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Surface-enhanced Raman scattering: a new optical probe in molecular biophysics and biomedicine
(2010)
Sensitive and detailed molecular structural
information plays an increasing role in molecular biophysics
and molecular medicine. Therefore, vibrational
spectroscopic techniques, such as Raman scattering, which
provide high structural information content are of growing
interest in biophysical and biomedical research. Raman
spectroscopy can be revolutionized when the inelastic
scattering process takes place in the very close vicinity of
metal nanostructures. Under these conditions, strongly
increased Raman signals can be obtained due to resonances
between optical fields and the collective oscillations of the
free electrons in the metal. This effect of surface-enhanced
Raman scattering (SERS) allows us to push vibrational
spectroscopy to new limits in detection sensitivity, lateral
resolution, and molecular structural selectivity. This opens
up exciting perspectives also in molecular biospectroscopy.
This article highlights three directions where SERS can offer interesting new capabilities. This includes SERS as a
technique for detecting and tracking a single molecule, a
SERS-based nanosensor for probing the chemical composition
and the pH value in a live cell, and the effect of socalled
surface-enhanced Raman optical activity, which
provides information on the chiral organization of molecules
on surfaces.
Two-photon vibrational spectroscopy for biosciences based on surface-enhanced hyper-Raman scattering
(2006)
In Vivo Molecular Probing of Cellular Compartments with Gold Nanoparticles and Nanoaggregates
(2006)
Surface-enhanced Raman (SERS) signatures were measured from single living cells at different times after the uptake of gold nanoparticles. The spectra are indicative of chemical changes in the environment of the nanostructures over time. The increase of the SERS signal strength and parallel TEM studies indicate the formation of nanoaggregates providing optimum SERS enhancement for ultrasensitive probing inside the endosomal compartment. The results have implications for medical and biotechnology applications of SERS nanosensors in cells.