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    <title language="eng">Statistical analysis plan for HOMESIDE: a randomised controlled trial for home-based family caregiver-delivered music and reading interventions for people living with dementia</title>
    <abstract language="eng">Abstract&#13;
 Background&#13;
 Most people with dementia live in the community, not in residential care. Therefore, quality informal care for them is critical for managing behavioural and psychological symptoms of dementia (BPSD). Music therapy has been shown to reduce BPSD. However, no randomised controlled trial has examined the effects of music interventions delivered by caregivers in home settings. The HOME-based caregiver-delivered music intervention for people living with dementia (HOMESIDE) trial aims to evaluate the effectiveness of a 12-week music intervention in addition to standard care for BPSD. This article describes the statistical analysis plan.&#13;
 &#13;
 Methods and analysis&#13;
 HOMESIDE is a large, pragmatic international three-arm parallel-group randomised controlled trial. Dyads (persons with dementia and caregiver) in Australia, Germany, the UK, Poland and Norway were randomised to receive music and standard care, reading and standard care or standard care alone. The primary outcome is BPSD (proxy) of the person living with dementia, measured using the Neuropsychiatric Inventory-Questionnaire (NPI-Q) at 90 and 180 days post-randomisation. Longitudinal analysis will compare NPI-Q severity between music and standard care versus standard care alone. Secondary outcomes include quality of life and depression (both person with dementia and caregiver), cognition (person with dementia only), distress, resilience, competence and caregiver-patient relationship (caregiver only). Treatment effects will be obtained at 90 and 180 days post-randomisation, where applicable. Safety outcomes (adverse events, hospitalisations, deaths) will be summarised.&#13;
 &#13;
 Discussion&#13;
 This statistical analysis plan provides a detailed methodology for the analysis of HOMESIDE and will improve the validity of the study and reduce the potential for bias.&#13;
 &#13;
 Trial registration&#13;
 Australian New Zealand Clinical Trials Registry ACTRN12618001799246. Registered on November 05, 2018. ClinicalTrials.gov NCT03907748. Registered on April 09, 2019.</abstract>
    <parentTitle language="eng">Trials</parentTitle>
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Therefore, quality informal care for them is critical for managing behavioural and psychological symptoms of dementia (BPSD). Music therapy has been shown to reduce BPSD. However, no randomised controlled trial has examined the effects of music interventions delivered by caregivers in home settings. The HOME-based caregiver-delivered music intervention for people living with dementia (HOMESIDE) trial aims to evaluate the effectiveness of a 12-week music intervention in addition to standard care for BPSD. This article describes the statistical analysis plan.&lt;\/jats:p&gt;\n              &lt;\/jats:sec&gt;&lt;jats:sec&gt;\n                &lt;jats:title&gt;Methods and analysis&lt;\/jats:title&gt;\n                &lt;jats:p&gt;HOMESIDE is a large, pragmatic international three-arm parallel-group randomised controlled trial. Dyads (persons with dementia and caregiver) in Australia, Germany, the UK, Poland and Norway were randomised to receive music and standard care, reading and standard care or standard care alone. The primary outcome is BPSD (proxy) of the person living with dementia, measured using the Neuropsychiatric Inventory-Questionnaire (NPI-Q) at 90 and 180\u00a0days post-randomisation. Longitudinal analysis will compare NPI-Q severity between music and standard care versus standard care alone. Secondary outcomes include quality of life and depression (both person with dementia and caregiver), cognition (person with dementia only), distress, resilience, competence and caregiver-patient relationship (caregiver only). Treatment effects will be obtained at 90 and 180\u00a0days post-randomisation, where applicable. Safety outcomes (adverse events, hospitalisations, deaths) will be summarised.&lt;\/jats:p&gt;\n              &lt;\/jats:sec&gt;&lt;jats:sec&gt;\n                &lt;jats:title&gt;Discussion&lt;\/jats:title&gt;\n                &lt;jats:p&gt;This statistical analysis plan provides a detailed methodology for the analysis of HOMESIDE and will improve the validity of the study and reduce the potential for bias.&lt;\/jats:p&gt;\n              &lt;\/jats:sec&gt;&lt;jats:sec&gt;\n                &lt;jats:title&gt;Trial registration&lt;\/jats:title&gt;\n                &lt;jats:p&gt;Australian New Zealand Clinical Trials Registry ACTRN12618001799246. Registered on November\u00a005, 2018. 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    <author>Vanessa Pac Soo</author>
    <author>Felicity A. Baker</author>
    <author>Tanara Vieira Sousa</author>
    <author>Helen Odell-Miller</author>
    <author>Karette Stensæth</author>
    <author>Thomas Wosch</author>
    <author>Anna A. Bukowska</author>
    <author>Jeanette Tamplin</author>
    <author>Nicola Lautenschlager</author>
    <author>Sabine Braat</author>
    <author>Karen E. Lamb</author>
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