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- Bone (3) (entfernen)
A variation of the cross polarization (CP) experiment is discussed. The method requires two scans where the difference signal is equivalent to the I spin magnetization that is transferred to the S spins. The acquired signal is equivalent to F1 sum projection of a two-dimensional (2D) heteronuclear correlation experiment and is obtained by just two scans without the need to increment the indirect time domain t1. Any polarization transfer method and any kind of spin manipulations during the t1 incrementation period of a 2D NMR experiment can be applied. The method allows fast measurements of the CP transfer, particularly if various S spins signal overlap and is good for spectral editing of I spin signals with contact to S spins. Various examples for biomaterials are presented. Most importantly, this novel approach is ideal for detailed investigations of organicmineral interfaces in bone, here demonstrated for O-phospho-L-serine as simple model compound.
A solid-state NMR comparison of the mineral structure in bone from diseases joints in the horse
(2007)
In this work, subchondral cortical bone material is investigated from the joints of five horses, three of which presented with no clinical signs or radiographic signs of osteoarthritis and two of which suffered osteoarthritis joint disease, as judged by clinical and radiographic assessment and histological findings. The horse is a good model for osteoarthritis in humans, so the aim of this study is to use nuclear magnetic resonance (NMR) for a detailed investigation of the bone structure in bone material affected by osteoarthritis. In particular, we report on the assessment of the mineral structure of these samples as viewed by solid-state NMR.