A Suggestive Association of Fuchs Heterochromic Cyclitis with Cytotoxic T Cell Antigen 4 Gene Polymorphism
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Abstract
Background: Fuchs heterochromic cyclitis (FHC) is a chronic inflammatory eye disease, usually presenting as unilateral anterior uveitis. Up to date no disease susceptibility genes have been described for FHC. Methods: The allele frequency of HLA DRB1 and DQB1, polymorphisms of the tumour necrosis factor (TNF) _ promoter region (–376, –308, –238), the promoter (–318), first exon (+49) and (AT)n repeat polymorphism of the cytotoxic T cell antigen 4 (CTLA4) gene were analysed in 44 FHC patients and 139 healthy controls. Results: The CTLA4 –318 C/T genotype was increased in FHC patients [odds ratio (OR) 3.0, 95% confidence interval (CI) 1.4–6.5], as well as long CTLA4 (AT)n microsatellite alleles with more than 16 AT repeats (OR 2.6, 95% CI 1.3–5.3). A trend towards the –308 G/A TNF- _ genotype was found in the patient cohort, whereas no difference in HLA class II allele distribution was observed. Conclusion: CTLA4 but not TNF- _ or HLA class II DRB1 and DQB1 may represent a candidate gene for disease susceptibility in FHC.