TY - JOUR A1 - Alves, Caroline L. A1 - Wissel, Lennart A1 - Capetian, Philipp A1 - Thielemann, Christiane T1 - Functional connectivity and convolutional neural networks for automatic classification of EEG data JF - Clinical Neurophysiology KW - Elektroencephalographie KW - Neuronales Netz Y1 - 2022 U6 - https://doi.org/https://doi.org/10.1016/j.clinph.2022.01.086 VL - 2022 IS - 137 SP - e37 EP - e47 ER - TY - JOUR A1 - Bouillet, Thomas A1 - Ciba, Manuel A1 - Alves, Caroline L. A1 - Rodrigues, Francisco A. A1 - Thielemann, Christiane A1 - Colin, Morvane A1 - Buée, Luc A1 - Halliez, Sophie T1 - Revisiting the involvement of tau in complex neural network remodeling: analysis of the extracellular neuronal activity in organotypic brain slice co-cultures JF - Journal of Neural Engineering N2 - Objective: Tau ablation has a protective effect in epilepsy due to inhibition of the hyperexcitability/hypersynchrony. Protection may also occur in transgenic models of Alzheimer's disease by reducing the epileptic activity and normalizing the excitation/inhibition imbalance. However, it is difficult to determine the exact functions of tau, because tau knockout (tauKO) brain networks exhibit elusive phenotypes. In this study, we aimed to further explore the physiological role of tau using brain network remodeling. Approach: The effect of tau ablation was investigated in hippocampal-entorhinal slice co-cultures during network remodeling. We recorded the spontaneous extracellular neuronal activity over two weeks in single-slice cultures and co-cultures from control and tauKO mice. We compared the burst parameters and applied concepts and analytical tools intended for the analysis of the network synchrony and connectivity. Main results: Comparison of the control and tauKO co-cultures revealed that tau ablation had an anti-synchrony effect on the hippocampal-entorhinal two-slice networks at late stages of culture, in line with the literature. Differences were also found between the single-slice and co-culture conditions, which indicated that tau ablation had differential effects at the sub-network scale. For instance, tau ablation was found to have an anti-synchrony effect on the co-cultured hippocampal slices throughout the culture, possibly due to a reduction in the excitation/inhibition ratio. Conversely, tau ablation led to increased synchrony in the entorhinal slices at early stages of the co-culture, possibly due to homogenization of the connectivity distribution. Significance: The new methodology presented here proved useful for investigating the role of tau in the remodeling of complex brain-derived neural networks. The results confirm previous findings and hypotheses concerning the effects of tau ablation on neural networks. Moreover, the results suggest, for the first time, that tau has multifaceted roles that vary in different brain sub-networks. KW - Neuronales Netz KW - Alzheimerkrankheit KW - Gehirn KW - Schnittpräparat Y1 - 2022 U6 - https://doi.org/DOI 10.1088/1741-2552/aca261 VL - 2022 IS - November SP - 1 EP - 2 ER - TY - CHAP A1 - Seitz, Christopher A1 - Krini, Mohammed T1 - Schätzung der Spektralen Einhüllenden - Ein Vergleich von Tiefen Neuronalen Netzen und Codebüchern T2 - 20th Electronic Speech Signal Processing Conference (ESSV ’19), Dresden KW - Sprachverarbeitung KW - Neuronales Netz Y1 - 2019 VL - 2019 ER - TY - THES A1 - Köhler, Tim T1 - Auswirkungen elektromagnetischer Strahlung auf die elektrophysiologischen Eigenschaften neuronaler und kardialer Zellnetzwerke KW - Neuronales Netz KW - Elektromagnetische Strahlung Y1 - 2019 UR - https://tuprints.ulb.tu-darmstadt.de/id/eprint/8544 ER - TY - THES A1 - Mayer, Margot T1 - Einfluss ionisierender Strahlung auf die elektrophysiologischen Eigenschaften sich entwickelnder neuronaler Netzwerke KW - Ionisierende Strahlung KW - Neuronales Netz Y1 - 2017 UR - http://nbn-resolving.de/urn:nbn:de:tuda-tuprints-70283 ER - TY - THES A1 - Nick, Christoph T1 - Mikrointegrierte Nanostrukturen mit hohem Aspektverhältnis als neuronale Schnittstelle KW - Neuronales Netz KW - Mikroelektrode Y1 - 2015 UR - http://tuprints.ulb.tu-darmstadt.de/4595/7/Dissertation%20-%20Christoph%20Nick.pdf ER -