Osteo-radio-necrosis (ORN) and bisphosphonate-related osteonecrosis of the jaws (BRONJ): the histopathological differences under the clinical similarities

Language
en
Document Type
Article
Issue Date
2015-01-27
Issue Year
2014
Authors
Mitsimponas, Konstantinos T.
Moebius, Patrick
Amann, Kerstin
Stockmann, Philipp
Schlegel, Karl-Andreas
Neukam, Friedrich-Wilhelm
Wehrhan, Falk
Editor
Abstract

Objectives: Both Osteoradionecrosis (ORN) and Bisphosphonate associated osteonecrosis of the jaws (BRONJ) present clinically as regions of exposed necrotic bone. The study aimed to demonstrate the histopathological differences behind the observed clinical similarities. Study Design: Ten ORN specimens and ten BRONJ specimens were used, as well as ten samples of normal mandibular bone as control. Two bone-specific stainings were used, i.e. Sirius Red for the study of the relative presence of collagen types I and III and toluidine blue for the study the osteon density. Results: The Red Green Blue (RGB)-analysis of the specimens stained with Sirius Red identified significant differences between the chromatic patterns observed in bone preparations of patients suffering from ORN when compared to both BRONJ and control samples. Moreover, the osteon density of the BRONJ samples was significantly lower when compared to ORN and normal bone samples. Conclusions: The demonstrated differences in the bone architecture and in the bone collagen content between the two pathological conditions most likely reflect underlying pathophysiological differences.

Journal Title
International Journal of Clinical and Experimental Pathology
Volume
7
Issue
2
Citation
International Journal of Clinical and Experimental Pathology 4.2 (2014):S. 496 - 508. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925894/>
DOI
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