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Autor

  • Garg, A. (1)
  • Grunwald, I. (1)
  • Haag, R. (1)
  • Kerkhoff, Y. (1)
  • Kulka, M.W. (1)
  • Nickl, P. (1)
  • Nie, C. (1)
  • Radnik, Jörg (1)
  • Salz, D. (1)

Schlagworte

  • Dendritic polyglycerol (1)
  • Mussel-inspired adhesives (1)
  • Repelling surface coatings (1)
  • Surface-initated grafting (1)

Organisationseinheit der BAM

  • 6 Materialchemie (1)
  • 6.1 Oberflächenanalytik und Grenzflächenchemie (1)

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Surface-Initiated Grafting of Dendritic Polyglycerol from Mussel-Inspired Adhesion-Layers for the Creation of Cell-Repelling Coatings (2020)
Kulka, M.W. ; Nie, C. ; Nickl, P. ; Kerkhoff, Y. ; Garg, A. ; Salz, D. ; Radnik, Jörg ; Grunwald, I. ; Haag, R.
Biofouling is a major challenge in the application of textiles, biosensors, and biomedical implants. In the current work, a straightforward method for the solvent-free polymerization of antifouling dendritic polyglycerol (dPG) from mussel-inspired dendritic polyglycerol (MI-dPG) coatings on hydrophilic titanium dioxide (TiO2) and hydrophobic polydimethylsiloxane (PDMS) is reported. Surface characterization is performed by static water contact angle (CA) measurements, X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). Significant lower CA values are obtained after dPG grafting from MI-dPG-coated TiO2 and MI-dPG coated PDMS. Furthermore, XPS shows a time-dependent increase of the CO bond content upon dPG grafting from MI-dPG-coated TiO2 and MI-dPG-coated PDMS. Analysis of the surface morphology by SEM shows a clear time-dependent increase in the surface roughness upon dPG grafting from MI-dPG-coated TiO2 and MIdPG-coated PDMS. When the viability of two adhesive cell types is studied via LIVE/DEAD staining, a strong reduction in the cell density is observed after the dPG grafting from MI-dPG-coated TiO2 and MI-dPG-coated PDMS (a decrease of >95% in all cases). The combined results show that biocompatible but highly cell-repelling surfaces are efficiently constructed via the grafting of dPG from MI-dPG-coated TiO2 and MI-dPG-coated PDMS.
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