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In the present work, a series of spherically defined [60]fullerene multiple adducts with up to four independently addressable addend zones was synthesized and characterized. For that purpose, a novel concept for the regioselective synthesis of [60]fullerene trisadducts exhibiting an e,e,e addition pattern was developed. Following a tether-directed remote approach, excellent regioselectivity was observed for the threefold BINGEL cyclopropanation of tripodal malonate systems based on 1,3,5-trisubstituted benzene derivatives. Due to the template assisted synthesis, the three unsymmetrically substituted malonate addends are spherically arranged as one single in/out isomer creating two topologically well defined regions, namely one polar and one equatorial addend zone. Extending this synthetic concept to [3:3] hexakisadducts resulted in the formation of novel fullerene derivatives bearing up to four spherically defined addend zones arranged like degrees of latitudes on the fullerene core. Selective functionalization of the equatorial addend zone of these novel fullerene derivatives could be easily achieved by simple modifications of the outer terminus of the malonate units. Due to their trigonal distribution around the equatorial belt of the fullerene core, these functional units were shown to impact effectively the intermolecular interactions of the fullerene derivatives. Therefore, a fine-tuning of the equatorial functionalization greatly affected properties such as solubility or aggregation phenomena. For a selective functionalization of the polar addend zone, removal of the structure-determined focal benzene moiety was achieved by means of appropriate deprotection protocols. Since the functional groups in this addend zone were highly preorganized and in close contact to each other, intramolecular interactions predominated. Due to the rigid preorganization and close proximity of their reactive groups, polarly functionalized e,e,e trisadducts could be promising hosts or ligand systems for the supramolecular complexation of complementary hydrogen bonding guests or appropriate metal ions. By combining both selective equatorial and polar functionalization, a series of or orthogonally functionalized e,e,e trisadducts could be designed and synthesized. In case of different functionalities in the two distinct addend zones, these fullerene derivatives are first examples of a novel class of e,e,e trisadducts exhibiting unsymmetrically substituted malonate addends in a spherically well defined manner. In the second part of this work, superoxide inhibition was investigated by standard assays and direct kinetic measurements in DMSO for some water-soluble fullerene derivatives in cooperation with the IVANOVIC-BURMAZOVIC group. For the first time, the catalytic dismutation of superoxide radical anions by fullerene derivatives could be directly verified. In coorporation with C-SIXTY Inc. and PHYLONIX Pharmaceuticals Inc. first in vivo investigations were carried out concerning the toxicity and cytoprotective activity of the water-soluble fullerene derivatives in zebrafish embryos as model systems for mammals. In the third part, the developed concept of spherically well-defined addend zones was extended to [3:3] hexakisadducts. By adding another tripodal malonate tether to the unmodified hemisphere of e,e,e trisadducts, novel highly functionalized fullerene derivatives with up to four defined addend regions could be synthesized in good yields. As first examples for these kinds of novel fullerene based supramolecular building blocks, a series of amphiphilic monomers with a spherically defined arrangement of both hydrophilic and lipophilic moieties could be designed and synthesized.