 - https://doi.org/10.3389/conf.fnins.2016.93.00013 VL - 2016 IS - MEA Meeting 2016 ER - TY - CHAP A1 - Krüger, Malte ED - Górka, Jakub T1 - Mobile payments: the second wave T2 - Transforming payment systems in Europe : Palgrave Macmillan studies in banking and financial institutions KW - Elektronischer Zahlungsverkehr Y1 - 2016 SP - 214 EP - 235 ER -