@article{LuethyHeyer2000, author = {L{\"u}thy, Anja and Heyer, R.}, title = {Einkauf im virtuellen Markt}, series = {In: Krankenhaus Umschau 69(2000)3, S. 160 - 166}, journal = {In: Krankenhaus Umschau 69(2000)3, S. 160 - 166}, year = {2000}, language = {de} } @inproceedings{Muendemann2000, author = {M{\"u}ndemann, Friedhelm}, title = {Multimedia = Multilearning? Chances and Impacts of New Media in Telematics-Based learning}, series = {In: Book of abstracts / Online Educa Berlin : 6th International Conference on Technology Supported Learning \& Training ; November 30 - December 01, 2000. - Bonn : IWH-Verl., 2000 ISBN 3-925144-09-9}, booktitle = {In: Book of abstracts / Online Educa Berlin : 6th International Conference on Technology Supported Learning \& Training ; November 30 - December 01, 2000. - Bonn : IWH-Verl., 2000 ISBN 3-925144-09-9}, pages = {61 -- 65}, year = {2000}, language = {en} } @article{LuethyLotzeLeiskeetal.2000, author = {L{\"u}thy, Anja and Lotze, I. and Leiske, M. and Rossi, R.}, title = {Qualit{\"a}tsmanagement und Kundenorientierung: Befragung zuweisender Kinder{\"a}rzte einer Berliner Kinderklinik}, series = {Zeitschrift f{\"u}r {\"a}rztliche Fortbildung und Qualit{\"a}tssicherung : ZaeFQ 94(2000), S. 31 - 35}, journal = {Zeitschrift f{\"u}r {\"a}rztliche Fortbildung und Qualit{\"a}tssicherung : ZaeFQ 94(2000), S. 31 - 35}, year = {2000}, language = {de} } @article{Muendemann2000, author = {M{\"u}ndemann, Friedhelm}, title = {Standards f{\"u}r Telelern-Betreuer}, series = {In: Wissensmanagement (2000) 3, S. 41 - 44}, journal = {In: Wissensmanagement (2000) 3, S. 41 - 44}, pages = {41 -- 44}, year = {2000}, language = {de} } @inproceedings{Muendemann2000, author = {M{\"u}ndemann, Friedhelm}, title = {TeleCoaches: Aufgaben, Ausbildung}, series = {In: Campus 2000 : Lernen in neuen Organisationsformen / [Ges. f{\"u}r Medien in der Wissenschaft]. Friedrich Scheuermann (Hrsg.). - M{\"u}nster [u.a.] : Waxmann, 2000. - (Medien in der Wissenschaft ; 10) ISBN 3-89325-925-2}, booktitle = {In: Campus 2000 : Lernen in neuen Organisationsformen / [Ges. f{\"u}r Medien in der Wissenschaft]. Friedrich Scheuermann (Hrsg.). - M{\"u}nster [u.a.] : Waxmann, 2000. - (Medien in der Wissenschaft ; 10) ISBN 3-89325-925-2}, pages = {411 -- 413}, year = {2000}, language = {de} } @article{MerkleAckermannBecketal.2000, author = {Merkle, E. and Ackermann, S. and Beck, Eberhard and J{\"a}ger, W. and Lang, N.}, title = {High-Dose versus Low-Dose Cisplatin Chemotherapy plus Treosulfan in Epithelial Ovarian Carcinoma FIGO II-IV: Results of a Prospective Randomized Trial}, series = {In: Onkologie 23(2000)3, 232-238}, journal = {In: Onkologie 23(2000)3, 232-238}, pages = {232 -- 238}, year = {2000}, abstract = {Summary Background: Combination chemotherapies of platinum compounds with alkylating agents have been the standard treatment for patients with advanced ovarian carcinoma over the last decades. The recent development of taxans has added a group of new promising agents; however, long-term results are not yet available. Platin derivates have proven to be an indispensable part in combination chemotherapies for ovarian carcinoma. The dose intensity of cisplatin is, however, still a matter of debate. We report on the long-term results of a prospective randomized trial comparing two dosages of cisplatin combined with treosulfan in patients with advanced epithelial ovarian cancer. Patients and Methods: Between 1988 and 1995, 125 patients with ovarian cancer (FIGO stage II-IV) were randomized to receive 4 cycles (28-day intervals) of either cisplatin 100 mg/m2 (high dose, HD) or 50 mg/m2 (low dose, LD) in combination with 5 g/m2 treosulfan after primary cytoreductive surgery. Postoperative residual tumor was absent in 39 patients (HD: 16; LD: 23), < 2 cm in 61 patients (HD: 36; LD: 25) and > 2 cm in 25 patients (HD: 13; LD: 12). 65 and 60 patients received HD and LD cisplatin, respectively. Second-look surgery was optional. Results:The overall response rate was 70.0\% (HD: 70.9\%; LD: 68.9\%). Pathological complete response (CR) was seen in 45 patients (37.5\%), clinical CR in 23 patients (19.2\%), partial response (PR) in 16 patients (13.3\%), stable disease (SD) in 2 patients, and progression of disease (PD) in 34 patients (28.3\%). 5 patients were not assessable for response. Overall median survival was 25.6 (HD: 26.9, LD: 25.2) months. The overall disease-free survival for responders was 19.6 and 24.7 months (HD and LD, respectively). HD chemotherapy did not result in any significant survival benefit in completely resected patients: HD: 39.8 months versus LD: 49.5 months. In suboptimally debulked patients (residual tumor < 2 cm), median survival was 24.1 months (HD) versus 22.6 months (LD). In patients with residual tumors > 2 cm median survival was 14.6 months (HD) versus 15.5 months (LD). Significantly less side effects were seen in the LD group: anemia (p = 0.008); nephrotoxicity (p = 0.014); alopecia (p = 0.017). Conclusions: Our data suggest that LD cisplatin-based chemotherapy is as effective as HD chemotherapy in patients with advanced epithelial ovarian cancer, but is far less toxic. Copyright © 2000 S. Karger GmbH, Freiburg}, language = {en} } @article{BeckVincentiLichtetal.2000, author = {Beck, Eberhard and Vincenti, D. and Licht, P. and Berkholz, A. and J{\"a}ger, W. and Lang, N. and Merkle, E.}, title = {In vitro activity of human chorionic gonadotropin (hCG)--doxorubicin conjugates against ovarian cancer cells}, series = {In: Anticancer research 20(2000)5A, pg 3001-6}, journal = {In: Anticancer research 20(2000)5A, pg 3001-6}, pages = {3001 -- 3006}, year = {2000}, abstract = {BACKGROUND Despite radical surgery and the introduction of novel chemotherapeutic agents, the prognosis of ovarian cancer remains poor. Since in the past the potential role of gonadotropins in the induction and progression of ovarian cancer has been discussed, we conjugated doxorubicin to human chorionic gonadotropin (hCG) in order to specifically target ovarian cancer cells. MATERIALS AND METHODS Doxorubicin was conjugated to hCG via glutaraldehyde. 48 hours post seeding, NIH:OVCAR 3 cells were treated with various concentrations of hCG-conjugated and non-conjugated doxorubicin for 2 hours. Cells were cultured for a total of 168 hours. Cell growth was monitored by a crystal violet assay. RESULTS Conjugating doxorubicin to hCG resulted in an average specific uptake of 22 mol doxorubicin per mol protein (range 3.0-43.3 mol). Incubating NIH:OVCAR 3 cells for 2 hours with the conjugate led to a more than 8 fold increase of the IC50 values compared to non-conjugated doxorubicin (0.55 microM versus 4.43 microM). The antiproliferative activity of both conjugated and free doxorubicin was detectable up to 168 hours post treatment. CONCLUSIONS The present experiments clearly demonstrate a more than 8-fold increase in cytotoxicity of the conjugates compared to free doxorubicin. It was also shown that this effect was not restricted to an acute toxic event but that it resulted in a prolonged antiproliferative activity.}, language = {en} } @inproceedings{HesselLoeweHaverkampetal.2000, author = {Hessel, V. and L{\"o}we, H. and Haverkamp, V. and Wille, Ch. and Ehrfeld, W. and Lutz, N. and M{\"o}llmann, Klaus-Peter and Pinno, Frank and Herweck, Th.}, title = {Dynamic monitoring of fluid equipartition and heat release in a falling film microreactor using real-time thermography}, series = {In: MICRO.tec 2000 : applications - trends - visions ; proceedings / VDE World Microtechnologies Congress, September 25 - 27, 2000, Expo 2000, Hannover, Germany. Organized by VDE Association for Electrical, Electronic \& Information Technologies. Sponsored by EUREL ... . - Berlin ; Offenbach : VDE-Verl. - Vol. 2. - 2000. - S. 349 - 354. - ISBN 3-8007-2579-7}, booktitle = {In: MICRO.tec 2000 : applications - trends - visions ; proceedings / VDE World Microtechnologies Congress, September 25 - 27, 2000, Expo 2000, Hannover, Germany. Organized by VDE Association for Electrical, Electronic \& Information Technologies. Sponsored by EUREL ... . - Berlin ; Offenbach : VDE-Verl. - Vol. 2. - 2000. - S. 349 - 354. - ISBN 3-8007-2579-7}, pages = {349 -- 354}, year = {2000}, language = {en} } @inproceedings{KarstaedtMoellmannPinno2000, author = {Karst{\"a}dt, Detlef and M{\"o}llmann, Klaus-Peter and Pinno, Frank}, title = {Anschauliche W{\"a}rmelehre im Unterricht: Visualisierung thermischer Vorg{\"a}nge.}, series = {In: Vortr{\"a}ge / Physikertagung, Deutsche Physikalische Gesellschaft, Fachausschuß Didaktik der Physik 1999 (2000), S. 489-494}, booktitle = {In: Vortr{\"a}ge / Physikertagung, Deutsche Physikalische Gesellschaft, Fachausschuß Didaktik der Physik 1999 (2000), S. 489-494}, pages = {489 -- 494}, year = {2000}, language = {de} } @article{Vollmer2000, author = {Vollmer, Michael}, title = {Wahlverhalten von Sch{\"u}lern der Sekundarstufe II im Fach Physik seit 1990 im bundesweiten Vergleich}, series = {Physik in der Schule 38 (2000) 5, 351-354}, journal = {Physik in der Schule 38 (2000) 5, 351-354}, pages = {351 -- 354}, year = {2000}, language = {de} }