TY - JOUR A1 - Trittel, Torsten A1 - Klopp, Christoph A1 - Harth, Kirsten A1 - Stannarius, Ralf T1 - Stability and Rupture of Liquid Crystal Bridges under Microgravity JF - Crystals KW - smectic liquid-crystals KW - Rayleigh-Plateau instability KW - TEXUS suborbital rocket KW - microgravity Y1 - 2022 U6 - https://doi.org/https://doi.org/10.3390/cryst12081092 VL - 12 IS - 8 PB - MDPI ER - TY - JOUR A1 - Weber, Simon B. A1 - Stein, Stefan A1 - Pilgermann, Michael A1 - Schrader, Thomas T1 - Attack Detection for Medical Cyber-Physical Systems – A Systematic Literature Review JF - IEEE Access N2 - The threat situation due to cyber attacks in hospitals is emerging and patient life is at risk. One significant source of potential vulnerabilities is medical cyber-physical systems (MCPS). Detecting intrusions in this environment faces challenges different from other domains, mainly due to the heterogeneity of devices, the diversity of connectivity types, and the variety of terminology. To summarize existing results, we conducted a structured literature review (SLR) following the guidelines of Kitchenham et al. for SLRs in software engineering. We developed six research questions regarding detection approach, detection location, included features, adversarial focus, utilized datasets, and intrusion prevention. We identified that most researchers focused on an anomaly-based detection approach at the network layer. The primary focus was on the detection of malicious insiders. While several researchers used publicly available datasets for training and testing their algorithms, the lack of suitable datasets resulted in the development of testbeds consisting of various medical devices. Based on the results, we formulated five future research topics. First, the special conditions of hospital networks, the MCPS deployed within them, and the contrasts to other IT and OT environments should be examined. Thereupon, MCPS-specific datasets should be created that allow researchers to address the health domain’s unique requirements and possibilities. At the same time, endeavors aimed at standardization in this area should be supported and expanded. Moreover, the use of medical context for attack detection should be further explored. Last but not least, efforts for MCPS-tailored intrusion prevention should be intensified. This way, the emerging threat landscape can be addressed, IT security in hospitals can be improved, and patient health can be protected. Y1 - 2023 U6 - https://doi.org/10.1109/ACCESS.2023.3270225 IS - 11 SP - 41796 EP - 41815 PB - IEEE ER - TY - JOUR A1 - Kolláth, Zoltán A1 - Hajdu, Tamás A1 - Degen, Tobias A1 - Jechow, Andreas A1 - Sztakovics, János T1 - Conversion between measurement units used for night sky quality assessment with multispectral (RGB) cameras JF - Journal of Quantitative Spectroscopy and Radiative Transfer N2 - In recent years, many studies have shown that light pollution adversely affects wildlife, ecosystems, and human well-being. To assess and mitigate these impacts, it is crucial that measurements of night sky quality are reliable and comparable across sites and instruments. However, the lack of standardised night sky brightness metrology and the use of a wide variety of measurement instruments with varying spectral responsivity and field-specific measurement units hinder meaningful comparison. We collected night sky spectra from 44 nights at dark locations (existing and proposed dark sky parks). Based on this observational dataset, we created a larger random set of spectra. These data served to fit conversion parameters for a wide variety of units. We demonstrate that RGB cameras, when used as multichannel measuring devices, enable the retrieval of measurements that facilitate conversions between different units. Furthermore, even airglow can be quantified from a given measurement, enabling the determination of oxygen and sodium emission line contributions. Since this contribution is not negligible, quantitative measurements of its magnitude are crucial for accurately assessing light pollution at dark-sky sites. Using our spectral measurement database, we constructed the most probable transformation from the cameras’ R, G, and B channel 𝑑𝑠𝑢 values to other units, such as the astronomical Bessel V band magnitudes. The unit conversion formulas provided in this paper are valid for mildly polluted sites (existing and proposed dark sky places), in the 21-22 magV∕arcsec2 range. Y1 - 2025 U6 - https://doi.org/10.1016/j.jqsrt.2025.109636 VL - 347 SP - 1 EP - 10 PB - Elsevier ER - TY - JOUR A1 - Schumann, Sophia A1 - Stoilova, Velizara A1 - Bortoletto, Enrico A1 - Piva, Elisabetta A1 - Pacchini, Sara A1 - Mozzi, Gloria A1 - Jechow, Andreas A1 - Marion, Andrea A1 - Bertotto, Daniela A1 - Erlandson, Ann A1 - Hölker, Franz A1 - Greenberg, Larry A1 - Santovito, Gianfranco T1 - Impact of artificial light at night (ALAN) on cardiac function and acute oxidative stress physiology in migratory brown trout smolts JF - Environmental Pollution N2 - Light pollution poses significant ecological challenges for nocturnal animals reliant on natural light for migration, orientation, and circadian rhythms. The physiological effects of abrupt exposure to artificial light at night (ALAN) on migratory fish, such as the light experienced passing near illuminated infrastructures, remain poorly understood. This study investigates the physiological responses of brown trout (Salmo trutta) smolts to low-intensity (0.02 lx) and short-term (30 s) ALAN, simulating nocturnal migration light conditions near illuminated bridges. To evaluate the influence of social dynamics, trout were tested individually (solitary) or in groups of six. Using continuous cardiac monitoring with data storage tags, alongside analyses of oxidative stress markers and adenylate kinase (AK) activity in the heart, we identified distinct patterns of physiological responses. Solitary fish exhibited significant heart rate variability (HRV) increases following repeated ALAN exposure, suggesting impaired physiological regulation under repeated ALAN exposure. In contrast, trout in groups displayed consistently lower HRV over the entire 90-min experiment, implying that social dynamics likely influenced a sustained oxidative stress response, corroborated by increased AK activity. Oxidative stress markers further reflected social effects, with significant upregulation of key antioxidant enzymes (sod1, sod2, gpx1, gpx4) and elevated lipid peroxidation, identifying lipids as primary oxidative targets. The observed divergence between superoxide dismutase (SOD) activity and sod gene expression suggests adaptive post-transcriptional regulation to maintain redox balance under combined environmental and social stress. These findings reveal that social dynamics under ALAN can amplify physiological stress, potentially affecting migratory outcomes. Y1 - 2025 U6 - https://doi.org/10.1016/j.envpol.2025.126593 IS - 381 SP - 1 EP - 9 PB - Elsevier ER - TY - JOUR A1 - Fitz, Lukas R. G. A1 - Scheeg, Jochen T1 - Alternative digital platforms: comparative analysis through the lens of Corporate Aikido JF - Information Systems and e-Business Management N2 - Competing with dominant players in the digital platform (DP) economy is an increasingly complex and expensive endeavor for alternative digital platform (ADP) providers trying to disrupt established platform ecosystems. Nevertheless, ADPs position themselves deliberately in the competitive space of large competitors, targeting customer groups whose values and mindsets differ from mainstream DPs. Although there are many examples to find in practice, the variety of ADPs across different DP ecosystems and industries, especially in regards of strategic objectives, directions and characteristics, has not been researched in-depth yet. Based on a systematic, practice-based artifact review, this paper analyses and compares 105 ADPs in the competitive space of dominant DP ecosystem players. The study utilizes the theory of Corporate Aikido as an analytical framework, mapping the strategic elements of overthrowing established value propositions and turning a competitors’ strengths into weaknesses. Our findings indicate that privacy- and security-awareness, empowerment and inclusivity, premium quality and curation, open source and free access, uncensored, transparent and decentralized platforms as well as ecological and climate-friendly offers shape the landscape of alternative approaches in today’s DP economy. The results are subsequently discussed, yielding managerial implications and future opportunities for DP research. Y1 - 2025 U6 - https://doi.org/10.1007/s10257-025-00703-8 SP - 1 EP - 22 PB - Springer ER - TY - JOUR A1 - Frosch, Katharina A1 - Lindauer, Friederike T1 - Learning With Short Bursts: How Effectively Can We Build Competencies in Climate Change-Related Areas Based on Microlearning? JF - European Journal of Education N2 - The study examines the effectiveness of microlearning in developing the capacity to address climate change and adapt to environmental challenges. Conducted as an online field experiment with 140 participants, the study focused on the impacts of smartphone use as an illustrative learning domain for education in climate change-related areas. Using a pre–post research design and simultaneous equation models, the study found improvements in knowledge retention, with a median increase of 38%. The results indicated that the brief microlearning units also promoted sustainability action competencies, such as confidence in one's influence and willingness to act sustainably. This suggests that higher-order learning processes were also triggered, although to a much lesser extent. Furthermore, learner satisfaction was identified as a mediating variable for these positive outcomes. The study concludes that short bursts of knowledge delivered through microlearning activities can be used alongside traditional training methods to build the critical skills needed for initiatives such as the EU Green Deal. Y1 - 2025 U6 - https://doi.org/10.1111/ejed.70088 VL - 60 IS - 2 SP - 1 EP - 17 PB - Wiley ER - TY - JOUR A1 - Kalinkat, Gregor A1 - Jechow, Andreas A1 - Schroer, Sibylle A1 - Hölker, Franz T1 - Nocturnal pandas: conservation umbrellas protecting nocturnal biodiversity JF - Trends in Ecology & Evolution N2 - Light pollution is an emerging ecological threat. To mitigate its negative consequences, creative inter- and transdisciplinary solutions and societal interactions are needed. To this end, we introduce nocturnal umbrella species representative of light-sensitive biodiversity whose protection will safeguard vital ecosystem services and a wide range of co-occurring species. Y1 - 2025 U6 - https://doi.org/10.1016/j.tree.2025.05.006 VL - 40 IS - 8 SP - 736 EP - 739 PB - Elsevier ER - TY - JOUR A1 - Fitz, Lukas R. G. A1 - Scheeg, Jochen T1 - Coping Practices of Small- and Medium-Sized Enterprises Facing Power Asymmetry in Digital Platform Business JF - Strategic Change N2 - Digital platform (DP) enterprises have risen to the top of the global economy by inverting traditional business models. They earn money through matchmaking, transaction facilitation, and efficient orchestration of other stakeholders' resources. Small- and medium-sized enterprises (SMEs) play a decisive role in this success story: they offer products and services on many leading DPs and thereby feed platform networks as sellers and suppliers. On the other hand, while DPs enable SMEs to reach new customers and outsource costly managerial tasks, many SMEs struggle with the negative consequences of asymmetric power dynamics and dependency risks in platform business. This paper analyzes 14 cases of SMEs that face power asymmetry as DP value providers, unraveling challenges encountered and coping practices employed in this situation. The findings reveal that power asymmetry between dominant DPs and SMEs creates significant challenges, including exploitative relationships, loss of autonomy, surveillance pressures, and devaluation of SME contributions, while SMEs cope through disintermediation, multi-homing, individual resistance tactics, and striving for more equitable DP models. Moreover, three relationality types are identified: DPs being SMEs' “partners,” “tools,” and “necessary evil.” This article offers a new perspective on boundaries of SME strategies in the DP economy and contributes with empirical insights to the advancing field of entrepreneurial platform research. Y1 - 2025 U6 - https://doi.org/10.1002/jsc.2657 SP - 1 EP - 21 PB - Wiley ER - TY - JOUR A1 - Vollmer, Michael A1 - Eberhardt, Wolfgang T1 - Ein einfaches Modell für die Vorhersage von CO2 Konzentrationen in der Atmosphäre in Abhängigkeit von globalen CO2 Emissionen JF - PhyDid B, Didaktik der Physik, Beiträge zur DPG-Frühjahrstagung N2 - Es wird das vielleicht einfachst mögliche Modell vorgestellt, mit dem zeitabhängige CO2 Konzent-rationen c(t) in der Atmosphäre ausgehend von verschiedenen globalen Emissionsszenarien für CO2berechnet werden. Dazu wird eine einzelne inhomogene lineare Differenzialgleichung 1. Ordnung hergeleitet, deren Parameter sich aus den quantitativen Daten des global carbon project sowie Mauna Loa Daten für CO2 Konzentrationen errechnen. Das Modell wird erstens getestet am Zeitraum 1960 bis 2020 mit vergleichsweise guter quantitativer Übereinstimmung zu Messdaten. Zweitens wird für zwei typische IPCC Emissions-Szenarien ein Vergleich der Modellvorhersagen mit denen der kom-plexen IPCC Earth-System-Klimamodelle diskutiert mit qualitativer Übereinstimmung des zeitli-chen Verlaufs. Drittens werden Ergebnisse einiger ausgewählter neuer Emissionsszenarien präsen-tiert. Ungeachtet einiger Abweichungen zu komplexeren Klimamodellen zeichnet sich unser Mo-dell durch zwei wichtige Vorteile für die Lehre aus. Zum einen ist es sehr einfach für Studierende und begabte Schüler nutzbar, da die erforderliche Lösung der Differentialgleichung bereits mit han-delsüblicher Tabellenkalkulationssoftware wie z.B. Excel programmiert werden kann. Dadurch ge-stattet es zum anderen auch sehr einfach, den zeitlichen Verlauf von Emissionsszenarien zu verän-dern und innerhalb weniger Sekunden Veränderungen aufgrund geänderter Eingaben zu berechnen. Insofern eignet sich das Modell sehr gut als Einstieg in das Thema Klimamodellierung in einführen-den Hochschulvorlesungen zum Themenbereich Kohlenstoffkreislauf und Klimawandel. In der Schule kann es gegen Ende der Sekundarstufe 2 beispielsweise im Projektunterricht zum Themen-komplex Nachhaltigkeit in Physik und/oder Mathematik eingesetzt werden Y1 - 2024 UR - https://ojs.dpg-physik.de/index.php/phydid-b/article/view/1411 SN - 2191-379X VL - 1 IS - 1 SP - 379 EP - 388 PB - FU Berlin ER - TY - JOUR A1 - Klopp, Christoph A1 - Trittel, Torsten A1 - Stannarius, Ralf T1 - Coarsening of quasi two-dimensional emulsions formed by islands in free-standing smectic films JF - ChemPhysChem N2 - We study the coarsening behavior of assemblies of islands on smectic A freely suspended films in ISS microgravity experiments. The islands can be regarded as liquid inclusions in a two-dimensional fluid in analogy to liquid droplets of the discontinuous phase of an emulsion. The coarsening is effectuated by two processes, predominantly by island coalescence, but to some extend also by Ostwald ripening, whereby large islands grow at the expense of surrounding smaller ones. A peculiarity of this system is that the continuous and the discontinuous phases consist of the same material. We determine the dynamics, analyze the self-similar aging of the island size distribution and discuss characteristic exponents of the mean island growth. Y1 - 2024 U6 - https://doi.org/10.1002/cphc.202400166 VL - 25 IS - 12 SP - 1 EP - 12 PB - Wiley ER - TY - JOUR A1 - Vollmer, Michael T1 - Limitations of the eye and how to overcome them JF - Journal of Physics: Conference Series N2 - Human eyes have spatial, temporal, and spectral limitations which impose constraints on our perception. With appropriate optical devices and cameras, the limitations can be easily overcome. As a consequence, a huge variety of physical phenomena can be made accessible for teaching. Y1 - 2024 U6 - https://doi.org/10.1088/1742-6596/2750/1/012001 VL - 2750 IS - 1 SP - 1 EP - 10 ER - TY - JOUR A1 - Puzyrev, Dmitry A1 - Torsten, Torsten A1 - Harth, Kirsten A1 - Stannarius, Ralf T1 - Cooling of a granular gas mixture in microgravity JF - npj microgravity N2 - Granular gases are fascinating non-equilibrium systems with interesting features such as spontaneous clustering and non-Gaussian velocity distributions. Mixtures of different components represent a much more natural composition than monodisperse ensembles but attracted comparably little attention so far. We present the observation and characterization of a mixture of rod-like particles with different sizes and masses in a drop tower experiment. Kinetic energy decay rates during granular cooling and collision rates were determined and Haff’s law for homogeneous granular cooling was confirmed. Thereby, energy equipartition between the mixture components and between individual degrees of freedom is violated. Heavier particles keep a slightly higher average kinetic energy than lighter ones. Experimental results are supported by numerical simulations. Y1 - 2024 U6 - https://doi.org/10.1038/s41526-024-00369-5 VL - 10 IS - 1 SP - 1 EP - 9 PB - Springer CY - Brandenburg an der Havel ER - TY - JOUR A1 - Trittel, Torsten A1 - Puzyrev, Dmitry A1 - Harth, Kirsten A1 - Stannarius, Ralf T1 - Rotational and translational motions in a homogeneously cooling granular gas JF - npj microgravity N2 - A granular gas composed of monodisperse spherical particles was studied in microgravity experiments in a drop tower. Translations and rotations of the particles were extracted from optical video data. Equipartition is violated, the rotational degrees of freedom were excited only to roughly 2/3 of the translational ones. After stopping the mechanical excitation, we observed granular cooling of the ensemble for a period of three times the Haff time, where the kinetic energy dropped to about 5% of its initial value. The cooling rates of all observable degrees of freedom were comparable, and the ratio of rotational and translational kinetic energies fluctuated around a constant value. The distributions of translational and rotational velocity components showed slight but systematic deviations from Gaussians at the start of cooling. Y1 - 2024 U6 - https://doi.org/10.1038/s41526-024-00420-5 VL - 10 IS - 1 SP - 1 EP - 6 PB - Springer ER - TY - JOUR A1 - Jechow, Andreas A1 - Bumberger, Jan A1 - Palm, Bert A1 - Remmler, Paul A1 - Schreck, Günter A1 - Ogashawara, Igor A1 - Kiel, Christine A1 - Kohnert, Katrin A1 - Grossart, Hans-Peter A1 - Singer, Gabirel A. A1 - Nejstgaard, Jens C. A1 - Wollrab, Sabine A1 - Berger, Stella A. A1 - Hölker, Franz T1 - Characterizing and Implementing the Hamamatsu C12880MA Mini-Spectrometer for Near-Surface Reflectance Measurements of Inland Waters JF - Sensors N2 - In recent decades, inland water remote sensing has seen growing interest and very strong development. This includes improved spatial resolution, increased revisiting times, advanced multispectral sensors and recently even hyperspectral sensors. However, inland waters are more challenging than oceanic waters due to their higher complexity of optically active constituents and stronger adjacency effects due to their small size and nearby vegetation and built structures. Thus, bio-optical modeling of inland waters requires higher ground-truthing efforts. Large-scale ground-based sensor networks that are robust, self-sufficient, non-maintenance-intensive and low-cost could assist this otherwise labor-intensive task. Furthermore, most existing sensor systems are rather expensive, precluding their employability. Recently, low-cost mini-spectrometers have become widely available, which could potentially solve this issue. In this study, we analyze the characteristics of such a mini-spectrometer, the Hamamatsu C12880MA, and test it regarding its application in measuring water-leaving radiance near the surface. Overall, the measurements performed in the laboratory and in the field show that the system is very suitable for the targeted application. Y1 - 2024 U6 - https://doi.org/10.3390/s24196445 VL - 24 IS - 19 SP - 1 EP - 14 PB - MDPI ER - TY - JOUR A1 - Daupayev, Nursultan A1 - Engel, Christian A1 - Hirsch, Sören T1 - Two-to-One Trigger Mechanism for Event-Based Environmental Sensing JF - Sensors N2 - Environmental monitoring systems often operate continuously, measuring various parameters, including carbon dioxide levels (CO2), relative humidity (RH), temperature (T), and other factors that affect environmental conditions. Such systems are often referred to as smart systems because they can autonomously monitor and respond to environmental conditions and can be integrated both indoors and outdoors to detect, for example, structural anomalies. However, these systems typically have high energy consumption, data overload, and large equipment sizes, which makes them difficult to install in constrained spaces. Therefore, three challenges remain unresolved: efficient energy use, accurate data measurement, and compact installation. To address these limitations, this study proposes a two-to-one threshold sampling approach, where the CO2 measurement is activated when the specified T and RH change thresholds are exceeded. This event-driven method avoids redundant data collection, minimizes power consumption, and is suitable for resource-constrained embedded systems. The proposed approach was implemented on a low-power, small-form and self-made multivariate sensor based on the PIC16LF19156 microcontroller. In contrast, a commercial monitoring system and sensor modules based on the Arduino Uno were used for comparison. As a result, by activating only key points in the T and RH signals, the number of CO2 measurements was significantly reduced without loss of essential signal characteristics. Signal reconstruction from the reduced points demonstrated high accuracy, with a mean absolute error (MAE) of 0.0089 and root mean squared error (RMSE) of 0.0117. Despite reducing the number of CO2 measurements by approximately 41.9%, the essential characteristics of the signal were saved, highlighting the efficiency of the proposed approach. Despite its effectiveness in controlled conditions (in buildings, indoors), environmental factors such as the presence of people, ventilation systems, and room layout can significantly alter the dynamics of CO2 concentrations, which may limit the implementation of this approach. Future studies will focus on the study of adaptive threshold mechanisms and context-dependent models that can adjust to changing conditions. This approach will expand the scope of application of the proposed two-to-one sampling technique in various practical situations. Y1 - 2025 UR - https://www.mdpi.com/1424-8220/25/13/4107 U6 - https://doi.org/10.3390/s25134107 VL - 25 IS - 13 SP - 1 EP - 18 PB - MDPI ER - TY - JOUR A1 - Stein, Stefan A1 - Pilgermann, Michael A1 - Sedlmayr, Martin T1 - Systematic Evaluation of Manufacturer Disclosure Statements for Medical Device Security (MDS2) to Strengthen Hospital OT Security Measures – Lessons Learned JF - Studies in health technology and informatics N2 - The growing number of connected medical devices in hospitals poses serious operational technology (OT) security challenges. Effective countermeasures require a structured analysis of the communication interfaces and security configurations of individual devices. State of the art: Although Manufacturer Disclosure Statements for Medical Device Security (MDS2, Version 2019) offer relevant information, they are rarely integrated into cybersecurity workflows. Existing studies are limited in scope and lack scalable methodologies for systematic evaluation. Concept: This study analyzed 209 MDS2 documents and 161 security white papers to extract structured information on ports, protocols, and protective measures. Over 52,000 question–answer pairs were converted into a machine-readable format using customized parsing and validation routines. The aim was to establish whether this dataset could inform risk assessments and future applications involving Large Language Models (LLMs). Implementation: The analysis revealed 367 distinct ports, including common protocols such as HTTPS (443), DICOM (104), and RDP (3389), as well as vendor-specific proprietary ports. Approximately 40% of the devices used over 20 ports, indicating a broad attack surface. OCR errors and inconsistent formatting required manual corrections. A consolidated dataset was developed to support clustering, comparison across vendors and versions, and preparation for downstream LLM use, particularly via structured SBOM and configuration data. Lessons learned: Although no model training was conducted, the structured dataset can support AI-based OT security workflows. The findings highlight the critical need for up-to-date, machine-readable manufacturer data in standardized formats and schemas. Such information could greatly enhance the automation, comparability, and scalability of hospital cybersecurity measures. Y1 - 2025 U6 - https://doi.org/10.3233/SHTI251404 VL - 331 SP - 256 EP - 264 ER - TY - JOUR A1 - Vollmer, Michael T1 - Nachtsicht ins All mit dem bloßen Auge: Sag mir, wie weit die Sterne steh'n JF - Physik in unserer Zeit Y1 - 2025 U6 - https://doi.org/10.1002/piuz.202501751 VL - 2025 SP - 2 EP - 10 PB - Wiley ER - TY - JOUR A1 - Khuntsaria, Irakli A1 - Gachechiladze, Konstantine A1 - Liparta, Elene A1 - Kobulashvili, Tamar A1 - Jorbenadze, Mariam A1 - Revazishvili, Tamaz A1 - Mamiseishvili, Ana A1 - Kekelia, Elene A1 - Topuridze, Marina A1 - Sturua, Lela A1 - Schrader, Thomas A1 - Kldiashvili, Ekaterina T1 - Strategic implementation of HPV vaccination to eliminate cervical cancer in Georgia JF - Public Health in Practice N2 - Objectives Human Papillomavirus (HPV) is a prevalent sexually transmitted infection and a leading cause of cervical cancer. In Georgia, cervical cancer ranks as the fifth most common cancer among women, with approximately 330 new cases and 200 deaths reported annually. Despite the availability of effective HPV vaccines, national vaccination coverage remains low. This study aimed to evaluate HPV vaccination coverage, analyze cervical cancer incidence trends, and model the potential impact of increased vaccination uptake on cancer prevention outcomes in Georgia. Study design A retrospective observational study was conducted using national health registry data and modeling projections to assess the burden of cervical cancer and estimate the effect of scaled vaccination coverage. Methods National health databases were used to analyze HPV vaccination rates and cervical cancer incidence. Descriptive statistics, chi-square tests, and linear regression were applied to identify trends and disparities. Additionally, a dynamic transmission model was developed to simulate the 10-year impact of increasing HPV vaccination coverage on cervical cancer incidence. Results The crude cervical cancer incidence rate was 15.7 per 100,000 women, with an age-standardized rate of 10.6 per 100,000. In 2022, only 38 % of eligible girls aged 13–18 received the first HPV vaccine dose, and 26 % completed the second dose. Regional disparities in vaccination and screening were noted, and overall screening coverage declined to 13,890 women screened in 2022. Modeling showed that increasing vaccine coverage to 60 % could reduce cervical cancer incidence by 50 % (preventing ∼163 cases); coverage of 80 % and 90 % could reduce incidence by 70 % and 85 %, preventing 228 and 276 cases, respectively. Conclusion Low HPV vaccination uptake in Georgia (38 % first dose and 26 % dull coverage) and declining screening limit cervical cancer prevention. Modeling shows that increasing vaccination coverage to 60–90 % could prevent 163–276 cases over the next decade. Strengthening vaccination and screening strategies is essential to move forward elimination. Y1 - 2025 U6 - https://doi.org/10.1016/j.puhip.2025.100679 VL - 2025 IS - 10 SP - 1 EP - 4 PB - Elsevier ER - TY - JOUR A1 - Levina, Olga A1 - Lindauer, Friederike A1 - Revina, Aleksandra T1 - A Participatory Workshop Design for Engaging Young People in IT Sustainability JF - Education Science N2 - This paper presents an approach to teaching and consolidating skills in the context of sustainability “Prototyping Sustainability–Designing Sustainable IT” (ProS), using the workshop format for participatory and creative learning. The workshop integrates principles from Education for Sustainable Development (ESD), transformative and experiential learning, participatory design, and critical reflection on the digital age to engage participants in critically examining the environmental, economic, and social impacts of digital technologies in the context of Sustainable Development Goals (SDGs). Structured in five modular phases, from self-reflection and knowledge activation to collaborative prototyping and peer evaluation, the workshop offers a hands-on, gamified learning experience centred on real-world sustainability challenges. Learners create user-centred paper-based prototypes for digital products using tactile materials, persona-driven scenarios and knowledge of sustainable product characteristics gained in the workshop. Outcome measurement is supported through pre- and post-workshop surveys, peer voting templates, and paper-based prototype artefacts, enabling rich insight into behavioural intentions and learning gains. The paper discusses the educational value and sustainability relevance of the workshop engaging young people in critically reflecting on the environmental, economic, and social consequences of digitalization. Finally, it highlights challenges and limitations and proposes directions for future research. Y1 - 2025 U6 - https://doi.org/10.3390/educsci15121570 IS - 15 (12) PB - MDPI ER - TY - JOUR A1 - Mushunuri, Ashwini A1 - Adesoji, Oluyomi A1 - Krause, Roland A1 - May, Patrick A1 - Lerche, Holger A1 - Becker, Albert A1 - Grimm, Daniela A1 - Nothnagel, Michael A1 - Schulz, Herbert T1 - Genetic risk factor identification for common epilepsies guided by integrative omics data analysis JF - Epilepsia N2 - Objective Genetic generalized epilepsies (GGEs) comprise the most common genetically determined epilepsy syndromes, following a complex mode of inheritance. Although many important common and rare genetic factors causing or contributing to these epilepsies have been identified in the past decades, many features of the genetic architecture are still insufficiently understood. This study integrates genome-wide association study (GWAS) data from the International League Against Epilepsy Consortium on Complex Epilepsies with transcriptome-wide association studies to identify genes whose genetically regulated expression levels are associated with epilepsy. Methods To achieve this, we used multiple computational approaches, including MAGMA, a tool for gene analysis of GWAS data, and its derivatives E-MAGMA and H-MAGMA, to improve gene mapping accuracy by utilizing tissue-specific expression and chromatin interaction data. Furthermore, we developed ME-MAGMA to incorporate methylation quantitative trait loci data, providing insights into epigenetic factors. Results We identified a total of 897 false discovery rate-corrected (<.05) candidates. These include voltage-gated calcium channels, voltage-gated potassium channels, and other genes such as NPRL2, CACNB2, and KCNT1 associated with epilepsy pathogenesis that act as key players in neuronal communication and signaling in the brain. Significance In this study, we propose new candidate genes to expand the dataset of potential epilepsy-causing genes. Further research on these genes may enhance our understanding of the complex regulatory mechanisms underlying GGE and other types of epilepsy, potentially revealing targets for therapeutic intervention. Y1 - 2025 U6 - https://doi.org/10.1111/epi.70021 PB - Wiley ER -