VCAM-1 serum levels are associated with arthropathy in hereditary haemochromatosis

Language
en
Document Type
Article
Issue Date
2017-01-26
Issue Year
2013
Authors
Nell-Duxneuner, Valerie
Axmann, Roland
Husar-Memmer, Emma
Dallos, Tomáš
Datz, Christian
Stadlmayr, Andreas
Aigner, Elmar
Englbrecht, Matthias
Schett, Georg
Zwerina, Jochen
Editor
Abstract

Objectives: The aim of this study was to assess the role of vascular adhesion molecule 1 (VCAM-1) in patients with hereditary haemochromatosis (HH) with or without arthropathy.

Methods: Sera from a large cross-sectional cohort of unselected HH patients (n=147) were obtained and compared to an age-matched and sex-matched control group. Serum levels of VCAM-1 were measured by ELISA and were correlated with clinical measures.

Results: VCAM-1 serum levels were elevated in HH patients as compared to matched controls (mean 913±456 vs 654±451 ng/ml, p<0.0001). Within the HH patient group, VCAM-1 levels were much higher in patients with arthropathy and joint replacement surgery. VCAM-1 levels correlated well with radiographic measures of HH arthropathy (r=0.36, p<0.0001). Multivariate regression analysis confirmed a highly significant association of VCAM-1 serum levels and the presence of HH arthropathy, independent from diabetes, body mass index and age.

Conclusions: VCAM-1 serum levels emerge as a biomarker for haemochromatosis arthropathy.

Journal Title
Annals of the Rheumatic Diseases
Volume
72
Issue
12
Citation
Annals of the Rheumatic Diseases 72.12 (2013): S. 2006-2010. <http://ard.bmj.com/content/72/12/2006>
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