@inproceedings{KriniMirzaRodemer2016, author = {Krini, Mohammed and Mirza, Zafar Baig and Rodemer, Klaus}, title = {A Practical Beamformer-Postfilter System for Microphone Arrays on Seat Belts}, series = {12. ITG Symposium Speech Communication (ITG'16), Paderborn}, volume = {2016}, booktitle = {12. ITG Symposium Speech Communication (ITG'16), Paderborn}, year = {2016}, subject = {Sicherheitsgurt}, language = {en} } @article{RajanKriniSchmidt2016, author = {Rajan, Vasudev Kandade and Krini, Mohammed and Schmidt, Gerhard}, title = {Signal Processing Techniques for Seat Belt Micro-phone Arrays}, series = {EURASIP Journal on Advances in Signal Processing}, volume = {2016}, journal = {EURASIP Journal on Advances in Signal Processing}, year = {2016}, subject = {Signalverarbeitung}, language = {en} } @article{FlachsCiba2016, author = {Flachs, Dennis and Ciba, Manuel}, title = {Cell-based sensor chip for neurotoxicity measurements in drinking water}, series = {L{\´e}kař a technika - Clinician and Technology}, volume = {46}, journal = {L{\´e}kař a technika - Clinician and Technology}, number = {2}, pages = {46 -- 50}, year = {2016}, abstract = {Our drinking water contains residues of pharmaceuticals. A sub-group of these contaminants are neuro-active substances, the antiepileptic carbamazepine being one of the most relevant. For assessment of the neurotoxicity of this drug at a sub-therapeutic level, a cell-based sensor chip platform has been realized and characterized. For this purpose, a microelectrode array chip was designed and processed in a clean room and optimized in terms of low processing costs and good recording properties. For characterization of the system neuronal cells were plated on microelectrode array chips and electrical activity was measured as a function of applied carbamazepine concentration. We found that the relative spike rate decreased with increasing drug concentration resulted in IC50 values of around 36 μM. This value is five orders of magnitude higher than the maximal dose found in drinking water. IC50 values for burst rate, burst duration and synchrony were slightly higher, suggesting spike rate being a more sensitive parameter to carbamazepine.}, subject = {Mikroelektrode}, language = {en} } @article{OsterDausErbesetal.2016, author = {Oster, Stefan and Daus, Andreas and Erbes, Christian and Goldhammer, Michael and Bochtler, Ulrich and Thielemann, Christiane}, title = {Long-term electromagnetic exposure of developing neuronal networks: A flexible experimental setup}, series = {Bioelectromagnetics}, volume = {2016}, journal = {Bioelectromagnetics}, number = {37}, doi = {10.1002/bem.21974}, pages = {264 -- 278}, year = {2016}, abstract = {Neuronal networks in vitro are considered one of the most promising targets of research to assess potential electromagnetic field induced effects on neuronal functionality. A few exposure studies revealed there is currently no evidence of any adverse health effects caused by weak electromagnetic fields. Nevertheless, some published results are inconsistent. Particularly, doubts have been raised regarding possible athermal biological effects in the young brain during neuronal development. Therefore, we developed and characterized a flexible experimental setup based on a transverse electromagnetic waveguide, allowing controlled, reproducible exposure of developing neuronal networks in vitro. Measurement of S-parameters confirmed very good performance of the Stripline in the band of 800-1000 MHz. Simulations suggested a flexible positioning of cell culture dishes throughout a large exposure area, as specific absorption rate values were quite independent of their position (361.7 ± 11.4 mW/kg) at 1 W, 900 MHz. During exposure, thermal drift inside cellular medium did not exceed 0.1 K. Embryonic rat cortical neurons were cultivated on microelectrode array chips to non-invasively assess electrophysiological properties of electrogenic networks. Measurements were taken for several weeks, which attest to the experimental setup being a reliable system for long-term studies on developing neuronal tissue.}, subject = {Neuronales Netz}, language = {en} } @inproceedings{MayerArrizabalagaRitteretal.2016, author = {Mayer, Margot and Arrizabalaga, Onetsine and Ritter, Sylvia and Thielemann, Christiane}, title = {Human Embryonic Stem Cell Derived Neurospheres - A Novel Three Dimensional Model For Neurotoxicological Studies}, series = {Frontiers}, volume = {2016}, booktitle = {Frontiers}, number = {MEA Meeting 2016}, doi = {10.3389/conf.fnins.2016.93.00081}, year = {2016}, abstract = {At present, most neurotoxicological studies in the field of microelectrode array (MEA) technology are based on in vivo or in vitro animal models, particularly in mice or rats. These models contributed much to our knowledge about molecular and cellular mechanisms of neurotoxins affecting the central nervous system. Yet, animal models are not necessarily capable to forecasting the effectiveness of treatment in clinical trials. Therefore the development and characterization of suitable neuronal cell models derived from human cells is emerging in the field of toxicity testing. In this study, we present neurospheres (NS) as a new three dimensional (3D) neuronal cell model based on human embryonic stem cells (hESC), coupled onto microelectrode arrays (MEA). This cell-based assay serves as platform to investigate effects of neuroactive substances on network communication. In order to characterize the neurospheres' reaction, the well-known GABA receptor antagonist bicuculline and the sodium channel blocker carbamazepine are applied. Preliminary results reveal anticipated and physiologically reasonable alterations in network activity. Thus, we have the first evidence that hESC derived NS are a promising 3D cell model for neurotoxicity testing. In further studies, this model will be used to investigate effects of ionizing radiation on network signaling.}, subject = {Mikroelektrode}, language = {en} } @inproceedings{KoerbitzerKraussSchneideretal.2016, author = {K{\"o}rbitzer, Berit Silke and Krauß, Peter and Schneider, J{\"o}rg and Thielemann, Christiane}, title = {Characterization Of Graphene-Coated Microelectrode Arrays For Recording And Stimulation Of Neuronal Cells}, series = {Frontiers}, volume = {2016}, booktitle = {Frontiers}, number = {MEA Meeting 2016}, doi = {10.3389/conf.fnins.2016.93.00013}, year = {2016}, subject = {Mikroelektrode}, language = {en} }