Filtern
Erscheinungsjahr
- 2014 (1)
Dokumenttyp
- Beitrag zu einem Sammelband (1) (entfernen)
Sprache
- Englisch (1) (entfernen)
Referierte Publikation
- nein (1) (entfernen)
Schlagworte
- NMR (1)
- Online (1)
- Process analytical technology (1)
- Quantification (1)
Quantitative online NMR spectroscopy of technical mixtures: on the fly quantification of fluids
(2014)
In this paper quantitative NMR spectroscopy is demonstrated as a tool for process analytical technology (PAT) in order to obtain real time information from dynamic processes. Different methods for quantification are presented and as a result the limit of detection for NMR measurement could be determined to 3.3 mg kg-1 (ethanol in water). As model processes esterification reactions and dissolution of pharmaceutical formulations are presented and important process parameters are extracted. Furthermore it is demonstrated that not only 1H-NMR spectroscopy can be used for process monitoring but also 13C-NMR for technical mixtures.