TY - CHAP A1 - Beck, Eberhard A1 - Moldenhauer, A. A1 - Kiesewetter, F. A1 - Jäger, W. A1 - Woldt, L. A1 - Lang, N. T1 - Analysis of CA 125 production and release by ovarian cancer cells in vitro T2 - In: Current tumor diagnosis : applications, clinical relevance, research - trends / 7th Symposium on Tumor Markers, Hamburg 1993 ; Satellite Symposium Cancer of the Lung - State and Trends in Diagnosis and Therapy. Ed. by R. Klapdor. - München [u.a.] : Zuckschwerdt, 1994. - ISBN 3-88603-509-3 Y1 - 1994 SP - 187 EP - 191 ER - TY - JOUR A1 - Beck, Eberhard A1 - Hofmann, M. A1 - Bernhardt, G. A1 - Jäger, W. A1 - Wildt, L. A1 - Lang, N. T1 - In vitro activity of immunoconjugates between cisplatin and an anti CA125 monoclonal antibody on ovarian cancer cell lines JF - In: Cell Biophysics 24/25(1994)1-3, 163-173 N2 - Cis-diammine dichloro platinum (II) (CDDP), is a highly potent antineoplastic agent that is used in the treatment of ovarian cancer. However, the clinical use of CDDP is restricted by its severe side effects. In order to reduce these side effects and to enhance its therapeutic efficacy, we developed specific immunoconjugates consisting of the murine monoclonal antibody OC125 and CDDP, using diethylene triamine pentaacetic acid (DTPA) as a linker. The coupling efficiencies of the different preparations synthesized, varied between 1.10±0.42 and 2.65±1.60 mol of CDDP per mol of antibody protein. Despite the chemical modification of the antibody molecule, specific binding activity of the OC125-CDDP conjugates toward the CA125 antigen was maintained as was demonstrated by means of immunohisto-/cytochemical staining of frozen sections of ovarian cancer tissue, amniotic epithelium, and the CA125 positive ovarian cancer cell line NIH:OVCAR 3. The antiproliferative activity of the immunoconjugates was tested against the human ovarian cancer cell lines NIH:OVCAR3 and SKOV 3, applying a kinetic crystal violet microassay. Despite the promising results obtained with the specific immuno-staining of the target cells, no significant antiproliferative activity of our immunoconjugates against the cell lines tested was observed. One possible explanation for the lack of antitumor activity could be the fact that CA125 is released in large amounts by the NIH:OVCAR 3 cells. This may have prevented an efficient immunotargeting of the cancer cells by the formation of soluble immune complexes. Y1 - 1994 SN - 0163-4992 SP - 163 EP - 173 ER - TY - JOUR A1 - Beck, Eberhard A1 - Russo, Pietro A1 - Gliozzo, Biancamaria A1 - Jäger, Wolfram A1 - Papa, Vincenzo A1 - Wildt, Ludwig A1 - Pezzino, Vincenzo A1 - Lang, Norbert T1 - Identification of insulin and insulin-like growth factor I (IGF I) receptors in ovarian cancer JF - In: Gynecologic Oncology 53(1994)2, 196–201 N2 - Abstract The objective of this study was to test if specific insulin and insulin-like growth factor I (IGF I) receptors are expressed in ovarian cancer tissue. Thirteen tissue specimens from primary ovarian cancers, 1 specimen from a primary peritoneal carcinoma, 10 specimens from metastatic lesions of ovarian carcinomas, and 4 specimens from recurrent ovarian cancers together with 13 normal ovaries were tested for their content of insulin and IGF-I receptors, by the application of specific insulin and IGF-I receptor radioimmunoassays. The insulin receptor (IR) and IGF-I receptor (IGF R) content in the primary tumors varied between 23.8-321.4 and 16.4-554.2 ng/0.1 mg DNA, respectively. Metastatic lesions contained between 12.3 and 226.7 ng IR/0.1 mg DNA and between 7.5 and 459.4 ng IGF R/0.1 mg DNA. In recurrent tumors the receptor concentrations were in the range of 41.5-79.8 and 48.9-160.9 ng/0.1 mg DNA for insulin and IGF-I receptors, respectively. Normal ovarian tissue contained between 12.2 and 150.1 ng IR and between 21.4 and 420.1 ng IGF R per 0.1 mg DNA, respectively. As both insulin and IGF-I receptors are present in ovarian cancer tissue, the effects of insulin and IGF-I as potential growth factors in ovarian cancer should be further investigated. Copyright © 1994 Academic Press. All rights reserved. Y1 - 1994 SN - 0090-8258 SP - 196 EP - 201 ER - TY - JOUR A1 - Beck, Eberhard A1 - Russo, P. A1 - Papa, V. A1 - Jäger, W. A1 - Pezzino, V. A1 - Wildt, L. A1 - Vigneri, R. A1 - Lang, N. T1 - Nachweis von Insulin-Rezeptoren (IR) in Ovarialkarzinomgewebe JF - In: Archives of Gynecology and Obstetrics December 254(1993)Iss. 1-4, 1053-1054 Y1 - 1993 SN - 0932-0067 SP - 1053 EP - 1054 ER - TY - CHAP A1 - Bittl, A. A1 - Beck, Eberhard A1 - Jäger, W. A1 - Wildt, L. T1 - Untersuchungen zur Amenorrhoe unter adjuvanter CMF-Chemotherapie bei Mammakarzinom-Patientinnen T2 - In: Zytostatikabedingte Nebenwirkungen : Symposium in Pommersfelden, 3. - 4. Juli 1992; 26 Tabellen / Bd.-Hrsg.: N. Lang; W. Jäger. - München [u.a.] : Zuckschwerdt, 1992. - (Aktuelle Onkologie ; 68). - ISBN: 3-88603-458-5 Y1 - 1993 SP - 10 EP - 14 ER - TY - CHAP A1 - Mündemann, Friedhelm T1 - Kommunikationsmanagement in Telelern-Szenarien T2 - In: Berufsbildung '99 : fit im Beruf - fit für die Zukunft ; Dokumentation ; Nürnberg 1. bis 4. Dezember 1999 / [Fachausstellung für Aus- und Weiterbildung und 7. Bayerischer Berufsbildungskongress]. - München : Bayerisches Staatsministerium für Arbeit und Sozialordnung, Familie, Frauen und Gesundheit, 1999. - (Studien und Berichte zur Berufsbildung) Y1 - 1999 SP - 160 EP - 161 ER - TY - JOUR A1 - Mündemann, Friedhelm T1 - Online only? JF - In: Das Forum : Zeitschr. d. Volkshochschulen Bayerns, (1998) 2, S. 2-9 ISSN 0176-3687 KW - Mediendidaktik KW - Computerunterstützter Unterricht KW - Fernuntericht KW - Volkshochschule Y1 - 1998 SP - 2 EP - 9 ER - TY - JOUR A1 - Lüthy, Anja T1 - Employer Branding: Was Kliniken von anderen Branchen lernen können JF - In: HeilberufeScience 3 (2012), S. 18 Y1 - 2012 UR - link.springer.com/content/pdf/10.1007%2Fs16024-012-0128-x SP - 18 ER - TY - CHAP A1 - Buchmann, Uta A1 - Lüthy, Anja T1 - Umfassendes Dienstleistungsmarketing – Pflichtaufgabe für Krankenhäuser T2 - In: Patient Krankenhaus : Wie Kliniken der Spagat zwischen Ökonomie und medizinischer Spitzenleistung gelingt / hrsg. von Ulrich Korff. - Wiesbaden : Gabler, 2012. - ISBN: 978-3-8349-7189-0; 978-3-8349-3433-8 (ISBN der Printausgabe) N2 - Krankenhäuser müssen noch viel lernen, wenn es darum geht, ihre Leistungen kundenorientiert – auch über die medizinischen Kernleistungen hinaus – erfolgreich zu vermarkten. Von einem systematischen Dienstleistungsmarketing sind viele Häuser noch weit entfernt. Ein professionell praktiziertes Dienstleistungsmarketing – von der grundlegenden Strategie bis zur operativen Umsetzung – ist jedoch die Grundvoraussetzung, um sich im Wettbewerb um Patienten erfolgreich zu behaupten. Y1 - 2012 UR - http://link.springer.com/chapter/10.1007/978-3-8349-7189-0_16 SP - 177 EP - 191 ER - TY - JOUR A1 - Gebauer, Gerhard A1 - Mueller, Natalia A1 - Fehm, Tanja A1 - Berkholz, Alexander A1 - Beck, Eberhard A1 - Jaeger, Wolfram A1 - Licht, Peter T1 - Expression and regulation of luteinizing hormone/human chorionic gonadotropin receptors in ovarian cancer and its correlation to human chorionic gonadotropin–doxorubicin sensitivity JF - In: American Journal of Obstetrics & Gynecology 190 (2004), Iss. 6, pp. 1621-1628 N2 - Objective Ovarian cancer cell lines and tissues express gonadotropin receptors. Conjugation of cytostatics to ligands of these receptors may increase the specificity of cytotoxic drugs. Study design Toxicity of doxorubicin–human chorionic gonadotropin conjugates was determined in 4 ovarian cancer cell lines. Expression and regulation of luteinizing hormone/human chorionic gonadotropin receptors were analyzed before and after treatment with human chorionic gonadotropin, epidermal growth factor, and 8-bromo-cyclic adenosine monophosphate with a nested reverse transcriptase–polymerase chain reaction approach. Results Toxicity of human chorionic gonadotropin–doxorubicin conjugates was increased compared with unconjugated doxorubicin in OVCAR-3 cells. However, drug conjugates failed to demonstrate increased toxicity in other cell lines, especially after preincubation with human chorionic gonadotropin. All cell lines expressed luteinizing hormone/human chorionic gonadotropin receptors. Receptor expression in OVCAR-3 cells was not effected by human chorionic gonadotropin, endothelial growth factor, or 8-bromo-cyclic adenosine monophosphate treatment. In other cell lines, receptor expression was down-regulated by these agents. Conclusion Cytotoxic activity of doxorubicin was increased specifically by conjugation to human chorionic gonadotropin. However, the regulation of luteinizing hormone/human chorionic gonadotropin receptor expression and other compounds may reduce the drug-uptake of the conjugates. Y1 - 2004 SP - 1621 EP - 1624 ER - TY - JOUR A1 - Gebauer, Gerhard A1 - Fehm, Tanja A1 - Beck, Eberhard A1 - Berkholz, Alexander A1 - Licht, Peter A1 - Jäger, Wolfram T1 - Cytotoxic effect of conjugates of doxorubicin and human chorionic gonadotropin (hCG) in breast cancer cells JF - In: Breast Cancer Research and Treatment 77(2003)2, pp. 125-131 N2 - Cytotoxic activity of drug conjugates of human chorionic gonadotropin (hCG) and doxorubicin alone was investigated compared to doxorubicin in breast cancer cells with and without expression of hCG receptors. Expression of hCG receptor was determined in MCF-7 and MB231 breast cancer cell line using a multiplex nested rt-PCR approach. The entire sequence of mRNA encoding for hCG receptor was detected in MCF-7 but not in MB231 breast cancer cell line. Cytostatic effect of doxorubicin–hCG conjugates was investigated in these cell lines in comparison to unconjugated doxorubicin. The number of viable cells was determined after 24, 48, 72, 96, and 120 h. To exclude non-specific uptake of the carrier hCG from the culture media, a similar experiment was performed with albumin–doxorubicin conjugates. The number of viable cells decreased in a concentration depending manner after doxorubicin and hCG–doxorubicin conjugate treatment. However, the cytotoxic effect of hCG–doxorubicin conjugate was 10-fold increased compared to unconjugated doxorubin in hCG-receptor positive MCF-7 but not in hCG-receptor negative MB231 cells. Albumin–doxorubicin conjugates showed no increased toxicity compared to doxorubicin. We conclude that the cytotoxic effect of hCG–doxorubicin conjugates is mediated specifically via the hCG receptor. By using hCG conjugates, the development of more selective cytostatics can be achieved. Y1 - 2003 UR - http://link.springer.com/article/10.1023%2FA%3A1021301001208 SP - 125 EP - 131 ER - TY - JOUR A1 - Gebauer, Gerhard A1 - Fehm, Tanja A1 - Merkle, Elisabeth A1 - Beck, Eberhard A1 - Lang, Norbert A1 - Jäger, Wolfram T1 - Epithelial Cells in Bone Marrow of Breast Cancer Patients at Time of Primary Surgery: Clinical Outcome During Long-Term Follow-Up JF - In: J. Clin. Oncol. 19(2001)16, 3669 – 3674 N2 - PURPOSE: To evaluate the detection of epithelial cells in bone marrow of breast cancer patients as an indicator of metastatic disease. PATIENTS AND METHODS: Between 1989 and 1994, bone marrow biopsies were performed on 393 breast cancer patients during primary surgery. Specimens were stained immunocytochemically for epithelial cells expressing cytokeratins or the epithelial membrane antigen. The long-term outcomes of these patients were analyzed in this study. RESULTS: In 166 of 393 patients, epithelial cells were found in bone marrow (BM) aspirates. These patients were designated BM+. The rate of tumor recurrence or cancer-related death was significantly higher in BM+ patients than in BM− patients. Multivariate analysis using the Cox regression model revealed BM status as a prognostic parameter independent of tumor size and axillary lymph node status. However, tumor size and axillary lymph node status were clearly superior prognostic parameters. CONCLUSION: Disseminated epithelial cells in BM are associated with poor clinical outcome in breast cancer patients. However, the presence of these cells is not a sufficient parameter to predict growing metastases in the majority of patients, suggesting that epithelial cells in the BM of breast cancer patients at the time of surgery have limited metastatic potential. The role of these cells needs to be further evaluated. Y1 - 2001 SP - 3669 EP - 3674 ER - TY - JOUR A1 - Merkle, E. A1 - Ackermann, S. A1 - Beck, Eberhard A1 - Jäger, W. A1 - Lang, N. T1 - High-Dose versus Low-Dose Cisplatin Chemotherapy plus Treosulfan in Epithelial Ovarian Carcinoma FIGO II–IV: Results of a Prospective Randomized Trial JF - In: Onkologie 23(2000)3, 232-238 N2 - Summary Background: Combination chemotherapies of platinum compounds with alkylating agents have been the standard treatment for patients with advanced ovarian carcinoma over the last decades. The recent development of taxans has added a group of new promising agents; however, long-term results are not yet available. Platin derivates have proven to be an indispensable part in combination chemotherapies for ovarian carcinoma. The dose intensity of cisplatin is, however, still a matter of debate. We report on the long-term results of a prospective randomized trial comparing two dosages of cisplatin combined with treosulfan in patients with advanced epithelial ovarian cancer. Patients and Methods: Between 1988 and 1995, 125 patients with ovarian cancer (FIGO stage II–IV) were randomized to receive 4 cycles (28-day intervals) of either cisplatin 100 mg/m2 (high dose, HD) or 50 mg/m2 (low dose, LD) in combination with 5 g/m2 treosulfan after primary cytoreductive surgery. Postoperative residual tumor was absent in 39 patients (HD: 16; LD: 23), < 2 cm in 61 patients (HD: 36; LD: 25) and > 2 cm in 25 patients (HD: 13; LD: 12). 65 and 60 patients received HD and LD cisplatin, respectively. Second-look surgery was optional. Results:The overall response rate was 70.0% (HD: 70.9%; LD: 68.9%). Pathological complete response (CR) was seen in 45 patients (37.5%), clinical CR in 23 patients (19.2%), partial response (PR) in 16 patients (13.3%), stable disease (SD) in 2 patients, and progression of disease (PD) in 34 patients (28.3%). 5 patients were not assessable for response. Overall median survival was 25.6 (HD: 26.9, LD: 25.2) months. The overall disease-free survival for responders was 19.6 and 24.7 months (HD and LD, respectively). HD chemotherapy did not result in any significant survival benefit in completely resected patients: HD: 39.8 months versus LD: 49.5 months. In suboptimally debulked patients (residual tumor < 2 cm), median survival was 24.1 months (HD) versus 22.6 months (LD). In patients with residual tumors > 2 cm median survival was 14.6 months (HD) versus 15.5 months (LD). Significantly less side effects were seen in the LD group: anemia (p = 0.008); nephrotoxicity (p = 0.014); alopecia (p = 0.017). Conclusions: Our data suggest that LD cisplatin-based chemotherapy is as effective as HD chemotherapy in patients with advanced epithelial ovarian cancer, but is far less toxic. Copyright © 2000 S. Karger GmbH, Freiburg Y1 - 2000 SP - 232 EP - 238 ER - TY - CHAP A1 - Beck, Eberhard A1 - Sciacca, Laura A1 - Pandini, Giuseppe A1 - Jaeger, Wolfram A1 - Pezzino, Vincenzo T1 - Measurement of IGF-1 Receptor Content in Tissues and Cell Lines by Radioimmunoassay (RIA) and ELISA Techniques T2 - In: Ovarian Cancer : Methods and Protocols / ed. by John M. S. Bartlett. - Totowa, NJ : Humana Press, 2001. - Totowa, NJ : Humana Press, 2001. - (Methods in Molecular Medicine™ ; 39). - ISBN: 978-1-592-59071-1; 978-0-89603-583-6 (ISBN der Printausgabe) N2 - The IGF-1 receptor (IGF-1-R) belongs to the tyrosine kinase growth factor receptor family. It is structurally similar to, but distinct from, the insulin receptor, with which it shares a 70% homology. As expected, it crossreacts with insulin and, vice versa, insulin receptor crossreacts with IGF-1. Numerous studies suggest that IGF-1-R is very important for mitogenesis and is essential for phenotype transformation, at least in rodents (1). In particular, the IGF-1-R has been described in human breast cancer (2-4) and ovarian cancer (5) tissues and in cultured human breast cancer cell lines (6,7). Y1 - 2001 SP - 485 EP - 492 ER - TY - JOUR A1 - Beck, Eberhard A1 - Vincenti, D. A1 - Licht, P. A1 - Berkholz, A. A1 - Jäger, W. A1 - Lang, N. A1 - Merkle, E. T1 - In vitro activity of human chorionic gonadotropin (hCG)--doxorubicin conjugates against ovarian cancer cells JF - In: Anticancer research 20(2000)5A, pg 3001-6 N2 - BACKGROUND Despite radical surgery and the introduction of novel chemotherapeutic agents, the prognosis of ovarian cancer remains poor. Since in the past the potential role of gonadotropins in the induction and progression of ovarian cancer has been discussed, we conjugated doxorubicin to human chorionic gonadotropin (hCG) in order to specifically target ovarian cancer cells. MATERIALS AND METHODS Doxorubicin was conjugated to hCG via glutaraldehyde. 48 hours post seeding, NIH:OVCAR 3 cells were treated with various concentrations of hCG-conjugated and non-conjugated doxorubicin for 2 hours. Cells were cultured for a total of 168 hours. Cell growth was monitored by a crystal violet assay. RESULTS Conjugating doxorubicin to hCG resulted in an average specific uptake of 22 mol doxorubicin per mol protein (range 3.0-43.3 mol). Incubating NIH:OVCAR 3 cells for 2 hours with the conjugate led to a more than 8 fold increase of the IC50 values compared to non-conjugated doxorubicin (0.55 microM versus 4.43 microM). The antiproliferative activity of both conjugated and free doxorubicin was detectable up to 168 hours post treatment. CONCLUSIONS The present experiments clearly demonstrate a more than 8-fold increase in cytotoxicity of the conjugates compared to free doxorubicin. It was also shown that this effect was not restricted to an acute toxic event but that it resulted in a prolonged antiproliferative activity. KW - Antineoplastic Agents KW - Cell Division KW - Cell Survival KW - Chorionic Gonadotropin KW - Drug Synergism Y1 - 2000 SP - 3001 EP - 3006 ER - TY - CHAP A1 - Claus, D. A1 - Beck, Eberhard A1 - Gmeiner, H.J. A1 - Puschmann, E. A1 - Brunhölzl, C. A1 - Jäger, W. A1 - Neundörfer, B. T1 - Neurotoxische Nebenwirkungen von Zytostatika T2 - In: Ophthalmoneurologie, Therapiekontrolle, Prävention : 65. Jahrestagung vom 23. - 26. September 1992 in Saarbrücken/ hrsg. von K. Schimrigk ... Unter Mitwirkung von M. Grundmann ... - Berlin, 1992. - (Verhandlungen der Deutschen Gesellschaft für Neurologie ; 7) (Tagung / Deutsche Gesellschaft für Neurologie ; 65). - ISBN: 3-924171-14-9 Y1 - 1992 SP - 738 EP - 740 ER - TY - CHAP A1 - Beck, Eberhard A1 - Hofmann, M. A1 - Kiesewetter, F. A1 - Jäger, W. A1 - Wildt, L. A1 - Lang, N. T1 - Analysis of CA 125 release by ovarian cancer cells in vitro T2 - In: Tumor associated antigens, oncogenes, receptors, cytokines in tumor diagnosis and therapy at the beginning of the nineties / 6th Symposium on Tumor Markers, Hamburg, [December 9. - 11. 1991] ; Satellite Symposium Cancer of the Breast - State and Trends in Diagnosis and Therapy. Ed. by R. - München [u.a.] : Zuckschwerdt, 1992. - ISBN 3-88603-444-5 Y1 - 1992 SP - 117 EP - 121 ER - TY - CHAP A1 - Beck, Eberhard A1 - Seidinger, M. A1 - Schneider, G. A. A1 - Schuster, M. A1 - Berg, A. A1 - Jäger, W. A1 - Wildt, L. A1 - Lang, N. T1 - Toxische Schädigungen des Gehörs unter Cisplatinhaltiger Chemotherapie bei Patientinnen mit gynäkologischen Tumoren T2 - In: Zytostatikabedingte Nebenwirkungen : Symposium in Pommersfelden, 3. - 4. Juli 1992 ; 26 Tabellen / Bd-Hrsg.: N. Lang ... - München [u.a.] : Zuckschwerdt, 1993. - Aktuelle Onkologie ; 8). - ISBN: 3-88603-458-5 Y1 - 1992 SP - 5 EP - 9 ER - TY - CHAP A1 - Jäger, W. A1 - Löffler, B. A1 - Beck, Eberhard A1 - Bellmann, O. A1 - Wolf, A. A1 - Mund-Hoym, S. A1 - Sauerbrei, W. A1 - Wildt, L. A1 - Lang, N. T1 - Retrospective analysis of GnRH analogue administration in patients with advanced ovarian cancer T2 - In: GnRH analogues and cancer : plus a review of the treatment of uterine leiomyomata; the proceedings of the 2. International Symposium on GnRH Analogues in Cancer and Human Reproduction, Geneva, November 1990 / ed. by B. Lunenfeld. - Carnforth, Lancs. [u.a.] : Parthenon Publ., 1992. - (Advances in the study of GnRH analogues ; 4). - ISBN: 1-85070-328-0 Y1 - 1992 SP - 69 EP - 76 ER - TY - CHAP A1 - Mieke, Christian T1 - Portfoliogestütztes Roadmapping in der Technologievorausschau T2 - In: Interdisziplinarität und Komplexität / Konferenz für Wirtschafts- und Sozialkybernetik KyWi 2012 vom 28. bis 29. Juni 2012 in Aachen. [Gesellschaft für Wirtschafts- und Sozialkybernetik e.V. ; Institut für Unternehmenskybernetik]. Hrsg. von Sabina Jeschke ... - Berlin : Duncker & Humblot , 2012. - (Wirtschaftskybernetik und Systemanalyse ; Bd. 27) 978-3-428-13955-2 Y1 - 2012 SP - 37 EP - 44 ER - TY - CHAP A1 - Mieke, Christian A1 - Braunisch, Dirk T1 - Steuerungsmöglichkeiten für die rückführende Logistik T2 - In: Innovative Produktionswirtschaft : Jubiläumsschrift zu 20 Jahren produktionswirtschaftlicher Forschung an der BTU Cottbus / Christian Mieke ; Dirk Braunisch (Hrsg.) . - Berlin : Logos-Verl., 2012. - (PTI ; Bd. 2) 978-3-8325-3177-5 Y1 - 2012 SP - 292 EP - 312 ER - TY - BOOK ED - Mieke, Christian T1 - Innovative Produktionswirtschaft : Jubiläumsschrift zu 20 Jahren produktionswirtschaftlicher Forschung an der BTU Cottbus KW - Produktionswirtschaft KW - Forschung und Entwicklung KW - Innovationsmanagement KW - Supply Chain Management KW - Wettbewerbsfähigkeit Y1 - 2012 SN - 978-3-8325-3177-5 PB - Logos-Verl. CY - Berlin ER - TY - CHAP A1 - Mieke, Christian T1 - Prozess-Roadmapping - Werkzeug zur Planung von Prozess-Innovationen T2 - In: Innovative Produktionswirtschaft : Jubiläumsschrift zu 20 Jahren produktionswirtschaftlicher Forschung an der BTU Cottbus / Christian Mieke ; Dirk Braunisch (Hrsg.) . - Berlin : Logos-Verl., 2012. - (PTI ; Bd. 2) 978-3-8325-3177-5 Y1 - 2013 SP - 101 EP - 114 ER - TY - JOUR A1 - Löwe, Katharina A1 - Dalijono, Taufan T1 - Entwicklung eines Operatorunterstützungssystems zur Steigerung der Sicherheit hochautomatisierter verfahrenstechnischer Anlagen JF - In: Chemie Ingenieur Technik / Special Issue: 60 Jahre GVT 84 (2012) 11, 2027–2034 Y1 - 2012 SP - 2027 EP - 2034 ER - TY - JOUR A1 - Widiputri, Diah Indriani A1 - Löwe, Katharina A1 - Löher, Heinz-Josef T1 - Systematic approach to incorporate human factors into a process plant design JF - In : Process Safety Progress 28 (2009) 4, S. 347–355 N2 - Despite the increasing number of accidents in process industry caused by human error, there are still too few efforts devoted to this area. This is mainly caused by people's tendency to overestimate human's capability in interacting with their working environment and moreover by the unavailability of reliable analysis methods. Because of the current lack of adequate methods, human factors (HF) analysis is not widely performed in process industry. Some HF techniques developed in the process industry were examined regarding their practical applicability and were unfortunately proved to be unsuitable for an elaborate HF analysis. Therefore, a new approach was developed, which provides a systematic way in performing a qualitative HF analysis to achieve a safer operation and decrease the number of human failure events. HF consideration during the design of a process plant is the key to minimize accidents caused by human error in process industry. Thus, an approach to incorporate HF into design phase is described in this article, which can help achieving a safer operation as early as possible with minimized costs. © 2009 American Institute of Chemical Engineers Process Saf Prog 2009 Y1 - 2009 UR - http://onlinelibrary.wiley.com/doi/10.1002/prs.10328/abstract SN - 1066-8527 SP - 347 EP - 355 ER - TY - JOUR A1 - Löwe, Katharina A1 - Kariuki, S. G. T1 - Integrating Human Factors in the Process Hazard Analysis JF - In: Reliability Engineering & System Safety 92 (2007) 12, pp 1764-1773 Y1 - 2007 SN - 0951-8320 SP - 1764 EP - 1773 ER - TY - JOUR A1 - Kariuki, S. Gitahi A1 - Vadillo, E. Mayor A1 - Löwe, Katharina T1 - Human factors assessment technique for the chemical process industry JF - In : Chemical Engineering & Technology 30 (2007) 10, pp 1319-1327 Y1 - 2007 UR - http://onlinelibrary.wiley.com/doi/10.1002/ceat.200700203/abstract SN - 0930-7516 SP - 1319 EP - 1327 ER - TY - JOUR A1 - Löwe, Katharina A1 - Widiputri, D. I. A1 - Löher, H.-J. T1 - Entwicklung eines Anwenderprogramms zur Optimierung der Bediensicherheit einer verfahrenstechnischen Anlage JF - In: Chemie Ingenieur Technik 79 (2007) 10, S. 1649-1655 Y1 - 2007 UR - http://onlinelibrary.wiley.com/doi/10.1002/cite.200700088/abstract SN - 1522-2640 SP - 1649 EP - 1655 ER - TY - JOUR A1 - Löwe, Katharina A1 - Kariuki, S. G. T1 - Increasing Human Reliability in the Chemical Process Industry using Human Factors Techniques JF - In: Process Safety and Environmental Protection 84 (2006) 3, pp 200-207 Y1 - 2006 SN - 0957-5820 SP - 200 EP - 207 ER - TY - JOUR A1 - Löwe, Katharina A1 - Löher, H.-J. A1 - Castro, J. A1 - Dalijono, T. T1 - Reducing human error by improvement of design and organization JF - In: Process Safety and Environmental Protection, 84 (2006) 3, pp 191-199 Y1 - 2006 SN - 0957-5820 SP - 191 EP - 199 ER - TY - JOUR A1 - Dalijono, T. A1 - Löwe, Katharina A1 - Löher, H.-J. T1 - Development and Verification of a New Approach for Operator Action Analysis JF - In: Process Safety and Environmental Protection 83 (2005) 4, pp 331–337 Y1 - 2005 SN - 0957-5820 SP - 331 EP - 337 ER - TY - JOUR A1 - Dalijono, Taufan A1 - Löwe, Katharina A1 - Löher, H.-J. T1 - Methoden zur Beurteilung von Bedienhandungen verfahrenstechnischer Anlagen JF - In: Automatisierungstechnische Praxis : atp 46 (2004), S. 61-68 Y1 - 2004 SN - 0178-2320 SP - 61 EP - 68 ER - TY - JOUR A1 - Hanspach, J. A1 - Pinno, Frank T1 - Concentration dependent diffusion of water in polyamide 6 JF - In: acta polymerica, 43 (1992), 210-213 Y1 - 1992 SP - 210 EP - 213 ER - TY - JOUR A1 - Karstädt, Detlef A1 - Möllmann, Klaus-Peter A1 - Pinno, Frank A1 - Vollmer, Michael T1 - Anschauliche Wärmelehre im Unterricht: ein Beitrag zur Visualisierung thermischer Vorgänge JF - In: Praxis der Naturwissenschaften / Physik 48(1999 )5, S. 24-31 Y1 - 1999 SP - 24 EP - 31 ER - TY - CHAP A1 - Hessel, V. A1 - Löwe, H. A1 - Haverkamp, V. A1 - Wille, Ch. A1 - Ehrfeld, W. A1 - Lutz, N. A1 - Möllmann, Klaus-Peter A1 - Pinno, Frank A1 - Herweck, Th. T1 - Dynamic monitoring of fluid equipartition and heat release in a falling film microreactor using real-time thermography T2 - In: MICRO.tec 2000 : applications - trends - visions ; proceedings / VDE World Microtechnologies Congress, September 25 - 27, 2000, Expo 2000, Hannover, Germany. Organized by VDE Association for Electrical, Electronic & Information Technologies. Sponsored by EUREL ... . - Berlin ; Offenbach : VDE-Verl. - Vol. 2. - 2000. - S. 349 - 354. - ISBN 3-8007-2579-7 Y1 - 2000 SP - 349 EP - 354 ER - TY - JOUR A1 - Karstädt, Detlef A1 - Möllmann, Klaus-Peter A1 - Pinno, Frank A1 - Vollmer, Michael T1 - There is more to see than eyes can detect: visualization of energy transfer processes and the laws of radiation for physics education JF - In: The Physics Teacher 39 (2001), 371-376 Y1 - 2001 SP - 371 EP - 376 ER - TY - CHAP A1 - Henke, S. A1 - Karstädt, Detlef A1 - Möllmann, Klaus-Peter A1 - Pinno, Frank A1 - Vollmer, Michael T1 - Challenges in infrared imaging: low emissivities of hot gases, metals, and metallic cavities T2 - In: InfraMation 2004 : proceedings / sponsored and published by the Inframation Training Center .... - Vol. 5, 355-363 Y1 - 2004 SP - 355 EP - 363 ER - TY - CHAP A1 - Henke, S. A1 - Karstädt, Detlef A1 - Möllmann, Klaus-Peter A1 - Pinno, Frank A1 - Vollmer, Michael T1 - Identification and suppression of thermal reflections in infrared thermal imaging T2 - In: InfraMation 2004 : proceedings / sponsored and published by the Inframation Training Center .... - Vol. 5, 287-298 Y1 - 2004 SP - 287 EP - 298 ER - TY - CHAP A1 - Pinno, Frank A1 - Karstädt, Detlef A1 - Möllmann, Klaus-Peter A1 - Vollmer, Michael T1 - Using infrared thermography for optimization, quality control and minimization of damages of floor heating systems, T2 - In: InfraMation 2005 : proceedings / sponsored and published by the Inframation Training Center .... Vol. 6, 313-322 Y1 - 2005 SP - 313 EP - 322 ER - TY - CHAP A1 - Vollmer, Michael A1 - Karstädt, Detlef A1 - Möllmann, Klaus-Peter A1 - Pinno, Frank T1 - IR Thermography of microwave ovens T2 - In: InfraMation 2005 : proceedings / sponsored and published by the Inframation Training Center .... Vol.6, 29-40 Y1 - 2005 SP - 29 EP - 40 ER - TY - CHAP A1 - Möllmann, Klaus-Peter A1 - Karstädt, Detlef A1 - Pinno, Frank A1 - Vollmer, Michael T1 - Selected critical applications for thermography: convections in fluids, selective emitters and highly reflecting materials T2 - In: InfraMation 2005 : proceedings / sponsored and published by the Inframation Training Center .... Vol.6, 161-174 Y1 - 2005 SP - 161 EP - 174 ER - TY - CHAP A1 - Möllmann, Klaus-Peter A1 - Karstädt, Detlef A1 - Pinno, Frank A1 - Vollmer, Michael T1 - Thermal image quality – Visualization of spatial and thermal resolution in thermal imaging T2 - In: InfraMation proceedings Vol. 7 (2006), 79-92 Y1 - 2006 SP - 79 EP - 92 ER - TY - CHAP A1 - Pinno, Frank A1 - Karstädt, Detlef A1 - Möllmann, Klaus-Peter A1 - Vollmer, Michael T1 - Energy savings for an old factory building by optimisation of the heating system T2 - In: InfraMation 2006 : proceedings / sponsored and published by the Inframation Training Center ... Vol. 7, 253-262 Y1 - 2006 SP - 253 EP - 262 ER - TY - CHAP A1 - Vollmer, Michael A1 - Karstädt, Detlef A1 - Möllmann, Klaus-Peter A1 - Pinno, Frank T1 - Influence of gaseous species on thermal infrared imaging T2 - In: InfraMation 2006 : proceedings / sponsored and published by the Inframation Training Center .... Vol.7, 65-78 Y1 - 2006 SP - 65 EP - 78 ER - TY - CHAP A1 - Pinno, Frank A1 - Möllmann, Klaus-Peter A1 - Vollmer, Michael T1 - Cost and energy savings for a factory building after modernizing the heating system T2 - In: InfraMation 2007 : proceedings / sponsored and published by the Inframation Training Center .... Vol.8, 521-527 Y1 - 2007 SP - 521 EP - 527 ER - TY - CHAP A1 - Vollmer, Michael A1 - Möllmann, Klaus-Peter A1 - Pinno, Frank T1 - Looking through matter: quantitative IR imaging when observing through IR windows T2 - In: InfraMation 2007 : proceedings / sponsored and published by the Inframation Training Center .... Vol. 8, 109-127 Y1 - 2007 SP - 109 EP - 127 ER - TY - CHAP A1 - Vollmer, Michael A1 - Karstädt, Detlef A1 - Möllmann, Klaus-Peter A1 - Pinno, Frank T1 - Es gibt mehr zu sehen, als unsere Augen wahrnehmen - Sinnvoller Einsatz von Infrarotkameras in der Lehre T2 - In: CD zur Frühjahrstagung des Fachverbandes Didaktik der Physik in der Deutschen Physikalischen Gesellschaft, Bremen 2001 : Beiträge der Frühjahrstagung der DPG Bremen 2001 / Red.: V. Nordmeier . - Berlin : Lehmanns, 2001. - ISBN 3-931253-87-2 Y1 - 2001 ER - TY - CHAP A1 - Karstädt, Detlef A1 - Möllmann, Klaus-Peter A1 - Pinno, Frank T1 - Anschauliche Wärmelehre im Unterricht: Visualisierung thermischer Vorgänge. T2 - In: Vorträge / Physikertagung, Deutsche Physikalische Gesellschaft, Fachausschuß Didaktik der Physik 1999 (2000), S. 489-494 Y1 - 2000 SP - 489 EP - 494 ER - TY - JOUR A1 - Karstädt, Detlef A1 - Möllmann, Klaus-Peter A1 - Pinno, Frank A1 - Vollmer, Michael T1 - Sehen im Infrarot - Grundlagen und Anwendungen der Thermographie JF - In: Physik in unserer Zeit, 29 (1998) 1, S. 6-15. - ISSN: 0031-9252 Y1 - 1998 U6 - https://doi.org/10.1002/piuz.19980290103 SP - 6 EP - 15 ER - TY - BOOK A1 - Vollmer, Michael A1 - Möllmann, Klaus-Peter T1 - Infrared thermal imaging : fundamentals, research and applications KW - Infrarotthermographie Y1 - 2010 SN - 978-3-527-40717-0 N1 - Abstract: Filling the gap for a comprehensive, hands-on and practical guide for practitioners in public and private R&D labs, the wide range of examples taken from science, industry and medicine allow readers to choose those closest to their own individual tasks. (Quelle: DNB) - Inhaltsverzeichnis: http://d-nb.info/1000249905/04 PB - Wiley-VCH CY - Weinheim ER - TY - BOOK A1 - Vollmer, Michael T1 - Lichtspiele in der Luft : atmosphärische Optik für Einsteiger KW - Optisches Phänomen Y1 - 2006 SN - 978-3-8274-1361-1 PB - Elsevier, Spektrum Akad. Verl. CY - München ER - TY - BOOK A1 - Kreibig, Uwe A1 - Vollmer, Michael T1 - Opticals properties of metal clusters T3 - Springer series in materials science - 25 KW - Metallcluster KW - Optische Eigenschaft Y1 - 1994 SN - 3-540-57836-6 SN - 0-387-57836-6 PB - Springer CY - Berlin [u.a.] ER -