We present an in situ PXRD investigation of the mechanochemical cocrystal formation of pyrazinamide with pimelic acid in two milling jar materials. In the steel jar a polymorph transformation presenting an exception of Ostwald’s rule of stages is observed.
- Cocrystal formation of pyrazinamide with dicarboxylic acids
proceeds either directly or via a crystalline intermediate.
- Two new crystal structures were discovered by in situ investigations.