Filtern
Erscheinungsjahr
Dokumenttyp
- Zeitschriftenartikel (19)
- Vortrag (8)
- Beitrag zu einem Tagungsband (4)
- Posterpräsentation (3)
Schlagworte
- Fluorescence (16)
- Microfluidics (9)
- Smartphone (6)
- Fluoreszenz (4)
- MIP (4)
- Mikrofluidik (4)
- Rapid test (3)
- Test strip (3)
- Adulteration (2)
- Air quality (2)
Organisationseinheit der BAM
- 1 Analytische Chemie; Referenzmaterialien (25)
- 1.9 Chemische und optische Sensorik (25)
- 8 Zerstörungsfreie Prüfung (6)
- 8.1 Sensorik, mess- und prüftechnische Verfahren (6)
- 1.8 Umweltanalytik (3)
- 4 Material und Umwelt (2)
- 4.0 Abteilungsleitung und andere (2)
- 4.1 Biologische Materialschädigung und Referenzorganismen (1)
- P Präsident (1)
- PST Präsidiale Stabsstelle (1)
Paper des Monats
- ja (2)
Eingeladener Vortrag
- nein (8)
Because of the globally increasing prevalence of diabetes, the need for accurate, efficient and at best miniaturized automated analytical systems for sugar detection is still urgent. The development of molecular probes for sugar based on boronic acid receptors1 offers an excellent alternative to the kinetically slow enzyme-based sugar sensors. Moreover, by coupling such chelating units with rhodamines, fluorescein or BODIPY moieties, colorimetric and/or highly fluorescent sugar sensing schemes can be obtained.2 In this work, a boronic acid-functionalized BODIPY probe is described; it binds selectivity to fructose's adjacent diols to form cyclic boronate esters in partially aqueous solutions, with a broad pH range compatibility and a sensitivity in the micromolar range. To enhance the applicability of the fluorometric test in the sense described above, integration with a microfluidic sensor was achieved. The miniaturization of chemical analysis systems yields many functional and economical benefits such as low cost, ease of use, high stability and good portability. With similar selectivity and sensitivity, fructose was detected by fluorescence in real time in the chip, and an assay for the straightforward detection of sugar in sodas was achieved.
A novel synthetic strategy toward highly fluorinated BODIPY dyes with exceptional photostabilities relying on sustainable gold catalysis has been developed. A key to the tailored pyrrole precursors is the gold catalysis performed in ionic liquids as the reaction medium, allowing a facile recycling of the catalysts. The dyes prepared are well-matching with the spectral windows of popular rhodamine dyes and possess high brightness while showing a distinctly higher photostability than the rhodamines especially in aprotic solvents.