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Open Science Support Centre was established by Central Library of Charles University in January 2020. Its main focus is to provide support in areas of Open Access and Research Data Management. Even though Open Science principles are not yet widely adopted in Czechia, Open Science Support Centre managed to find its place in the university's ecosystem and we would like to share our experience. The talk will briefly introduce the current situation regarding Open Science at our university and in Czechia in general, and summarize our goals and activities. It will also discuss inter-university cooperation on both national and international levels, which proves to be invaluable in mainstreaming of Open Science.