TY - JOUR A1 - Oster, Stefan A1 - Daus, Andreas A1 - Erbes, Christian A1 - Goldhammer, Michael A1 - Bochtler, Ulrich A1 - Thielemann, Christiane T1 - Long‐term electromagnetic exposure of developing neuronal networks: A flexible experimental setup JF - Bioelectromagnetics N2 - Neuronal networks in vitro are considered one of the most promising targets of research to assess potential electromagnetic field induced effects on neuronal functionality. A few exposure studies revealed there is currently no evidence of any adverse health effects caused by weak electromagnetic fields. Nevertheless, some published results are inconsistent. Particularly, doubts have been raised regarding possible athermal biological effects in the young brain during neuronal development. Therefore, we developed and characterized a flexible experimental setup based on a transverse electromagnetic waveguide, allowing controlled, reproducible exposure of developing neuronal networks in vitro. Measurement of S‐parameters confirmed very good performance of the Stripline in the band of 800–1000 MHz. Simulations suggested a flexible positioning of cell culture dishes throughout a large exposure area, as specific absorption rate values were quite independent of their position (361.7 ± 11.4 mW/kg) at 1 W, 900 MHz. During exposure, thermal drift inside cellular medium did not exceed 0.1 K. Embryonic rat cortical neurons were cultivated on microelectrode array chips to non‐invasively assess electrophysiological properties of electrogenic networks. Measurements were taken for several weeks, which attest to the experimental setup being a reliable system for long‐term studies on developing neuronal tissue. KW - RF exposure setup KW - mobile communication frequencies KW - SAR dosimetry KW - microelectrode array KW - electrophysiology KW - Neuronales Netz KW - Mikroelektrode KW - Array Y1 - 2016 U6 - https://doi.org/10.1002/bem.21974 VL - 2016 IS - 37 SP - 264 EP - 278 ER - TY - CHAP A1 - Oster, Stefan A1 - Daus, Andreas A1 - Goldhammer, Michael A1 - Bochtler, Ulrich A1 - Thielemann, Christiane T1 - A Flexible RF Exposure Setup for Long-term Electrophysiological Investigations on Biological Samples in Vitro T2 - Progress In Electromagnetics Research Symposium Abstracts, Stockholm, Schweden KW - Neuronales Netz KW - Array KW - Mikroelektrode Y1 - 2013 ER - TY - CHAP A1 - Daus, Andreas A1 - Oster, Stefan A1 - Erbes, Christian A1 - Goldhammer, Michael A1 - Bochtler, Ulrich A1 - Thielemann, Christiane T1 - Electromagnetic exposure of neuronal networks on microelectrode arrays T2 - U.R.S.I. Landesausschuss in der Bundesrepublik Deutschland e.V., Kleinheubacher Tagung, Miltenberg, Abstracts KW - Neuronales Netz KW - Mikroelektrode KW - Array Y1 - 2013 SP - 29 EP - 30 ER -