TY - JOUR A1 - Alves, Caroline A1 - Ciba, Manuel A1 - de O Toutain, Thaise GL A1 - Moura Porto, Joel Augusto A1 - de Sena, Eduardo Pondé A1 - Thielemann, Christiane A1 - Rodrigues, Francisco A T1 - On the advances in machine learning and complex network measures to an EEG dataset from DMT experiments JF - Journal of Physics: Complexity N2 - There is a growing interest in the medical use of psychedelic substances, as preliminary studies using them for psychiatric disorders have shown positive results. In particular, one of these substances is N, N-dimethyltryptamine (DMT), an agonist serotonergic psychedelic that can induce profound alterations in the state of consciousness. In this work, we use an exploratory tool to reveal DMT-induced changes in brain activity using EEG data and provide new insights into the mechanisms of action of this psychedelic substance. We used a two-class classification based on (A) the connectivity matrix or (B) complex network measures derived from it as input to a support vector machine. We found that both approaches could detect changes in the brain's automatic activity, with case (B) showing the highest AUC (89%), indicating that complex network measurements best capture the brain changes that occur due to DMT use. In the second step, we ranked the features that contributed the most to this result. For case (A), we found that differences in the high alpha, low beta, and delta frequency bands were most important in distinguishing between the state before and after DMT inhalation, which is consistent with the results described in the literature. Further, the connection between the temporal (TP8) and central cortex (C3) and between the precentral gyrus (FC5) and the lateral occipital cortex (P8) contributed most to the classification result. The connection between regions TP8 and C3 has been found in the literature associated with finger movements that might have occurred during DMT consumption. However, the connection between cortical areas FC5 and P8 has not been found in the literature and is presumably related to the volunteers' emotional, visual, sensory, perceptual, and mystical experiences during DMT consumption. For case (B), closeness centrality was the most crucial complex network measure. Furthermore, we discovered larger communities and longer average path lengths when DMT was used and the converse when not, showing that the balance between functional segregation and integration had been disrupted. These findings support the idea that cortical brain activity becomes more entropic under psychedelics. Overall, a robust computational workflow has been developed here with interpretability of how DMT (or other psychedelics) modify brain networks and insights into their mechanism of action. Finally, the same methodology applied here may help interpret EEG time series from patients who consumed other psychedelic drugs. KW - Neuronales Netz KW - Halluzinogen Y1 - 2024 U6 - https://doi.org/10.1088/2632-072X/ad1c68 VL - 2024 IS - 1 SP - 1 EP - 2 ER - TY - JOUR A1 - Stier, Simon P. A1 - Xu, Xukuan A1 - Gold, Lukas A1 - Möckel, Michael T1 - Ontology-Based Battery Production Dataspace and Its Interweaving with Artificial Intelligence-Empowered Data Analytics JF - Energy Technology N2 - Heart disease, also known as cardiovascular disease, encompasses a variety of heart conditions that can result in sudden death for many people. Examples include high blood pressure, ischaemia, irregular heartbeats and pericardial effusion. Electrocardiogram (ECG) signal analysis is frequently used to diagnose heart diseases, providing crucial information on how the heart functions. To analyse ECG signals, quantile graphs (QGs) is a method that maps a time series into a network based on the time-series fluctuation proprieties. Here, we demonstrate that the QG methodology can differentiate younger and older patients. Furthermore, we construct networks from the QG method and use machine-learning algorithms to perform the automatic diagnosis, obtaining high accuracy. Indeed, we verify that this method can automatically detect changes in the ECG of elderly and young subjects, with the highest classification performance for the adjacency matrix with a mean area under the receiver operating characteristic curve close to one. The findings reported here confirm the QG method’s utility in deciphering intricate, nonlinear signals like those produced by patient ECGs. Furthermore, we find a more significant, more connected and lower distribution of information networks associated with the networks from ECG data of the elderly compared with younger subjects. Finally, this methodology can be applied to other ECG data related to other diseases, such as ischaemia. KW - Batterie KW - Künstliche Intelligenz Y1 - 2024 UR - https://onlinelibrary.wiley.com/doi/epdf/10.1002/ente.202301305 U6 - https://doi.org/https://doi.org/10.1002/ente.202301305 VL - 2024 IS - 2301305 SP - 1 EP - 13 ER - TY - JOUR A1 - Trent, Davis A1 - Thielemann, Christiane A1 - Monici, Monica T1 - How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms? JF - npj Microgravity N2 - Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment offers the unique opportunity to carry out experiments without gravity, helping us not only to understand the effects of gravitational alterations on biological systems but also the mechanisms underlying mechanoperception and cell/tissue response to mechanical and gravitational stresses. Despite the progress made so far, for future space exploration programs it is necessary to increase our knowledge on the mechanotransduction processes as well as on the molecular mechanisms underlying microgravity-induced cell and tissue alterations. This white paper reports the suggestions and recommendations of the SciSpacE Science Community for the elaboration of the section of the European Space Agency roadmap “Biology in Space and Analogue Environments” focusing on “How are cells and tissues influenced by gravity and what are the gravity perception mechanisms?” The knowledge gaps that prevent the Science Community from fully answering this question and the activities proposed to fill them are discussed. KW - Zellkultur KW - Schwere KW - Raumfahrtbiologie Y1 - 0024 UR - https://rdcu.be/dyCjL U6 - https://doi.org/10.1038/s41526-024-00357-9 VL - 2014 IS - 10 / 16 SP - 1 EP - 7 ER - TY - JOUR A1 - Kefer, Stefan A1 - Limbach, Tobias A1 - Pape, Natalie A1 - Klamt, Kathrin A1 - Schmauss, Bernhard A1 - Hellmann, Ralf T1 - Birefringence in Injection-Molded Cyclic Olefin Copolymer Substrates and Its Impact on Integrated Photonic Structures JF - Polymers N2 - This contribution quantifies the birefringence within injection-molded cyclic olefin copolymer plates and discusses its impact on the mechanical properties of the plates. It also focuses on the impact of birefringence on integrated waveguides and Bragg gratings and provides fabrication guidelines for such structures. The anisotropy in all three dimensions of the workpiece is examined by means of polarimetry and a prism coupler. It is found that the birefringence is inhomogenously distributed within the workpieces, whereas the maximum birefringence not only varies locally, but also depends on the observation direction. Overall, a maximum birefringence of 10 × 10−4 is found at the plate’s surface near the injection gate. The anisotropy then reduces exponentially towards the center of the workpiece and saturates at 1.8 × 10−4, in a depth of 0.4 mm. Thus, the birefringence strongly affects near-surface photonic structures. It is found that, depending on their orientation and the local birefringence of the substrate, waveguides and Bragg gratings fabricated with comparable parameters behave completely differently in terms of polarization-dependent optical attenuation, cross-sectional intensity distribution and Bragg reflection signal. For example, the support of the TM mode can vary between total loss and an optical attenuation of 0.9 dB × cm−1. In consequence, this study underlines the importance of quantifying the birefringent state of an injection-molded cyclic olefin copolymer workpiece if it is supposed to serve as a substrate for integrated photonic structures. The study furthermore demonstrates that birefringence effects can be omitted by burying the photonic structures deeper into the volume of the thermoplastic. KW - cyclic olefin copolymer KW - birefringence KW - integrated photonics KW - Bragg grating KW - injection molding KW - Bragg-Reflektor KW - Wellenleiter KW - Doppelbrechung Y1 - 2024 UR - https://www.mdpi.com/2073-4360/16/2/168 U6 - https://doi.org/10.3390/polym16020168 VL - 16 IS - 2 SP - 168 EP - 168 ER - TY - JOUR A1 - Dobrovolskij, Dascha A1 - Stark, Hans-Georg T1 - Synthetic demand data generation for individual electricity consumers: Inpainting JF - Energy and AI N2 - In this contribution we deal with the problem of producing “reasonable” data, when considering recorded energy consumption data, which are at certain sections incomplete and/or erroneous. This task is important, when energy providers employ prediction models for expected energy consumption, which are based on past recorded consumption data, which then of course should be reliable and valid. In a related contribution Yilmaz (2022), GAN-based methods for producing such “artificial data” have been investigated. In this contribution, we describe an alternative and complementary method based on signal inpainting, which has been successfully applied to audio processing Lieb and Stark (2018). After giving a short overview of the theory of proximity-based convex optimization, we describe and adapt an iterative inpainting scheme to our problem. The usefulness of this approach is demonstrated by analyzing real-world-data provided by a German energy supplier. KW - Energieverbrauch KW - Energieversorgungsunternehmen Y1 - 2024 VL - 15 IS - Januar 2024 SP - 100312 EP - 100320 ER - TY - JOUR A1 - Raiyn, Jamal A1 - Weidl, Galia T1 - Predicting Autonomous Driving Behavior through Human Factor Considerations in Safety-Critical Events JF - Smart Cities N2 - This paper investigates the ability of autonomous driving systems to predict outcomes by considering human factors like gender, age, and driving experience, particularly in the context of safety-critical events. The primary objective is to equip autonomous vehicles with the capacity to make plausible deductions, handle conflicting data, and adjust their responses in real-time during safety-critical situations. A foundational dataset, which encompasses various driving scenarios such as lane changes, merging, and navigating complex intersections, is employed to enable vehicles to exhibit appropriate behavior and make sound decisions in critical safety events. The deep learning model incorporates personalized cognitive agents for each driver, considering their distinct preferences, characteristics, and requirements. This personalized approach aims to enhance the safety and efficiency of autonomous driving, contributing to the ongoing development of intelligent transportation systems. The efforts made contribute to advancements in safety, efficiency, and overall performance within autonomous driving systems. To describe the causal relationship between external factors like weather conditions and human factors, and safety-critical driver behaviors, various data mining techniques can be applied. One commonly used method is regression analysis. Additionally, correlation analysis is employed to reveal relationships between different factors, helping to identify the strength and direction of their impact on safety-critical driver behavior. Keywords: car following; decision making; driving behavior; naturalistic driving studies; safety-critical events; cognitive vehicles 1. Introduction Despite the increasing prevalence of vehicle automation, the persistently high number of car crashes remains a concern. Safety-critical events in human-driven scenarios have become more intricate and partially uncontrollable due to unforeseen circumstances. Investigating human driving behavior is imperative to establish traffic baselines for mixed traffic, encompassing traditional, automated, and autonomous vehicles (AVs). Various factors, such as weather conditions affecting visibility in longitudinal car-following (CF) behavior [1,2], influence human driving behavior [3]. Car-following behavior, illustrating how a following vehicle responds to the lead vehicle in the same lane, is a crucial aspect. Existing car-following models often make assumptions about homogeneous drivers, neglecting significant heterogeneity in driving experience, gender, character, emotions, and sociological, psychological, and physiological traits. Failing to account for this heterogeneity hampers a comprehensive understanding of car-following behavior, limiting model accuracy and applicability. In the development of more realistic car-following models for mixed traffic, acknowledging the diversity among drivers is crucial. By including individual variations such as risk-taking tendencies, reaction times, decision-making processes, and driving styles, the modeling of real-world driving complexities can be improved. Simplifying drivers into a few categories overlooks the richness and variety of their characteristics, prompting the need for a more comprehensive approach to capture nuances within different driver profiles. To address these Smart Cities KW - Autonomes Fahrzeug KW - Mensch-Maschine-Kommunikation Y1 - 2024 UR - https://www.mdpi.com/2624-6511/7/1/18 U6 - https://doi.org/https://doi.org/10.3390/ smartcities7010018 VL - 7 IS - 1 SP - 460 EP - 474 ER - TY - CHAP A1 - Rötzel, Peter A1 - Fehrenbacher, Dennis T1 - Information Overload in Decision Support Systems T2 - International Symposium on Accounting Information Systems KW - Information Overload KW - Information Systems KW - Controlling KW - Entscheidungsunterstützungssystem KW - Information KW - Überlastung Y1 - 0024 VL - 2024 CY - Paphos ER - TY - JOUR A1 - Flachs, Dennis A1 - Zhukov, Sergey A1 - Zech, Isabella A1 - Schreck, Timo A1 - Belle, Stefan A1 - von Seggern, Heiinz A1 - Kupnik, Mario A1 - Altmann, Alexander Anton A1 - Thielemann, Christiane T1 - Enzymatic Self-Degradable PLA-Based Electrets JF - Journal of Polymers and the Environment N2 - In recent years, the demand for sustainable and degradable materials and electronic devices has increased significantly. Among a range of biodegradable polymers, poly(lactic acid) (PLA) is a good alternative to conventional petrol-based polymers because of its attractive mechanical properties and its easy processability. Recently, PLA has also been described as a promising dielectric material with piezoelectric and electret properties. We expect that PLA—after further optimization— will play an important role as a material for environmentally friendly sensors in the future, where first applications such as air filters and pressure sensors have already been proposed. However, degradation under normal ambient conditions is very slow, and an accelerated and controllable degradation process is highly desirable for any type of PLA-based sensors. Enzymatic hydrolysis with embedded enzymes has been proposed as an approach to accelerate and control degradation. In this work, we investigate the properties of PLA in terms of dielectric and mechanical properties with a focus on its ability to store charges after the enzyme proteinase K (Trit. album) has been incorporated. Results reveal that proteinase K has a positive effect on the charge stability of solvent-cast PLA electrets after complete evaporation of the solvent. Furthermore, we observed a concentration-dependent acceleration of mass loss in a Tris-HCl buffer. A fast degradation within only one day occurred at a concentration of 6 wt% proteinase K. KW - Biologisch abbaubarer Kunststoff Y1 - 2024 U6 - https://doi.org/Journal of https://doi.org/10.1007/s10924-024-03240-6 VL - 2024 IS - 1 SP - 1 EP - 11 ER - TY - CHAP A1 - Sauer, Jonas A1 - Hoppe, Florian A1 - Bruhm, Hartmut T1 - Modellierung des Antriebsstrangs einer Textilmaschine zum Zweck der modellbasierten Steuerung T2 - Tagungsband AALE 2024, 20. Konferenz N2 - Zur Produktion von gewirkten Textilien werden mehrere Nadeln auf eine Legebarre gesetzt, die durch Servoantriebe positioniert werden. Aufgrund der erzwungenen Bewegung kann der Antriebsstrang bei hohen Drehzahlen zur Schwingung angeregt werden. Die richtige Wahl der Steuerkurven ist daher eine sehr wichtige und anspruchsvolle Aufgabe, die durch ein Antriebsstrangmodell unterstützt werden soll. Dafür wird am Beispiel eines Teststands ein Modell des Antriebsstranges in MATLAB/Simulink® entwickelt. Für das Antriebsstrangmodell müssen eine geeignete Modellordnung und Modellparameter gewählt werden. Die unbekannten Modellparameter werden durch eine Parameteridentifikation ermittelt. Mit einer Validierung wird ein geeignetes Anregungsspektrum für die Bestimmung der Modellordnung und die Parameteridentifikation ermittelt. KW - Textilmaschine KW - Triebstrang KW - MATLAB KW - SIMULINK KW - Modellierung KW - Grey-Box-Modell KW - Parameteridentifikation KW - MATLAB/ Simulink® KW - Inverses Modell KW - Input Shaping Y1 - 2024 U6 - https://doi.org/https://doi.org/10.33968/2024.33 VL - 2024 ER - TY - CHAP A1 - Smeets, Mario A1 - Rötzel, Peter T1 - The Moderating Role of Non-Monetary Gamification in Reducing Algorithm Aversion in the Adoption of AI-based Decision Support Systems T2 - ECIS - European Conference on Information Systems N2 - Integrating artificial intelligence (AI) into decision-making processes is key to improving organizational performance. However, trust in AI-based decision support systems (DSSs), similar to other information systems, is important for successful integration. A disruptive phenomenon, “algorithm aversion”, can impede AI trust and, thus, acceptance. Although AI recommendations outperform human recommendations in different decision-making fields, individuals underweight recommendations from AI-based DSSs compared to human decision-makers due to a lack of AI trust. We conducted a lab experiment to investigate the role of AI recommendations in workplace-related tasks, first focusing on the mediating effect of AI trust and the negative impact of algorithm aversion on decision-making performance and the moderating effect of technical competence. Second, we analyzed the ability of gamification to reduce this phenomenon. We provide evidence regarding how to enhance decision-making performance when AI recommendations are deployed and identify countermeasures against algorithm aversion to facilitate the adoption of AI-based DSSs. KW - Decision Support Systems KW - Algorithm Aversion KW - Gamification KW - Künstliche Intelligenz KW - Gamification Y1 - 2024 VL - 2024 IS - 1 ER - TY - RPRT A1 - Jost, Thomas A1 - Mink, Reimund T1 - Central bank losses and commercial bank profits - unexpected and unfair? T2 - IMFS Working Paper Series No. 199 N2 - The Eurosystem and the Deutsche Bundesbank will incur substantial losses in 2023 that are likely to persist for several years. Due to the massive purchases of securities in the last 10 years, especially of government bonds, the banks' excess reserves have risen sharply. The resulting high interest payments to the banks since the turnaround in monetary poli-cy, with little income for the large-scale securities holdings, led to massive criticism. The banks were said to be making "unfair" profits as a result, while the fiscal authorities had to forego the previously customary transfers of central bank profits. Populist demands to limit bank profits by, for example, drastically increasing the minimum reserve ratios in the Eurosystem to reduce excess reserves are creating new severe problems and are neither justified nor helpful. Ultimately, the EU member states have benefited for a very long time from historically low interest rates because of the Eurosystem's extraordinary loose monetary policy and must now bear the flip side consequences of the massive expansion of central bank balance sheets during the necessary period of monetary policy normalisa-tion. KW - Notenbank KW - Geldpolitik KW - Geschäftsbank KW - Deutsche Bundesbank KW - Central bank losses, monetary policy, ecb, minimum reserve Y1 - 2024 UR - https://www.econbiz.de/Record/central-bank-losses-and-commercial-bank-profits-unexpected-and-unfair-jost-thomas/10014476309 ER - TY - GEN A1 - Jost, Thomas A1 - Mink, Reimund T1 - How to deal with the negative effects of inflated central bank balance sheets? N2 - Due to the massive purchases of securities in the last 15 years central banks incur substantial losses likely to persist for several years. On the other hand, the banking sector gains large profits from interest payments on their excess reserves holdings. Central banks and fiscal authorities must now bear the flip side consequences of their bond purchase programs. Populist demands to limit bank profits by drastically increasing minimum reserve ratios in the Eurosystem are creating new severe problems. Instead, a consistent and faster normalisation of central bank balance sheets would be desirable. Central banks should also no longer be central players in government bond markets to restore the lost boundaries between fiscal and monetary policy. KW - Europäische Zentralbank KW - Geldpolitik KW - Notenbank KW - ecb, minimum reserve, monetary policy Y1 - 2024 UR - https://www.suerf.org/wp-content/uploads/2024/04/SUERF-Policy-Brief-860_Jost-Mink.pdf SP - 1 EP - 4 ER - TY - BOOK A1 - Hofmann, Georg Rainer A1 - Scheidler, Percy T1 - Chief Qualification Officer (CQO) und Weiterbildungsmentoren N2 - Alte Weisheiten wie „Schuster bleib bei deinem Leisten!“ oder auch „Was das Hänschen nicht lernt, das lernt der Hans nimmermehr“ haben in der heutigen, sich wandelnden Arbeitswelt ihren Sinn verloren. Das bedeutet, dass sich die komplette Belegschaft lebenslang weiterbilden muss, idealerweise mit Unterstützung des Arbeitgebers. In der Veröffentlichung "Chief Qualification Officers (CQOs) und Weiterbildungsmentoren - Thesen und Argumente" wird unter anderem das paradoxe Verhältnis von Arbeitslosigkeit und Fachkräftemangel erläutert, das Marktversagen im Weiterbildungsmarkt beschrieben und die Forderung nach einem Weiterbildungsbeauftragten (CQO) begründet. KW - Weiterbildungsmentoren KW - Weiterbildung KW - Erwachsenenbildung KW - Lebenslanges Lernen Y1 - 2024 UR - https://www.mainproject.eu/shop SN - 978-3-9826305-0-2 ER - TY - JOUR A1 - Szewczyk, Nathaniel J. A1 - Monici, Monica A1 - Thielemann, Christiane T1 - How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems? JF - npj Microgravity N2 - Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, “Biology in Space and Analogue Environments”, focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: “How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?” The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed. KW - Weltraumforschung KW - Biowissenschaften Y1 - 2024 U6 - https://doi.org/DOI: 10.1038/s41526-024-00395-3 VL - 2024 IS - 10 SP - 1 EP - 5 ER - TY - JOUR A1 - Sallum, Loriz Francisco A1 - Alves, Caroline A1 - Thielemann, Christiane A1 - Rodrigues, Francisco A. T1 - Revealing patterns in major depressive disorder with machine learning and networks JF - medrxiv N2 - Major depressive disorder (MDD) is a multifaceted condition that affects millions of people worldwide and is a leading cause of disability. There is an urgent need for an automated and objective method to detect MDD due to the limitations of traditional diagnostic approaches. In this paper, we propose a methodology based on machine and deep learning to classify patients with MDD and identify altered functional connectivity patterns from EEG data. We compare several connectivity metrics and machine learning algorithms. Complex network measures are used to identify structural brain abnormalities in MDD. Using Spearman correlation for network construction and the SVM classifier, we verify that it is possible to identify MDD patients with high accuracy, exceeding literature results. The SHAP (SHAPley Additive Explanations) summary plot highlights the importance of C4-F8 connections and also reveals dysfunction in certain brain areas and hyperconnectivity in others. Despite the lower performance of the complex network measures for the classification problem, assortativity was found to be a promising biomarker. Our findings suggest that understanding and diagnosing MDD may be aided by the use of machine learning methods and complex networks. KW - Depression KW - Elektroencephalographie KW - Maschinelles Lernen Y1 - 2024 U6 - https://doi.org/doi.org/10.1101/2024.06.07.24308619 VL - 2024 IS - 1 SP - 1 EP - 17 ER - TY - JOUR A1 - Sauer, Timm A1 - Gorks, Manuel A1 - Spielmann, Luca A1 - Zindler, Klaus A1 - Jumar, Ulrich T1 - Adaptive self-learning controllers with disturbance compensation for automatic track guidance of industrial trucks JF - SICE Journal of Control, Measurement and System Integration N2 - This paper presents an extended control concept for automatic track guidance of industrial trucks in intralogistic systems. It is based on Reinforcement Learning (RL), a method of Artificial Intelligence (AI). The presented approach is able to adapt itself to different industrial truck variants and to the associated specific vehicle parameters. In order to avoid starting the whole training of the controller for each truck variant from scratch, the training process is divided into two steps. In the first step, the controller is trained on a simplified linear model using parameters of a nominal vehicle variant. Based on this, the control parameters are only fine-tuned in the second step using a more complex nonlinear model, representing the real industrial truck. In this way, the controller is adapted to the actual truck variant and the corresponding parameter values. By using the nonlinear model, it can be ensured that the forklift’s dynamic is approximated within the entire operating range, even at high steering angles. Moreover, the influence of the disturbance variable of the system (path curvature) is compensated by considering this a priori knowledge within the control design. Therefore, the Artificial Neural Networks (ANN) of the RL controller and the observation vector are suitably adjusted. In this way, the occurring path curvatures can be considered in both training steps and the control parameters can be optimized accordingly. Thus, the influence of the disturbance variable can be compensated, which significantly improves the control quality. In order to demonstrate this, the new approach is compared to an RL control concept, which is not considering the disturbance variable and to a classical two-degrees-of-freedom (2DoF) control approach. KW - Flurförderer KW - Spurführung KW - Künstliche Intelligenz Y1 - 2023 U6 - https://doi.org/10.1080/18824889.2023.2183009 VL - 2023 IS - Vol. 16, No. 1 SP - 84 EP - 97 ER - TY - CHAP A1 - Weber, Maximilian A1 - Pedell, Burkhard A1 - Rötzel, Peter T1 - Resilience-Oriented Management Control Systems as a Translation Mechanism of Resilience Strategy into Managerial Action—A Systematic Review T2 - 45th Annual Congress of the European Accounting Association KW - Management KW - Kontrollsystem KW - Resilienz Y1 - 2023 VL - 2023 IS - 45 SP - 1 EP - 43 ER - TY - JOUR A1 - Alves, Caroline A1 - Toutain, Thaise A1 - Aguiar, Patricia A1 - Pineda, Aruane M. A1 - Roster, Kirstin A1 - Thielemann, Christiane A1 - Porto, Joel A1 - Rodrigues, Francisco A. T1 - Diagnosis of autism spectrum disorder based on functional brain networks and machine learning JF - Scientific Reports N2 - Autism is a multifaceted neurodevelopmental condition whose accurate diagnosis may be challenging because the associated symptoms and severity vary considerably. The wrong diagnosis can affect families and the educational system, raising the risk of depression, eating disorders, and self-harm. Recently, many works have proposed new methods for the diagnosis of autism based on machine learning and brain data. However, these works focus on only one pairwise statistical metric, ignoring the brain network organization. In this paper, we propose a method for the automatic diagnosis of autism based on functional brain imaging data recorded from 500 subjects, where 242 present autism spectrum disorder considering the regions of interest throughout Bootstrap Analysis of Stable Cluster map. Our method can distinguish the control group from autism spectrum disorder patients with high accuracy. Indeed the best performance provides an AUC near 1.0, which is higher than that found in the literature. We verify that the left ventral posterior cingulate cortex region is less connected to an area in the cerebellum of patients with this neurodevelopment disorder, which agrees with previous studies. The functional brain networks of autism spectrum disorder patients show more segregation, less distribution of information across the network, and less connectivity compared to the control cases. Our workflow provides medical interpretability and can be used on other fMRI and EEG data, including small data sets. KW - Maschinelles Lernen KW - Gehirn KW - Neuronales Netz KW - Autismus Y1 - 2023 UR - https://rdcu.be/dcwIP U6 - https://doi.org/https://doi.org/10.1038/s41598-023-34650-6 VL - 2023 IS - 13/8072 SP - 1 EP - 20 ER - TY - JOUR A1 - Thielemann, Christiane A1 - Krstić, Nenad A1 - Jüttner, Jens A1 - Giegerich, Lars A1 - Mayer, Margot A1 - Knuth, Monika A1 - Müller, Achim T1 - 3D printed biosensor for continuous glucose measurement in cell cultures JF - Annals of 3D Printed Medicine N2 - A novel 3D-printed glucose sensor is presented for cell culture application. Glucose sensing was performed using a fluorescence resonance energy transfer (FRET)-based assay principle based on ConA and dextran. Both molecules are encapsulated in alginate microspheres and embedded in the UV-curable, stable hydrogel polyvinyl alcohol (PVA). The rheology of the formulation was adapted to obtain good properties for an extrusion-based printing process. The printed sensor structures were tested for their ability to detect glucose in vitro. A proportional increase in fluorescence intensity was observed in a concentration range of 0 - 2 g/L glucose. Tests with HEK cell cultures also showed good cell compatibility and excellent adhesion properties on plasma-treated Petri dishes. The printed sensors were able to detect the glucose decay associated with the metabolic activities of the fast-growing HEK cells in the cell culture medium over ten days. The proof-of-principle study shows that metabolic processes in cell cultures can be monitored with the new printed sensor using a standard fluorescence wide-field microscope. KW - Bioprinting, FRET, Enzyme-free glucose sensor, PVA hydrogel KW - Biosensor KW - 3D-Druck KW - Zellkultur Y1 - 2023 U6 - https://doi.org/https://doi.org/10.1016/j.stlm.2023.100111 VL - 2023 IS - - SP - - EP - - ER - TY - CHAP A1 - Rötzel, Peter A1 - Bustorff, Naomi A1 - Kokott, Peter T1 - Analysis of the Impact of Recommendations from Intelligent Expert Systems on Personal Trust and Decision-Making Performance KW - Artificial Intelligence KW - Trust KW - Intelligent Expert Systems KW - Künstliche Intelligenz KW - Vertrauen Y1 - 2023 ER -