Chemische Charakterisierung und Spurenanalytik
Filtern
Erscheinungsjahr
- 2021 (114) (entfernen)
Dokumenttyp
- Zeitschriftenartikel (54)
- Vortrag (38)
- Posterpräsentation (14)
- Sonstiges (3)
- Buchkapitel (2)
- Beitrag zu einem Sammelband (1)
- Beitrag zu einem Tagungsband (1)
- Newsletter (1)
Sprache
- Englisch (114) (entfernen)
Schlagworte
- HR-CS-GFMAS (6)
- Microplastic (6)
- Process Analytical Technology (6)
- ICP-MS (5)
- Machine learning (5)
- NMR spectroscopy (5)
- Reference material (5)
- TED-GC/MS (5)
- Amperometry (4)
- Benchtop-NMR (4)
- Cancer (4)
- Industry 4.0 (4)
- Laser ablation (4)
- Mass Spectroscopy (4)
- Metabolomics (4)
- Metrology (4)
- Microbiologically influenced corrosion (4)
- Mycotoxins (4)
- Single cell analysis (4)
- Archaea (3)
- Cyclic voltammetry (3)
- Electrochemistry (3)
- Immunoassay (3)
- Isotope (3)
- Isotope dilution (3)
- Lithium (3)
- Ochratoxin A (3)
- SC-ICP-ToF-MS (3)
- Soil (3)
- Synchrotron (3)
- Traceability (3)
- Absolute isotope ratio (2)
- Affinity Chromatography (2)
- Analytic (2)
- Antagonists (2)
- Antibodies (2)
- Archaeometry (2)
- Artificial Neural Networks (2)
- Atomic absorption spectrometry (2)
- BAMline (2)
- Calibration (2)
- Cement (2)
- Certification (2)
- Certified reference material (2)
- Chemical characterization (2)
- Copper (2)
- DNA (2)
- Dosimetry (2)
- Environmental analysis (2)
- Extractable organically bound fluorine (EOF) (2)
- FFF-3D-Printer (2)
- FPLC (2)
- Finow Canal (2)
- Food analysis (2)
- HPLC (2)
- Heart failure (2)
- High resolution-continuum source-graphite furnace molecular absorption spectrometry (HR-CS-GFMAS) (2)
- Homogeneity (2)
- Human serum (2)
- Imaging (2)
- Ionization (2)
- Legacy pollution (2)
- MALDI-TOF MS (2)
- Methylmercury (2)
- Microbe interactions (2)
- Modular Production (2)
- Nanomaterial (2)
- Nanoparticle (2)
- PEG (2)
- PFAS (2)
- Per- and polyfluorinated alkyl substances (PFASs) (2)
- Polyethylene glycole (2)
- Quality Control (2)
- Quality assurance (2)
- Quality testing (2)
- Referenzmaterialien (2)
- Retrospective analysis (2)
- Sc-ICP-ToF-MS (2)
- Silanes (2)
- Stability (2)
- Sulfur (2)
- Triple isotope fractionation (2)
- UFP (2)
- Uncertainty (2)
- 2-propanol oxidation (1)
- AAS (1)
- AFM (1)
- Accreditation (1)
- Additive Manufacturing (1)
- Additive manufacturing (1)
- Adsorbable organically bound fluorine (AOF) (1)
- Adsorption (1)
- Affinity Extraction (1)
- Affinity Separation (1)
- Air analysis (1)
- AlCl (1)
- Alcohol electrooxidation (1)
- Algorithms (1)
- Allergy (1)
- Alzheimer’s disease (1)
- Amino acid analysis (1)
- Amyloid-beta (1)
- Anode (1)
- Antibody Purification (1)
- Antibody quantification (1)
- Artificial Intelligence (1)
- Artificial intelligence (1)
- Artificial neural networks (1)
- Atomic Absorption Spectrometry (1)
- Automated Purification (1)
- Autonomous chemistry (1)
- Battery (1)
- Battery aging (1)
- Bawit (1)
- Bayesian Optimization (1)
- Bbeverages (1)
- Bio engineering (1)
- BioProScale (1)
- Bioapatite (1)
- Biodiesel fuel (1)
- Biological & biomedical applications (1)
- Biotechnology (1)
- Bisphenol-A (1)
- Blood-brain barrier (1)
- Border surveillance (1)
- Borosilicate Glass (1)
- Borosilicate glass (1)
- Brain (1)
- CE/MC-ICP-MS (1)
- CRM (1)
- Cadmium (1)
- Cardiolipins (1)
- Catalysts (1)
- Cathode (1)
- CdSe/ZnS quantum Dots (1)
- Cell (1)
- Cellular uptake (1)
- Chamber measurement (1)
- Chemical Process Control (1)
- Chemical Safety (1)
- Chemical composition (1)
- Chemiluminescence (1)
- Chlorides (1)
- Chlorine (1)
- Citizen Science (1)
- Cocoa (1)
- Column holder (1)
- Combustion (1)
- Combustion ion chromatography (CIC) (1)
- Comparative test (1)
- Concentration step (1)
- Confiscation (1)
- Construction (1)
- Consumer Products (1)
- Coptic manuscripts (1)
- Core/shell nanoparticle (1)
- Corophium volutator (1)
- Crystallization (1)
- Customs (1)
- Cyber-Physical Systems (1)
- Cyber-physical systems (1)
- Cycloparaphenylenes (1)
- Density functional theory (1)
- Desorption (1)
- Detection (1)
- Diagenesis (1)
- Diagnosis (1)
- Diagnostic Antibodies (1)
- Diastolic dysfunction (1)
- Diatomic molecule (1)
- Diclofenac (1)
- Diesel exhaust (1)
- Digital Transformation (1)
- Digital transformation (1)
- Direct alcohol fuel cells (1)
- Dispersive-XAS (1)
- Dityrosine (1)
- Dose (1)
- Down Stream Processing (1)
- Drawings (1)
- Drug search (1)
- Drug trafficking (1)
- EOF (1)
- EPMA (1)
- ETV (1)
- ETV/ICP-MS (1)
- Editorial (1)
- Electrocatalysis (1)
- Electrochemical energy conversion (1)
- Electrochemical real-time mass spectrometry (1)
- Electrohpresis (1)
- Electronic nose (1)
- Elemental analysis (1)
- Elementspezies & Isotope (1)
- Emerging Contaminants (1)
- Emerging contaminants (1)
- Emission Test Chamber (1)
- Emission spectroscopy (1)
- Environmental & life science application (1)
- Ergot alkaloids (1)
- Esterification (1)
- European Reference Material (1)
- Exhaust (1)
- Extraction (1)
- Fast single pulse response (1)
- Filter crucible (1)
- Flame retardants (1)
- Fluorescence (1)
- Fluorination (1)
- Fluorine sum parameter (1)
- Food (1)
- Food Analysis (1)
- Formaldehyde (1)
- Fusarium mycotoxin (1)
- GD-MS (1)
- GD-OES (1)
- GDMS (1)
- Gas chromatography (1)
- Gaussian process (1)
- Glass (1)
- Glass Support (1)
- Glucose (1)
- Graphite furnace (1)
- H/D-Exchange (1)
- HERFD-XAS (1)
- HT22 (1)
- Hay fever (1)
- HeLa (1)
- High-Speed Separations (1)
- High-resolution (1)
- High-resolution continuum source atomic absorption spectrometer (1)
- High-resolution continuum source graphite furnace atomic absorption spectrometry (1)
- High-resolution mass spectrometry (1)
- Host–guest systems (1)
- Hot-pressing (1)
- Human Plasma (1)
- Hydrazinolysis (1)
- Hydrodynamic model (1)
- Hydrogen (1)
- Hydrolytic resistance (1)
- Hypothalamus (1)
- IC (1)
- ICP-MS & HR-CS-GFMAS (1)
- ICP-OES (1)
- ICP-ToF-MS (1)
- ILC (1)
- ISO 16000-6 (1)
- ISO 17025 (1)
- ISO/IEC 17025 (1)
- IgG determination (1)
- Illicit drug (1)
- Immunosensor (1)
- Indoor air (1)
- Industry 4.0, (1)
- Ink analysis (1)
- Ink fingerprint (1)
- Inorganic Reference Materials (1)
- Inter-laboratory comparison (1)
- Interlaboratory key comparison (1)
- Internal Standard (1)
- International drug trade (1)
- Iron (1)
- Isotope dilution mass spectrometry (1)
- Isotope reference material (1)
- Isotopes (1)
- Isotopic analysis (1)
- Kopplungstechniken (1)
- LA-(MC-)ICP-MS (1)
- LA-ICP-MS (1)
- LA-ICP-SFMS (1)
- LA/ICP-MS Imaging (1)
- LC-MS/MS (1)
- Lactate (1)
- Laser induced plasma deposition (1)
- Laser metal deposition (LMD) (1)
- Leonardo da Vinci (1)
- Lightning talk (1)
- Lipidomics (1)
- Lipids (1)
- Lithium isotope (1)
- Lithium-ion batteries (1)
- Liver X receptor (1)
- MALDI (1)
- MALDI-ToF MS (1)
- MRI (1)
- Macrocycles (1)
- Magnetic beads (1)
- Magnetic resonance imaging (1)
- Mass Spectrometry (1)
- Mass spectrometry (1)
- Material analysis (1)
- Mechanism (1)
- Medicinal application (1)
- Mercury speciation (1)
- Meta-study (1)
- Metal toxicity (1)
- Metal uptake (1)
- Metformin (1)
- Microdialysis (1)
- Microplastic particles (1)
- Microplastics (1)
- Microplastics analytic (1)
- Mikroplastik (1)
- Mikroplastik Massegehalt (1)
- Mixed ink (1)
- Mobile analysis (1)
- Mobile device (1)
- Modular production (1)
- Molecular imaging (1)
- Molecular marker (1)
- Molecular recognition (1)
- Monoamine oxidase B (1)
- Monoclonal Antibodies (1)
- Monolith (1)
- Multi-collector inductively coupled plasma-mass spectrometry (ICP-MS) (1)
- Multivariate analysis (1)
- Nanocarrier (1)
- Nanoplastic (1)
- Narcotics (1)
- Near-infrared refectography (1)
- Network (1)
- Neural Network (1)
- Nitrotyrosine (1)
- Non-invasive analysis (1)
- Nontarget analysis (1)
- Nuclear Magnetic Resonance Spectroscopy (1)
- Nuclear magnetic resonance spectroscopy (1)
- Nuclear receptor (1)
- Online NMR spectroscopy (1)
- Open Science (1)
- Optical isotopic spectrometry (1)
- Optical sensor (1)
- Organically bound fluorine (1)
- Organophosphate esters (1)
- Outdoor odor emissions (1)
- Oxygen evolution reaction (1)
- PAHs (1)
- PANIC (1)
- PEGomics (1)
- PLS regression (1)
- Papyrus (1)
- Parkinsons's disease (1)
- Peptide analysis (1)
- Pharmacy (1)
- Phosphorus (1)
- Photocatalysis (1)
- Plasma chemistry (1)
- Plastic bottles (1)
- Polycapillaries (1)
- Polyclonal Antibodies (1)
- Polycyclic aromatic hydrocarbons (1)
- Polylactide (1)
- Polymers (1)
- Poster presentation (1)
- Pouch cell (1)
- Priority effect (1)
- Process analytical technology (1)
- Process control (1)
- Process industry (1)
- Programmed cell death (1)
- Prostate cancer (1)
- Protein (1)
- Protein A (1)
- Protein Purification (1)
- Provenance (1)
- Prussian blue (1)
- Purification (1)
- Purity assessment (1)
- Quantitative NMR Spectroscopy (1)
- Quantitative bioimaging (1)
- Quantum dot (1)
- Quick-XAS (1)
- RXES (1)
- Radiation (1)
- Raman spectroscopy (1)
- Reference materials (1)
- Regeneration (1)
- Release kinetics (1)
- Robustness (1)
- Round robin test (1)
- SAXS (1)
- SERS (1)
- SI (1)
- SOM-SM (1)
- Safety (1)
- Screen-printed electrodes (1)
- Screening (1)
- Screening method (1)
- Seawater (1)
- Secondary alcohols (1)
- Sediment (1)
- Separation (1)
- Serum (1)
- Silicon (1)
- Single cell (1)
- Sintered Material (1)
- Size (1)
- Smartphone (1)
- Soda-lime glass (1)
- Solid support (1)
- Solid-liquid extraction (1)
- Solvents (1)
- Spark plasma sintering (1)
- Special issue, young analytical scientists (1)
- Speciation Analysis (1)
- Speciation analysis (1)
- Species-specific Isotope Analysis (1)
- Spectrometry (1)
- Spectroscopy (1)
- Sputtering (1)
- Sr isotopes (1)
- Stakeholders (1)
- Storage Technologies (1)
- Sum parameter method (1)
- Supramolecular chemistry (1)
- Surface chemistry (1)
- Surface coating (1)
- TD-GC-MS (1)
- TXRF-XAS (1)
- Tantalum oxyfluorides (1)
- Tau (1)
- Tetramethylammonium hydroxide (1)
- Therapeutic Antibodies (1)
- Thermal Desorption (1)
- Thermal Extraction (1)
- Thermal desorption (1)
- Thermal model (1)
- Thermoanalytic (1)
- Tissue (1)
- Titanium dioxide (1)
- Titanium hydride (1)
- Total element determination (1)
- Toys (1)
- Trace analysis (1)
- Transferrin (1)
- Truffles (1)
- Two-phase system (1)
- VAMAS (1)
- VOC (1)
- Vanadium redox flow battery (1)
- Vegetable edible oil (1)
- Volatile marker (1)
- Volatile organic compounds (1)
- Water (1)
- Water analysis (1)
- Wooden toys (1)
- Writing inks (1)
- X-ray fuorescence (1)
- XANES (1)
- XRF (1)
- Zinc (1)
- lank characterization (1)
- pL-droplets (1)
- qNMR (1)
- tandard addition (1)
Organisationseinheit der BAM
- 1 Analytische Chemie; Referenzmaterialien (87)
- 1.1 Anorganische Spurenanalytik (35)
- 6 Materialchemie (25)
- 1.7 Organische Spuren- und Lebensmittelanalytik (17)
- 1.8 Umweltanalytik (16)
- 1.4 Prozessanalytik (15)
- 4 Material und Umwelt (14)
- 1.6 Anorganische Referenzmaterialien (13)
- 6.3 Strukturanalytik (11)
- 6.6 Physik und chemische Analytik der Polymere (9)
Eingeladener Vortrag
- nein (38)
This study shows remarkably different features between the oxidation of secondary and primary C₃-C₅ alcohols. The oxidation of primary alcohols is controlled by the oxidative removal of blocking adsorbates, such as CO, formed after the dissociative adsorption of alcohol molecules. Conversely, secondary alcohols do not undergo dissociative adsorption and therefore their oxidation is purely controlled by the energetics of the elementary reaction steps. In this respect, a different role of ruthenium is revealed for the electrooxidation of primary and secondary alcohols on bimetallic platinum-ruthenium catalysts. Ruthenium enhances the oxidation of primary alcohols via the established bifunctional mechanism, in which the adsorption of (hydr)oxide species that are necessary to remove the blocking adsorbates is favored. In contrast, the oxidation of secondary alcohols is enhanced by the Ru-assisted stabilization of an O-bound intermediate that is involved in the potential-limiting step. This alternative pathway enables the oxidation of secondary alcohols close to the equilibrium potential.
Mass Spectrometry (MS) and Nuclear Magnetic Resonance Spectroscopy (NMR) are critical components of every industrial chemical process as they provide information on the concentrations of individual compounds and by-products. These processes are carried out manually and by a specialist, which takes a substantial amount of time and prevents their utilization for real-time closed-loop process control. This paper presents recent advances from two projects that use Artificial Neural Networks (ANNs) to address the challenges of automation and performance-efficient realizations of MS and NMR. In the first part, a complete toolchain has been developed to develop simulated spectra and train ANNs to identify compounds in MS. In the second part, a limited number of experimental NMR spectra have been augmented by simulated spectra to train an ANN with better prediction performance and speed than state-of-theart analysis. These results suggest that, in the context of the digital transformation of the process industry, we are now on the threshold of a possible strongly simplified use of MS and MRS and the accompanying data evaluation by machine-supported procedures, and can utilize both methods much wider for reaction and process monitoring or quality control.
Under the auspices of the Protein Analysis Working Group (PAWG) of the Comité Consultatif pour la Quantité de Matière (CCQM) a pilot study, CCQM-P216, was coordinated by the Chinese National Institute of Metrology (NIM), National Research Council of Canada (NRC) and the Bureau International des Poids et Mesures (BIPM). Eleven Metrology Institutes or Designated Institutes and the BIPM participated in the first phase of the pilot study (Part 1). The purpose of this pilot study was to develop measurement capabilities for larger proteins using a recombinant humanized IgG monoclonal antibody against Spike glycoprotein of SARS-CoV-2 (Anti-S IgG mAb) in solution. The first phase of the study was designed to employ established methods that had been previously studies by the CCQM Protein Analysis Working Group, involving the digestion of protein down to the peptide or amino acid level. The global coronavirus pandemic has also led to increased focus on antibody quantitation methods. IgG are among the immunoglobulins produced by the immune system to provide protection against SARS-CoV-2. Anti-SARS-CoV-2 IgG can therefore be detected in samples from affected patients. Antibody tests can show whether a person has been exposed to the SARS-CoV-2, and whether or not they potentially show lasting immunity to the disease. With the constant spread of the virus and the high pressure of re-opening economies, antibody testing plays a critical role in the fight against COVID-19 by helping healthcare professionals to identify individuals who have developed an immune response, either via vaccination or exposure to the virus. Many countries have launched large-scale antibody testing for COVID-19. The development of measurement standards for the antibody detection of SARS-CoV-2 is critically important to deal with the challenges of the COVID-19 pandemic. In this study, the SARS-CoV-2 monoclonal antibody is being used as a model system to build capacity in methods that can be used in antibody quantification. Amino acid reference values with corresponding expanded uncertainty of 36.10 ± 1.55 mg/kg, 38.75 ± 1.45 mg/kg, 18.46 ± 0.78 mg/kg, 16.20 ± 0.67 mg/kg and 30.61 ± 1.30 mg/kg have been established for leucine, valine, phenylalanine, isoleucine and proline, respectively. Agreement between nearly all laboratories was achieved for the amino acid analysis within 2 to 2.5 %, with one participant achieving markedly higher results due to a technical issue found in their procedure; this result was thus excluded from the reference value calculations. The relatively good agreement within a laboratory between different amino acids was not dissimilar to previous results for peptides or small proteins, indicating that factors such as hydrolysis conditions and calibration procedures could be the largest sources of variability. Peptide reference values with corresponding expanded uncertainty of 4.99 ± 0.28 mg/kg and 6.83 ± 0.65 mg/kg have been established for ALPAPIEK and GPSVFPLAPSSK, respectively. Not surprisingly due to prior knowledge from previous studies on peptide quantitation, agreement between laboratories for the peptide-based analysis was slightly poorer at 3 to 5 %, with one laboratory's result excluded for the peptide GPSVFPLAPSSK. Again, this level of agreement was not significantly poorer than that achieved in previous studies with smaller or less complex proteins. To reach the main text of this paper, click on Final Report.
In this paper, we discuss the importance of scientifically investigating cultural artefacts in a non-invasive way. Taking as test case Leonardo da Vinci’s Manuscript with anatomic drawings and notes, which is stored in Weimar, we clarify fundamental steps in the chronology of this folio. By means of microscopy, infrared reflectography, UV photography, and X-ray fluorescence analysis, we were able to identify various types of sketching material and several varieties of iron gall ink. For his sketches, Leonardo used two different sketching tools, a lead pencil and a graphite pencil, as well as several types of ink for developing these sketches into drawings. With regard to ink, it is important to observe that there is no difference between the ink Leonardo used for drawing and the ink he used for writing text. Based on the materials analysed, we suggest a chronology for the creation of this unique folio.
Previous studies have shown that desktop 3D printers (Fused Filament Fabrication) emit high numbers of particulate matter, mainly as ultrafine particles (UFP, particle diameter less than 100 nm). However, the chemical composition of emitted particles has been less extensively investigated. In this study, we therefore focused on the chemical composition of particles emitted from 3D printing. The measurements were conducted in a 1 m³ emission test chamber. Emitted particles were sampled by a 13-stage low-pressure cascade impactor onto aluminum foils and then analyzed by TD-GC/MS to identify their organic compounds. Nine commercial filaments made from basic polymers such as Acrylonitrile Butadiene Styrene (ABS), Acrylonitrile Styrene Acrylate (ASA), Polycarbonate (PC), Poly(methyl methacrylate) (PMMA), Nylon, High Performance Polystyrene (HIPS) and a copper-filled Polylactide (PLA) were investigated. The results show that the organic components of the particles are primarily plastic additives such as plasticizer, antioxidant agents, lubricants, UV-absorbers and UV-stabilizers from the filaments.
Increasing contamination of environmental waters with pharmaceuticals represents an emerging threat for the drinking water quality and safety. In this regard, fast and reliable analytical methods are required to allow quick countermeasures in case of contamination. Here, we report the development of a magnetic bead-based immunoassay (MBBA) for the fast and cost-effective determination of the analgesic diclofenac (DCF) in water samples, based on diclofenac-coupled magnetic beads and a robust monoclonal anti-DCF antibody. A novel synthetic strategy for preparation of the beads resulted in an assay that enabled for the determination of diclofenac with a significantly lower limit of detection (400 ng/L) than the respective enzyme-linked immunosorbent assay (ELISA). With shorter incubation times and only one manual washing step required, the assay demands for remarkably shorter time to result (< 45 min) and less equipment than ELISA. Evaluation of assay precision and accuracy with a series of spiked water samples yielded results with low to moderate intra- and inter-assay variations and in good agreement with LC–MS/MS reference analysis. The assay principle can be transferred to other, e.g., microfluidic, formats, as well as applied to other analytes and may replace ELISA as the standard immunochemical method.
The CCQM-K148.a comparison was coordinated by the BIPM on behalf of the CCQM Organic Analysis Working Group for NMIs and DIs which provide measurement services in organic analysis under the CIPM MRA. It was undertaken as a "Track A" comparison within the OAWG strategic plan. CCQM-K148.a demonstrates capabilities for assigning the mass fraction content of a solid organic compound having moderate molecular complexity, where the compound has a molar mass in the range (75 - 500) g/mol and is non-polar (pKow < −2), when present as the primary organic component in a neat organic solid and where the mass fraction content of the primary component in the material is in excess of 950 mg/g.
Participants were required to report the mass fraction of Bisphenol A present in one supplied unit of the comparison material. Participants using a mass balance method for the assignment were also required to report their assignments of the impurity components present in the material. Methods used by the seventeen participating NMIs or DIs were predominantly based on either stand-alone mass balance (summation of impurities) or qNMR approaches, or the combination of data obtained using both methods. The results obtained using thermal methods based on freezing-point depression methods were also reported by a limited number of participants. There was excellent agreement between assignments obtained using all three approaches to assign the BPA content.
The assignment of the values for the mass fraction content of BPA consistent with the KCRV was achieved by most of the comparison participants with an associated relative standard uncertainty in the assigned value in the range (0.1 - 0.5)%.
The vanadium redox flow battery (VRFB) is currently a potential candidate for stationary energy storage. A major challenge is the unintended vanadium transport through the separator, which results in a fade of capacity. To overcome this issue, it is necessary to understand the transport processes in the membrane on a more fundamental level. In this work, the vanadium species distribution in Nafion™ 117 after cyclization was investigated. Two membranes, one from a charged VRFB and another from a discharged VRFB, were analyzed using ultraviolet–visible spectroscopy (UV/VIS) and X-ray absorption near edge structure spectroscopy (XANES). Little difference between the two membranes was recognizable according to the UV/VIS results. In comparison, the XANES results showed that the membrane from the charged VRFB contains more V3+ than VO2+, whereas for the discharged case, more VO2+ is present in the membrane.
Confocal Micro X-ray fluorescence analysis (μXRF) is a powerful method for the destruction-free investigation of the elemental composition of various samples in three dimensions. Quantitative results rely heavily on the transmission properties of polycapillary optics, used in confocal setups.
Different models for the functional correlation between energy and transmission of a polycapillary half-lens are compared with experimental data, established with a monochromatic confocal laboratory setup [1], as well as Monte-Carlo-Simulations [2]. The effect of the different approaches on quantitative results are compared using well known SRMs, ranging from thick samples to thin layers and structured materials.
Along with this the basic principles for quantitative evaluations of XRF spectra taken with confocal setups are presented, and compared with experimental results.
ML@BAMLINE
(2021)