Chemische Charakterisierung und Spurenanalytik
Filtern
Dokumenttyp
- Zeitschriftenartikel (367)
- Vortrag (363)
- Posterpräsentation (155)
- Beitrag zu einem Tagungsband (16)
- Sonstiges (16)
- Forschungsdatensatz (7)
- Buchkapitel (6)
- Dissertation (5)
- Forschungsbericht (3)
- Beitrag zu einem Sammelband (1)
Sprache
- Englisch (787)
- Deutsch (150)
- Mehrsprachig (3)
- Polnisch (1)
Schlagworte
- ICP-MS (46)
- Laser ablation (36)
- Nanoparticle (34)
- Process Analytical Technology (34)
- Synchrotron (33)
- BAMline (30)
- Fluorescence (28)
- Mikroplastik (28)
- PFAS (23)
- HR-CS-GFMAS (22)
- Mass spectrometry (22)
- TED-GC/MS (22)
- XRF (22)
- Metrology (21)
- Prozessanalytik (20)
- LA-ICP-MS (19)
- Traceability (19)
- CONSENS (17)
- Fluorine (17)
- HR-CS-MAS (17)
- Imaging (17)
- LIBS (17)
- Microplastic (17)
- Online NMR Spectroscopy (17)
- Microplastics (16)
- Benchtop-NMR (15)
- Immunoassay (15)
- Machine learning (15)
- Mycotoxins (15)
- Prozessindustrie (15)
- Reference material (15)
- Automation (14)
- Cell (14)
- Absolute isotope ratio (12)
- Bioimaging (12)
- NMR spectroscopy (12)
- qNMR (12)
- Electrochemistry (11)
- Isotope analysis (11)
- Isotope dilution (11)
- Modular Production (11)
- Online NMR spectroscopy (11)
- Soil (11)
- Digitalisierung (10)
- ELISA (10)
- Industry 4.0 (10)
- Isotope ratio (10)
- Mechanochemistry (10)
- Nanoparticles (10)
- Plasma modeling (10)
- Uncertainty (10)
- Calibration (9)
- Cancer (9)
- Copper (9)
- Isotope (9)
- Lithium (9)
- Magnesium (9)
- Mass-Spectrometry (9)
- Online-NMR-Spektroskopie (9)
- Per- and Polyfluoroalkyl substances (PFAS) (9)
- Process Industry (9)
- Quality assurance (9)
- TED-GC-MS (9)
- XANES (9)
- CRM (8)
- GD-OES (8)
- LC-MS/MS (8)
- MALDI-TOF MS (8)
- Mass Spectrometry (8)
- Measurement uncertainty (8)
- NMR-Spektroskopie (8)
- Optical spectroscopy (8)
- Reaction Monitoring (8)
- Reference materials (8)
- Single cell analysis (8)
- Spectroscopy (8)
- Amperometry (7)
- Analytik (7)
- Benchtop NMR (7)
- Datenanalyse (7)
- Extractable organically bound fluorine (EOF) (7)
- Gold (7)
- High resolution-continuum source-graphite furnace molecular absorption spectrometry (HR-CS-GFMAS) (7)
- Isotopes (7)
- Laser induced plasma (7)
- Process analytical technology (7)
- Referenzmaterialien (7)
- Speciation analysis (7)
- Sulfur (7)
- Transformationsprodukte (7)
- Capillary electrophoresis (6)
- Data Analysis (6)
- HR-CS-AAS (6)
- Hydrogen (6)
- In situ (6)
- Industrie 4.0 (6)
- Isotope dilution mass spectrometry (6)
- Lanthanide (6)
- Lithium Ion Batteries (6)
- MC-ICP-MS (6)
- Metabolomics (6)
- Per- and polyfluorinated alkyl substances (PFASs) (6)
- Quantitative NMR Spectroscopy (6)
- Quantum yield (6)
- Reproducibility (6)
- SI traceability (6)
- Transformation products (6)
- Analysis (5)
- Analytical Chemistry (5)
- Antibody (5)
- CCQM (5)
- Cement (5)
- Comparability (5)
- Delta value (5)
- Ergot alkaloids (5)
- Estrogens (5)
- Food (5)
- Food analysis (5)
- GC-MS (5)
- GDMS (5)
- HRMS (5)
- ISO-Guide 35 (5)
- Immunohistochemistry (5)
- Isotope fractionation (5)
- Isotopic analysis (5)
- Magnetic resonance imaging (5)
- Method development (5)
- Molecularly imprinted polymers (5)
- Plasma (5)
- Plasma diagnostics (5)
- Process industry (5)
- Provenance (5)
- Quantification (5)
- Single cell (5)
- Spectrometry (5)
- Surface chemistry (5)
- Triple isotope fractionation (5)
- Umweltsimulation (5)
- VOC (5)
- Validation (5)
- Water (5)
- XRD (5)
- Acoustic levitation (4)
- Antikörper (4)
- Artificial neural networks (4)
- Battery (4)
- Bayesian Statistics (4)
- Bioconjugation (4)
- Certification (4)
- Certified reference material (4)
- Chemometrics (4)
- Combustion Ion Chromatography (4)
- Combustion ion chromatography (CIC) (4)
- DNA (4)
- Diatoms (4)
- Environmental analysis (4)
- Gadolinium (4)
- Graphite furnace (4)
- HPLC (4)
- Human serum (4)
- Hyphenated techniques (4)
- ISO 16000-6 (4)
- Indirect Hard Modeling (4)
- Indirect hard modeling (4)
- Interlaboratory Comparison (4)
- Isotope reference material (4)
- Labeling (4)
- Luminescence (4)
- MALDI (4)
- Mass Spectroscopy (4)
- Messunsicherheit (4)
- Microbiologically influenced corrosion (4)
- Microwave inductively coupled atmospheric pressure mass spectrometry (MICAP-MS) (4)
- Modular production (4)
- Multi-element analysis (4)
- Mycotoxin (4)
- Nanomaterial (4)
- Nanomaterials (4)
- Nitrogen plasma (4)
- Pollen (4)
- Polylactide (4)
- Process monitoring (4)
- Purity (4)
- Quality Control (4)
- Real-time process monitoring (4)
- SC-ICP-ToF-MS (4)
- SPM (4)
- Sc-ICP-ToF-MS (4)
- Screening (4)
- Sewage sludge (4)
- Single cell-ICP-ToF-MS (4)
- Smarte Sensoren (4)
- Software (4)
- Solid-liquid extraction (4)
- Synthesis (4)
- TXRF (4)
- Transformation product (4)
- Trichodiene (4)
- Tumor metabolism (4)
- UFP (4)
- Volatile organic compounds (4)
- Warfarin (4)
- Wastewater (4)
- Zinc (4)
- Absolute fluorometry (3)
- Adsorbable organically bound fluorine (AOF) (3)
- Amoxicillin (3)
- Antibodies (3)
- Archaea (3)
- Archaeometry (3)
- Atomic absorption spectrometry (3)
- BFR (3)
- Benchtop NMR spectroscopy (3)
- Biosensor (3)
- Boron (3)
- Borosilicate glass (3)
- Brain (3)
- Böden (3)
- CIC (3)
- COVID-19 (3)
- Cells (3)
- Chemical characterization (3)
- Cocoa (3)
- Coded Aperture (3)
- Conventional isotope ratio (3)
- Coulometric sensors (3)
- Cyclic voltammetry (3)
- Datenkonzepte (3)
- Diagnostics (3)
- Diatomic molecule (3)
- Diclofenac (3)
- Digital Transformatioin (3)
- Digitalisation (3)
- Digitization (3)
- Dosimetry (3)
- Dye (3)
- EN 16516 (3)
- EOF (3)
- Effect based Method (3)
- Elektrochemie (3)
- Elektrolyseverfahren (3)
- FIB (3)
- Fatty acid metabolism (3)
- Fertilizer (3)
- Gas chromatography (3)
- Gaussian process (3)
- Hydrolysis (3)
- Hydrolytic resistance (3)
- ICP-ToF-MS (3)
- ILC (3)
- Interlaboratory comparison (3)
- Iron (3)
- Isotope amount ratio (3)
- Isotope delta value (3)
- Isotopenanalyse (3)
- Laser Ablation (3)
- Lifetime (3)
- Lipidomic profile (3)
- Lithium isotope (3)
- Lithium-ion batteries (3)
- MS based method (3)
- Machine Learning (3)
- Mass cytometry (3)
- Mercury (3)
- Metabolic stress (3)
- Mikroplastik-Analytik (3)
- Multicollector-ICP-MS (3)
- Multimodal (3)
- Mycotoxin Biomarker (3)
- Mykotoxine (3)
- NIR (3)
- NMR Spectroscopy (3)
- Nanocrystal (3)
- Nanoparticles separation capillary electrophoresis asymmetrcial flow field flow fractionation (3)
- Nanopartikel (3)
- Neural network (3)
- Nickel (3)
- Nontarget analysis (3)
- Ochratoxin A (3)
- Peptide library (3)
- Pesticide (3)
- Polymer (3)
- Polymers (3)
- Probennahme (3)
- Process Control (3)
- Process Monitoring (3)
- Purity assessment (3)
- Quantum dot (3)
- R package (3)
- RBD (3)
- RFA (3)
- Referenzmaterial (3)
- Reliable measurements (3)
- Risk assessment (3)
- SARS-CoV-2 (3)
- SAXS (3)
- SPE HR-CS GF MAS (3)
- Sampling (3)
- Sampling techniques (3)
- Silane (3)
- Size (3)
- Stability (3)
- Standardisation (3)
- Standardization (3)
- Steel (3)
- Tire wear (3)
- Trinkwasser (3)
- Ultrasound (3)
- VVOCs (3)
- WWTP (3)
- Water analysis (3)
- X-ray fluorescence (3)
- ZRM (3)
- AAS (2)
- AF4 (2)
- AFM (2)
- Abwasser (2)
- Accurate mass (2)
- Adsorption (2)
- Advanced nanomaterials (2)
- Affinity Chromatography (2)
- Affinity chromatography (2)
- Aktivkohle (2)
- Albumin (2)
- Analytic (2)
- Analytical Sciences (2)
- Analytical method (2)
- Antagonists (2)
- Array (2)
- Artificial Inelligence (2)
- Artificial Neural Networks (2)
- Artificial intelligence (2)
- Assay (2)
- Asymmetrical flow field flow fractionation (AF4) (2)
- BODIPY (2)
- Batteries (2)
- Bayesian Optimization (2)
- Benchtop NMR Spectroscopy (2)
- Benz[a]anthracene (BaA) (2)
- Benzo[a]pyrene (BaP) (2)
- Betriebspunktoptimierung (2)
- Biomarker (2)
- Biosensing (2)
- Biotechnology (2)
- Biotransformation (2)
- CE/MC-ICP-MS (2)
- CXC (2)
- Cadmium (2)
- Calcium (2)
- Calcium monofluoride (2)
- Capillary electrophoresis (CE) (2)
- Carrier gas hot extraction (2)
- Cascade impactor (2)
- Chemiluminescence (2)
- Chlorine (2)
- Chromatography (2)
- Cleaning (2)
- Compact NMR Spectroscopy (2)
- Compound annotation (2)
- Core-shell particles (2)
- Corona (2)
- Corrosion (2)
- Crystalinity (2)
- Crystallization (2)
- Cyanide in soil (2)
- Cyclization (2)
- D2XRF (2)
- Datenauswertung (2)
- Datenvorbehandlung (2)
- Degradation (2)
- Delta values (2)
- Depth-profiling (2)
- Derivatization (2)
- Diagenesis (2)
- Diagnosis (2)
- Digitale Transformation (2)
- Dissolution (2)
- Dynamische Lichtstreuung (2)
- Düngemittel (2)
- E. coli (2)
- EC/LC/MS (2)
- EDX (2)
- EXAFS (2)
- Electrocatalysis (2)
- Electrochemical oxidation (2)
- Electrospray ionization (2)
- Environmental pollutants (2)
- Environmental simulation (2)
- Environmental speciation (2)
- Ergot (2)
- Extracellular matrix (2)
- Extrahierbar organisch gebundenes Fluor (EOF) (2)
- FFF-3D-Printer (2)
- FPLC (2)
- FTIR (2)
- Finow Canal (2)
- Fluor (2)
- Fluxomics (2)
- Food safety (2)
- Gas analysis (2)
- Gas chromatography (GC) (2)
- Gas pressure influence (2)
- Gaschromatography-Mass Spectrometry (2)
- General Earth and Planetary Sciences (2)
- General Materials Science (2)
- Glasmalfarben (2)
- Glow Discharge Mass Spectrometry (2)
- Graphite (2)
- HPLC-MS (2)
- Halogene (2)
- Halogens (2)
- Hapten Immunoassay (2)
- Harmonisation (2)
- Heart failure (2)
- Herkunftsbestimmung (2)
- High-resolution MS (2)
- History of the research work of Norbert Jakubowski (2)
- Homogeneity (2)
- Humboldt Codices (2)
- Hybridoma (2)
- Hydrazinolysis (2)
- Hydrogen Storage (2)
- ICP-TOF-MS (2)
- IDMS (2)
- IR (2)
- ISO 17025 (2)
- ISO Guide 35 (2)
- Immuno-assay (2)
- Immunosensor (2)
- Indirect Hard Modelling (2)
- Inductively Coupled Plasma Mass Spectrometry (2)
- Instrumentation (2)
- Interferences (2)
- Internal Standard (2)
- Ionische Flüssigkeiten (2)
- Ionization (2)
- Ionophore Antibiotika (2)
- Isotope Dilution (2)
- Isotope dilution (ID) (2)
- Isotope ratios (2)
- Isotopic fractionation (2)
- Isotopic shift (2)
- Klärschlamm (2)
- LA-ICP-MS with cellular resolution (2)
- LFIA (2)
- Lab of the Future (2)
- Lab-on-a-chip (2)
- Laboratory 4.0 (2)
- Laser-induced XUV spectroscopy (2)
- Legacy pollution (2)
- Li-ion battery (2)
- Lipidomics (2)
- Liquid chromatography (LC) (2)
- Lithium batteries (2)
- Low-field NMR Spectroscopy (2)
- Low-field NMR spectroscopy (2)
- MALDI TOF MS (2)
- MALDI-TOF-MS (2)
- MDG (2)
- MOSES (2)
- MRI (2)
- MYCN (2)
- Magnetic beads (2)
- Mass spectrometry (MS) (2)
- Massenspektrometrie (2)
- MefHySto (2)
- Metals (2)
- Metformin (2)
- Methylmercury (2)
- Metrologie (2)
- Microbe interactions (2)
- Microbiological influenced corrosion MIC (2)
- Microdroplet generator (2)
- Microfluidics (2)
- Mobile phase (2)
- Modulare Produktion (2)
- Molar mass (2)
- Molecular absorption spectrometry (2)
- Mono-hydride (2)
- Monoclonal Antibodies (2)
- Multicellular spheroid (2)
- Multivariate analysis (2)
- Multivariate data analysis (2)
- NMR (2)
- NMR Validation (2)
- Nano (2)
- Network (2)
- Nitrogen (2)
- Nitrotyrosine (2)
- Non-metal analysis (2)
- Non-metals (2)
- Oberflächengewässer (2)
- Oberflächenwasser (2)
- Optischer Spektroskopie (2)
- Oxygen sensor (2)
- PANIC (2)
- PBFSM (2)
- PEG (2)
- Partial Least Squares Regression (2)
- Passive sampling (2)
- Peptide analysis (2)
- Permethrin (2)
- Pharmaceuticals (2)
- Phosphorus (2)
- Photocatalysis (2)
- Photodegradation (2)
- Pollutants (2)
- Polycyclic aromatic hydrocarbon (PAH) (2)
- Polyethylene glycole (2)
- Polymer 3R (2)
- Polypropylen (2)
- Polystyrol (2)
- Probenahme (2)
- Probenvorbereitung (2)
- Protein (2)
- Protein analysis (2)
- Proteins (2)
- Prozesskontrolle (2)
- Quality Assurance (2)
- Quality control (2)
- Quality testing (2)
- Quantitative NMR spectroscopy (2)
- Quantitative spectroscopy (2)
- Quantum dots (2)
- Raman (2)
- Raman spectroscopy (2)
- Recovery (2)
- Referenzmaterial-Herstellung (2)
- Remediation (2)
- Retrospective analysis (2)
- Ring resonator (2)
- Ringversuch (2)
- SBA-15 (2)
- SC-ICP-MS (2)
- SEM (2)
- SERS (2)
- SHS (2)
- SI (2)
- SPE (2)
- Safety (2)
- Sample preparation (2)
- Schadstoffaustrag (2)
- Schadstoffe (2)
- Schwebstoffe (2)
- Sediment (2)
- Semiconductor (2)
- Sensor (2)
- Sensorbeschichtung (2)
- Sensors (2)
- Silanes (2)
- Silver nanoparticles (2)
- Single Cell (2)
- Single cell ICP-MS (2)
- Single particle ICP-MS (2)
- Smart Sensors (2)
- Solid phase extraction (SPE) (2)
- Specialty Chemicals (2)
- Speciation Analysis (2)
- Spike-Protein (2)
- Spurenfeuchtemessung (2)
- Sr isotopes (2)
- Standards (2)
- Standarisierung (2)
- Structural Health Monitoring (2)
- Sum Parameter (2)
- Sum parameter (2)
- Surface coating (2)
- Surface water (2)
- TGA-FTIR (2)
- Temperature (2)
- Thermal extraction (2)
- Thermogravimetrie (2)
- Tissue (2)
- Total cyanide (2)
- Toxicity (2)
- Toxicity testing (2)
- Trace Analysis (2)
- Trace analysis (2)
- Trace elements (2)
- Trace humidity measurement (2)
- Ultraschall (2)
- Umwelt (2)
- Umweltverhalten (2)
- Virus (2)
- WFD (2)
- Wasseraufbereitung (2)
- Wasserstoff (2)
- Whole water samples (2)
- XAFS (2)
- 150th anniversary of BAM (1)
- 2,5-dihydroxyacetophenone (1)
- 2-propanol oxidation (1)
- 280 nm (1)
- 3D printing (1)
- 3D ultrastructural analysis (1)
- 3D-printing (1)
- 5-Bromouracil (1)
- 6xHis (1)
- A4F (1)
- AAAA (1)
- ABC (1)
- ABID (1)
- ACE2 (1)
- ACE2-Rezeptor (1)
- AG nanoparticle (1)
- AKR (1)
- ANAKON (1)
- ANOVA (1)
- AOF (1)
- ATCUN (1)
- AU nanoparticle (1)
- Absorption spectrometry (1)
- Accreditation (1)
- Accuracy (1)
- Acidic oxygen evolution reaction (1)
- Acrylamide (1)
- Acute myocardial infarction (1)
- Additive (1)
- Additive Manufacturing (1)
- Additive manufacturing (1)
- Aeroacoustics (1)
- Affinity (1)
- Affinity Extraction (1)
- Affinity Separation (1)
- Affinity extraction (1)
- Affinitätschromatographie (1)
- Affinitätskonstante (1)
- Aflatoxins (1)
- Africa (1)
- Aging (1)
- Aging Mechanisms (1)
- Aging mechanisms (1)
- Air analysis (1)
- Air filter samples (1)
- Air particulate matter (1)
- Air traffic (1)
- Air-coupled ultrasound (1)
- Airport (1)
- Akaike information criterion picker (1)
- AlCl (1)
- Alcohol electrooxidation (1)
- Algen (1)
- Algorithms (1)
- Alkylierung (1)
- Allergy (1)
- Altenuene (1)
- Alteration (1)
- Alternaria mycotoxins (1)
- Aluminium (1)
- Aluminiumoxid (1)
- Aluminum (1)
- Aluminum alloys (1)
- Aluminum oxide (1)
- Alzheimer disease (1)
- Alzheimer’s disease (1)
- Ambient pressure laser ionization (1)
- Amino acid analysis (1)
- Amplification (1)
- Amyloid (1)
- Amyloid-beta (1)
- Analyse (1)
- Analyseverfahren (1)
- Analytical chemistry (1)
- Analytical methods (1)
- Analytical science (1)
- Analytical standards (1)
- Analytics (1)
- Analytische Methode (1)
- Anemia (1)
- Anilinopyridine (1)
- Anion receptors (1)
- Anion recognition (1)
- Anode (1)
- Anthropocene (1)
- Anti-cancer (1)
- Antibiotics (1)
- Antibody Purification (1)
- Antibody Quantification (1)
- Antibody conjugates (1)
- Antibody identification (1)
- Antibody quantification (1)
- Antibody-gated indicator delivery (1)
- Antifouling biocides (1)
- Antifouling-Biozide (1)
- Antikensammlung Berlin (1)
- Antikörpermarkierung (1)
- Anwendungsmöglichkeiten (1)
- App (1)
- Applied optical spectroscopy (1)
- Arbeitsanleitung (1)
- Archean ocean (1)
- Archäometrie (1)
- Aromatic amino acid analysis (1)
- Aromatische Aminosäureanalytik (1)
- Arsenite (1)
- Artificial Intelligence (1)
- Arzneimittel (1)
- Ashes (1)
- Aspergillus (1)
- Atmospheric aerosol (1)
- Atomabsorptionsspektrometrie (1)
- Atomic Absorption Spectrometry (1)
- Atomic Force Microscopy (1)
- Atomic absorption spectroscopy (1)
- Atomic and molecular physics, and optics (1)
- Atomic layer deposition (1)
- Atomic spectrometry (1)
- Atomic spectroscopy (1)
- Atomic weights (1)
- Aufbereitung (1)
- Augmented data (1)
- Automated Purification (1)
- Automated image analysis (1)
- Automated single cell-ICP-ToF-MS (1)
- Automated system (1)
- Automatisierung (1)
- Autonomous chemistry (1)
- Autophagy (1)
- Aviation (1)
- Avogadro constant (1)
- BAM Data Store (1)
- BBodSchV (1)
- BCA (1)
- BCA test (1)
- BERM (1)
- BLE Bluetooth low energy (1)
- BPA (1)
- BPA removal (1)
- BSA (1)
- Back-side integration (1)
- Bacterial lysates (1)
- Bakterien (1)
- Barium (1)
- Basic Statistics (1)
- Basic solvent (1)
- Battery aging (1)
- Baustoffe (1)
- Bawit (1)
- Bayes (1)
- Bbeverages (1)
- Bead injection spectroscopy (1)
- Bead-based assay (1)
- Beamline (1)
- Bernstorf (1)
- Betonfahrbahndecken (1)
- Betonschwellen (1)
- Bewitterung (1)
- Bias (1)
- Big Data (1)
- Big science (1)
- Binder (1)
- Bio engineering (1)
- Bio-apatite (1)
- BioProScale (1)
- Bioactive glass (1)
- Bioapatite (1)
- Biochemistry (1)
- Biochip (1)
- Bioconjugates (1)
- Biodiesel fuel (1)
- Biogenic carbonates (1)
- Bioinformatics (1)
- Biological & biomedical applications (1)
- Biological boron recycling (1)
- Biomarkers (1)
- Biopolymers Probes (1)
- Biosensors (1)
- Bioseparation (1)
- Biosilicification (1)
- Biosynthesis (1)
- Biotests (1)
- Bismuth (1)
- Bisphenol A (1)
- Bisphenol-A (1)
- Bisphenols (1)
- Bitumen und bitumenhaltige Bindemittel (1)
- Bivalves (1)
- Block copolymer (1)
- Blood-brain barrier (1)
- Boden (1)
- Bombs (1)
- Bone matrix (1)
- Border surveillance (1)
- Boron isotope (1)
- Boron isotope fractionation (1)
- Boron isotopic composition (1)
- Boron monohydride (1)
- Borosilicate Glass (1)
- Bradford (1)
- Bradford-Assay (1)
- Brassica napus (1)
- Breath (1)
- Bunsen-Kirchhoff-Preis (1)
- CCMV (1)
- CCQM key comparison (1)
- CE (1)
- CE-ICP-MS (1)
- CF LIBS algorithms (1)
- CMC (1)
- CMOS (1)
- CRP (1)
- CT simulation (1)
- CaCl emission bands (1)
- CaF (1)
- Caenorhabditis elegans (1)
- Calcification (1)
- Calibration standards (1)
- Calibration-free LIBS (1)
- Cancer awareness measure (1)
- Cancer cells (1)
- Cancer risk (1)
- Cancer therapy (1)
- Canine olfactometry (1)
- Capecitabine (1)
- Capillary electrophoresis-mass spectrometry (1)
- Carbodiimide crosslinking (1)
- Carbon (1)
- Carbon cycle (1)
- Carbon steel corrosion (1)
- Carboxyl group (1)
- Cardiac troponin (1)
- Cardiolipins (1)
- Cardiovascular (1)
- Carrier (1)
- Cascade filtration (1)
- Catalysis (1)
- Catalysts (1)
- Cathode (1)
- Cathode material (1)
- Causes leading to scientific misconduct (1)
- Cconventional method (1)
- CdSe/ZnS quantum Dots (1)
- CellenONE (1)
- Cellular trafficking (1)
- Cellular uptake (1)
- Central Taurus (1)
- Certified reference materials (1)
- Ceruloplasmin (1)
- Chamber measurement (1)
- Channel access (1)
- Charge Transfer (1)
- Cheese (1)
- Chemical Process Control (1)
- Chemical Production (1)
- Chemical Safety (1)
- Chemical and material safety (1)
- Chemical composition (1)
- Chemical coverage (1)
- Chemical protein modification (1)
- Chemical reactors (1)
- Chemical sensors (1)
- Chemical transformation (1)
- Chemische Prozesskontrolle (1)
- Chemometric (1)
- Chemometrie (1)
- Chemometrik (1)
- Chemometry (1)
- Chenopodium album (1)
- Chicken antibodies (1)
- Chip (1)
- Chip-Screening (1)
- Chlorides (1)
- Chlorine determination (1)
- Chronic kidney disease (1)
- Circular economy (1)
- Cispaltin (1)
- Citizen Science (1)
- Civil engineering (1)
- Classical primary measurement method (CPM) (1)
- Classification (1)
- Cleavable probe (1)
- Cleavage (1)
- Climate (1)
- Climate Changes (1)
- Climate change (1)
- Clinical samples (1)
- Clones (1)
- Cluster (1)
- Cobalt deposition (1)
- Cocaine (1)
- Cocrystal (1)
- Cocrystals (1)
- Color X-ray Camera (1)
- Colorimetric Test (1)
- Coltan (1)
- Column holder (1)
- Combinatorial library (1)
- Combinatorial screening (1)
- Combustion (1)
- Compact NMR (1)
- Compact NMR spectroscopy (1)
- Comparative test (1)
- Competitive Immunoassay (1)
- Complementary MS (1)
- Complex (1)
- Complexation (1)
- Compost (1)
- Computed tomography (1)
- Comsumer good samples (1)
- Concentration step (1)
- Concrete (1)
- Conductometry (1)
- Confiscation (1)
- Confocal laser scanning microscopy (1)
- Conjugate (1)
- Construction (1)
- Construction Products (1)
- Consumer Products (1)
- Consumer products (1)
- Continuous Manufacturing (1)
- Continuous Sensor (1)
- Continuous processes (1)
- Continuum source atomic absorption spectrometry (1)
- Contrast agent (1)
- Conventional isotope ratios (1)
- Cooper (1)
- Coordination polymers (1)
- Coptic manuscripts (1)
- Core-shell nanoparticles (1)
- Core/shell nanoparticle (1)
- Corona virus (1)
- Coronavirus (1)
- Corophium volutator (1)
- Corundum (1)
- Coumarin (1)
- Counting detector (1)
- Coupling reactions (1)
- Cr(III) (1)
- Cr(III) complex (1)
- Crossreactivity (1)
- Crude oil (1)
- Cryo-soft X-ray tomography (1)
- Cryoadsorption (1)
- Cultural heritage (1)
- Curse tablets (1)
- Customs (1)
- Cyanide (1)
- Cyber-Physical Systems (1)
- Cyber-physical Lab (1)
- Cyber-physical system (1)
- Cyber-physical systems (1)
- Cyclisierung (1)
- Cycloparaphenylenes (1)
- Cylic Voltammetry (1)
- Cytoplasm (1)
- Cytoplasmic remodeling (1)
- D-glucose (1)
- DC-Arc (1)
- DCF (1)
- DEA (1)
- DHAP (1)
- DLS (1)
- DNA origami (1)
- DNA radiation damage (1)
- DNA strand break (1)
- DNA strand breaks (1)
- Damage-associated molecular patterns (DAMPs) (1)
- Data Analyses (1)
- Data Fusion (1)
- Data conversion (1)
- Data manipulation (1)
- Data processing (1)
- Datenerfassung (1)
- Dating (1)
- Deactivation pathways (1)
- Dead Sea Scrolls (1)
- Debromination (1)
- Debye-Waller parameter (1)
- Deep work (1)
- Delivery system (1)
- Delta scale (1)
- Dementia (1)
- Dendrite growth (1)
- Dendritic polyglycerol sulfate (1)
- Density functional theory (1)
- Density separation (1)
- Depht profiling (1)
- Depth profile (1)
- Depth profiles (1)
- Desorption (1)
- Detection (1)
- Detector deadtime (1)
- Detektion (1)
- Detektion von Mikroplastik (1)
- Deuterium (1)
- Deuterium enriched water (1)
- Diagnostic Antibodies (1)
- Diastolic dysfunction (1)
- Diatom (1)
- Diatom, Bacteria (1)
- Diatomeenanalytik (1)
- Diatomic (1)
- Diatomic molecules (1)
- Diesel exhaust (1)
- Diffusion (1)
- Digestion (1)
- Digital Radiology (1)
- Digital Transformation (1)
- Digital laboratory (1)
- Digital transformation (1)
- Digital twins (1)
- Digitaler Zwilling (1)
- Digitalization (1)
- Dimerization (1)
- Dip-stick assay (1)
- Direct alcohol fuel cells (1)
- Direct loop control (1)
- Direct metal assay (1)
- Dispersions (1)
- Dispersive-XAS (1)
- Dityrosine (1)
- Doppler effect (1)
- Dose (1)
- Down Stream Processing (1)
- Downstream processing (1)
- Drawings (1)
- Dried fig (1)
- Droplets (1)
- Druckfeuchte (1)
- Drug search (1)
- Drug trafficking (1)
- Drug transporters (1)
- Drugs (1)
- Dual mode detector (1)
- Duftstoffe (1)
- Duplex stainless steels (1)
- Durchflusszytometrie (1)
- Dye monomers (1)
- Dyes/pigments (1)
- EC/MS (1)
- ECR (1)
- EDC (1)
- EDTAD (1)
- EDX Analysis (1)
- EMN (1)
- EMPIR (1)
- EPICS (1)
- EPMA (1)
- EPR spectroscopy (1)
- EQS (1)
- ESEM (1)
- ESI-MS (1)
- ESMA (1)
- ETV (1)
- ETV/ICP-MS (1)
- EU-WFD (1)
- Early Earth (1)
- Easy-use device (1)
- Echtzeitoptimierungsverfahren (1)
- Ecotoxicity (1)
- Ecotoxicological Assessment (1)
- Ecotoxicological Testing (1)
- Ecotoxicology testing (1)
- Ectoine (1)
- Ectoine radiation protection (1)
- Editorial (1)
- Egypt (1)
- Einzelzellanalyse (1)
- Elastin-specific contrast agent ESMA (1)
- Elastin-specific molecular agent (1)
- Electrochemical (1)
- Electrochemical Reactor (1)
- Electrochemical energy conversion (1)
- Electrochemical real-time mass spectrometry (1)
- Electrochemistry mass spectrometry (1)
- Electrohpresis (1)
- Electromagnetic (1)
- Electron number density (1)
- Electronic Lab Notebook (ELN) (1)
- Electronic lab notebook (ELN) (1)
- Electronic nose (1)
- Electrospray (1)
- Elektronenmikroskopie (1)
- Elektronisches Laborbuch (1)
- Element Specific Bioimaging Using Laser Ablation (1)
- Elemental Impurities (1)
- Elemental analysis (1)
- Elemental composition (1)
- Elemental fingerprints (1)
- Elementspezies & Isotope (1)
- Elutionsverfahren (1)
- Emergency (1)
- Emerging Contaminants (1)
- Emerging brominated flame retardant (1)
- Emerging contaminants (1)
- Emerging pollutants (1)
- Emerging/novel brominated flame retardant (1)
- Emission (1)
- Emission Test Chamber (1)
- Emission Testing (1)
- Emission line profiles (1)
- Emission reference materials (1)
- Emission spectroscopy (1)
- Emission test chamber (1)
- Emissions (1)
- Endocrine disruptor (1)
- Endokrine Disruptoren (1)
- Energy Gases (1)
- Energy input (1)
- Energy storage (1)
- Energy transfer (1)
- Environment (1)
- Environment-material interactions (1)
- Environmental & life science application (1)
- Environmental impacts (1)
- Enzyme Immobilisation (1)
- Epoxy (1)
- Equilibrium isotope fractionation (1)
- Escherichia coli (1)
- Esterification (1)
- Ethyl glucuronide (1)
- Ethylenediaminetetraacetic acid (1)
- Etofenprox (1)
- European Reference Material (1)
- Exhaust (1)
- Experimental design (1)
- Explosives (1)
- Exposure (1)
- Expression (1)
- Extended X-ray absorption fine structure (1)
- Extractable organic fluorine (1)
- Extraction (1)
- Extraktion (1)
- FAIR research data management (1)
- FTIR spectroscopy (1)
- FTIR-Spektroskopie (1)
- Fab Fragment (1)
- Faecal contamination (1)
- Fake news (1)
- False Positives (1)
- Farbenlehre (1)
- Faseroptische Sensoren (1)
- Faseroptische Sensorik (1)
- Fast flow GD (1)
- Fast single pulse response (1)
- Fatty acid desaturation (1)
- Fatty acid synthesis (1)
- Fatty acid uptake (1)
- Fatty acids (1)
- Fe nanoparticles metabolism (1)
- Feldintegration (1)
- Fenton (1)
- Fenton’s reagent (1)
- Festphasenextraktion (1)
- Fibre-optic sensors (1)
- Field integration (1)
- Field test (1)
- Filter crucible (1)
- Filtration (1)
- Fingerprint (1)
- First Principles (1)
- Flame retardants (1)
- Flammschutzmittel (1)
- Flow Chemistry (1)
- Flow NMR (1)
- Flow injection immunoassay (1)
- Fluidics (1)
- Fluorescence lifetime (1)
- Fluorescence sensing (1)
- Fluoreszenz (1)
- Fluorination (1)
- Fluorine Detection (1)
- Fluorine sum parameter (1)
- Fluorouracil (1)
- Flux Analysis (1)
- Folic acid (1)
- Food Analysis (1)
- Food contaminants (1)
- Food fermentation (1)
- Food web (1)
- Formaldehyd (1)
- Formaldehyde (1)
- Formulation additives (1)
- Forschungsbedarf (1)
- Forschungsdatenmanagement (1)
- Fow injection analysis (1)
- Fragmentation activation (1)
- Fraktionierte Filtration (1)
- Framework (1)
- Fresenius (1)
- Fresenius Lecture (1)
- Fresenius lecture (1)
- Functional group (1)
- Fundamental science (1)
- Fundamentals (1)
- Fungicide (1)
- Fusarium (1)
- Fusarium mycotoxin (1)
- GC/ICP-ToF-MS (1)
- GD-MS (1)
- GDOES (1)
- GF-MAS (1)
- GMAW (1)
- GUI (1)
- Gadofosveset (1)
- Gadolinium-based contrast agent (1)
- Gadolinium-based contrast agents (GBCAs) (1)
- Gadovist (1)
- Gas Analysis (1)
- Gas Reference Material (1)
- Gas purity (1)
- Gaschromatographie-Massenspektrometrie (1)
- Gassensoren (1)
- Gassensorik (1)
- Gated hybrid material (1)
- Gaussian Process (1)
- Geführte Ultraschallwellen (1)
- General Chemistry (1)
- General Medicine (1)
- Genetics (1)
- Geochemistry (1)
- Geochemistry and Petrology (1)
- Geological Storage (1)
- Geological material (1)
- Geological thermometer (1)
- Geophysics (1)
- Geothermal engineering (1)
- Germanium chlorides (1)
- Germanium sulfide (1)
- Gerätekommunikation (1)
- Gilding (1)
- Github (1)
- Glas (1)
- Glass (1)
- Glass Support (1)
- Glass paints (1)
- Gleisoberbau (1)
- Glow Discharge (1)
- Glow-discharge (1)
- Glucose (1)
- Glycosaminoglycan (1)
- Goethe (1)
- Gold nanocluster (1)
- Gold nanoparticles (1)
- Gold-Nanopartikel (1)
- Grand challenges (1)
- Graphit (1)
- Gravimetric preparation (1)
- Gravimtric isotope mixtures (1)
- Greek curse tablets (1)
- Ground water (1)
- Group profile (1)
- Größenausschlusschromatographie (1)
- Gutachten (1)
- GxP (1)
- Gypsum (1)
- H/D-Austausch (1)
- H/D-Exchange (1)
- H2020 (1)
- H2Safety@BAM (1)
- HDF5 (1)
- HERFD-XAS (1)
- HF free Digestion (1)
- HLA (1)
- HPLC-DAD/FLD (1)
- HPLC-ICP-MS (1)
- HPLC-MS/MS (1)
- HPLC–MS (1)
- HT22 (1)
- HTS (1)
- Halomonas elongata (1)
- Hamonisierung (1)
- Handbook (1)
- Handheld (1)
- Harmonisierung (1)
- Harsh environment (1)
- Hay fever (1)
- Hazardous substances (1)
- HeLa (1)
- Heart attack (1)
- Heat flow (1)
- Heavy crude oil (1)
- Heavy metals (1)
- Heißgasextraktion (1)
- Hepatocellular carcinoma (1)
- HexaHis-Tag (1)
- Hierarchical cluster analysis (1)
- High pH (1)
- High pressure experiments (1)
- High purity (1)
- High purity material (1)
- High repetition-rate (1)
- High throughput (1)
- High-Speed (1)
- High-Speed Separations (1)
- High-fired gypsum mortar (1)
- High-frequency arc discharge (1)
- High-purity elements (1)
- High-resolution (1)
- High-resolution absorption isotopic spectrometry (1)
- High-resolution continuum source atomic absorption spectrometer (1)
- High-resolution continuum source graphite furnace atomic absorption spectrometry (1)
- High-resolution continuum source molecular absorption spectrometry (1)
- High-resolution mass spectrometry (1)
- High-resolution synchrotron XRF (1)
- His6 (1)
- His8 (1)
- Histology (1)
- Hochauflösende Massenspektrometrie (1)
- Hochdurchsatzscreening (1)
- Holistic science (1)
- Holographic microscopy (1)
- Hormone (1)
- Host–guest systems (1)
- Hot electrons (1)
- Hot-pressing (1)
- Human Plasma (1)
- Human papillomavirus (1)
- Hybridization (1)
- Hydrated silicate melts (1)
- Hydrazin (1)
- Hydrodynamic chromatography (HDC) (1)
- Hydrodynamic model (1)
- Hydrogen Metrology (1)
- Hydrogen Purity (1)
- Hydrogen Storage Materials (1)
- Hydrogen adsorption storage (1)
- Hydrogen analysis (1)
- Hydrogen reduction (1)
- Hydrogenation (1)
- Hydrogenierung (1)
- Hydrolysis products (1)
- Hydrothermal fluid (1)
- Hydroxylation (1)
- Hypothalamus (1)
- IAQ (1)
- IC (1)
- IC50 (1)
- ICH guideline Q3D (1)
- ICP (1)
- ICP MS (1)
- ICP-AES (1)
- ICP-MS & HR-CS-GFMAS (1)
- ICP-MS/MS (1)
- ICP-OES (1)
- ICP-TOFMS (1)
- IIoT (1)
- IMAC purification (1)
- ISO REMCO (1)
- ISO/IEC 17025 (1)
- IUTA (1)
- Identity (1)
- IgG determination (1)
- IgY (1)
- Iinductively coupled plasma mass spectrometry (1)
- Iisotopic signature (1)
- Illicit drug (1)
- Image manipulation (1)
- Image unsharpness (1)
- Imaging Mass Cytometry (1)
- Imaging condition (1)
- Imaging mass cytometry (1)
- Immuno assay (1)
- Immuno-Assays (1)
- Immunoaffinity extraction (1)
- Immunoassays (1)
- Immunocapture (1)
- Immunofluorescence (1)
- Immunology (1)
- Immunometric assay (1)
- Immunometric biosensor (1)
- Immunpräzipitation (1)
- Implant material (1)
- Impurity assessment (1)
- In situ EXAFS (1)
- In situ SAXS/WAXS (1)
- In situ measurement (1)
- In situ studies (1)
- In vitro (1)
- In vivo imaging (1)
- Indoor Air Quality (1)
- Indoor Products (1)
- Indoor air (1)
- Indoor air quality (1)
- Inductively Coupled Mass Spectroscopy (1)
- Inductively coupled plasma mass spectroscopy (1)
- Industrial and Manufacturing Engineering (1)
- Industrial gypsum (1)
- Industrielle Analytik (1)
- Industry 4.0, (1)
- Inflammation (1)
- Infrastruktur (1)
- Inhalation exposure (1)
- Ink analysis (1)
- Ink fingerprint (1)
- Inlet ionization (1)
- Inline NMR Spectroscopy (1)
- Inorganic Reference Materials (1)
- Inorganic chemical analysis (1)
- Insecticide (1)
- Instrument Communication (1)
- Instrument control (1)
- Instrumental isotope fractionation (1)
- Instrumentation utilization (1)
- Integrated Processes (1)
- Integrating sphere spectroscopy (1)
- Integrating sphere spectroscopy, (1)
- Inter-laboratory comparison (1)
- Interlaboratory key comparison (1)
- International drug trade (1)
- Interner Standard (1)
- Ion mobility (1)
- Ionische Flüssigkeit (1)
- Ionizing radiation (1)
- Ionmobility spectrometry (1)
- Ionophore (1)
- Ionophore Antibiotics (1)
- Ionophore antibiotic (1)
- Ionophore antibiotics (1)
- Iposomes (1)
- Ir DNA staining approach (1)
- Iridium oxide (1)
- Iron Complex (1)
- Iron disorders (1)
- Iron isotopes (1)
- Iron nanoparticles (1)
- Iron oxide (1)
- Isotope Labelling (1)
- Isotope anaylsis (1)
- Isotope delta (1)
- Isotope dilution analysis (1)
- Isotope mixtures (1)
- Isotope purification (1)
- Isotope-labeled (1)
- Isotopic dilution (1)
- Isotopic fingerprints (1)
- Isotopologue Distribution (1)
- Iterative real-time optimization (1)
- Java GUI (1)
- Job plot (1)
- Kalibriertransfer (1)
- Kapillarelektrophorese-Massenspektrometrie (1)
- Kidney (1)
- Kilogram (1)
- Kinetic isotope fractionation (1)
- Kinetics (1)
- Kjeldahl (1)
- Klassifizierung (1)
- Klimawechsellagerung (1)
- Klon A1.1.1 (1)
- Klon EW75C (1)
- Kläranlage (1)
- Knowledge representation (1)
- Komplementäre Massenspektrometrie (1)
- Konjugate (1)
- Kopplungstechniken (1)
- Kreuzreaktion (1)
- Kristallolgraphie (1)
- Kupferazid (1)
- Künstlicher Intelligenz (1)
- L-alanine (1)
- LA-(MC-)ICP-MS (1)
- LA-ICP-SFMS (1)
- LA/ICP-MS Imaging (1)
- LAMIS (1)
- LC-HRMS (1)
- LC-MS/MS peptide quantification (1)
- LC-UV absorbance (1)
- LC/HRMS (1)
- LIP-AAS (1)
- LIP-LIF (1)
- Lab-on-a-Chip (1)
- Lab-on-chip (1)
- Labor 4.0 (1)
- Labor der Zukunft (1)
- Laboratory automation (1)
- Laboratory management (1)
- Lactate (1)
- Lacunary Keggin ion (1)
- Ladder sequencing (1)
- Lanthanoid (1)
- Lapis lazuli (1)
- Lasalocid (1)
- Laser (1)
- Laser Ablation Molecular Absorption spectrometry (1)
- Laser Ablation/Imaging (1)
- Laser Doppler vibrometer (1)
- Laser ablation inductively coupled plasma–mass spectrometry imaging (LA-ICP-MSI) (1)
- Laser ablation-inductively coupled plasma-mass spectrometry (1)
- Laser beam welding (1)
- Laser induced XUV spectroscopy (1)
- Laser induced breakdown Spectrocopy (LIBS) (1)
- Laser induced plasma deposition (1)
- Laser metal deposition (LMD) (1)
- Laser spectroscopy (1)
- Laser-induced Breakdown Spectroscopy (1)
- Lastwechsel (1)
- Lateral flow assay (1)
- Lateral flow test (1)
- Lead ions (1)
- Lead isotope composition (1)
- Lead isotopes (1)
- Lebensmittel (1)
- Leckdetektion (1)
- Leonardo da Vinci (1)
- Levitation (1)
- Library (1)
- Ligand design (1)
- Ligands (1)
- Light chain (1)
- Lightning talk (1)
- Lignin (1)
- Linear Regression (1)
- Linear dynamic range (1)
- Lipid metabolism (1)
- Lipids (1)
- Liquid chromatography (1)
- Liquid chromatography-mass spectrometry (1)
- Liver X receptor (1)
- Low energy electrons (1)
- Low-energy electrons (1)
- Luminescence lifetime (1)
- Luminol (1)
- Lung cancer (1)
- Lymnaea stagnalis (1)
- Lysergic acid hydrazide (1)
- Lysosome (1)
- MALDI Imaging (1)
- MALDI Imaging MS (1)
- MALDI-TOF Massenspektrometrie (1)
- MALDI-ToF MS (1)
- MALDI-ToF-MS (1)
- MAS NMR spectroscopy (1)
- MC-TIMS (1)
- MCC (1)
- MDG ICP-ToF-MS (1)
- MICAP-MS (1)
- MIPs (1)
- MOF (1)
- MOUSE (1)
- MR Angiography (1)
- MR imaging (1)
- MRFA (1)
- MS-ICP-MS (1)
- MS/MS (1)
- MST (1)
- Machine-Assisted Workflows (1)
- Macrocycles (1)
- Macrophagen (1)
- Macrophages (1)
- Magnesium delta values (1)
- Magnesium isotope ratios (1)
- Magnesium monofluoride (1)
- Magnetic nanocatalyst (1)
- Magnetically stabilized (1)
- Magnetpartikel (1)
- Maia detector (1)
- Maillard reaction (1)
- Mammals (1)
- Mangesium (1)
- Manufacturing (1)
- Mass Isotopomer Distribution (1)
- Mass contents (1)
- Mass spectroscopy (MS) (1)
- Mass-spectrometry (1)
- Material - Environment interaction (1)
- Material Science (1)
- Material analysis (1)
- Material characterization (1)
- Material science (1)
- Materialfeuchte (1)
- Materials emissions test (1)
- Materials science and engineering (1)
- Materialuntersuchungen (1)
- Mathematics and Statistics (1)
- Matrices (1)
- Matrix independent calibration (1)
- Matrix separation (1)
- Matrix-assisted laser desorption ionization–mass spectrometry imaging (MALDI-MSI) (1)
- Matrixeffekte (1)
- Measurement (1)
- Measurement data conversion (1)
- Measurement space (1)
- Measuremment uncertainty (1)
- Mechanism (1)
- Mechanochemical synthesis (1)
- Medicinal application (1)
- Medieval glasses (1)
- Melanoidin (1)
- Melanoidine (1)
- Mercury solution (1)
- Mercury speciation (1)
- Mesoporous materials (1)
- Mesoporous particles (1)
- Mesoporous silica (1)
- Meta-study (1)
- Metabolic Flux (1)
- Metabolism (1)
- Metabolismus (1)
- Metabolites (1)
- Metabolization (1)
- Metal complexes (1)
- Metal nanoclusters (1)
- Metal nanoparticles (1)
- Metal sublimation (1)
- Metal toxicity (1)
- Metal uptake (1)
- Metal-Tag (1)
- Metal-tag (1)
- Metalloprotein (1)
- Metal−organic frameworks (1)
- Method (1)
- Methoden (1)
- Methodenentwicklung Böden (1)
- Methodology (1)
- Metrics (1)
- Metrologie zur Wasserstoffspeicherung (1)
- Metrology in chemistry (1)
- Micro Reactor (1)
- Micro-Hydrocyclone (1)
- Micro-XRF (1)
- Micro-chamber (1)
- Micro-sublimation (1)
- Microbial proteomics (1)
- Microdialysis (1)
- Microdosimetry (1)
- Microemulsion (1)
- Microfluidic (1)
- Microfluidic Chip (1)
- Microfluidic system (1)
- Microparticles (1)
- Microplastic analysis (1)
- Microplastic mass (1)
- Microplastic particles (1)
- Microplastic pathways (1)
- Microplastic-induced effects (1)
- Microplastics analytic (1)
- Microplastics sampling (1)
- Microplastics standardisation (1)
- Microplatic (1)
- Microscopy (1)
- Microwave plasma (1)
- Migration (1)
- Mikroplastik Böden (1)
- Mikroplastik Massegehalt (1)
- Mikroplastik in Luft (1)
- Mikroplastikreferenzmaterial (1)
- Miniaturization (1)
- Mining (1)
- Missing wedge (1)
- Mixed ink (1)
- Mixture toxicity (1)
- Mobile analysis (1)
- Mobile analytics (1)
- Mobile device (1)
- Modeling (1)
- Modellbasierte Optimierung (1)
- Modelling (1)
- Modified mycotoxins (1)
- Modifier adaptation (1)
- Modifier-Adaptation (1)
- Moisture measurements (1)
- Mole (1)
- Molecular Biology (1)
- Molecular analysis (1)
- Molecular dynamics simulations (1)
- Molecular emission (1)
- Molecular imaging (1)
- Molecular imprinted polymers (1)
- Molecular imprinting (1)
- Molecular marker (1)
- Molecular recognition (1)
- Molecular spectra (1)
- Molecular spectrum (1)
- Molecular-MRI (1)
- Molecule (1)
- Monensin (1)
- Monitoring (1)
- Monoamine oxidase B (1)
- Monoclonal Antibody (1)
- Monoclonal antibodies (1)
- Monoclonal antibody (1)
- Monoelemental solutions (1)
- Monolith (1)
- Monolithic column (1)
- Monoterpene (1)
- Motor controller (1)
- Moxidectin (1)
- Mud volcanoe fluids (1)
- Multi-collector inductively coupled plasma-mass spectrometry (ICP-MS) (1)
- Multielemental analysis (1)
- Multielementanalytik (1)
- Multielementanalytik in kurzen transienten Signalen (1)
- Multimodale Analytik (1)
- Multiple sclerosis (1)
- Multiple-injection sample-standard bracketing (1)
- Multiplexing (1)
- Multivariate Analyse (1)
- Multivariate Data Analysis (1)
- Multivariate Datenanalyse (1)
- Multivariate Datenauswertung (1)
- Multivariate Statistics (1)
- Multivariate analyses (1)
- Muon tomography (1)
- Mutationen (1)
- Mycotoxin Analysis (1)
- Mycotoxin-Biomarker (1)
- Mykotoxin-Biomarker (1)
- N-capsid (1)
- NAMUR (1)
- NIR Spectroscopy (1)
- NIR Spektroskopie (1)
- NIR emitter (1)
- NIR spectroscopy (1)
- NIR-II (1)
- NIST-mAb 8671 (1)
- NMR Accreditation (1)
- NMR Method Validation (1)
- NMR Spektroskopie (1)
- NMR spetroscopy (1)
- NMR validation (1)
- NSO-Heterozyklen (1)
- NXsas (1)
- NaCl-Methode (1)
- Nahinfrarotspektroskopie (1)
- Nano-carrier (1)
- NanoPlattform (1)
- Nanobody (1)
- Nanocarrier (1)
- Nanocluster (1)
- Nanodiamant (1)
- Nanomaterialien (1)
- Nanoparticle characterization (1)
- Nanoparticles with same nominal diameter (1)
- Nanoparticles with same nominal diameter; surface coating; two-dimensional off-line coupling (1)
- Nanoplastic (1)
- Nanoplastics (1)
- Nanotoxicity (1)
- Naphthalene (Nap) (1)
- Narcotics (1)
- Nasschemie (1)
- Natural language processing (1)
- NeXus (1)
- Near Infrared Spectroscopy (1)
- Near edge X-ray absorption fine structure spectroscopy (1)
- Near-infrared refectography (1)
- Nebra (1)
- Neodymium (1)
- Neural Network (1)
- Neural networks (1)
- Neutralisierende Antikörper (1)
- New ecotoxicological testing tools (1)
- Nichtmetall-Analytik (1)
- Nichtmetalle (1)
- Nickel chelate (1)
- Niederfeld-NMR-Spektroskopie (1)
- Niobcarbid (1)
- Nitration (1)
- Nitroaromaten (1)
- Nitrogen microwave inductively coupled atmospheric pressure mass spectrometry (1)
- Nitromoschus (1)
- Noise (1)
- Non metals (1)
- Non-destructive testing (1)
- Non-invasive analysis (1)
- Non-metals analysis (1)
- Non-target (1)
- Non-targeted analysis (1)
- Nondestructive testing (1)
- Nondestructive testing techniques (1)
- Nontargeted approach (1)
- Normen (1)
- Normung (1)
- Nuclear Magnetic Resonance (1)
- Nuclear Magnetic Resonance Spectroscopy (1)
- Nuclear magnetic resonance spectroscopy (1)
- Nuclear receptor (1)
- Nucleocapsid (1)
- Nucleocapsid-Protein (1)
- OBOC (1)
- OECD (1)
- Oberflächenwasser und Boden (1)
- Oil analysis (1)
- On-line CE/MC-ICP-MS (1)
- On-site detection (1)
- Online biosensor (1)
- Online-NMR spectroscopy (1)
- Online-RFA-Spektroskopie (1)
- Ontology (1)
- Open Science (1)
- Open science (1)
- OpenBIS (1)
- Optical detection (1)
- Optical emission spectroscopy (1)
- Optical isotopic spectrometry (1)
- Optical sensor (1)
- Optical spectrometry (1)
- Optimierung (1)
- Optimization (1)
- Optimum magnification (1)
- Ordinary Portland cement (1)
- Ore provenance (1)
- Organic calibration solution (1)
- Organic contaminants (1)
- Organically bound fluorine (1)
- Organophosphate esters (1)
- Outdoor odor emissions (1)
- Outreach (1)
- Oxidative metabolism (1)
- Oxygen (1)
- Oxygen evolution reaction (1)
- Oxygen isotope ratios (1)
- P-aminothiophenol (1)
- PAH (1)
- PAHs (1)
- PAK (1)
- PARCI-MS (1)
- PEGomics (1)
- PEM-Wasserelektrolyse (1)
- PFAS TOP Assay soil contamination (1)
- PGAA (1)
- PIC technology (1)
- PIXE (1)
- PLS regression (1)
- PP (1)
- PRORA (1)
- PS (1)
- PXRD (1)
- Paper mills (1)
- Papier (1)
- Papyrus (1)
- Parkinsons's disease (1)
- Partial least square discriminant analysis (PLS-DA) (1)
- Particle (1)
- Particle size distribution (1)
- Partikel (1)
- Pattern recognition receptor (1)
- Pb isotopes (1)
- Peptid-Aptamer (1)
- Peptid-Synthese (1)
- Peptidbibliothek (1)
- Peptidbibliotheken (1)
- Peptide (1)
- Peptide library screening (1)
- Peptide losses (1)
- Peptide mass fingerprinting (1)
- Peptides (1)
- Peptides and Proteins (1)
- Peptidsequenzierung (1)
- Per- and polyfluorinated alkly substances (PFASs) (1)
- Periplasma (1)
- Peristaltic pumps (1)
- Peroxidase (1)
- Pflanzenvirus (1)
- Pharmaceutical (1)
- Pharmaceutical Drugs (1)
- Pharmacopoeial Reference Standards (1)
- Pharmacy (1)
- Pharmazeutika (1)
- Phase field method (1)
- Phenothrin (1)
- Phenylalanine (1)
- Phospholipids (1)
- Phosphonate esters (1)
- Phosphonates (1)
- Phosphor (1)
- Photochemistry (1)
- Photodynamische Inaktivierung (1)
- Photokatalyse (1)
- Photoluminescence (1)
- Photonic Integrated Circuits (1)
- Photonic Sensor (1)
- Photonic biosensor (1)
- Photooxidation (1)
- Photosensibilisator (1)
- Photosensitization (1)
- Phthalocyanin (1)
- Physical and theoretical chemistry (1)
- Physical twin (1)
- Phytoliths (1)
- Pigment analyses (1)
- Pilot comparison (1)
- Planetary science (1)
- Plant tissue (1)
- Plant-model mismatch (1)
- Plants (1)
- Plasma chemistry (1)
- Plasma fundamentals (1)
- Plasma induced luminescence (1)
- Plasma processes (1)
- Plasmaspectrochemistry (1)
- Plastic bottles (1)
- Point-Of-Care-Diagnostics (1)
- Polarised light microscopy (1)
- Polishing (1)
- Pollen extract (1)
- Pollen grains (1)
- Pollenkörner (1)
- Pollution (1)
- Polycapillaries (1)
- Polyclonal Antibodies (1)
- Polycyclic aromatic hydrocarbons (1)
- Polyethyleneglycol (1)
- Polyethylenimine (1)
- Polymer blends (1)
- Polymer membrane (1)
- Polymere (1)
- Polymere Eigenschaften (1)
- Polymorph (1)
- Polymorphs (1)
- Polyoxometalates (1)
- Polyurethanes (1)
- Pomodore (1)
- Pore fluids (1)
- Porphyrin (1)
- Portland cement (1)
- Portland clinker (1)
- Poster presentation (1)
- Pouch cell (1)
- Pozessindustrie (1)
- Precision Profile (1)
- Priam's treasure (1)
- Primary difference measurement method (PDM) (1)
- Primary standard (1)
- Primary transfer standards (PTSs) (1)
- Primäre Kalibriersubstanzen (1)
- Principal component analysis (1)
- Principal component analysis (PCA) (1)
- Priority effect (1)
- Prisma (1)
- Probe (1)
- Procee Analytical Technology (1)
- Process control (1)
- Process intelligence (1)
- Process-NMR (1)
- Production (1)
- Proficiency testing (1)
- Programmed cell death (1)
- Prostate cancer (1)
- Protein A (1)
- Protein G (1)
- Protein Purification (1)
- Protein content (1)
- Protein imaging (1)
- Protein nitration (1)
- Protein oligomerization (1)
- Protein quantification (1)
- Protein test (1)
- Provenance studies (1)
- Provenancing (1)
- Prozess-Sensoren 4.0 (1)
- Prozess-Steuerung (1)
- Prozessanalysentechnik (1)
- Prozesslabor (1)
- Prussian blue (1)
- Präzision (1)
- Präzisionsprofil (1)
- Pt-based drugs (1)
- PtNP (1)
- Pulsed-GD-SFMS (1)
- Pulverization (1)
- Purification (1)
- Purity determination (1)
- Pyrethroid (1)
- Pyrethroids (1)
- Pyrolysis (1)
- Python (1)
- QC (1)
- QI-Digital (1)
- QNMR (1)
- Quadratic approximation (MAWQA) (1)
- Quality (1)
- Quality Infrastructure (1)
- Qualitätskontrolle (1)
- Qualitätssicherung (1)
- Quantitative bioimaging (1)
- Quantitative determination (1)
- Quantitative protein analysis (1)
- Quantum Mechanics (1)
- Quick-XAS (1)
- Qumranrollen (1)
- RAMAN (1)
- RSSI Received Signal Strength Indicator (1)
- RUSEKU (1)
- RXES (1)
- Radiation (1)
- Radiation damage (1)
- Raid test (1)
- Raman microspectroscopy (1)
- Raman-Spektroskopie (1)
- Rapid test (1)
- Rat/human liver microsomes (1)
- Rational design (1)
- Reactor control (1)
- Real-time Process Monitoring (1)
- Real-time imaging (1)
- Real-time quality control (1)
- Recombinant Antibody (1)
- Recombinant antibody (1)
- Recombinant protein (1)
- Reference (1)
- Reference Material (1)
- Reference Materials (1)
- Reference measurements (1)
- Reference procedure (1)
- Refractory alloys (1)
- Regeneration (1)
- Region of interest (1)
- Reifenabrieb (1)
- Reinstmetalle (1)
- Reinststoffe (1)
- Rekombinante Antikörper (1)
- Release kinetics (1)
- Reliabiilty (1)
- Renal disease (1)
- Renewable Energy (1)
- Research (1)
- Research Agenda (1)
- Research Data Infrastructure (1)
- Research Data Management (1)
- Research data management (1)
- Resonance wavelength shift (1)
- Reverse time migration (1)
- Reversible covalent hydrazine chemistry (RCHC) (1)
- Revision of the SI (1)
- Rhizopus (1)
- Rhizopus and Aspergillus oryzae (1)
- Rhodamine (1)
- River (1)
- River water sulfate (1)
- Robustness (1)
- Round robin exercise (1)
- Round robin test (1)
- Röntgenfluoreszenz (1)
- Rückverstromung (1)
- SAFIA (1)
- SBA-16 (1)
- SDHI-fungicide (1)
- SDS-PAGE (1)
- SI Traceability (1)
- SI-traceability (1)
- SI-traceable (1)
- SIDA-LC-MS/MS (1)
- SMASH (1)
- SOM-SM (1)
- Salinomycin (1)
- Salt (1)
- Sample treatment (1)
- Sample-sample bracketing (1)
- Sapphire (1)
- Sata corrections (1)
- Scale anchor (1)
- Scattering (1)
- Schadensanalyse (1)
- Schadstofftransfer (1)
- Schieneninfrastruktur (1)
- Science (1)
- Scientific misconduct (1)
- Screen-printed electrodes (1)
- Screening method (1)
- Seawater (1)
- Secondary alcohols (1)
- Sedimentation box (SB) (1)
- Sedimentationskasten (1)
- Sedimenttaionskasten (1)
- Selenium (1)
- Self-assembly (1)
- Semantic data integration (1)
- Semantic interoperability (1)
- Semiconductor nanocrystals (1)
- SensRef (1)
- Sensing (1)
- Sensor network (1)
- Sensor response (1)
- Sensorik (1)
- Separation (1)
- Sequence coverage (1)
- Sequence dependence (1)
- Sequencing (1)
- Sequenzierung (1)
- Sers (1)
- Serum (1)
- Sewage treatment plant (1)
- Shiny-App (1)
- Shortwave infrared (1)
- Si isotope fractionation (1)
- Si isotopes (1)
- Si wafer filter (1)
- Sialic acid (1)
- Signal enhancement (1)
- Silanization (1)
- Silbernanopartikel (1)
- Silica diagenesis (1)
- Silicon (1)
- Silicon Photonics (1)
- Silicon chlorides (1)
- Silver artefacts (1)
- Simultaneous determination (1)
- Single Particle (1)
- Single cell-ICP-MS (1)
- Single particle spectroscopy (1)
- Single particle-ICP-ToF-MS (1)
- Single-cell analysis (1)
- Sintered Material (1)
- Sintering (1)
- Size exclusion chromatography (1)
- Slags (1)
- Small-angle scattering (1)
- Smart Laboratoy (1)
- Smart sensors (1)
- Smart test laboratories (1)
- Smarte Aktoren (1)
- Smarte Laborgeräte (1)
- Smartphone (1)
- Smartphone readout device (1)
- Society of hair testing (1)
- Soda-lime glass (1)
- Soft-templated mesoporous films (1)
- Soil available boron (1)
- Soils (1)
- Solid microanalysis (1)
- Solid state NMR (1)
- Solid support (1)
- Solid-phase extraction (1)
- Solvent-free (1)
- Solvents (1)
- Sonochemical synthesis (1)
- Sorghum (1)
- Spannbetonschwelle (1)
- Spark plasma sintering (1)
- Spatial Heterodyne Spectrometer (1)
- Spatial heterodyne spectrometer (1)
- Spatial information (1)
- Special issue, young analytical scientists (1)
- Species-specific Isotope Analysis (1)
- Species-specific Isotope ratios (1)
- Species-unspecific on-line isotope dilution (1)
- Spectrochemical analysis (1)
- Spectrocube (1)
- Spectrometer (1)
- Speiseöle (1)
- Speroid (1)
- Spheroid (1)
- Spielzeug (1)
- Spike protein (1)
- Spinel (1)
- Sportböden (1)
- Spurenfeuchte in Gasen (1)
- Sputtering (1)
- Sr and Nd isotope analysis (1)
- Sr isotope analysis (1)
- Stable isotopes (1)
- Stable-Isotope-Dilution-Analysis (1)
- Stained glass windows (1)
- Stained glasses (1)
- Stakeholders (1)
- Standard (1)
- Static Mixing (1)
- Statistical analysis (1)
- Statistics (1)
- Storage Technologies (1)
- Strain identification (1)
- Strontium (1)
- Strontium isotope (1)
- Structural Biology (1)
- Structural Health Monitoring (SHM) (1)
- Sub-doppler spectroscopy (1)
- Sulfur isotopes (1)
- Sulfur species conversion (1)
- Sulfur-copper-sepration (1)
- Sulfur-matrix separation (1)
- Sulphur isotope (1)
- Sum Parameter Method (1)
- Sum parameter method (1)
- Supramolecular chemistry (1)
- Surface waters (1)
- Surfacewaters (1)
- Suspended particulate matter (SPM) (1)
- Sustainability and the Environment (1)
- Sustainable Food Safety (1)
- Sustainable Production (1)
- Suzuki coupling (1)
- Synchrotron FTIR (1)
- TCE (1)
- TD-GC-MS (1)
- TEM (1)
- TGA-MS (1)
- TMB (1)
- TNT (1)
- TXRF-XAS (1)
- Tag (1)
- Tandem MS (1)
- Tantalum oxyfluorides (1)
- Target (1)
- Tattoo inks (1)
- Tau (1)
- Tau protein (1)
- Tausalzeintrag (1)
- Temperature Control (1)
- Temperatures (1)
- Terbutryne (1)
- Terminology (1)
- Terrorism (1)
- Tesserae (1)
- Test strip (1)
- Test strips (1)
- Testbed (1)
- Tetramethylammonium hydroxide (1)
- Textile fibres (1)
- The MOUSE (1)
- Therapeutic Antibodies (1)
- Therapeutic Drug Monitoring (1)
- Thermal Desorption (1)
- Thermal Extraction (1)
- Thermal analysis (1)
- Thermal conductivity device (1)
- Thermal decomposition (1)
- Thermal degradation (1)
- Thermal desorption (1)
- Thermal equilibrium (1)
- Thermal extraction desorption-gas chromatography/mass spectrometry (TED-GC/MS), monitoring (1)
- Thermal extraction-desorption gas chromatography mass spectrometry (1)
- Thermal model (1)
- Thermal treatment (1)
- Thermo-desorption (1)
- Thermoanalyse (1)
- Thermoanalysis (1)
- Thermoanalytic (1)
- Thermoanalytical methods (1)
- Thermoanalytics (1)
- Thermoanalytik (1)
- Thermoplastic filaments (1)
- Thermostating (1)
- Thin metal alloy layers (1)
- Thin tissue sections (1)
- Time of flight (1)
- Time-gated Raman-Spektroskpie (1)
- Tire Wear (1)
- Tire particles (1)
- Tissue soldering (1)
- Titanium dioxide (1)
- Titanium hydride (1)
- Tools to combat scientific misconduct (1)
- Topical collection: Analytical Methods and Applications in the Materials and Life Sciences (1)
- Total element determination (1)
- Toxic metals (1)
- Toxikologie (1)
- Toys (1)
- Trace humdity measurement (1)
- Transcriptomic (1)
- Transesterification (1)
- Transferrin (1)
- Transformation Product (1)
- Transformation Products (1)
- Transformations products (1)
- Transient signal (1)
- Trialkoxysilane (1)
- Triazine herbicide (1)
- Trichodien (1)
- Trinitrotoluol (1)
- Trojan silver artefacts (1)
- Truffle (1)
- Truffles (1)
- Tryptic digest (1)
- Tutzing-Symposion (1)
- Two-dimensional off-line coupling (1)
- Two-phase system (1)
- Type-I pyrethroids (1)
- Tyrosine (1)
- UV Bestrahlung (1)
- UV irradiation (1)
- Ultrasensitive (1)
- Umlaufkühler (1)
- Umwelt-Speziation (1)
- Uncertainty Evaluation (1)
- Underwater LIBS (1)
- Unsicherheit (1)
- Upconversion (1)
- Uptake rate (1)
- Urban (1)
- Urine (1)
- VAMAS (1)
- VIS (1)
- VIS- Spektroskopie (1)
- VO (1)
- VOC Emission (1)
- VRF (1)
- Vacuum ionization (1)
- Vacuum ultraviolet (VUV) light (1)
- ValidNMR (1)
- Validation trial (1)
- Validierung (1)
- Vanadium (1)
- Vanadium redox flow battery (1)
- Vanadiumcarbid (1)
- Vegetable edible oil (1)
- Vergleichuntersuchung (1)
- Verwertung Bodenmaterial (1)
- Veterinary drugs (1)
- Vhh (1)
- Vibrational Sum-Frequency Generation Spectroscopy (1)
- Viscosity (1)
- Visualization (1)
- Volatile marker (1)
- Volatile organic compounds; (1)
- Volatiles (1)
- WAXS (1)
- Wasser (1)
- Wasserproben (1)
- Wasserstoff-Qualität (1)
- Wasserstoffspeicher (1)
- Wasserzeichen (1)
- Waste (1)
- Water samples (1)
- Water stable isotope analysis (1)
- Weathering (1)
- Weighing Uncertainty (1)
- Welding (1)
- Wolframcarbid (1)
- Wooden toys (1)
- Writing inks (1)
- X-Ray Fluorescence (1)
- X-ray absorption spectroscopy (1)
- X-ray and electron diffraction (1)
- X-ray fluorescence spectroscopy (1)
- X-ray fuorescence (1)
- X-ray photoelectron spectroscopy (1)
- X-ray scattering (1)
- X-ray spectroscopy (1)
- XAS (1)
- XRCD method (1)
- Xerogel (1)
- Yerba mate tea (1)
- ZIF-8 (1)
- ZVEI (1)
- Zearalenone (1)
- Zearalenone sulfate (1)
- Zebrafisch (1)
- Zenodo (1)
- Zerstörungsfreie Prüfung (1)
- Zertifizierung (1)
- ZfP (1)
- Zinc analysis (1)
- Zirconium (1)
- Zn (1)
- Zr-Modifier (1)
- Zyklisierung (1)
- a-zearalenol (1)
- aRTist (1)
- battery aging mechanism (1)
- bell pepper (1)
- boron (1)
- current collector corrosion (1)
- delta value (1)
- depth profiles (1)
- electrocatalysis (1)
- ion optics (1)
- isotope fractionation (1)
- lank characterization (1)
- magnetic nanocatalysts (1)
- measurement uncertainty (1)
- metabolism (1)
- microplastics, sampling, sampling techniques, water (1)
- microstructural changes (1)
- nanostructured (1)
- openBIS (1)
- p-Aminothiophenol (1)
- p-Nitrothiophenol (1)
- pH sensor (1)
- pL-droplets (1)
- sc-ICP-ToF-MS (1)
- silicon (1)
- single cell-ICP-ToF-MS (1)
- single particle-ICP-ToF-MS (1)
- spICP-MS (1)
- species-specific isotope information (1)
- tandard addition (1)
- µJ-DPSS laser (1)
- Ägyptisches Museum Berlin (1)
- β-lactam (1)
Organisationseinheit der BAM
- 1 Analytische Chemie; Referenzmaterialien (704)
- 1.1 Anorganische Spurenanalytik (260)
- 6 Materialchemie (190)
- 1.4 Prozessanalytik (140)
- 1.7 Organische Spuren- und Lebensmittelanalytik (112)
- 1.6 Anorganische Referenzmaterialien (104)
- 6.3 Strukturanalytik (101)
- 1.8 Umweltanalytik (95)
- 4 Material und Umwelt (72)
- 6.6 Physik und chemische Analytik der Polymere (70)
Paper des Monats
- ja (5)
In dieser Arbeit wurden drei verschiedene Nanomaterialien auf ihre Bindungsfähigkeit zu Proteinen untersucht. Zu Beginn standen dabei die Herstellung stabiler Dispersionen der einzelnen Nanopartikel und die Stabilität der gebildeten Konjugate im Vordergrund. Der Nachweis einer erfolgreichen Konjugatbildung, sprich der Beschichtung von Nanopartikel mit Proteinen, wurde sowohl qualitativ mittels DLS-Messungen als auch über quantitative Protein-Bestimmungen erbracht. Für die Quantifizierung konnten verschiedene Methoden eingesetzt werden. Neben der klassischen Vorgehensweise, welche indirekt über die Quantifizierung von ungebundenem Protein im Überstand erfolgt, konnten ihm Rahmen dieser Arbeit verschiedene direkte Bestimmungsmethoden entwickelt werden. So wurden mittels kolorimetrischer Tests, wie dem BCA-Assay und dem Bradford-Assay, Nanodiamantdispersionen mit Hilfe einer Korrekturwellenlänge vermessen und quantifiziert. Ebenso zum Einsatz kam die Methode der Aminosäureanalytik, welche aufgrund ihrer guten Rückführbarkeit auf Aminosäurestandards Ergebnisse mit hoher Richtigkeit generieren kann und ebenso die Detektion kleiner Proteinmengen möglich macht.
Nach den erfolgten quantitativen Betrachtungen wurden die Protein-beschichteten Nanopartikel auf ihre Anwendbarkeit als Analoga von Virus-like Particles (VLP) bei einer Immunisierung zur Gewinnung von polyklonalen Antikörpern gegen humanes Ceruloplasmin in Kaninchen überprüft. Es konnte mittels ELISA gezeigt werden, dass die Konjugate erfolgreich für die Herstellung von Antikörpern eingesetzt werden können und im zeitlichen Verlauf einer Immunisierung eine Steigerung des Antikörper-Titers zu erreichen ist.
Quantifizierung der Schädigung von DNA in wässriger Lösung unter direkter Elektronenbestrahlung
(2018)
To cure cancer radiation therapy is used to kill tumor cells.
It is based on radiation induced damage to biomolecules.
Especially DNA damage is of key interest due to its central role in apoptosis and mutation.
Because of the high amount of water in biological tissue, most of the damage is caused by the secondary particles produced by the inelastic scattering of ionizing radiation and water.
A detailed understanding of the underlying molecular processes under physiological conditions is the prerequisite to develop more efficient therapies.
Goal of this work is to quantify the DNA damage caused by ionizing radiation in dependence of the inelastic scattering events and the energy deposit within the microscopic target volume of biological relevance.
The irradiations have to be performed in liquid, under consideration of the chemical environment.
Therefore, a new combination of experiment and Monte-Carlo simulations was developed and tested.
To make it possible to irradiate liquids with electrons within scanning electron microscopes a new sample holder was constructed incorporating an electron transparent nanomembrane.
It makes it possible to irradiate DNA, proteins or cells at different pH, salinity and in the presence of cosolutes.
%The most important results of this work are as follows:
The median lethal dose for a model system of plasmid DNA and water was determined by the combination of experimental data, particle scattering simulations (Geant4-DNA) and diffusion calculations as D0.5=(1.7+-0.3) Gy.
From the convolution of plasmid positions and the spatially resolved energy deposit, as determined by electron scattering simulations, the histogram of the energy deposit within the target volume of the plasmids and the microscopic median lethal energy deposit was calculated as E0.5=6+-4eV.
It could be deduced that on average less than two ionization events are sufficient to cause a single-strand-break.
The relation of single-strand-breaks (SSB) to double-strand-breaks (DSB), which is of importance for microdosimetric modeling, was determined as SSB:DSB = 12:1.
The presented method for the determination of microscopic dose-damage relations was further extended to be applicable for general irradiation experiments.
It becomes independent of the type of primary radiation used, the experimental geometry, and the diffusional properties of the molecules under investigation.
This way different experimental systems with varying, inhomogeneous energy deposit characteristics become comparable with each other, which is not possible when only macroscopic averaged values are taken into account.
In addition, the radiation protection properties of the compatible solute ectoine, as well as its influence on the water properties and biomolecules were investigated.
%In addition, the influence of the compatible solute ectoine on water, biomolecules and its radiation protection properties were investigated.
Raman spectroscopy revealed a concentration dependent increase of the collective water modes in the OH-stretching region, which was found to be independent of the sodium chloride concentration.
Molecular dynamic simulations showed that the zwitterionic properties of ectoine lead to its half-chair conformation.
The hydrogen bonds in the first hydration shell are more stable and have an increased lifetime compared to the bulk water.
Irradiation experiments with DNA in the presence of 1M ectoine revealed an increase of the survival rate by a factor of 1.41 as compared to the absence of ectoine.
The protective properties of ectoine result from the increase of the inelastic scattering probabilities of low energy electrons at the acoustic vibrational modes of water and its properties as OH-radical scavenger.
This was shown by Raman spectroscopy and electron paramagnetic resonance measurements (EPR).
Proline has been widely used for various cocrystallization applications, including pharmaceutical cocrystals. Combining enantiopure and racemic flurbiprofen and proline, we discovered 18 new crystal structures. Liquid-assisted grinding proved highly efficient to explore all the variety of crystal forms. A unique combination of stateof-the-art characterization techniques, comprising variable temperature in situ X-ray diffraction and in situ ball-milling, along with other physicochemical methods and density functional theory calculations, was indispensable for identifying all the phases. Analyzing the results of in situ ball-milling, we established a stepwise mechanism for the formation of several 1:1 cocrystals via an intermediate 2:1 phase. The nature of the solvent in liquidassisted grinding was found to significantly affect the reaction rate and, in some cases, the reaction pathway.
We designed and synthesized triphenylamine based and coumarin fused rhodamine hybrid dyes and characterized using 1H, 13C NMR and HR-LCMS analysis. Both the newly synthesized hybrid dyes were found to show red shifted absorption as well as emissions and large Stokes shift (40e68 nm) as compared to the small Stokes shift (25e30 nm) of reported dyes Rhodamine B and 101. Photophysical properties of these dyes were studied in different solvents and according to the solvents acidity or basicity they preferred to remain in their spirocyclic or open form in different ratio. We studied the spirocyclic as well as open form derivatives of these dyes for their viscosity sensitivity in three different mixture of solvents i.e. polar-protic [EtOH-PEG 400], polar-aprotic [toluene-PEG 400] and non-polaraprotic [toluene-paraffin]. They are found to show very high viscosity sensitivity in polar-protic mixture of solvents [EtOH-PEG 400] and hence concluded that both polarity as well as viscosity factor worked together for the higher emission enhancement rather than only viscosity factor. As these dyes showed very high viscosity sensitivity in their spirocyclic as well as open form, they can be utilized as viscosity sensors in visible as well as deep red region. We also correlated our experimental finding theoretically by using Density Functional theory computations.
A frequently studied environmental contaminant is the active substance diclofenac, which is removed insufficiently in sewage treatment plants. Since its inclusion in the watch list of the EU Water Framework Directive, the concentrations in surface waters will be determined throughout Europe. For this, still, more precise analytical methods are needed. As a reference, HPLC-MS is frequently employed. One of the major metabolites is 4’-hydroxydiclofenac (4’-OH-DCF). Also, diclofenac lactam is important for assessing degradation and transformation. Aceclofenac (ACF), the glycolic acid ester of diclofenac is used as a drug, too, and could potentially be cleaved to yield diclofenac again. In various sewage treatment plant influent samples, diclofenac, 4’-OH-DCF, DCF lactam and ACF could be determined with detection limits of 3 µg/L, 0.2 µg/L, 0.17 µg/L and 10 ng/L, respectively.
The overall interest in nanotoxicity, triggered by the increasing use of nanomaterials in the material and life sciences, and the synthesis of an ever increasing number of new functional nanoparticles calls for standardized test procedures1,2 and for efficient approaches to screen the potential genotoxicity of these materials. Aiming at the development of fast and easy to use, automated microscopic methods for the determination of the genotoxicity of different types of nanoparticles, we assess the potential of the fluorometric γH2AX assay for this purpose. This assay, which can be run on an automated microscopic detection system, relies on the detection of DNA double strand breaks as a sign for genotoxicity3. Here, we provide first results obtained with broadly used nanomaterials like CdSe/CdS and InP/ZnS quantum dots as well as iron oxide, gold, and polymer particles of different surface chemistry with previously tested colloidal stability and different cell lines like Hep-2 and 8E11 cells, which reveal a dependence of the genotoxicity on the chemical composition as well as the surface chemistry of these nanomaterials. These studies will be also used to establish nanomaterials as positive and negative genotoxicity controls or standards for assay performance validation for users of this fluorometric genotoxicity assay. In the future, after proper validation, this microscopic platform technology will be expanded to other typical toxicity assays.
The recently reported luminescent chromium(III) complex 13+ ([Cr(ddpd)2]3+; ddpd=N,N’-dimethyl-N,N’-dipyridine-2-yl-pyridine-2,6-diamine) shows exceptionally strong near-IR emission at 775 nm in water under ambient conditions (F=11%) with a microsecond lifetime as the ligand design in 13+ effectively eliminates non-radiative decay pathways, such as photosubstitution, back-intersystem crossing, and trigonal twists. In the absence of energy acceptors, such as dioxygen, the remaining decay pathways are energy transfer to high energy solvent and ligand oscillators, namely OH and CH stretching vibrations. Selective deuteration of the solvents and the ddpd ligands probes the efficiency of these oscillators in the excited state deactivation. Addressing these energytransfer pathways in the first and second coordination sphere furnishes a record 30% quantum yield and a 2.3 millisecond lifetime for a metal complex with an earth-abundant metal ion in solution at room temperature.
In der Berliner Sammlung "Manuscripta Americana" befinden sich Fragmente von Bilderhandschriften, die Alexander von Humboldt 1804 in Mexiko erwarb und der Königlichen Bibliothek schenkte. Die in der frühen Kolonialzeit hergestellten verschiedenartigen Codices waren damals schon nicht mehr an den Orten ihrer ursprünglichen Verwendung. Entsprechend ihres Seltenheitswertes gelangten einzelne Schriftstücke seit der Conquista in die Bestände bedeutender Persönlichkeiten. Hierzu fertigte man auch Abschriften oder Kopien an, oder zerstückelte sogar einzelne Blätter, so dass die Darstellungen auf den abgetrennten Fragmenten oft nur zum Teil abgebildet vorliegen.
Um herauszufinden, ob einige Schriftstücke der "Humboldt Codices" in Bezug zu einander stehen, werden die Dokumente, ihre Symbole und Schriftzeichen und das zur Herstellung verwendete Material miteinander verglichen.
Mit den für die Analyse von Manuskripten bewährten Untersuchungsmethoden werden Papier und Farbmittel identifiziert. Hierzu zählen Raman-, FTIR-, Röntgenfluoreszenz- und VIS- Spektroskopie. Charakteristisch für die Herstellung von schriftlichen Dokumenten in der Kolonialzeit von Amerika ist die Verwendung von indigenem Material wie Papier aus Baumrinde und Pflanzenfarben zusammen mit den aus Europa bekannten Materialien. Geklärt wird, inwieweit neben den bekanntesten Farbstoffen wie Cochenille, Mayablau oder Mischungen mit Tonmineralen auch mineralische Pigmente zum Einsatz kamen.
Vorgestellt werden die auf Tafel 36 in den "Vues des Cordillères et Monuments des Peuples Indigènes de l`Amerique, Voyage de Humboldt et Bonpland" abgebildeten Fragmente. Die hier von Humboldt vorgenommene Zusammenstellung wird mit der Farbpalette der in Berlin archivierten originalen Schriftstücke verglichen. Die Interpretation der Ergebnisse gibt einen Hinweis auf die Zuordnung oder auch Zusammengehörigkeit dieser einzigartigen Dokumente amerikanischer Geschichte. Hierbei wird die Frage aufgeworfen, inwiefern davon auszugehen ist, dass diese mit weiteren Fragmenten in Verbindung gebracht werden können, was für die Beleuchtung der kulturhistorischen Zusammenhänge von großer Bedeutung ist.
Cost-effective water cleaning approaches using improved Treatment technologies, for instance based on catalytic processes with high activity catalysts, are urgently needed. The aim of our study was to synthesize efficient Fenton-like photo-catalysts for rapid degradation of persistent organic micropollutants in aqueous medium. Iron-based nanomaterials were chemically synthesized through simple procedures by immobilization of either iron(II) oxalate (FeO) or iron(III) citrate (FeC) on magnetite (M) nanoparticles stabilized with polyethylene glycol (PEG). Various investigation techniques were performed in order to characterize the freshly prepared catalysts. By applying advanced oxidation processes, the effect of catalyst dosage, hydrogen peroxide concentration and UV-A light exposure were examined for Bisphenol A (BPA) conversion, at laboratory scale, in mild conditions. The obtained results revealed that BPA degradation was rapidly enhanced in the presence of low-concentration H2O2, as well as under UV-A light, and is highly dependent on the surface characteristics of the catalyst. Complete photo-degradation of BPA was achieved over the M/PEG/FeO catalyst in less than 15 minutes. Based on the catalytic performance, a hierarchy of the tested catalysts was established: M/PEG/FeO > M/PEG/FeC > M/PEG. The results of cytotoxicity assay using MCF-7 cells indicated that the aqueous samples after treatment are less cytotoxic.
Non-invasive Cereal Analysis by GC-MS detection of Trichodiene as a Volatile Mycotoxin Biomarker
(2018)
Due to the increasing consumption of cereals worldwide, the monitoring of growth, storage and processing is becoming more and more crucial. Particularly when stored, infested grains breed fungal clusters (“hot spots”) in which mycotoxins greatly exceed allowed maximum levels. Because of their unpredictable presence, current sample drawing and procedures for mycotoxin analysis represent a complex challenge for operators, involving invasive and cost intensive steps.
Therefore, new time- and labour-saving mycotoxin control methods including sampling and analysis steps are needed. A possible approach is the non-invasive analysis of the homogeneous gas phase above the crops, instead of analyzing random samples. However, this procedure requires microbial volatile organic compounds (MVOC´s) being released by the samples and representing the present mycotoxins. Previous investigations revealed trichodiene to be a precursor in trichothecenes biosynthesis – one of the largest mycotoxin groups with over 180 compounds. Due to its non-functionalized sesquiterpene structure, trichodiene has already been quantified using Headspace GC-MS methods (for instance]). Thereby, it can possibly be used as a biomarker for trichothecene contamination in foodstuff.
However, further investigations are necessary. The correlation between trichodiene concentration in the gas phase and trichothecenes mass fraction in the sample must be examined closely to draw conclusions about the exact trichothecene content within samples. Realizing this idea, would widely extend the applicability of trichodiene and enormously simplify trichothecene quantification. Hence, this first step of an ongoing study aims to develop a laboratory reference method using trichodiene as volatile biomarker to quantify trichothecenes in cereals. Static headspace and SPME-enrichment coupled to gas chromatography with mass spectrometry (GC-MS) were employed. In a second step, this reference method is intended to validate new approaches for fast on-site screening of trichodiene in cereals.