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<export-example>
  <doc>
    <id>1515</id>
    <completedYear>2018</completedYear>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>93</pageFirst>
    <pageLast>100</pageLast>
    <pageNumber/>
    <edition/>
    <issue>16</issue>
    <volume>2018</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2018-02-01</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">High LET radiation shows no major cellular and functional effects on primary cardiomyocytes in vitro</title>
    <abstract language="eng">It is well known that ionizing radiation causes adverse effects on various mammalian tissues. However, there is little information on the biological effects of heavy ion radiation on the heart. In order to fill this gap, we systematically examined DNA-damage induction and repair, as well as proliferation and apoptosis in avian cardiomyocyte cultures irradiated with heavy ions such as titanium and iron, relevant for manned space-flight, and carbon ions, as used for radiotherapy. Further, and to our knowledge for the first time, we analyzed the effect of heavy ion radiation on the electrophysiology of primary cardiomyocytes derived from chicken embryos using the non-invasive microelectrode array (MEA) technology. As electrophysiological endpoints beat rate and field action potential duration were analyzed.&#13;
&#13;
The cultures clearly exhibited the capacity to repair induced DNA damage almost completely within 24 h, even at doses of 7 Gy, and almost completely recovered from radiation-induced changes in proliferative behavior. Interestingly, no significant effects on apoptosis could be detected. Especially the functionality of primary cardiac cells exhibited a surprisingly high robustness against heavy ion radiation, even at doses of up to 7 Gy. In contrast to our previous study with X-rays the beat rate remained more or less unaffected after heavy ion radiation, independently of beam quality. The only change we could observe was an increase of the field action potential duration of up to 30% after titanium irradiation, diminishing within the following three days. This potentially pathological observation may be an indication that heavy ion irradiation at high doses could bear a long-term risk for cardiovascular disease induction.</abstract>
    <parentTitle language="eng">Life Sciences in Space Research</parentTitle>
    <identifier type="doi">10.1016/j.lssr.2018.01.001</identifier>
    <enrichment key="copyright">0</enrichment>
    <licence>Keine Lizenz - es gilt das deutsche Urheberrecht</licence>
    <author>Anja Heselich</author>
    <author>Johannes Frieß</author>
    <author>Sylvia Ritter</author>
    <author>Naja Benz</author>
    <author>Paul Layer</author>
    <author>Christiane Thielemann</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cardiomyocytes</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Heavy ion irradiation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Space radiation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Electrophysiology</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>MEA-technology</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Zellkultur</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Herzmuskelzelle</value>
    </subject>
    <collection role="forschungsschwerpunkte" number="">Artifical Intelligence and Data Science</collection>
    <collection role="forschungsschwerpunkte" number="">Clean Tech</collection>
    <collection role="forschungsschwerpunkte" number="">Intelligent Sensors and Signals</collection>
    <collection role="forschungsschwerpunkte" number="">Material Testing &amp; Sensor Technology</collection>
  </doc>
  <doc>
    <id>61</id>
    <completedYear>2013</completedYear>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2013-12-06</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Electrophysiologic and Molecular Characteristics of Cardiomyocytes after Heavy Ion Irradiation in the frame of the ESA IBER-10 Program</title>
    <parentTitle language="eng">Heavy Ion in Therapie and Space Radiation Symposium  (HITSRS2013),  2013, Chiba, Japan</parentTitle>
    <licence>Keine Lizenz - es gilt das deutsche Urheberrecht</licence>
    <author>Johannes Frieß</author>
    <author>Sylvia Ritter</author>
    <author>Andreas Daus</author>
    <author>Paul Layer</author>
    <author>Christiane Thielemann</author>
    <author>Anja Heselich</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Herzmuskelzelle</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Ionenbestrahlung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Schweres Ion</value>
    </subject>
    <collection role="forschungsschwerpunkte" number="">Artifical Intelligence and Data Science</collection>
    <collection role="forschungsschwerpunkte" number="">Clean Tech</collection>
    <collection role="forschungsschwerpunkte" number="">Intelligent Sensors and Signals</collection>
    <collection role="forschungsschwerpunkte" number="">Clean Tech</collection>
    <collection role="forschungsschwerpunkte" number="">Material Testing &amp; Sensor Technology</collection>
  </doc>
  <doc>
    <id>205</id>
    <completedYear>2011</completedYear>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>560</pageFirst>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2014-02-13</completedDate>
    <publishedDate>2014-05-06</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Cellular effects of space radiation with relevance to cardiovascular diseases</title>
    <parentTitle language="eng">Life in Space for Life on Earth</parentTitle>
    <note>IBER-10</note>
    <enrichment key="review.accepted_by">2</enrichment>
    <licence>Keine Lizenz - es gilt das deutsche Urheberrecht</licence>
    <author>Christiane Thielemann</author>
    <author>Sylvia Ritter</author>
    <author>Paul Layer</author>
    <author>Johannes Frieß</author>
    <author>Andreas Daus</author>
    <author>Frederik Steger</author>
    <author>Anja Heselich</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Kardiovaskuläre Krankheit</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Ionisierende Strahlung</value>
    </subject>
    <collection role="forschungsschwerpunkte" number="">Artifical Intelligence and Data Science</collection>
    <collection role="forschungsschwerpunkte" number="">Clean Tech</collection>
    <collection role="forschungsschwerpunkte" number="">Intelligent Sensors and Signals</collection>
    <collection role="forschungsschwerpunkte" number="">Clean Tech</collection>
    <collection role="forschungsschwerpunkte" number="">Material Testing &amp; Sensor Technology</collection>
  </doc>
  <doc>
    <id>639</id>
    <completedYear>2015</completedYear>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>10</pageLast>
    <pageNumber/>
    <edition/>
    <issue>777</issue>
    <volume>2015</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2015-05-01</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Electrophysiologic and cellular characteristics of cardiomyocytes after X-ray irradiation</title>
    <parentTitle language="eng">Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis</parentTitle>
    <enrichment key="copyright">0</enrichment>
    <licence>Keine Lizenz - es gilt das deutsche Urheberrecht</licence>
    <author>Johannes Frieß</author>
    <author>Anja Heselich</author>
    <author>Sylvia Ritter</author>
    <author>Angelina Haber</author>
    <author>Nicole Kaiser</author>
    <author>Paul Layer</author>
    <author>Christiane Thielemann</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Herzmuskelzelle</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Röntgenbestrahlung</value>
    </subject>
    <collection role="forschungsschwerpunkte" number="">Artifical Intelligence and Data Science</collection>
    <collection role="forschungsschwerpunkte" number="">Clean Tech</collection>
    <collection role="forschungsschwerpunkte" number="">Intelligent Sensors and Signals</collection>
    <collection role="forschungsschwerpunkte" number="">Material Testing &amp; Sensor Technology</collection>
  </doc>
  <doc>
    <id>642</id>
    <completedYear>2013</completedYear>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>report</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation>GSI Helmholtzzentrum für Schwerionenforschung</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2015-06-09</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Effect of X-rays and titanium ions on cardiomyocyte cultures</title>
    <enrichment key="copyright">0</enrichment>
    <licence>Keine Lizenz - es gilt das deutsche Urheberrecht</licence>
    <author>Johannes Frieß</author>
    <author>Anja Heselich</author>
    <author>Sylvia Ritter</author>
    <author>Paul Layer</author>
    <author>Christiane Thielemann</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Herzmuskelzelle</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Röntgenbestrahlung</value>
    </subject>
    <collection role="forschungsschwerpunkte" number="">Artifical Intelligence and Data Science</collection>
    <collection role="forschungsschwerpunkte" number="">Clean Tech</collection>
    <collection role="forschungsschwerpunkte" number="">Intelligent Sensors and Signals</collection>
    <collection role="forschungsschwerpunkte" number="">Material Testing &amp; Sensor Technology</collection>
  </doc>
  <doc>
    <id>652</id>
    <completedYear>2012</completedYear>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>report</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation>GSI Helmholtzzentrum für Schwerionenforschung</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2015-06-09</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Electrophysiological Effects of Heavy Ion Irradiation on Cardiomyocytes</title>
    <enrichment key="copyright">0</enrichment>
    <licence>Keine Lizenz - es gilt das deutsche Urheberrecht</licence>
    <author>Johannes Frieß</author>
    <author>Anja Heselich</author>
    <author>Sylvia Ritter</author>
    <author>Andreas Daus</author>
    <author>Paul Layer</author>
    <author>Christiane Thielemann</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Herzmuskelzelle</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Elektrophysiologie</value>
    </subject>
    <collection role="forschungsschwerpunkte" number="">Artifical Intelligence and Data Science</collection>
    <collection role="forschungsschwerpunkte" number="">Clean Tech</collection>
    <collection role="forschungsschwerpunkte" number="">Intelligent Sensors and Signals</collection>
    <collection role="forschungsschwerpunkte" number="">Material Testing &amp; Sensor Technology</collection>
  </doc>
  <doc>
    <id>650</id>
    <completedYear>2013</completedYear>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName/>
    <publisherPlace>Darmstadt, Deutschland</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2015-06-09</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Electrophysiological characteristics of cardiomyocytes after heavy ion exposure</title>
    <parentTitle language="deu">Jahrestagung der Gesellschaft für biologische Strahlenforschung</parentTitle>
    <enrichment key="copyright">0</enrichment>
    <licence>Keine Lizenz - es gilt das deutsche Urheberrecht</licence>
    <author>Johannes Frieß</author>
    <author>Anja Heselich</author>
    <author>Sylvia Ritter</author>
    <author>Christiane Thielemann</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Herzmuskelzelle</value>
    </subject>
    <collection role="forschungsschwerpunkte" number="">Artifical Intelligence and Data Science</collection>
    <collection role="forschungsschwerpunkte" number="">Clean Tech</collection>
    <collection role="forschungsschwerpunkte" number="">Intelligent Sensors and Signals</collection>
    <collection role="forschungsschwerpunkte" number="">Material Testing &amp; Sensor Technology</collection>
  </doc>
  <doc>
    <id>653</id>
    <completedYear>2012</completedYear>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName/>
    <publisherPlace>Aberdeen, Schottland, UK</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2015-06-09</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">IBER10 - Cellular effects of space radiation with relevance to cardiovascular diseases</title>
    <parentTitle language="eng">European Space Agency - Life in Space for Life on Earth</parentTitle>
    <enrichment key="copyright">0</enrichment>
    <licence>Keine Lizenz - es gilt das deutsche Urheberrecht</licence>
    <author>Christiane Thielemann</author>
    <author>Sylvia Ritter</author>
    <author>Paul Layer</author>
    <author>Johannes Frieß</author>
    <author>Andreas Daus</author>
    <author>Frederik Steger</author>
    <author>Anja Heselich</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Kosmische Strahlung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Kardiovaskuläre Krankheit</value>
    </subject>
    <collection role="forschungsschwerpunkte" number="">Artifical Intelligence and Data Science</collection>
    <collection role="forschungsschwerpunkte" number="">Clean Tech</collection>
    <collection role="forschungsschwerpunkte" number="">Intelligent Sensors and Signals</collection>
    <collection role="forschungsschwerpunkte" number="">Material Testing &amp; Sensor Technology</collection>
  </doc>
  <doc>
    <id>1543</id>
    <completedYear>2014</completedYear>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>report</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2015-01-01</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Combined effects of ionizing radiation and cardio-active drugs on human iPSC-derived cardiomyocytes</title>
    <parentTitle language="deu">GSI SCIENTIFIC REPORT 2014</parentTitle>
    <identifier type="doi">10.15120/GR-2015-1-APPA-HEALTH-37</identifier>
    <enrichment key="copyright">0</enrichment>
    <licence>Keine Lizenz - es gilt das deutsche Urheberrecht</licence>
    <author>Johannes Frieß</author>
    <author>Anja Heselich</author>
    <author>Sylvia Ritter</author>
    <author>Paul Layer</author>
    <author>Christiane Thielemann</author>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Herzmuskelzelle</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>swd</type>
      <value>Ionisierende Strahlung</value>
    </subject>
    <collection role="forschungsschwerpunkte" number="">Artifical Intelligence and Data Science</collection>
    <collection role="forschungsschwerpunkte" number="">Clean Tech</collection>
    <collection role="forschungsschwerpunkte" number="">Intelligent Sensors and Signals</collection>
    <collection role="forschungsschwerpunkte" number="">Material Testing &amp; Sensor Technology</collection>
  </doc>
</export-example>
