TY - CHAP A1 - Makrushin, Andrey A1 - Hildebrandt, Mario A1 - Fischer, Robert A1 - Kiertscher, Tobias A1 - Dittmann, Jana A1 - Vielhauer, Claus T1 - Advanced techniques for latent fingerprint detection and validation using a CWL device T2 - In: Proceedings of SPIE 8436, 84360V. 2012. N2 - The technology-aided support of forensic experts while investigating crime scenes and collecting traces becomes a more and more important part in the domains of image acquisition and signal processing. The manual lifting of latent fingerprints using conventional methods like the use of carbon black powder is time-consuming and very limited in its scope of application. New technologies for a contact-less and non-invasive acquisition and automatic processing of latent fingerprints, promise the possibilities to inspect much more and larger surface areas and can significantly simplify and speed up the workflow. Furthermore, it allows multiple investigations of the same trace, subsequent chemical analysis of the residue left behind and the acquisition of latent fingerprints on sensitive surfaces without destroying the surface itself. In this work, a FRT MicroProf200 surface measurement device equipped with a chromatic white-light sensor CWL600 is used. The device provides a gray-scale intensity image and 3D-topography data simultaneously. While large area scans are time-consuming, the detection and localization of finger traces are done based on low-resolution scans. The localized areas are scanned again with higher resolution. Due to the broad variety of different surface characteristics the fingerprint pattern is often overlaid by the surface structure or texture. Thus, image processing and classification techniques are proposed for validation and visualization of ridge lines in high-resolution scans. Positively validated regions containing complete or sufficient partial fingerprints are passed on to forensic experts. The experiments are provided on a set of three surfaces with different reflection and texture characteristics, and fingerprints from ten different persons. © (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Y1 - 2012 U6 - https://doi.org/10.1117/12.922235 ER - TY - CHAP A1 - Fischer, Robert A1 - Kiertscher, Tobias A1 - Gruhn, Stefan A1 - Scheidat, Tobias A1 - Vielhauer, Claus ED - De Decker, Bart T1 - From Biometrics to Forensics: A Feature Collection and first Feature Fusion Approaches for latent Fingerprint Detection using a Chromatic White Light (CWL) Sensor T2 - In: Communications and multimedia security : 13th IFIP TC 6 TC 11 international conference ; proceedings / CMS 2012, Canterbury, UK, September 3 - 5, 2012 N2 - Application of non-invasive scan technologies for acquisition of latent fingerprints promise a better support of forensic and dactyloscopic experts when securing evidence at crime scenes. Furthermore, non-destructive acquisition preserve the chance of subsequent chemical and forensic analysis of left residue. Based on results of an ongoing research project with sensor industry partners, this paper presents a collection of 28 statistical, gradient-, and spectral density-based features for latent fingerprint detection using low resolution scans. Within this work a chromatic white light (CWL) sensor is used for image acquisition. Furthermore, based on concepts of biometric fusion, a taxonomy for possible fusion strategies is presented and very first results for three different strategies on decision level are discussed. Experimental evaluation is performed based on scans of 1680 latent fingerprints on three different surfaces. The results show very good performance on planar, non-absorbing surfaces with uniform reflection characteristics with an detection rate of 2.51% in the best case. On the other hand difficulties are arising from surfaces with non-uniform/predictable reflection characteristics. T3 - Lecture notes in computer science - 7394 Y1 - 2012 SN - 978-3-642-32804-6 U6 - https://doi.org/10.1007/978-3-642-32805-3_21 SP - 207 EP - 210 PB - Springer CY - Berlin ER - TY - CHAP A1 - Kiertscher, Tobias A1 - Vielhauer, Claus A1 - Leich, Marcus T1 - Automated Forensic Fingerprint Analysis: A Novel Generic Process Model and Container Format T2 - In: Biometrics and ID management : proceedings / COST 2101 European Workshop BioID 2011, Brandenburg (Havel), Germany, March 8 - 10, 2011. Claus Vielhauer ... (ed.). - Berlin : Springer, 2011. - (Lecture Notes in Computer Science ; 6583). – ISBN 978-3-642-19529-7. - S. 262 - 273 N2 - The automated forensic analysis of latent fingerprints poses a new challenge. While for the pattern recognition aspects involved, the required processing steps can be related to fingerprint biometrics, the common biometric model needs to be extended to face the variety of characteristics of different surfaces and image qualities and to keep the chain of custody. Therefore, we introduce a framework for automated forensic analysis of latent fingerprints. The framework consists of a generic process model for multi-branched process graphs w.r.t. security aspects like integrity, authenticity and confidentiality. It specifies a meta-model to store all necessary data and operations in the process, while keeping the chain of custody. In addition, a concept for a technical implementation of the meta-model is given, to build a container format, which suits the needs of an automated forensic analysis in research and application. KW - automated forenic analysis KW - automated dactyloscopy KW - multi-branched biometric process KW - forensic container format Y1 - 2011 U6 - https://doi.org/10.1007/978-3-642-19530-3_24 ER - TY - CHAP A1 - Kiertscher, Tobias A1 - Fischer, Robert A1 - Vielhauer, Claus T1 - Latent Fingerprint Detection using a spectral Texture Feature T2 - In: Proceedings of the 2011 ACM SIGMM Multimedia and Security Workshop : September 29 - 30, 2011, Buffalo, New York, USA / sponsored by ACM SIGMM. - New York : ACM, 2011. - S. 27-32. - ISBN 978-1-4503-0806-9 N2 - Technologies for advancing and supporting criminalistic forensic are an upcoming challenge with rising importance within the domain of multimedia security and forensic. For example the acquisition and automated analysis of latent fingerprints, using high resolution 3D scanners, appears to be a promising area of research. Within the paper we will give a detailed demarcation of biometric and forensic fingerprint analysis. We will introduce the aim of a partly automated process for forensic fingerprint acquisition, detection, and processing. Based on the idea of splitting the overall scan process into a fast, low resolution coarse scan and a high resolution detailed scan, different approaches and algorithms has to be evaluated, whether they are feasible for detecting latent fingerprints. Referring to the subject of biometrics and emerging applications, this work will show an approach of a novel Fourier-based spectral texture feature for detecting latent fingerprints in low resolution grey-scale images. Our work is based on data that is acquired using a chromatic white light sensor (CWL), which provides intensity and topographic information of the scanned surface areas. While using a very limited set of different surfaces so far, our first experiments have shown good results on flat and non structured surfaces. Using the presented feature, it is possible to detect latent fingerprints on these surfaces. Even on slightly structured surfaces, like wood imitation, the application of the spectral density feature yields promising results. However the first evaluation of the spectral density feature has also shown some serious limitations of its use on low resolution images. Y1 - 2011 U6 - https://doi.org/10.1145/2037252.2037259 ER - TY - RPRT A1 - Löwe, Michael A1 - Wikarski, Dietmar A1 - Han, Yanbo T1 - Higher order object nets and their application to workflow modeling T2 - Technische Universität Berlin / Fachbereich Informatik: Forschungsberichte des Fachbereiches Informatik ; Bericht-Nr. [19]95,34 Y1 - 1995 PB - Leiter der Fachbibliothek Informatik, Sekretariat FR 5-4 CY - Berlin ER - TY - RPRT T1 - Petri net tools - a comparative study T2 - Technische Universität Berlin / Fachbereich Informatik: Forschungsberichte des Fachbereiches Informatik ; Bericht-Nr. [19]97,4 Y1 - 1997 ER - TY - JOUR A1 - Heiner, Monika A1 - Ventre, Giorgio A1 - Wikarski, Dietmar T1 - A Petri net based methodology to integrate qualitative and quantitative analysis JF - In: Information & Software Technology Volume 36(994)7, S. 435–441 N2 - An innovative net-based methodology to integrate qualitative and quantitative analysis of distributed software systems is outlined, and an on-going prototype implementation of a related graphic-oriented tool kit is sketched. The proposed method combines qualitative analysis, monitoring and testing as well as quantitative analysis on the basis of a net-based intermediate representation of the distributed software system under consideration. All transformations (from the distributed software system into a first Petri net model, and between the different kinds of net models) can be made formally, and therefore automated to a high degree. The evaluation of quantitative properties is based on so-called object nets which are obtained by a property-preserving structural compression and quantitative expansion of the qualitative model. In this way, the frequency and delay attributes necessary to generate quantitative models are provided by the monitoring and testing component. Y1 - 1994 ER - TY - JOUR A1 - Wikarski, Dietmar T1 - Netze - Wie man über sie und mit ihrer Hilfe kommunizieren kann (Teil 3 und Schluss) JF - In: Log in : informatische Bildung und Computer in der Schule 17(1997)6, 48- Y1 - 1997 ER - TY - JOUR A1 - Wikarski, Dietmar T1 - Wie man über sie und mit ihrer Hilfe kommunizieren kann (Teil 2) JF - In: Log in : informatische Bildung und Computer in der Schule 17(1997)3/4, 76 - Y1 - 1997 ER - TY - JOUR A1 - Wikarski, Dietmar T1 - Wie man über sie und mit ihrer Hilfe kommunizieren kann (Teil 1 -- Einführung) JF - In: Log in : informatische Bildung und Computer in der Schule 17(1997)2, 41 - Y1 - 1997 ER - TY - CHAP A1 - Kim, Hong-Gee A1 - Fillies, Christian A1 - Smith, Bob A1 - Wikarski, Dietmar T1 - Visualizing a Dynamic Knowledge Map Using Semantic Web Technology T2 - In: Engineering and deployment of cooperative information systems : first international conference ; proceedings / EDCIS 2002, Beijing, China, September 17 - 20, 2002. Yanbo Han ... (ed.). - Berlin [u.a.] : Springer. - 2002. - (Lecture notes in computer science ; Vol. 2480). - S. 130 - 140. - ISBN 3-540-44222-7 N2 - Visual knowledge maps are being used to improve the communication processes within global organizations. Knowledge maps are graphical presentations of ontological knowledge as well as of business processes. Especially for enterprises working in a multi-cultural space the explicit formaliza-tion of knowledge and business rules using graphical models seems to be a very promising approach in order to improve discussion and learning processes. Publishing and automatic inference or search techniques are becoming available due to the latest standards for Semantic Web worked out by W3C. This article gives an impression how to create end user interfaces for the ”Corporate Knowledge Base” using MS Office and Visio with the modeling tool SemTalk. Several problems on capturing and maintaining large scale knowledge bases are discussed. Specific attention is given to the problem of weighting and association of information from orthogonal ontologies, which arises while using the same concepts in different graphical scenarios. Y1 - 2002 U6 - https://doi.org/10.1007/3-540-45785-2_10 ER - TY - CHAP A1 - Faustmann, Gert A1 - Wikarski, Dietmar T1 - Exception Handling in Petri-Net-based Workflow Management T2 - In: Practical aspects of knowledge management : proceedings of the first international conference, Basel, Switzerland, October 30 - 31, 1996 / PAKM '96, [The First International Conference on Practical Aspects of Knowledge Management. Schweizer Informatiker-Gesellschaft; Swiss Group for Artificial Intelligence and Cognitive Science. Ed. by: Michael Wolf ...]. - Zürich, 1996. - Vol. 1. Y1 - 1996 ER - TY - CHAP A1 - Han, Yanbo A1 - Himmighöfer, Jürgen A1 - Schaaf, Thorsten A1 - Wikarski, Dietmar T1 - Management of Workflow Resources to Support Runtime Adaptability and System Evolution T2 - In: Practical aspects of knowledge management : proceedings of the first international conference, Basel, Switzerland, October 30 - 31, 1996 / PAKM '96, [The First International Conference on Practical Aspects of Knowledge Management. Schweizer Informatiker-Gesellschaft; Swiss Group for Artificial Intelligence and Cognitive Science. Ed. by: Michael Wolf ...]. - Zürich, 1996. - Vol. 1. Y1 - 1996 ER - TY - JOUR A1 - Wikarski, Dietmar T1 - An introduction to modular process nets JF - In: TR : Technical Report / International Computer Science Institute 96-019 N2 - Modular process nets are a graphical and formal notation for the representation of technical and business process models containing concurrent activities. Originally this class of Petri nets was developed for the modeling, analysis, simulation and control of workflows and computer-based process control systems, but it is also suitable for use in all other areas where a formal but comprehensible description of complex processes is needed. After a description of the basic aims and design decisions for modular process nets, the report gives a brief introduction to low-level Petri nets including different types of transition rules and aspects of the descriptive and prescriptive use of process models. The main and most innovative points which are explained in more detail are the introduction of a hierarchical module concept for nets and the definition of elementare process nets. The module concept is part of a more general ("object-based") approach to Petri nets allowing severaltypes of ab straction, whereas the main points of elementary process nets are synchronous and asynchronous communication between separately interpreted net instances via events and token passing. Modular process nets are low-level Petri nets equipped with these module and communication concepts and optionally enhanced by die use of a task concept, a method known from the areas of computer-supported cooperative work (CSCW) and work-flow management. Because the report is aimed at a systematic and easy-to-understand introduction to modular process nets, it provides a precise explanation of this net class which is kept as informal as possible and enhanced by some typical application examples KW - CSCW KW - modular net KW - object net KW - petri net KW - workflow management Y1 - 1996 ER - TY - CHAP A1 - Adametz, H. A1 - Barthel, B. A1 - Faustmann, G. A1 - Fleischer, J. A1 - Messer, B. A1 - Wikarski, Dietmar T1 - Konzepte flexibler Workflow-Management-Systeme T2 - In: Telekooperations-Systeme in dezentralen Organisationen : Tagungsband zum Workshop der GI-Fachgruppe 5.5.1 "CSCW in Organisationen" vom 22.-23. Februar 1996 / Kurt Sandkuhl ... (Hrsg.) . - Berlin [u.a.] : ISST, 1996. - ( ISST-Berichte ; 31/96 ). - S. 7 - 32 Y1 - 1996 ER - TY - CHAP A1 - Wikarski, Dietmar T1 - Modular Nets and Object Nets: A Unifying View T2 - In: Workshop Concurrency, Specification & Programming : October 12 - 15, 1994 / L. Czaja ... Hrsg.: Professoren des Institutes für Informatik. [Humboldt-Universität Berlin] . - Berlin : Professoren des Inst. für Informatik. - 1994. - (Informatik-Berichte ; 36) Y1 - 1994 ER - TY - BOOK A1 - Wikarski, Dietmar A1 - Heiner, Monika T1 - On the application of markovian object nets to integrated qualitative and quantitative software analysis T3 - ISST-Bericht ; 29 N2 - In this paper a Petri net based methodology is outlined for an integrated qualitative and quantitative analysis of parallel software systems which is based on different (Petri) net representations of die software system under consideration. The software validation methodology starts from the source text of a set of communicating processes which specify the system under development. From this source text skeleton, a Petri net representation of the general control structure of the system is generated. On this basis a set of reduction steps is defined for transforming the net into different intermediate representations all owing the validation of both qualitative and qualitative properties. Particular attention is paid to the validation of quantitative properties which is performed using a transformation into locally Markovian Object Nets (MONs). Models of this new class of modular Petri nets are obtained by property-preserving structural compression and by enhancement with quantitative i nformation This information is obtained in the form of frequency and delay parameters by monitoring testing the software on the basis of prototypes. Compared to a previous paper on the same topic /Heiner94/ the methodology as well presentation have been improved. In particular, a new, more comprehensive running example been selected and the object net approach is explained in much more detail. Y1 - 1995 PB - Fraunhofer-Inst. Software- und Systemtechnik CY - Berlin ER - TY - BOOK A1 - Heiner, Monika A1 - Wikarski, Dietmar T1 - An approach to Petri net based integration of qualitative and quantitative analysis of parallel systems N2 - An innovative net-based methodology to integrate qualitative and quantitative analysis of distributed software systems is outlined, and an on-going prototype implementation of a related graphic-oriented tool kit is sketched. The proposed method combines qualitative analysis, monitoring and testing as well as quantitative analysis on the basis of a net-based intermediate representation of the distributed software system under consideration. All transformations (from the distributed software system into a first Petri net model, and between the different kinds of net models) can be made formally, and therefore automated to a high degree. The evaluation of quantitative properties is based on so-called object nets which are obtained by a property-preserving structural compression and quantitative expansion of the qualitative model. In this way, the frequency and delay attributes necessary to generate quantitative models are provided by the monitoring and testing component. Y1 - 1994 PB - Techn. Univ., Fak. für Mathematik, Naturwiss. und Informatik CY - Cottbus ER - TY - CHAP A1 - Maruwasa, L. T. A1 - Wikarski, Dietmar T1 - Integrated local g2c-e-government and e-business for rural areas: Can a German public-private partnership model be exported to Namibia? T2 - In K. Boamah and J. P. Grundling (Eds.). Proceedings of the 5th International conference on entrepreneurship and innovation, October 24-25, 2007, Windhoek Namibia. - Windhoek : Polytechnic of Namibia & Tshwane University of Technology, South Africa. - 2007 N2 - Private Public Partnerships (PPP) have been proven as one solution to ensure that the public receive enhanced services delivery from government and other civic organizations. In countries such as Namibia where the effects of the digital divide are so pertinent, PPP can and should be used to narrow this divide and so bringing to the people the promises of e-government and its many benefits as outlined in Vision 2030 and National Development Plan 3 (NDP3). Furthermore, these Private Public Partnerships can help to contribute to economic growth in particular in the Small Medium Enterprises (SME) sector. This paper attempts to show that these effects can be well achieved in the Namibian context by using the experience of a research/prototype project conducted in Germany to establish a so-called Public Service Network. Y1 - 2007 ER - TY - CHAP A1 - Mündemann, Friedhelm T1 - Zertifizierte TeleCoach-Ausbildung T2 - In: Berufliche Bildung in Deutschland für das 21. Jahrhundert : Dokumentation des 4. Forums Berufsbildungsforschung 1999 an der Universität Paderborn / Franz-Josef Kaiser (Hrsg.). Bundesanstalt für Arbeit. - Nürnberg : Zentralamt der Bundesanst. für Arbeit, Geschäftsstelle für Veröff., 1999. - (Beiträge zur Arbeitsmarkt- und Berufsforschung ; 238) (Beiträge zur Berufsbildungsforschung der AG BFN ; Nr. 4) ISBN 978-3-7639-3926-8 Y1 - 1999 SP - 527 EP - 538 ER - TY - CHAP A1 - Mündemann, Friedhelm T1 - eModeration : der Trainer als Lernermöglicher T2 - In: Online-Tutorien : Beiträge zum Spezialkongress "Distance Learning" der AG-F im Rahmen der LEARNTEC 2002 / Ulrich Bernath (Hrsg.). - Oldenburg : BIS Bilbiotheks- und Informationssystem der Universität Oldenburg, 2002 ISBN 3-8142-0806-4 Y1 - 2002 SP - 7 EP - 19 ER - TY - CHAP A1 - Mündemann, Friedhelm T1 - Architekturaspekte autonomer wissensverarbeitender Systeme T2 - In: ICAS-Forum Innovation / Universität der Bundeswehr München und ICAS, Institut für Cybernetische Anthropologie Starnberg e.V. Jörg D. Becker ... (Hrsg.). - München, 1996 ISBN 3-9805065-0-9 Y1 - 1996 SP - 135 EP - 150 ER - TY - JOUR A1 - Mündemann, Friedhelm A1 - Schaedla, J. A1 - Koslowsky, Th. T1 - brains-online: ein Brandenburger Informationssystem macht den online-Zugriff auf multimediale Präsentationssysteme möglich JF - In: Informatik: Herausforderung für Wirtschaft und Wissenschaft : A: Informationsgesellschaft Brandenburg ; B: Projektpräsentation Brandenburger Unternehmen ; C: IuK-Leistungsträger der Brandenburger Hochschulen. - Potsdam, Ministerium für Wirtschaft, Mittelstand und Technologie des Landes Brandenburg, 1996. - (Informations- und Kommunikationstechnologien im Land Brandenburg ; 6) Y1 - 1996 SP - 134 ff ER - TY - CHAP A1 - Mündemann, Friedhelm T1 - Learning in Presence Courses and Tele-Learning: What can Tele-learning achieve at the present State of Technology? T2 - In: Book of abstracts : International Conference on Technology Supported Learning, December 2 - 4, 1998, Hotel InterContinental, Berlin. - Bonn : Internat. Where and How, 1998 ISBN 3-925144-09-9 Y1 - 1998 SP - 205 EP - 208 ER - TY - CHAP A1 - Mündemann, Friedhelm T1 - Multimedia = Multilearning? Chances and Impacts of New Media in Telematics-Based learning T2 - In: Book of abstracts / Online Educa Berlin : 6th International Conference on Technology Supported Learning & Training ; November 30 - December 01, 2000. - Bonn : IWH-Verl., 2000 ISBN 3-925144-09-9 Y1 - 2000 SP - 61 EP - 65 ER - TY - CHAP A1 - Mündemann, Friedhelm T1 - eLearning meets pharmaceutical field staff T2 - In: LinkLearnTec 2005 : 13. Europäischer Kongreß und Fachmesse für Bildungs- und Informationstechnologie. - Karlsruhe : Karlsruher Messe- und Kongress-GmbH, 2005. - CD-ROM Y1 - 2005 ER - TY - CHAP A1 - Mündemann, Friedhelm T1 - Qualified training for TeleCoaches T2 - In: Online Educa Berlin ; 5th International Conference on Technology Supported Learning ; November 13-15, 1996, Berlin ; book of abstracts. - Berlin : Internat. Where + How, 1999. - ISBN 3-925144-09-9 Y1 - 1999 SP - 120 EP - 123 ER - TY - CHAP T1 - Verwaltung und Region im Electronic Government BT - Tagungsdokumentation, Brandenburg 25. Januar 2002 T2 - Stiftungsreihe / Alcatel-SEL-Stiftung für Technische und Wirtschaftliche Kommunikationsforschung ; 44 KW - Bürgernahe Verwaltung ; Computerunterstützter Unterricht ; Internet ; Verwaltungsautomation ; Wissensmanagement ; Fernunterricht ; Kongress ; Brandenburg an der Havel Y1 - 2002 EP - 39 S. PB - Alcatel SEL Stiftung CY - Stuttgart ER - TY - CHAP A1 - Wikarski, Dietmar T1 - Kooperatives Informations- und Wissensmanagement – aus der Hochschule in der Region T2 - In: Verwaltung und Region im Electronic Government : Tagungsdokumentation, Brandenburg 25. Januar 2002. - Stuttgart : Alcatel SEL Stiftung, 2002. - (Stiftungsreihe / Alcatel-SEL-Stiftung für Technische und Wirtschaftliche Kommunikationsforschung ; 44) Y1 - 2002 SP - 20 EP - 25 CY - Stuttgart ER - TY - CHAP T1 - Prozessmodellierung in der Medizin : [Dokumentation der Tagung "MedPro2011 - Tagung zur medizinischen Prozessmodellierung", Fachhochschule Brandenburg, 14. April 2011] T3 - Stiftungsreihe / Alcatel-Lucent-Stiftung für Kommunikationsforschung - 98 KW - Medizin KW - Prozessanalyse KW - Kongress KW - Brandenburg <2011> Y1 - 2012 PB - Alcatel-Lucent-Stiftung CY - Stuttgart ER - TY - CHAP A1 - Wikarski, Dietmar T1 - Prozessmodellierung zur Qualitätssicherung in den Bereichen Medizin, Rehabilitation und Ausbildung – Konzepte, Erfahrungen und Maxime T2 - Prozessmodellierung in der Medizin : [Dokumentation der Tagung "MedPro2011 - Tagung zur medizinischen Prozessmodellierung", Fachhochschule Brandenburg, 14. April 2011] / Eberhard Beck, Tina Meissner, Thomas Schrader, Dietmar Wikarski ... - Stuttgart : Alcatel SEL Stiftung, 2012. - 66 S. - (Stiftungsreihe / Alcatel-SEL-Stiftung für Kommunikationsforschung im Stifterverband für die Deutsche Wissenschaft ; 98) Y1 - 2012 SP - 49 EP - 54 ER - TY - CHAP A1 - Heiner, M. A1 - Ventre, G. A1 - Wikarski, Dietmar T1 - A Petri Net based Tool Kit to integrate qualitative and quantitative analysis T2 - In: Transputer applications and systems '93 : proceedings of the 1993 World Transputer Congress, 20 - 22 September 1993, Aachen, Germany / ed. by R. Grebe ... [TTC, the Transputer Consortium] . - ( Transputer and occam engineering series ; 36 ). - ISBN 90-5199-140-1 Y1 - 1993 SP - 1317 ER - TY - CHAP A1 - Mündemann, Friedhelm T1 - Methodik und Didaktik synchroner Online-Seminare T2 - In: Online lehren : Planung und Gestaltung netzbasierter Weiterbildung / DIE. [Hrsg. Inst. Deutsches Institut für Erwachsenenbildung]. Heino Apel/Susanne Kraft (Hrsg.). - Bielefeld : Bertelsmann, 2003. - ISBN 3-7639-1865-5 Y1 - 2003 SP - 51 EP - 75 PB - Bertelsmann CY - Bielefeld ER - TY - JOUR A1 - Mündemann, Friedhelm T1 - Test Train Test Certify (T3C): Ein neues Bildungsmodell für lebensbegleitendes Lernen JF - In: B & B Agrar : die Zeitschrift für Bildung und Beratung 56(2003)4 Y1 - 2003 SP - 106 EP - 108 ER - TY - JOUR A1 - Lüthy, Anja A1 - Lotze, I. A1 - Leiske, M. A1 - Rossi, R. T1 - Qualitätsmanagement und Kundenorientierung: Befragung zuweisender Kinderärzte einer Berliner Kinderklinik JF - Zeitschrift für ärztliche Fortbildung und Qualitätssicherung : ZaeFQ 94(2000), S. 31 - 35 Y1 - 2000 ER - TY - JOUR A1 - Lüthy, Anja A1 - Heuser, Jürgen T1 - Das eigene Netz stricken : Nutzung eines Intranet in stationären Altenpflegeeinrichtungen JF - In: Heim + Pflege / H+P Special 30(1999) 7, S. 18-21 Y1 - 1999 ER - TY - JOUR A1 - Lüthy, Anja T1 - Gastkommentar Webbasiert durchatmen, statt in Papier ersticken JF - In: Klinikmanagement aktuell : KMA 10/1999, S. 48 Y1 - 1999 ER - TY - CHAP A1 - Lüthy, Anja A1 - Dehning, Markus T1 - Personalarbeit im Internet T2 - In: Personal-Jahrbuch 1999 : Wegweiser für zeitgemäße Personalarbeit. - Neuwied [u.a.] : Luchterhand. - Y1 - 1999 ER - TY - JOUR A1 - Lüthy, Anja T1 - Was ist eigentlich ein Intranet? JF - In: BALK Info 12(1998) Y1 - 1998 ER - TY - JOUR A1 - Diel, F. A1 - Lüthy, Anja T1 - Marketing, Jobsuche und Diskussionen am Schwarzen Brett: das Internet kann auch in der Altenpflege genutzt werden JF - In: Heim und Pflege / H+P-Special (1998)5, S- 1- 5 Y1 - 1998 ER - TY - JOUR A1 - Lüthy, Anja T1 - Das deutsche Gesundheitsnetz JF - In: Führen und Wirtschaften im Krankenhaus : F & W (1998)5, S. 448-450 Y1 - 1998 ER - TY - JOUR A1 - Lüthy, Anja A1 - Heuser, Jürgen T1 - Web-Technologie als Werkzeug qualitätsorientierten Klinikmanagement JF - In: Krankenhaus-Umschau (1998)7, S. 501-508 Y1 - 1998 ER - TY - JOUR A1 - Lüthy, Anja T1 - Pflegemanagement - Studierende präsentieren ihre Projektarbeiten der Öffentlichkeit JF - In GQMG Newsletter (1998)5 Y1 - 1998 ER - TY - JOUR A1 - Lüthy, Anja A1 - Möllering, Christoph T1 - Innovatives Personalmanagement im Krankenhaus JF - In: Personalwirtschaft (1998)7, S. 52-55 Y1 - 1998 ER - TY - JOUR A1 - Mündemann, Friedhelm T1 - Das T3C-Konzept am Beispiel von CELP JF - In: B & B Agrar : die Zeitschrift für Bildung und Beratung 56(2003)4 Y1 - 2003 SP - 109 ER - TY - JOUR A1 - Mündemann, Friedhelm T1 - Die Nachhaltigkeit des Bundesleitprojektes Virtuelle Fachhochschule (VFH) JF - In: Limpact 6 (2003) Y1 - 2003 SP - 3 EP - 5 ER - TY - JOUR A1 - Mündemann, Friedhelm T1 - E-Didaktik - Die Schulung mit der Maus JF - In: managerSeminare 46 (2001), S. 82 - 91 Y1 - 2001 SP - 82 EP - 91 ER - TY - JOUR A1 - Mündemann, Friedhelm T1 - E-Moderation - Der Trainer als Lernermöglicher JF - In: e-le@rning : Lernen mit neuen Medien 1 (2001), S. 18 - 26 Y1 - 2001 SP - 18 EP - 26 ER - TY - JOUR A1 - Mündemann, Friedhelm T1 - EDidaktik für Online-Seminare JF - In: In: DVV-Magazin Volkshochschule, 8 (2001) 4, S. 31-33 KW - Mediendidaktik KW - Fernunterricht KW - Erwachsenenbildung Y1 - 2001 SP - 31 EP - 33 ER - TY - JOUR A1 - Mündemann, Friedhelm T1 - Ein Ausflug nach eLearning county JF - Das Forum. - München (2001)3, S. 6 - 10 Y1 - 2001 SP - 6 EP - 10 ER - TY - JOUR A1 - Mündemann, Friedhelm T1 - eLearning county ist eine Reise wert JF - In: TOP : das Bildungs-Magazin der Deutschen Versicherungsakademie (2001) 1, S. 16 - 17 Y1 - 2001 SP - 16 EP - 17 ER - TY - JOUR A1 - Mündemann, Friedhelm T1 - Standards für Telelern-Betreuer JF - In: Wissensmanagement (2000) 3, S. 41 - 44 Y1 - 2000 SP - 41 EP - 44 ER - TY - CHAP A1 - Mündemann, Friedhelm T1 - TeleCoaches: Aufgaben, Ausbildung T2 - In: Campus 2000 : Lernen in neuen Organisationsformen / [Ges. für Medien in der Wissenschaft]. Friedrich Scheuermann (Hrsg.). - Münster [u.a.] : Waxmann, 2000. - (Medien in der Wissenschaft ; 10) ISBN 3-89325-925-2 Y1 - 2000 SP - 411 EP - 413 ER - TY - CHAP A1 - Mündemann, Friedhelm T1 - Kommunikationsmanagement in Telelern-Szenarien T2 - In: LearnTec 99 : 7. Europäischer Kongreß und Fachmesse für Bildungs- und Informationstechnologie; Tagungsband; [Karlsruhe, 9. - 11. Februar 1999] / Uwe Beck ... (Hrsg.). - Karlsruhe : Karlsruher Kongreß- und Ausstellungs-GmbH, 1999. - Karlsruhe : Karlsruher Kongreß- und Ausstellungs-GmbH, 1999. - (Schriftenreihe der Karlsruher Kongreß- und Ausstellungs-GmbH) Y1 - 1999 SP - 569 EP - 580 ER - TY - JOUR A1 - Lüthy, Anja T1 - Internet - Schlüssel zur Kommunikation und Information des Krankenhauses JF - In: Managment & Krankenhaus (1998)3, Y1 - 1998 ER - TY - CHAP A1 - Lüthy, Anja T1 - Personalarbeit im Internet T2 - In: Personal-Jahrbuch 1998 : Wegweiser für zeitgemäße Personalarbeit. - Neuwied : Luchterhand, 1998. - ISBN 3-472-03049-6 Y1 - 1998 ER - TY - JOUR A1 - Lüthy, Anja T1 - Was das Internet der Pflege bietet, Teil 1 JF - In: Heilberufe 52(1998)2 Y1 - 1998 ER - TY - JOUR A1 - Lüthy, Anja T1 - Was das Internet der Pflege bietet, Teil 2 JF - In: Heilberufe 52(1998)3 Y1 - 1998 ER - TY - JOUR A1 - Lüthy, Anja T1 - Rooming-in: Lästiges Übel oder Herausforderung? JF - In: Heilberufe 51(1997)11 Y1 - 1997 ER - TY - JOUR A1 - Lüthy, Anja T1 - Führungskräfte aus der Pflege JF - In: Führen und Wirtschaften im Krankenhaus : F & W (1997)5, S. 413-415 Y1 - 1997 ER - TY - JOUR A1 - Lüthy, Anja T1 - Nutzungsmöglichkeiten des Internet im Krankenhaus JF - In: Führen und Wirtschaften im Krankenhaus : F & W (1997)2, S. 121-128 Y1 - 1997 ER - TY - JOUR A1 - Lüthy, Anja T1 - Zeitmanagement für niedergelassene Anästhesisten JF - Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : ains 41(2006)7/8, S. 514-518 Y1 - 2006 ER - TY - JOUR A1 - Mieke, Christian T1 - Strategische Planung von Prozessvarianten mittels Prozess-Roadmapping JF - In: Industrie-Management : Zeitschrift für industrielle Geschäftsprozesse Bd. 28 (2012), 4, S.47-50. - ISSN 0179-2679, Y1 - 2012 SP - 47 EP - 50 ER - TY - JOUR A1 - Mieke, Christian T1 - Innovationsplanung mit portfoliogestützten Technologie-Roadmaps JF - In: Wissensmanagement (2012), 4, S. 14-16 . - ISSN: 1438-4426 Y1 - 2013 SP - 14 EP - 16 ER - TY - BOOK A1 - Mieke, Christian T1 - Technologiefrühaufklärung in Netzwerken KW - Technologiemanagement KW - Strategische Frühaufklärung KW - Netzwerkmanagement Y1 - 2006 SN - 978-3-8350-0445-0 N1 - Zugl.: Cottbus, Techn. Univ., Diss., 2005, u.d.T.: Mieke, Christian: Kooperative Technologiefrühaufklärung mittels szenariobasiertem Technologie-Roadmapping PB - Dt. Univ.-Verl. CY - Wiesbaden ER - TY - THES A1 - Mieke, Christian T1 - Kooperative Technologiefrühaufklärung mittels szenariobasiertem Technologie-Roadmapping Y1 - 2005 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:co1-000000795 ER - TY - JOUR ED - Wieneke-Toutaoui, Burghilde T1 - Studienführer 2013/14 BT - Studieren, Forschen, Leben N2 - Inhalt Allgemeine Informationen 1 Willkommen auf dem Campus (FHB) 6 Unser Studienangebot auf einen Blick 9 Die drei Fachbereiche im Überblick 10 Optimale Studienbedingungen 12 Vielfältige Serviceleistungen 14 Studierende im Gespräch 17 Beratung und Betreuung 20 Besuchertage 24 Zugang zum Studium 26 Informatik und Medien studieren 28 Fachbereich Informatik und Medien 30 Applied Computer Science (B.Sc.) 31 Informatik (B.Sc.) 35 Medizininformatik (B.Sc.) 39 Digitale Medien (M.Sc.) 42 Informatik (M.Sc.) 44 Technik studieren 48 Fachbereich Technik 50 IT-Elektronik (B.Eng.) 51 Maschinenbau (B.Eng.) 55 Mechatronik/Automatisierungssysteme (B.Eng.) 60 Mikrosystemtechnik und Optische Technologien (B.Eng.) 63 Energieeffizienz Technischer Systeme (M.Eng.) 67 Photonik (M.Eng.) 70 Wirtschaft studieren 72 Fachbereich Wirtschaft 74 Betriebswirtschaftslehre, Gründen – Führen – Steuern (B.Sc.) 75 Wirtschaftsinformatik (B.Sc.) 79 Betriebswirtschaftslehre, Innovativ – Integrativ – International (M.Sc.) 82 Security Management (M.Sc.) 85 Technologie- und Innovationsmanagement (M.Sc.) 88 Wirtschaftsinformatik (M.Sc.) 90 Fernstudium/Weiterbildung 92 Lebenslang lernen 94 Berufsbegleitender Bachelorstudiengang BWL (B.A.) 95 Onlinestudiengang Medieninformatik (B.Sc.) 100 Onlinestudiengang Medieninformatik (M.Sc.) 102 Security Management (M.Sc.) 104 Studienvorbereitungskurse 106 Weiterbildung für Ingenieure 107 Studentenleben 108 Kontaktliste 112 Abkürzungsverzeichnis 116 Anfahrtsplan in Brandenburg an der Havel 119 Campusplan 118 Impressum 119 T3 - Studienführer - 2013/14 Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:522-opus4-3420 SN - 978-3-9808266-5-5 PB - Fachhochschule Brandenburg CY - Brandenburg ER - TY - JOUR T1 - Studienführer Bachelor 2017/18 T3 - Studienführer - 2017/18 Y1 - 2017 SN - 2196-5242 PB - Technische Hochschule Brandenburg CY - Brandenburg an der Havel ER - TY - JOUR A1 - Beck, Eberhard A1 - Bittl, A. A1 - Koller, S. A1 - Merkle, E. A1 - Katalinic, A. A1 - Jäger, W. A1 - Lang, N. T1 - Erfassung der fetalen Retardierung mittels Ponderal Index und Gewichtsperzentilen Assessment of Fetal Retardation via Ponderal Index and Weight Percentiles JF - In: Geburtsh Frauenheilk 59(1999)2, 62-69 N2 - Zusammenfassung Intrauterin wachstumsretardierte Neugeborene konnten ihr genetisches Wachstumspotential aufgrund einer intrauterinen Mangelversorgung nicht realisieren und werden deshalb zu klein oder zu leicht geboren. Das Merkmal „zu leicht” wird mit Hilfe von Gewichtsperzentilen quantifiziert. Kinder mit einem Gewicht< 10. Perzentile werden als „small for gestational age” (SGA) bezeichnet. Diese Einteilung berücksichtigt jedoch nicht die Proportionen eines Neugeborenen, so daß vor allem asymmetrisch retardierte Neugeborene, deren Gewicht zwar die 10. Perzentile noch überschreitet, die jedoch für ihre Körpergröße untergewichtig sind, nicht erfaßt werden. Der Ponderal Index (PI) dagegen berücksichtigt sowohl Gewicht als auch Länge des Neugeborenen. Kinder mit einem PI < 10. Perzentile werden als „low Ponderal Index” (LPI) klassifiziert. Aus pädiatrischen Studien ist bekannt, daß LPI-Kinder vermehrt durch Hypoglykämien, Hypothermien, Hypokalzämien und Mekoniumaspirationen/Aspirationspneumonien gefährdet sind. Langzeiterhebungen zeigten eine verzögerte körperliche Entwicklung und gehäuft motorische oder neurologische Verhaltensauffälligkeiten sowie schulische Probleme. Fragestellung: Ziel der vorliegenden Arbeit war die Frage, ob Mangelgeborene, insbesondere LPI-Neugeborene, auch intrapartum einer erhöhten Gefährdung ausgesetzt sind. Methoden: Hierzu wurden 3687 Neugeborene retrospektiv erfaßt, die anhand von Perzentilenkurven des betrachteten Kollektivs als SGA, LPI, SGA/LPI oder Vergleichskollektiv klassifiziert wurden. Ergebnisse: Unterschiede im Geburtsmodus zwischen SGA- bzw. LPI-Mangelgeborenen und eutrophen Neugeborenen waren schwach ausgeprägt. Demgegenüber unterschied sich die Indikation, aufgrund deren ein geburtshilflicher Eingriff vorgenommen werden mußte deutlich. Bei 31 % aller operativ entbundenen LPI-Neugeborenen, 47 % der SGA-Neugeborenen und 52 % der SGA/LPI-Kinder erfolgte die operative Entbindung aus fetaler Indikation, im Vergleich zu 16 % des Normalkollektivs. Bezüglich des „fetal outcome”, das die Merkmale neonataler Säure-Basen-Status, Apgar-Wert, Verlegung in die Kinderklinik und perinatale Mortalität einbezog, verhielten sich die Gruppen SGA, LPI und SGA/LPI in gleicher Weise schlechter gegenüber dem Vergleichskollektiv. Die Unterschiede zwischen proportionierten (SGA) und dysproportionierten (LPI) Mangelgeborenen waren weniger deutlich. Schlußfolgerungen: Es zeigte sich, daß das gegenwärtige engmaschige, geburtshilfliche Management mit nahezu permanenter CTG-Überwachung sub partu Probleme rechtzeitig erkennen und beherrschen ließ. Die Erfassung des niedrigen Ponderal Index war zur Erkennung und Vermeidung subpartaler geburtshilflicher Risikofaktoren nicht entscheidend. N2 - Abstract Intrauterine growth retarded fetuses could not realize their genetic potential due to intrauterine malnutrition and could thus not reach an appropriate length or weight according to their gestational age. New born infants below the 10 th percentile are termed „small for gestational age” (SGA). However, this definition does not account for asymmetrically retarded infants who's birth weight is above the 10th percentile, but who are underweight for their length. In contrast the fetal Ponderal Index (PI) regards both fetal length and weight. New born infants with a PI <10th percentile are classified as „low Ponderal Index” (LPI). From pediatric studies it is well known that LPI infants are more likely threatened by hypoglycemia, hypothermia, hypocalcemia and meconium aspiration pneumonitis. Long term follow-up studies showed a retarded physical and mental development of these infants. Purpose: The current study followed the question if intrauterine growth retarded fetuses, esp. LPI infants are also at higher risk during labour. The data of 3687 new born infants were retrospectively analyzed. Study Design: According to their birth weight and length they were characterized as SGA, LPI, SGA/LPI or „appropriate for gestational age” AGA. The AGA infants together with the LGA infants were used as control group. Results: No significant differences in respect to birth modalities (i.e. vaginal delivery, cesarean section, operative vaginal delivery) could be detected between SGA-, LPI- and AGA infants. However, concerning the indication which formed the basis for an operative delivery, we found significant differences. In 31 % of all operatively delivered LPI new born, 47 % of the SGA infants and 52 % of the SGA/LPI group the indication for the operative management was based on fetal problems. This indication accounted for only 16 % of the operatively delivered infants in the control group. Regarding the fetal outcome, specified by the fetal acid base status, Apgar index, frequency of transfer to the neonatal intensive care unit, and perinatal mortality, no differences between LPI, SGA and SGA/LPI infants could be detected. Conclusion: We conclude that the current strategies of monitoring labour, e.g. by continuous CTG scanning, are sufficient to detect and master fetal problems. The detection of a „low Ponderal index” did not add any information concerning the management of labour. Y1 - 1999 SP - 62 EP - 69 ER - TY - JOUR A1 - Beck, Eberhard A1 - Moldenhauer, A. A1 - Merkle, E. A1 - Kiesewetter, F. A1 - Jäger, W. A1 - Wildt, L. A1 - Lang, N. T1 - CA 125 production an release by ovarian cancer cell lines in vitro JF - In: The international journal of biological markers 13(1998), 200 – 206 Y1 - 1998 SP - 200 EP - 206 ER - TY - JOUR A1 - Fehm, T. A1 - Beck, Eberhard A1 - Valerius, T. A1 - Gramatzki, M. A1 - Jäger, W. T1 - CA 125 elevations in patients with malignant lymphomas JF - In: Tumor Biology 19(1998), 283 – 289 Y1 - 1998 SP - 283 EP - 289 ER - TY - JOUR A1 - Beck, Eberhard A1 - Wagner, Maren A1 - Anselmino, Lisa A1 - Xu, Feng-ji A1 - Bast Jr., Robert C. A1 - Jäger, Wolfram T1 - Is OVX1 a suitable marker for endometrial cancer? JF - In: Gynecologic Oncology 65(1997) 2, 291–296 N2 - The single most common cause leading to the diagnosis of endometrial cancer is postmenopausal bleeding. Although most patients with early-stage disease (FIGO stage I and II) can be cured, prognosis worsens considerably with increasing stage. While serum CA 125 levels are elevated only in a significant proportion of patients with advanced disease, recently a new serum marker (OVX1) for the detection of early-stage endometrial cancer was reported. Serum OVX1 levels were measured using an OVX1 radioimmunoassay (RIA) or enzyme immunoassay (EIA) in 192 patients with endometrial cancer. CA 125 levels were measured in 112 patients using the CIS ELSA CA 125 kit. Apparently healthy females had mean serum OVX1 levels measured with the OVX1–EIA of 1.34 ± 0.74 U/ml, while patients with endometriosis had mean OVX1 serum levels of 3.15 ± 2.45 U/ml. The mean OVX1 serum level for endometrial cancer patients was 2.00 ± 1.32 U/ml. These values were 2.76 ± 1.62, 6.10 ± 4.66, and 5.37 ± 3.49, respectively, using the OVX1–RIA assay. Applying a cutoff value of 2.8 U/ml, serum OVX1–EIA levels in endometrial cancer patients were increased in 25 of 127 patients (19.7%) with stage I disease, 5 of 17 patients with stage II (29.4%), 5 of 22 patients (22.7%) with stage III, and 4 of 11 patients (36.4%) with stage IV disease. Using the OVX1–RIA and a cutoff of 7.2 U/ml, serum levels were increased in 22 of 127 (17.3%) stage I, 6 of 17 (35.3%) stage II, 5 of 22 (22.7%) stage III, and 6 of 11 (54.5%) stage IV patients. Serum CA 125 levels, determined in a total of 112 patients, were elevated above 35 U/ml in 12 of 79 patients (15.2%) with stage I, 4 of 12 patients (33.3%) with stage II, 8 of 13 patients (61.5%) with stage III, and all of 8 patients (100%) with stage IV disease. While a good correlation between serum CA 125 levels and the clinical stage of the disease was found, no correlation could be detected for OVX1 and stage. Y1 - 1997 SP - 291 EP - 296 ER - TY - JOUR A1 - Jäger, W. A1 - Sauerbrei, W. A1 - Beck, Eberhard A1 - Maassen, V. A1 - Stumpfe, M. A1 - Meier, W. A1 - Kuhn, W. A1 - Jänicke, F. T1 - Unbound MEDLINE A randomized comparison of triptorelin and tamoxifen as treatment of progressive ovarian cancer JF - In: Anticancer Research 15(1995)6B, 2639-2642 Y1 - 1995 SN - 0250-7005 SP - 2639 EP - 2642 ER - TY - CHAP A1 - Beck, Eberhard A1 - Moldenhauer, A. A1 - Kiesewetter, F. A1 - Jäger, W. A1 - Woldt, L. A1 - Lang, N. T1 - Analysis of CA 125 production and release by ovarian cancer cells in vitro T2 - In: Current tumor diagnosis : applications, clinical relevance, research - trends / 7th Symposium on Tumor Markers, Hamburg 1993 ; Satellite Symposium Cancer of the Lung - State and Trends in Diagnosis and Therapy. Ed. by R. Klapdor. - München [u.a.] : Zuckschwerdt, 1994. - ISBN 3-88603-509-3 Y1 - 1994 SP - 187 EP - 191 ER - TY - JOUR A1 - Beck, Eberhard A1 - Hofmann, M. A1 - Bernhardt, G. A1 - Jäger, W. A1 - Wildt, L. A1 - Lang, N. T1 - In vitro activity of immunoconjugates between cisplatin and an anti CA125 monoclonal antibody on ovarian cancer cell lines JF - In: Cell Biophysics 24/25(1994)1-3, 163-173 N2 - Cis-diammine dichloro platinum (II) (CDDP), is a highly potent antineoplastic agent that is used in the treatment of ovarian cancer. However, the clinical use of CDDP is restricted by its severe side effects. In order to reduce these side effects and to enhance its therapeutic efficacy, we developed specific immunoconjugates consisting of the murine monoclonal antibody OC125 and CDDP, using diethylene triamine pentaacetic acid (DTPA) as a linker. The coupling efficiencies of the different preparations synthesized, varied between 1.10±0.42 and 2.65±1.60 mol of CDDP per mol of antibody protein. Despite the chemical modification of the antibody molecule, specific binding activity of the OC125-CDDP conjugates toward the CA125 antigen was maintained as was demonstrated by means of immunohisto-/cytochemical staining of frozen sections of ovarian cancer tissue, amniotic epithelium, and the CA125 positive ovarian cancer cell line NIH:OVCAR 3. The antiproliferative activity of the immunoconjugates was tested against the human ovarian cancer cell lines NIH:OVCAR3 and SKOV 3, applying a kinetic crystal violet microassay. Despite the promising results obtained with the specific immuno-staining of the target cells, no significant antiproliferative activity of our immunoconjugates against the cell lines tested was observed. One possible explanation for the lack of antitumor activity could be the fact that CA125 is released in large amounts by the NIH:OVCAR 3 cells. This may have prevented an efficient immunotargeting of the cancer cells by the formation of soluble immune complexes. Y1 - 1994 SN - 0163-4992 SP - 163 EP - 173 ER - TY - JOUR A1 - Beck, Eberhard A1 - Russo, Pietro A1 - Gliozzo, Biancamaria A1 - Jäger, Wolfram A1 - Papa, Vincenzo A1 - Wildt, Ludwig A1 - Pezzino, Vincenzo A1 - Lang, Norbert T1 - Identification of insulin and insulin-like growth factor I (IGF I) receptors in ovarian cancer JF - In: Gynecologic Oncology 53(1994)2, 196–201 N2 - Abstract The objective of this study was to test if specific insulin and insulin-like growth factor I (IGF I) receptors are expressed in ovarian cancer tissue. Thirteen tissue specimens from primary ovarian cancers, 1 specimen from a primary peritoneal carcinoma, 10 specimens from metastatic lesions of ovarian carcinomas, and 4 specimens from recurrent ovarian cancers together with 13 normal ovaries were tested for their content of insulin and IGF-I receptors, by the application of specific insulin and IGF-I receptor radioimmunoassays. The insulin receptor (IR) and IGF-I receptor (IGF R) content in the primary tumors varied between 23.8-321.4 and 16.4-554.2 ng/0.1 mg DNA, respectively. Metastatic lesions contained between 12.3 and 226.7 ng IR/0.1 mg DNA and between 7.5 and 459.4 ng IGF R/0.1 mg DNA. In recurrent tumors the receptor concentrations were in the range of 41.5-79.8 and 48.9-160.9 ng/0.1 mg DNA for insulin and IGF-I receptors, respectively. Normal ovarian tissue contained between 12.2 and 150.1 ng IR and between 21.4 and 420.1 ng IGF R per 0.1 mg DNA, respectively. As both insulin and IGF-I receptors are present in ovarian cancer tissue, the effects of insulin and IGF-I as potential growth factors in ovarian cancer should be further investigated. Copyright © 1994 Academic Press. All rights reserved. Y1 - 1994 SN - 0090-8258 SP - 196 EP - 201 ER - TY - JOUR A1 - Beck, Eberhard A1 - Russo, P. A1 - Papa, V. A1 - Jäger, W. A1 - Pezzino, V. A1 - Wildt, L. A1 - Vigneri, R. A1 - Lang, N. T1 - Nachweis von Insulin-Rezeptoren (IR) in Ovarialkarzinomgewebe JF - In: Archives of Gynecology and Obstetrics December 254(1993)Iss. 1-4, 1053-1054 Y1 - 1993 SN - 0932-0067 SP - 1053 EP - 1054 ER - TY - CHAP A1 - Bittl, A. A1 - Beck, Eberhard A1 - Jäger, W. A1 - Wildt, L. T1 - Untersuchungen zur Amenorrhoe unter adjuvanter CMF-Chemotherapie bei Mammakarzinom-Patientinnen T2 - In: Zytostatikabedingte Nebenwirkungen : Symposium in Pommersfelden, 3. - 4. Juli 1992; 26 Tabellen / Bd.-Hrsg.: N. Lang; W. Jäger. - München [u.a.] : Zuckschwerdt, 1992. - (Aktuelle Onkologie ; 68). - ISBN: 3-88603-458-5 Y1 - 1993 SP - 10 EP - 14 ER - TY - CHAP A1 - Mündemann, Friedhelm T1 - Kommunikationsmanagement in Telelern-Szenarien T2 - In: Berufsbildung '99 : fit im Beruf - fit für die Zukunft ; Dokumentation ; Nürnberg 1. bis 4. Dezember 1999 / [Fachausstellung für Aus- und Weiterbildung und 7. Bayerischer Berufsbildungskongress]. - München : Bayerisches Staatsministerium für Arbeit und Sozialordnung, Familie, Frauen und Gesundheit, 1999. - (Studien und Berichte zur Berufsbildung) Y1 - 1999 SP - 160 EP - 161 ER - TY - JOUR A1 - Mündemann, Friedhelm T1 - Online only? JF - In: Das Forum : Zeitschr. d. Volkshochschulen Bayerns, (1998) 2, S. 2-9 ISSN 0176-3687 KW - Mediendidaktik KW - Computerunterstützter Unterricht KW - Fernuntericht KW - Volkshochschule Y1 - 1998 SP - 2 EP - 9 ER - TY - JOUR A1 - Lüthy, Anja T1 - Employer Branding: Was Kliniken von anderen Branchen lernen können JF - In: HeilberufeScience 3 (2012), S. 18 Y1 - 2012 UR - link.springer.com/content/pdf/10.1007%2Fs16024-012-0128-x SP - 18 ER - TY - CHAP A1 - Buchmann, Uta A1 - Lüthy, Anja T1 - Umfassendes Dienstleistungsmarketing – Pflichtaufgabe für Krankenhäuser T2 - In: Patient Krankenhaus : Wie Kliniken der Spagat zwischen Ökonomie und medizinischer Spitzenleistung gelingt / hrsg. von Ulrich Korff. - Wiesbaden : Gabler, 2012. - ISBN: 978-3-8349-7189-0; 978-3-8349-3433-8 (ISBN der Printausgabe) N2 - Krankenhäuser müssen noch viel lernen, wenn es darum geht, ihre Leistungen kundenorientiert – auch über die medizinischen Kernleistungen hinaus – erfolgreich zu vermarkten. Von einem systematischen Dienstleistungsmarketing sind viele Häuser noch weit entfernt. Ein professionell praktiziertes Dienstleistungsmarketing – von der grundlegenden Strategie bis zur operativen Umsetzung – ist jedoch die Grundvoraussetzung, um sich im Wettbewerb um Patienten erfolgreich zu behaupten. Y1 - 2012 UR - http://link.springer.com/chapter/10.1007/978-3-8349-7189-0_16 SP - 177 EP - 191 ER - TY - JOUR A1 - Gebauer, Gerhard A1 - Mueller, Natalia A1 - Fehm, Tanja A1 - Berkholz, Alexander A1 - Beck, Eberhard A1 - Jaeger, Wolfram A1 - Licht, Peter T1 - Expression and regulation of luteinizing hormone/human chorionic gonadotropin receptors in ovarian cancer and its correlation to human chorionic gonadotropin–doxorubicin sensitivity JF - In: American Journal of Obstetrics & Gynecology 190 (2004), Iss. 6, pp. 1621-1628 N2 - Objective Ovarian cancer cell lines and tissues express gonadotropin receptors. Conjugation of cytostatics to ligands of these receptors may increase the specificity of cytotoxic drugs. Study design Toxicity of doxorubicin–human chorionic gonadotropin conjugates was determined in 4 ovarian cancer cell lines. Expression and regulation of luteinizing hormone/human chorionic gonadotropin receptors were analyzed before and after treatment with human chorionic gonadotropin, epidermal growth factor, and 8-bromo-cyclic adenosine monophosphate with a nested reverse transcriptase–polymerase chain reaction approach. Results Toxicity of human chorionic gonadotropin–doxorubicin conjugates was increased compared with unconjugated doxorubicin in OVCAR-3 cells. However, drug conjugates failed to demonstrate increased toxicity in other cell lines, especially after preincubation with human chorionic gonadotropin. All cell lines expressed luteinizing hormone/human chorionic gonadotropin receptors. Receptor expression in OVCAR-3 cells was not effected by human chorionic gonadotropin, endothelial growth factor, or 8-bromo-cyclic adenosine monophosphate treatment. In other cell lines, receptor expression was down-regulated by these agents. Conclusion Cytotoxic activity of doxorubicin was increased specifically by conjugation to human chorionic gonadotropin. However, the regulation of luteinizing hormone/human chorionic gonadotropin receptor expression and other compounds may reduce the drug-uptake of the conjugates. Y1 - 2004 SP - 1621 EP - 1624 ER - TY - JOUR A1 - Gebauer, Gerhard A1 - Fehm, Tanja A1 - Beck, Eberhard A1 - Berkholz, Alexander A1 - Licht, Peter A1 - Jäger, Wolfram T1 - Cytotoxic effect of conjugates of doxorubicin and human chorionic gonadotropin (hCG) in breast cancer cells JF - In: Breast Cancer Research and Treatment 77(2003)2, pp. 125-131 N2 - Cytotoxic activity of drug conjugates of human chorionic gonadotropin (hCG) and doxorubicin alone was investigated compared to doxorubicin in breast cancer cells with and without expression of hCG receptors. Expression of hCG receptor was determined in MCF-7 and MB231 breast cancer cell line using a multiplex nested rt-PCR approach. The entire sequence of mRNA encoding for hCG receptor was detected in MCF-7 but not in MB231 breast cancer cell line. Cytostatic effect of doxorubicin–hCG conjugates was investigated in these cell lines in comparison to unconjugated doxorubicin. The number of viable cells was determined after 24, 48, 72, 96, and 120 h. To exclude non-specific uptake of the carrier hCG from the culture media, a similar experiment was performed with albumin–doxorubicin conjugates. The number of viable cells decreased in a concentration depending manner after doxorubicin and hCG–doxorubicin conjugate treatment. However, the cytotoxic effect of hCG–doxorubicin conjugate was 10-fold increased compared to unconjugated doxorubin in hCG-receptor positive MCF-7 but not in hCG-receptor negative MB231 cells. Albumin–doxorubicin conjugates showed no increased toxicity compared to doxorubicin. We conclude that the cytotoxic effect of hCG–doxorubicin conjugates is mediated specifically via the hCG receptor. By using hCG conjugates, the development of more selective cytostatics can be achieved. Y1 - 2003 UR - http://link.springer.com/article/10.1023%2FA%3A1021301001208 SP - 125 EP - 131 ER - TY - JOUR A1 - Gebauer, Gerhard A1 - Fehm, Tanja A1 - Merkle, Elisabeth A1 - Beck, Eberhard A1 - Lang, Norbert A1 - Jäger, Wolfram T1 - Epithelial Cells in Bone Marrow of Breast Cancer Patients at Time of Primary Surgery: Clinical Outcome During Long-Term Follow-Up JF - In: J. Clin. Oncol. 19(2001)16, 3669 – 3674 N2 - PURPOSE: To evaluate the detection of epithelial cells in bone marrow of breast cancer patients as an indicator of metastatic disease. PATIENTS AND METHODS: Between 1989 and 1994, bone marrow biopsies were performed on 393 breast cancer patients during primary surgery. Specimens were stained immunocytochemically for epithelial cells expressing cytokeratins or the epithelial membrane antigen. The long-term outcomes of these patients were analyzed in this study. RESULTS: In 166 of 393 patients, epithelial cells were found in bone marrow (BM) aspirates. These patients were designated BM+. The rate of tumor recurrence or cancer-related death was significantly higher in BM+ patients than in BM− patients. Multivariate analysis using the Cox regression model revealed BM status as a prognostic parameter independent of tumor size and axillary lymph node status. However, tumor size and axillary lymph node status were clearly superior prognostic parameters. CONCLUSION: Disseminated epithelial cells in BM are associated with poor clinical outcome in breast cancer patients. However, the presence of these cells is not a sufficient parameter to predict growing metastases in the majority of patients, suggesting that epithelial cells in the BM of breast cancer patients at the time of surgery have limited metastatic potential. The role of these cells needs to be further evaluated. Y1 - 2001 SP - 3669 EP - 3674 ER - TY - JOUR A1 - Merkle, E. A1 - Ackermann, S. A1 - Beck, Eberhard A1 - Jäger, W. A1 - Lang, N. T1 - High-Dose versus Low-Dose Cisplatin Chemotherapy plus Treosulfan in Epithelial Ovarian Carcinoma FIGO II–IV: Results of a Prospective Randomized Trial JF - In: Onkologie 23(2000)3, 232-238 N2 - Summary Background: Combination chemotherapies of platinum compounds with alkylating agents have been the standard treatment for patients with advanced ovarian carcinoma over the last decades. The recent development of taxans has added a group of new promising agents; however, long-term results are not yet available. Platin derivates have proven to be an indispensable part in combination chemotherapies for ovarian carcinoma. The dose intensity of cisplatin is, however, still a matter of debate. We report on the long-term results of a prospective randomized trial comparing two dosages of cisplatin combined with treosulfan in patients with advanced epithelial ovarian cancer. Patients and Methods: Between 1988 and 1995, 125 patients with ovarian cancer (FIGO stage II–IV) were randomized to receive 4 cycles (28-day intervals) of either cisplatin 100 mg/m2 (high dose, HD) or 50 mg/m2 (low dose, LD) in combination with 5 g/m2 treosulfan after primary cytoreductive surgery. Postoperative residual tumor was absent in 39 patients (HD: 16; LD: 23), < 2 cm in 61 patients (HD: 36; LD: 25) and > 2 cm in 25 patients (HD: 13; LD: 12). 65 and 60 patients received HD and LD cisplatin, respectively. Second-look surgery was optional. Results:The overall response rate was 70.0% (HD: 70.9%; LD: 68.9%). Pathological complete response (CR) was seen in 45 patients (37.5%), clinical CR in 23 patients (19.2%), partial response (PR) in 16 patients (13.3%), stable disease (SD) in 2 patients, and progression of disease (PD) in 34 patients (28.3%). 5 patients were not assessable for response. Overall median survival was 25.6 (HD: 26.9, LD: 25.2) months. The overall disease-free survival for responders was 19.6 and 24.7 months (HD and LD, respectively). HD chemotherapy did not result in any significant survival benefit in completely resected patients: HD: 39.8 months versus LD: 49.5 months. In suboptimally debulked patients (residual tumor < 2 cm), median survival was 24.1 months (HD) versus 22.6 months (LD). In patients with residual tumors > 2 cm median survival was 14.6 months (HD) versus 15.5 months (LD). Significantly less side effects were seen in the LD group: anemia (p = 0.008); nephrotoxicity (p = 0.014); alopecia (p = 0.017). Conclusions: Our data suggest that LD cisplatin-based chemotherapy is as effective as HD chemotherapy in patients with advanced epithelial ovarian cancer, but is far less toxic. Copyright © 2000 S. Karger GmbH, Freiburg Y1 - 2000 SP - 232 EP - 238 ER - TY - CHAP A1 - Beck, Eberhard A1 - Sciacca, Laura A1 - Pandini, Giuseppe A1 - Jaeger, Wolfram A1 - Pezzino, Vincenzo T1 - Measurement of IGF-1 Receptor Content in Tissues and Cell Lines by Radioimmunoassay (RIA) and ELISA Techniques T2 - In: Ovarian Cancer : Methods and Protocols / ed. by John M. S. Bartlett. - Totowa, NJ : Humana Press, 2001. - Totowa, NJ : Humana Press, 2001. - (Methods in Molecular Medicine™ ; 39). - ISBN: 978-1-592-59071-1; 978-0-89603-583-6 (ISBN der Printausgabe) N2 - The IGF-1 receptor (IGF-1-R) belongs to the tyrosine kinase growth factor receptor family. It is structurally similar to, but distinct from, the insulin receptor, with which it shares a 70% homology. As expected, it crossreacts with insulin and, vice versa, insulin receptor crossreacts with IGF-1. Numerous studies suggest that IGF-1-R is very important for mitogenesis and is essential for phenotype transformation, at least in rodents (1). In particular, the IGF-1-R has been described in human breast cancer (2-4) and ovarian cancer (5) tissues and in cultured human breast cancer cell lines (6,7). Y1 - 2001 SP - 485 EP - 492 ER - TY - JOUR A1 - Beck, Eberhard A1 - Vincenti, D. A1 - Licht, P. A1 - Berkholz, A. A1 - Jäger, W. A1 - Lang, N. A1 - Merkle, E. T1 - In vitro activity of human chorionic gonadotropin (hCG)--doxorubicin conjugates against ovarian cancer cells JF - In: Anticancer research 20(2000)5A, pg 3001-6 N2 - BACKGROUND Despite radical surgery and the introduction of novel chemotherapeutic agents, the prognosis of ovarian cancer remains poor. Since in the past the potential role of gonadotropins in the induction and progression of ovarian cancer has been discussed, we conjugated doxorubicin to human chorionic gonadotropin (hCG) in order to specifically target ovarian cancer cells. MATERIALS AND METHODS Doxorubicin was conjugated to hCG via glutaraldehyde. 48 hours post seeding, NIH:OVCAR 3 cells were treated with various concentrations of hCG-conjugated and non-conjugated doxorubicin for 2 hours. Cells were cultured for a total of 168 hours. Cell growth was monitored by a crystal violet assay. RESULTS Conjugating doxorubicin to hCG resulted in an average specific uptake of 22 mol doxorubicin per mol protein (range 3.0-43.3 mol). Incubating NIH:OVCAR 3 cells for 2 hours with the conjugate led to a more than 8 fold increase of the IC50 values compared to non-conjugated doxorubicin (0.55 microM versus 4.43 microM). The antiproliferative activity of both conjugated and free doxorubicin was detectable up to 168 hours post treatment. CONCLUSIONS The present experiments clearly demonstrate a more than 8-fold increase in cytotoxicity of the conjugates compared to free doxorubicin. It was also shown that this effect was not restricted to an acute toxic event but that it resulted in a prolonged antiproliferative activity. KW - Antineoplastic Agents KW - Cell Division KW - Cell Survival KW - Chorionic Gonadotropin KW - Drug Synergism Y1 - 2000 SP - 3001 EP - 3006 ER - TY - CHAP A1 - Claus, D. A1 - Beck, Eberhard A1 - Gmeiner, H.J. A1 - Puschmann, E. A1 - Brunhölzl, C. A1 - Jäger, W. A1 - Neundörfer, B. T1 - Neurotoxische Nebenwirkungen von Zytostatika T2 - In: Ophthalmoneurologie, Therapiekontrolle, Prävention : 65. Jahrestagung vom 23. - 26. September 1992 in Saarbrücken/ hrsg. von K. Schimrigk ... Unter Mitwirkung von M. Grundmann ... - Berlin, 1992. - (Verhandlungen der Deutschen Gesellschaft für Neurologie ; 7) (Tagung / Deutsche Gesellschaft für Neurologie ; 65). - ISBN: 3-924171-14-9 Y1 - 1992 SP - 738 EP - 740 ER - TY - CHAP A1 - Beck, Eberhard A1 - Hofmann, M. A1 - Kiesewetter, F. A1 - Jäger, W. A1 - Wildt, L. A1 - Lang, N. T1 - Analysis of CA 125 release by ovarian cancer cells in vitro T2 - In: Tumor associated antigens, oncogenes, receptors, cytokines in tumor diagnosis and therapy at the beginning of the nineties / 6th Symposium on Tumor Markers, Hamburg, [December 9. - 11. 1991] ; Satellite Symposium Cancer of the Breast - State and Trends in Diagnosis and Therapy. Ed. by R. - München [u.a.] : Zuckschwerdt, 1992. - ISBN 3-88603-444-5 Y1 - 1992 SP - 117 EP - 121 ER - TY - CHAP A1 - Beck, Eberhard A1 - Seidinger, M. A1 - Schneider, G. A. A1 - Schuster, M. A1 - Berg, A. A1 - Jäger, W. A1 - Wildt, L. A1 - Lang, N. T1 - Toxische Schädigungen des Gehörs unter Cisplatinhaltiger Chemotherapie bei Patientinnen mit gynäkologischen Tumoren T2 - In: Zytostatikabedingte Nebenwirkungen : Symposium in Pommersfelden, 3. - 4. Juli 1992 ; 26 Tabellen / Bd-Hrsg.: N. Lang ... - München [u.a.] : Zuckschwerdt, 1993. - Aktuelle Onkologie ; 8). - ISBN: 3-88603-458-5 Y1 - 1992 SP - 5 EP - 9 ER - TY - CHAP A1 - Jäger, W. A1 - Löffler, B. A1 - Beck, Eberhard A1 - Bellmann, O. A1 - Wolf, A. A1 - Mund-Hoym, S. A1 - Sauerbrei, W. A1 - Wildt, L. A1 - Lang, N. T1 - Retrospective analysis of GnRH analogue administration in patients with advanced ovarian cancer T2 - In: GnRH analogues and cancer : plus a review of the treatment of uterine leiomyomata; the proceedings of the 2. International Symposium on GnRH Analogues in Cancer and Human Reproduction, Geneva, November 1990 / ed. by B. Lunenfeld. - Carnforth, Lancs. [u.a.] : Parthenon Publ., 1992. - (Advances in the study of GnRH analogues ; 4). - ISBN: 1-85070-328-0 Y1 - 1992 SP - 69 EP - 76 ER - TY - GEN T1 - Lesesaal der Hochschulbibliothek N2 - Lesesaal 1. OG Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:522-opus4-3184 ER - TY - CHAP A1 - Mieke, Christian T1 - Portfoliogestütztes Roadmapping in der Technologievorausschau T2 - In: Interdisziplinarität und Komplexität / Konferenz für Wirtschafts- und Sozialkybernetik KyWi 2012 vom 28. bis 29. Juni 2012 in Aachen. [Gesellschaft für Wirtschafts- und Sozialkybernetik e.V. ; Institut für Unternehmenskybernetik]. Hrsg. von Sabina Jeschke ... - Berlin : Duncker & Humblot , 2012. - (Wirtschaftskybernetik und Systemanalyse ; Bd. 27) 978-3-428-13955-2 Y1 - 2012 SP - 37 EP - 44 ER - TY - CHAP A1 - Mieke, Christian A1 - Braunisch, Dirk T1 - Steuerungsmöglichkeiten für die rückführende Logistik T2 - In: Innovative Produktionswirtschaft : Jubiläumsschrift zu 20 Jahren produktionswirtschaftlicher Forschung an der BTU Cottbus / Christian Mieke ; Dirk Braunisch (Hrsg.) . - Berlin : Logos-Verl., 2012. - (PTI ; Bd. 2) 978-3-8325-3177-5 Y1 - 2012 SP - 292 EP - 312 ER - TY - BOOK ED - Mieke, Christian T1 - Innovative Produktionswirtschaft : Jubiläumsschrift zu 20 Jahren produktionswirtschaftlicher Forschung an der BTU Cottbus KW - Produktionswirtschaft KW - Forschung und Entwicklung KW - Innovationsmanagement KW - Supply Chain Management KW - Wettbewerbsfähigkeit Y1 - 2012 SN - 978-3-8325-3177-5 PB - Logos-Verl. CY - Berlin ER - TY - CHAP A1 - Mieke, Christian T1 - Prozess-Roadmapping - Werkzeug zur Planung von Prozess-Innovationen T2 - In: Innovative Produktionswirtschaft : Jubiläumsschrift zu 20 Jahren produktionswirtschaftlicher Forschung an der BTU Cottbus / Christian Mieke ; Dirk Braunisch (Hrsg.) . - Berlin : Logos-Verl., 2012. - (PTI ; Bd. 2) 978-3-8325-3177-5 Y1 - 2013 SP - 101 EP - 114 ER - TY - JOUR A1 - Löwe, Katharina A1 - Dalijono, Taufan T1 - Entwicklung eines Operatorunterstützungssystems zur Steigerung der Sicherheit hochautomatisierter verfahrenstechnischer Anlagen JF - In: Chemie Ingenieur Technik / Special Issue: 60 Jahre GVT 84 (2012) 11, 2027–2034 Y1 - 2012 SP - 2027 EP - 2034 ER - TY - JOUR A1 - Widiputri, Diah Indriani A1 - Löwe, Katharina A1 - Löher, Heinz-Josef T1 - Systematic approach to incorporate human factors into a process plant design JF - In : Process Safety Progress 28 (2009) 4, S. 347–355 N2 - Despite the increasing number of accidents in process industry caused by human error, there are still too few efforts devoted to this area. This is mainly caused by people's tendency to overestimate human's capability in interacting with their working environment and moreover by the unavailability of reliable analysis methods. Because of the current lack of adequate methods, human factors (HF) analysis is not widely performed in process industry. Some HF techniques developed in the process industry were examined regarding their practical applicability and were unfortunately proved to be unsuitable for an elaborate HF analysis. Therefore, a new approach was developed, which provides a systematic way in performing a qualitative HF analysis to achieve a safer operation and decrease the number of human failure events. HF consideration during the design of a process plant is the key to minimize accidents caused by human error in process industry. Thus, an approach to incorporate HF into design phase is described in this article, which can help achieving a safer operation as early as possible with minimized costs. © 2009 American Institute of Chemical Engineers Process Saf Prog 2009 Y1 - 2009 UR - http://onlinelibrary.wiley.com/doi/10.1002/prs.10328/abstract SN - 1066-8527 SP - 347 EP - 355 ER - TY - JOUR A1 - Löwe, Katharina A1 - Kariuki, S. G. T1 - Integrating Human Factors in the Process Hazard Analysis JF - In: Reliability Engineering & System Safety 92 (2007) 12, pp 1764-1773 Y1 - 2007 SN - 0951-8320 SP - 1764 EP - 1773 ER -