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- Chemische Modifizierung (1) (entfernen)
Since it´s first report in 2010, paper spray ionization mass spectrometry (PSI-MS),
has rapidly become a promising ionization method for ambient MS. It combines the simplicity
of direct analysis due to chromatographic retention of matrix elements and disposability
due to the usage of low-cost materials.
As a result the quantification of analytes out of complicated matrices, e.g. as of dried
blood spots is possible when internal standards are used. However, on the downside the
method exhibits a poor sensitivity and reproducibility. Especially the reproducibility suffers
from batch to batch fluctuations in the exact morphology and composition of the used
paper. Thus, so far the stability of consecutive measurements varies from tip to tip and
batch to batch.
This work shows the potentials of chemical modifications of cellulose chromatography paper
and their possible use for PSI-MS. The systematic comparison of the obtained data
exhibits a clear trend potentially paving the way of possibilities towards a future applicability
as a standard routine in analytical chemistry.