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    <publishedYear>2011</publishedYear>
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    <language>eng</language>
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    <pageLast>publication</pageLast>
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    <title language="eng">Hierarchical deconvolution of linear mixtures of high-dimensional mass spectra in micro-biology</title>
    <parentTitle language="eng">Proceedings of AIA 2011</parentTitle>
    <identifier type="doi">http://dx.doi.org/10.2316/P.2011.717-011</identifier>
    <enrichment key="opus.import.data">@INPROCEEDINGSSchleif2011a, Author = F.-M. Schleif and S. Simmuteit and T. Villmann, Title = Hierarchical deconvolution of linear mixtures of high-dimensional mass spectra in micro-biology, Booktitle = Proceedings of AIA 2011, Pages = CD-publication, DOI = http://dx.doi.org/10.2316/P.2011.717-011, Year = 2011,abstract = This paper introduces a hierarchical model for the description and deconvolution of composite patterns. The patterns are described in a basis system of spectral basis functions. The mixture coefficients for the composite patterns are determined by solving a linear mixture model with nonneg- ative coefficients. In life science research, wet-lab mixed samples of possible known basis substances occur regularly and cause a challenge for identification tasks. Also in case of known basis functions the problem is still complex, if the used basis is very sparse and the number of basis functions is very large. Simple approaches either try combining different basis spectra or incorporate blind source separation. Our proposed method is to use nonnegative least squares combined with a hierarchical prototype based learning model. We evaluate our method on mixtures of real and simulated composite patterns of mass spectrometry data from bacteria. Results show remarkable success and can be taken as a promising step in the new field of automatic unmixing of mixed cultures.</enrichment>
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    <enrichment key="opus.import.date">2025-07-15T08:47:15+00:00</enrichment>
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    <enrichment key="opus.import.id">6876159341a060.14275529</enrichment>
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    <author>Frank-Michael Schleif</author>
    <author>S. Simmuteit</author>
    <author>T. Villmann</author>
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