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We report on the use of a sprayable and thermogelating biomaterial (Poloxamer; a.k.a. Pluronic) in optical imaging of pH values, local oxygen and temperature. The material is highly biocompatible and easy to handle. We also show that the material is well permeable to oxygen (thus making it a good choice for use in oxygen sensors), and is stable in liquid solution and at elevated temperature. We demonstrate its applicability in optical sensors for oxygen, pH and temperature. This was accomplished by incorporating appropriate luminescent probes in various kinds of microparticles (which act as hosts for the probes and prevent dye leaching and aggregation), and then dispersing the microparticles in the thermogelating polymer. The resulting sensor gels were deposited on the surface of interest via spraying at temperatures of <20 °C. At these temperatures, the gels adhere well to the target, even on uneven surfaces such as skin, wounds, and bacterial cultures. If temperature is risen to above 25 °C, the gels form a thin and soft but solid sensing layer which, however, can be simply removed from surface of interest by cooling and wiping it off, or by washing with water. Sprayable thermogelating sensors present obvious advantages over other sensors by not causing damage to the surface of interest. In our perception, the sensing materials also have wide further applicability in sensors for other species including clinically relevant gases, enzyme substrates (such as glucose or lactate) and ions.
Europium 1,3-di(thienyl)propane-1,3-diones with outstanding properties for temperature sensing
(2015)
The synthesis of novel Eu complexes with 1,3-di(thienyl)propane-1,3-diones as ligands as well as their luminescence properties in different polymers are reported. The new temperature sensitive paints (TSPs) exhibit not only exceptional high temperature sensitivity over a wide range of temperatures but are also characterized by negligible pressure sensitivity and marked photostability. This is why they are outstandingly suitable for applications, e.g. in aerodynamics and hydrodynamics.
A luminescent probe for determination of pH was designed based on a Förster resonance energy transfer (FRET) system, combining a europium chelate as the donor and carboxynaphtho-fluorescein as a pH sensitive acceptor. The FRET system enables referenced pH detection in an exceptional broad dynamic range from pH 3 to 9.