Lessons Learned from 15 Years of KIMS and 5 Years of ACROSTUDY

Language
en
Document Type
Article
Issue Date
2013-02-25
Issue Year
2011
Authors
Luger, Anton
Feldt-Rasmussen, Ulla
Abs, Roger
Gaillard, Rolf C.
Buchfelder, Michael
Trainer, Peter
Brue, Thierry
Editor
Abstract

Background: Pharmacoepidemiological surveys provide a valuable contribution to the continued monitoring of drugrelated effects in patients with rare disorders. One of the earliest examples of this type of survey is KIGS (Pfizer International Growth Study Database), which has monitored the safety and effectiveness of growth hormone (GH) therapy in GH-deficient children since its inception in 1987. Following closely in the footsteps of KIGS is KIMS (Pfizer International Metabolic Database). As of 2009, KIMS has been collecting data on the long-term safety and clinical outcomes of GH replacement in GH-deficient adults for 15 years. Approximately 5 years ago, the ACROSTUDY database was established to monitor the long-term safety and effectiveness of pegvisomant in patients with acromegaly. Conclusions: By collecting data on the treatment of relatively rare conditions in routine clinical practice, pharmacoepidemio- logical surveys such as KIMS and ACROSTUDY provide valuable information on the safety and effectiveness of treatment with GH replacement and pegvisomant in the real world.

Journal Title
Hormone Research in Paediatrics 2011; 76(suppl 1): 33-38. <http://content.karger.com/ProdukteDB/produkte.asp?typ=pdf&doi=329156> © 2011 S. Karger AG, Basel
Citation

Hormone Research in Paediatrics 2011; 76(suppl 1): 33-38. http://content.karger.com/ProdukteDB/produkte.asp?typ=pdf&doi=329156 © 2011 S. Karger AG, Basel

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