@article{BestelAppalivanRienenetal.2017, author = {Bestel, Robert and Appali, Revathi and van Rienen, Ursula and Thielemann, Christiane}, title = {Effect of Morphologic Features of Neurons on the Extracellular Electric Potential: A Simulation Study Using Cable Theory and Electro-Quasi-Static Equations}, series = {Neural Computation}, volume = {2017}, journal = {Neural Computation}, number = {29}, doi = {10.1162/neco_a_01019}, pages = {2955 -- 2978}, year = {2017}, abstract = {Microelectrode arrays serve as an indispensable tool in electro-physiological research to study the electrical activity of neural cells, enabling measurements of single cell as well as network communication analysis. Recent experimental studies have reported that the neuronal geometry has an influence on electrical signaling and extracellular recordings. However, the corresponding mechanisms are not yet fully understood and require further investigation. Allowing systematic parameter studies, computational modeling provides the opportunity to examine the underlying effects that influence extracellular potentials. In this letter, we present an in silico single cell model to analyze the effect of geometrical variability on the extracellular electric potentials. We describe finite element models of a single neuron with varying geometric complexity in three-dimensional space. The electric potential generation of the neuron is modeled using Hodgkin-Huxley equations. The signal propagation is described with electro-quasi-static equations, and results are compared with corresponding cable equation descriptions. Our results show that both the geometric dimensions and the distribution of ion channels of a neuron are critical factors that significantly influence both the amplitude and shape of extracellular potentials.}, subject = {Mikroelektrode}, language = {en} } @phdthesis{Bestel2018, author = {Bestel, Robert}, title = {Simulation neuronaler Aktionspotentiale in Hinblick auf Zellform und Physiologie sowie deren Ableitung mittels extarzellul{\"a}rer Mikroelektroden}, doi = {10.18453/rosdok_id00002390}, school = {Technische Hochschule Aschaffenburg}, year = {2018}, subject = {Mikroelektrode}, language = {de} } @inproceedings{DausBestelThielemann2014, author = {Daus, Andreas and Bestel, Robert and Thielemann, Christiane}, title = {A multivariate spike-detection algorithm to assess activity patterns of three-dimensional in vitro models}, series = {MEA Meeting 2014, Reutlingen, Germany}, volume = {2014}, booktitle = {MEA Meeting 2014, Reutlingen, Germany}, issn = {2199-1596}, pages = {194 -- 195}, year = {2014}, subject = {Mikroelektrode}, language = {en} } @article{NickDausBesteletal.2013, author = {Nick, Christoph and Daus, Andreas and Bestel, Robert and Goldhammer, Michael and Steger, Frederik and Thielemann, Christiane}, title = {DrCell - a software tool for the analysis of cell signals recorded with extracellular microelectrodes}, series = {Signal processing: an international journal (SPIJ)}, volume = {7}, journal = {Signal processing: an international journal (SPIJ)}, number = {2}, pages = {96 -- 109}, year = {2013}, subject = {Mikroelektrode}, language = {de} }