This work addresses the fatigue strength of friction-welded joints for the drive pinion in heavy-duty trucks. Three different friction welding (FW) variants were tested for the joint between the pinion and the bevel of the shaft: (1) conventional FW using series materials, (2) conventional FW from dissimilar materials for every part, and (3) dissimilar joints by applying joint-site structure of FW. Each joint variant was compared to the series production part using a 4-point bending test. Results showed that the higher strength material slightly improved the fatigue strength of the conventional friction-welded joints. Despite the light weight of the component joined structurally at the site, the joint revealed a lower endurance limit compared to other variants. However, there has been little discussion on the weld zone position. The applied equivalent stresses on the weld zone of the joint-site structure are less similar to the position for the conventional FW. Characterization of the failure explains the extraordinary behaviors in relation to S-N curves.