Ingenieurwissenschaften und zugeordnete Tätigkeiten
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- Fluorescent and thermoresponsive nanoparticles (2) (entfernen)
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Dual orthogonal functionality in a single material is highly desirable in many fields such as bio-imaging, sensing, coating or diagnostic and therapy. However, combining two different functionalities in a precise and controlled way is still a challenging task.
Here we present how simply dual functional hybrid nanoparticles consisting of a silica core with a fluorescent and a thermoresponsive polymeric layers can be prepared. As a first step of this work, silica core particles were coated by a fluorescent layer using surface-initiated reversible addition-fragmentation chain transfer polymerization. Afterwards, the fluorescent silica nanoparticles were completely enclosed in a switchable protective coating made of thermoresponsive poly(N-isopropylacrylamide). The thermoresponsive poly(N-isopropylacrylamide) changes its properties with varying the surroundings temperature and this behavior is reversible and controllable. To the best of our knowledge these types of hybrid dual functional core-shell-shell nanoparticles have not yet been prepared, despite the prospect of many potential applications.
Dual orthogonal functionality in a single material is highly desirable in many fields such as bio-imaging, sensing, coating or diagnostic and therapy. However, combining two different functionalities in a precise and controlled way is still a challenging task.
Here we present how simply dual functional hybrid nanoparticles consisting of a silica core with a fluorescent and a thermoresponsive polymeric layers can be prepared. As a first step of this work, silica core particles were coated by a fluorescent layer using surface-initiated reversible addition-fragmentation chain transfer polymerization. Afterwards, the fluorescent silica nanoparticles were completely enclosed in a switchable protective coating made of thermoresponsive poly(N-isopropylacrylamide). The thermoresponsive poly(N-isopropylacrylamide) changes its properties with varying the surroundings temperature and this behavior is reversible and controllable. To the best of our knowledge these types of hybrid dual functional core-shell-shell nanoparticles have not yet been prepared, despite the prospect of many potential applications.