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An innovative net-based methodology to integrate qualitative and quantitative analysis of distributed software systems is outlined, and an on-going prototype implementation of a related graphic-oriented tool kit is sketched. The proposed method combines qualitative analysis, monitoring and testing as well as quantitative analysis on the basis of a net-based intermediate representation of the distributed software system under consideration. All transformations (from the distributed software system into a first Petri net model, and between the different kinds of net models) can be made formally, and therefore automated to a high degree. The evaluation of quantitative properties is based on so-called object nets which are obtained by a property-preserving structural compression and quantitative expansion of the qualitative model. In this way, the frequency and delay attributes necessary to generate quantitative models are provided by the monitoring and testing component.
An innovative net-based methodology to integrate qualitative and quantitative analysis of distributed software systems is outlined, and an on-going prototype implementation of a related graphic-oriented tool kit is sketched. The proposed method combines qualitative analysis, monitoring and testing as well as quantitative analysis on the basis of a net-based intermediate representation of the distributed software system under consideration. All transformations (from the distributed software system into a first Petri net model, and between the different kinds of net models) can be made formally, and therefore automated to a high degree. The evaluation of quantitative properties is based on so-called object nets which are obtained by a property-preserving structural compression and quantitative expansion of the qualitative model. In this way, the frequency and delay attributes necessary to generate quantitative models are provided by the monitoring and testing component.
Cis-diammine dichloro platinum (II) (CDDP), is a highly potent antineoplastic agent that is used in the treatment of ovarian cancer. However, the clinical use of CDDP is restricted by its severe side effects. In order to reduce these side effects and to enhance its therapeutic efficacy, we developed specific immunoconjugates consisting of the murine monoclonal antibody OC125 and CDDP, using diethylene triamine pentaacetic acid (DTPA) as a linker.
The coupling efficiencies of the different preparations synthesized, varied between 1.10±0.42 and 2.65±1.60 mol of CDDP per mol of antibody protein. Despite the chemical modification of the antibody molecule, specific binding activity of the OC125-CDDP conjugates toward the CA125 antigen was maintained as was demonstrated by means of immunohisto-/cytochemical staining of frozen sections of ovarian cancer tissue, amniotic epithelium, and the CA125 positive ovarian cancer cell line NIH:OVCAR 3.
The antiproliferative activity of the immunoconjugates was tested against the human ovarian cancer cell lines NIH:OVCAR3 and SKOV 3, applying a kinetic crystal violet microassay.
Despite the promising results obtained with the specific immuno-staining of the target cells, no significant antiproliferative activity of our immunoconjugates against the cell lines tested was observed.
One possible explanation for the lack of antitumor activity could be the fact that CA125 is released in large amounts by the NIH:OVCAR 3 cells. This may have prevented an efficient immunotargeting of the cancer cells by the formation of soluble immune complexes.
Identification of insulin and insulin-like growth factor I (IGF I) receptors in ovarian cancer
(1994)
Abstract
The objective of this study was to test if specific insulin and insulin-like growth factor I (IGF I) receptors are expressed in ovarian cancer tissue. Thirteen tissue specimens from primary ovarian cancers, 1 specimen from a primary peritoneal carcinoma, 10 specimens from metastatic lesions of ovarian carcinomas, and 4 specimens from recurrent ovarian cancers together with 13 normal ovaries were tested for their content of insulin and IGF-I receptors, by the application of specific insulin and IGF-I receptor radioimmunoassays. The insulin receptor (IR) and IGF-I receptor (IGF R) content in the primary tumors varied between 23.8-321.4 and 16.4-554.2 ng/0.1 mg DNA, respectively. Metastatic lesions contained between 12.3 and 226.7 ng IR/0.1 mg DNA and between 7.5 and 459.4 ng IGF R/0.1 mg DNA. In recurrent tumors the receptor concentrations were in the range of 41.5-79.8 and 48.9-160.9 ng/0.1 mg DNA for insulin and IGF-I receptors, respectively. Normal ovarian tissue contained between 12.2 and 150.1 ng IR and between 21.4 and 420.1 ng IGF R per 0.1 mg DNA, respectively. As both insulin and IGF-I receptors are present in ovarian cancer tissue, the effects of insulin and IGF-I as potential growth factors in ovarian cancer should be further investigated.
Copyright © 1994 Academic Press. All rights reserved.
A free boundary-value problem for a nonisothermal flow of two heavy viscous incompressible capillary liquids descibing a slot coating process is mathematically studied. The problem is stationary and two-dimensional and the Boussinesq approximation for the Navier-Stokes equations is used. The existence and uniqueness of a weak solution is proved in weighted Holder spaces for small data.
Deduktionssysteme
(1994)