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Identification of insulin and insulin-like growth factor I (IGF I) receptors in ovarian cancer
- Abstract The objective of this study was to test if specific insulin and insulin-like growth factor I (IGF I) receptors are expressed in ovarian cancer tissue. Thirteen tissue specimens from primary ovarian cancers, 1 specimen from a primary peritoneal carcinoma, 10 specimens from metastatic lesions of ovarian carcinomas, and 4 specimens from recurrent ovarian cancers together with 13 normal ovaries were tested for their content of insulin and IGF-I receptors, by the application of specificAbstract The objective of this study was to test if specific insulin and insulin-like growth factor I (IGF I) receptors are expressed in ovarian cancer tissue. Thirteen tissue specimens from primary ovarian cancers, 1 specimen from a primary peritoneal carcinoma, 10 specimens from metastatic lesions of ovarian carcinomas, and 4 specimens from recurrent ovarian cancers together with 13 normal ovaries were tested for their content of insulin and IGF-I receptors, by the application of specific insulin and IGF-I receptor radioimmunoassays. The insulin receptor (IR) and IGF-I receptor (IGF R) content in the primary tumors varied between 23.8-321.4 and 16.4-554.2 ng/0.1 mg DNA, respectively. Metastatic lesions contained between 12.3 and 226.7 ng IR/0.1 mg DNA and between 7.5 and 459.4 ng IGF R/0.1 mg DNA. In recurrent tumors the receptor concentrations were in the range of 41.5-79.8 and 48.9-160.9 ng/0.1 mg DNA for insulin and IGF-I receptors, respectively. Normal ovarian tissue contained between 12.2 and 150.1 ng IR and between 21.4 and 420.1 ng IGF R per 0.1 mg DNA, respectively. As both insulin and IGF-I receptors are present in ovarian cancer tissue, the effects of insulin and IGF-I as potential growth factors in ovarian cancer should be further investigated. Copyright © 1994 Academic Press. All rights reserved.…
Author: | Eberhard BeckGND, Pietro Russo, Biancamaria Gliozzo, Wolfram Jäger, Vincenzo Papa, Ludwig Wildt, Vincenzo Pezzino, Norbert Lang |
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ISSN: | 0090-8258 |
Parent Title (English): | In: Gynecologic Oncology 53(1994)2, 196–201 |
Document Type: | Article |
Language: | English |
Year of Publishing: | 1994 |
Date of Publication (online): | 2013/02/01 |
Release Date: | 2013/02/01 |
First Page: | 196 |
Last Page: | 201 |
University Bibliography: | Hochschulbibliografie |
Licence (German): | Creative Commons - Namensnennung, Nicht kommerziell, Keine Bearbeitung |