Sex-Dependent Decrease of Sphingomyelinase Activity During Alcohol Withdrawal Treatment

Language
en
Document Type
Article
Issue Date
2015-02-09
Issue Year
2014
Authors
Mühle, Christiane
Amova, Violina
Biermann, Teresa
Bayerlein, Kristina
Richter-Schmidinger, Tanja
Kraus, Thomas
Reichel, Martin
Gulbins, Erich
Kornhuber, Johannes
Editor
Abstract

ackground: In vitro and in vivo studies have demonstrated the role of the acid sphingomyelinase (ASM) in pathophysiological processes and alterations in response to ethanol exposure. Cellular and plasmatic ASM activities are increased in male alcohol dependent patients and decrease during physical withdrawal. Methods: Here, we analyzed the time course of ASM in male and also female acutely intoxicated patients during alcohol withdrawal and compared the activity levels to those under long-term maintenance treatment. Craving and further psychometric parameters were assessed by questionnaires. Results: The gradual decrease of serum ASM was confirmed in males (p<0.001) and continued to lower activities in long-term patients (p=0.001). The trend was similar in females (p=0.178), although the initial enzyme activities were significantly lower (p=0.035). ASM activity strongly correlated with the body mass index in males. The initial ASM activity and its decline during the first two days were associated with the improvement in scores for the Beck depression inventory, the obsessive compulsive drinking and the withdrawal syndrome scales. Conclusion: These data support the potential of ASM as a biomarker for the course of withdrawal therapy in males and provide the first associations of this enzyme with psychological variables such as craving and depression.

Journal Title
Cellular Physiology and Biochemistry
Volume
34
Issue
1
Citation
Cellular Physiology and Biochemistry 34.1 (2014): S. 71-81. <http://www.karger.com/Article/FullText/362985> © 2014 S. Karger AG, Basel
DOI
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