Low-Grade Endometrial Stromal Sarcoma - a Review

Language
en
Document Type
Article
Issue Date
2020-01-20
First published
2018-10-13
Issue Year
2018
Authors
Thiel, Falk C.
Halmen, Sonja
Editor
Publisher
S. Karger AG
Abstract

Like other uterine sarcomas, low-grade endometrial stromal sarcomas (LG-ESS) are a very rare tumor entity. In the past, research studies therefore discussed the various different types of the disease in combination. In addition, the classification of endometrial stromal tumors presented difficulties for quite some time so that in earlier studies it was not always possible to precisely distinguish between LG-ESS, high-grade endometrial stromal sarcoma, and undifferentiated uterine sarcoma. For LG-ESS, surgery with hysterectomy and adnexectomy is the first-line treatment. The benefits of lymphadenectomy and tumor debulking are unclear. Endocrine therapy with gestagens and aromatase inhibitors is under discussion to provide adjuvant treatment for patients with advanced stages of the disease. As radiotherapy only provides locoregional control, and in view of the usually good prognosis of patients with LG-ESS, its benefits need to be weighed against its side effects. In the case of recurrence, repeat surgery is the first choice. Further research studies viewing LG-ESS as a distinct entity are needed in order to improve treatment options for patients with LG-ESS.

Journal Title
Oncology Research and Treatment
Volume
41
Issue
11
Citation

Oncology Research and Treatment 41.11 (2018): S. 687-692. https://www.karger.com/Article/FullText/494225 © 2018 S. Karger GmbH, Freiburg

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