Exploration of different x-ray Talbot–Lau setups for dark-field lung imaging examined in a porcine lung

Language
en
Document Type
Article
Issue Date
2022-02-08
First published
2019-03-13
Issue Year
2019
Authors
Ludwig, Veronika
Seifert, Maria
Hauke, Christian
Hellbach, Katharina
Horn, Florian
Pelzer, Georg
Radicke, Marcus
Rieger, Jens
Sutter, Sven-Martin
Michel, Thilo
Editor
Publisher
IOP Publishing
Abstract

Abstract X-ray dark-field imaging is a promising technique for lung diagnosis. Due to the alveolar structure of lung tissue, a higher contrast is obtained by the dark-field image compared to the attenuation image. Animal studies indicate an enhancement regarding the detection of lung diseases in early stages. In this publication, we focus on the influence of different Talbot–Lau interferometer specifications while maintaining the x-ray source, sample magnification and detector system. By imaging the same porcine lung with three different grating sets, we analyze the contrast-to-noise ratio of the obtained dark-field images with respect to visibility and correlation length. We demonstrate that relatively large grating periods of the phase and of the analyzer grating are sufficient for high quality lung imaging at reasonable dose levels.

Journal Title
Physics in Medicine & Biology
Volume
64
Issue
6
Citation

Physics in Medicine & Biology 64.6 (2019): 065013. https://iopscience.iop.org/article/10.1088/1361-6560/ab051c

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