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NIR fluorescence imaging system for (pre)clinical applications: design, construction, and validation
(2023)
We developed, built, and validated a new versatile fluorescence imaging system. The system is intended to reliably test new tracers and contrast agents at different stages of (pre)clinical research. The system, in its current version, is optimized for the detection of ICG emission. The modular design enables to adapt the scanner to emerging spectral windows with traceable and standardized measurements conditions.
This contribution briefly summarizes the standardization activities in accordance with the "Nationale Roadmap Wasserstofftechnologien" and presents selected results on the activities in Germany with scope on hydrogen transport in pipelines. The talk was given during a panel discussion to set-up a steering committee for standardization for hydrogen pipelines and welding , coordinated by the International Institute of Welding.
As consequence of the European Green Deal and the European Commission's Circular Economy Action Plan, the product landscape in the EU will undergo fundamental changes. The legal requirements for products are being expanded, not least through the Proposal for an Ecodesign Regulation for Sustainable Products published by the European Commission in 2022. Following the current developments, requirements for the circularity of products will be increased next to the already existing minimum requirements for products’ energy efficiency. Following this development, the lead question has to be: Is the market, in particular small- and medium-sized enterprises, well prepared for this planned green transformation of our economy? The answer is: No, not yet.
What is needed are suitable standards for the implementation of these requirements to reduce additional burdens to an appropriate level and to support fair competition between all market actors concerned. The German Institute for Standardization, the German Commission for Electro-technical, Electronic & Information Technologies and the Association of German Engineers have conducted a review study with the aim of identifying fundamental needs for revising existing standards and for creating new standards - both of which are intended to support and accelerate the transformation of the current economy towards a Circular Economy. More than 700.000 normative documents were analyzed, and the results were discussed and consolidated with more than 1000 experts from manufacturers (organizations), consumer- and environmental organizations as well as from the public sector. As a result, more than 200 gaps in the standardization landscape were identified. In this study, we highlight and analyze the most important needs for standardization activities in the field of electrotechnical-, electronic- and ICT-products. In the discussion with the experts for electrotechnical-, electronic- and ICT products, it has been confirmed that a timely implementation of ambitious political decisions of a circular economy requires a normative basis to ensure its consistency. Furthermore, consensus between experts was that legislation in product regulation would be key and should not be extended to the area of waste legislation. As most important standardization activities accompanying product legislation, the following were identified: (i) creation of a set of indicators enabling a holistic assessment of product circularity, (ii) quality assurance of secondary raw materials and consumers awareness of the product circularity both enabled by appropriate analytics and (iii) clear regulation concerning product liability of repaired, refurbished or remanufactured products. One issue of relevance to all experts concerns the product safety, which must not, under any circumstances, decrease when changing product design to reach a higher degree of circularity. The mentioned and further standardization activities would be essential to kick the can down the circular economy road and are analyzed and summarized in this study.
The surface chemistry of nanomaterials controls their interaction with the environment and biological species and their fate and is hence also relevant for their potential toxicity. This has meanwhile led to an increasing interest in validated and preferably standardized methods for the determination and quantification of surface functionalities on nanomaterials and initiated different standardization projects within ISO/TC 229 and IEC/TC 113 as well as interlaboratory comparisons (ILCs) of different analytical methods for the quantification of surface coatings by OECD. Here we present the results of a first ILC on the quantification of the amount of amino functionalities on differently sized inorganic nanoparticles done by division Biophotonics and the National Research Council of Canada (NRC) and the PWI 19257 on the Characterization and Quantification of Surface Functional Groups and Coatings on Nanoobjects approved by ISO/TC 229 (WG2) in fall 2022 that will result in a VAMAS study on this topic organized by division Biophotonics. Key words: nanoparticles, surface analysis, surface functional groups, quantification, optical assay, qNMR, VAMAS, standardization, ICL, quality assurance, reference material.