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Autor

  • Natte, Kishore (3)
  • Orts Gil, Guillermo (2)
  • Rades, Steffi (2)
  • Österle, Werner (2)
  • Friedrich, Jörg Florian (1)
  • Girod, Matthias (1)
  • Hodoroaba, Vasile-Dan (1)
  • Kalbe, Henryk (1)
  • Lutzki, J. (1)
  • Maskos, M. (1)
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Erscheinungsjahr

  • 2013 (3) (entfernen)

Referierte Publikation

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Schlagworte

  • Nanoparticles (3) (entfernen)

Organisationseinheit der BAM

  • 5 Werkstofftechnik (3)
  • 5.1 Materialographie, Fraktographie und Alterung technischer Werkstoffe (3)
  • 6 Materialschutz und Oberflächentechnik (3)
  • 6.1 Oberflächenanalytik und Grenzflächenchemie (2)
  • 6.5 Polymere in Life Science und Nanotechnologie (2)

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Impact of polymer shell on the formation and time evolution of nanoparticle-protein corona (2013)
Natte, Kishore ; Friedrich, Jörg Florian ; Wohlrab, Sebastian ; Lutzki, J. ; von Klitzing, R. ; Österle, Werner ; Orts-Gil, Guillermo
The study of protein corona formation on nanoparticles (NPs) represents an actual main issue in colloidal, biomedical and toxicological sciences. However, little is known about the influence of polymer shells on the formation and time evolution of protein corona onto functionalized NPs. Therefore, silicapoly(ethylene glycol) core–shell nanohybrids (SNPs@PEG) with different polymer molecular weights (MW) were synthesized and exhaustively characterized. Bovine serum albumin (BSA) at different concentrations (0.1–6 wt%) was used as model protein to study protein corona formation and time evolution. For pristine SNPs and SNPs@PEG (MW = 350 g/mol), zeta potential at different incubation times show a dynamical evolution of the nanoparticle–protein corona. Oppositely, for SNPs@PEG with MW ≥2000 g/mol a significant suppression of corona formation and time evolution was observed. Furthermore, AFM investigations suggest a different orientation (side-chain or perpendicular) and Penetration depth of BSA toward PEGylated surfaces depending on the polymer length which may explain differences in protein corona evolution.
On the role of surface composition and curvature on biointerface formation and colloidal stability of nanoparticles in a protein-rich model system (2013)
Orts Gil, Guillermo ; Natte, Kishore ; Thiermann, Raphael ; Girod, Matthias ; Rades, Steffi ; Kalbe, Henryk ; Thünemann, Andreas F. ; Maskos, M. ; Österle, Werner
The need for a better understanding of nanoparticle–protein interactions and the mechanisms governing the resulting colloidal stability has been emphasised in recent years. In the present contribution, the short and long term colloidal stability of silica nanoparticles (SNPs) and silica–poly(ethylene glycol) nanohybrids (Sil–PEG) have been scrutinised in a protein model system. Well-defined silica nanoparticles are rapidly covered by bovine serum albumin (BSA) and form small clusters after 20 min while large agglomerates are detected after 10 h depending on both particle size and nanoparticle–protein ratio. Oppositely, Sil–PEG hybrids present suppressive protein adsorption and enhanced short and long term colloidal stability in protein solution. No critical agglomeration was found for either system in the absence of protein, proving that instability found for SNPs must arise as a consequence of protein adsorption and not to high ionic environment. Analysis of the small angle X-ray scattering (SAXS) structure factor indicates a short-range attractive potential between particles in the silica-BSA system, which is in good agreement with a protein bridging agglomeration mechanism. The results presented here point out the importance of the nanoparticle surface properties on the ability to adsorb proteins and how the induced or depressed adsorption may potentially drive the resulting colloidal stability.
Morphology of nanoparticles - A characterization using high-resolution SEM (2013)
Hodoroaba, Vasile-Dan ; Rades, Steffi ; Natte, Kishore ; Orts Gil, Guillermo ; Unger, Wolfgang
Potential candidates of reference nano-materials are manufactured and systematically characterized in particular with respect to their morphology (shape, size and size distribution) in the frame of the running large European project NanoValid. By exploiting the transmission operation mode in a SEM, known as T-SEM, it is demonstrated by means of three representative examples of nanoparticles how a quick morphological inspection up to a complete, metrological characterization is feasible.
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