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Recent developments in micromechanics and nanotribology have made adhesion effects very important in the study of actual contact formation and sliding friction. The present work considers the experimental and simulation data on the formation of the adhesion contact and sliding friction for rough surfaces. The simulation of discrete contact was carried out using the AFM images of topography as a source of real surface geometry at micro/nanoscale. The proposed approach of contact modelling is not using the statistical parameters of roughness, but it provides the estimation of the additional adhesion induced contact areas and their influence on sliding friction. The friction law of Bowden and Tabor was used for validation of simulation and experimental data. Furthermore, the workhardening effect was taken into account in simulation of sliding friction, and this enabled to reach a more successful fit of experimental data. The obtained results of the computer simulations will provide a way of studying the movable contact or at least transition from static to dynamic friction at the micro/nanoscale level.