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Scalable covalently functionalized black phosphorus hybrids for broadspectrum virucidal activity
- At the onset of viral outbreaks, broad-spectrum antiviral materials are crucial before specific therapeutics become available. We report scalable, biodegradable black phosphorus (BP) hybrids that provide mutation-resilient virucidal protection. BP sheets, produced via an optimized mechanochemical process, are covalently functionalized with 2-azido-4,6-dichloro- 1,3,5-triazine to form P=N bonds. Fucoidan, a sulfated polysaccharide with intrinsic antiviral activity, and hydrophobic chains are then incorporated to achieve irreversible viral deactivation. The material exhibits strong antiviral inhibition and complete virucidal activity against multiple viruses, including recent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants. It maintains high biocompatibility, remains effective against viral mutations, and is shelf stable for at least five month. The combination of biodegradability, scalable synthesis, and synergistic antiviral and virucidal mechanisms establishesAt the onset of viral outbreaks, broad-spectrum antiviral materials are crucial before specific therapeutics become available. We report scalable, biodegradable black phosphorus (BP) hybrids that provide mutation-resilient virucidal protection. BP sheets, produced via an optimized mechanochemical process, are covalently functionalized with 2-azido-4,6-dichloro- 1,3,5-triazine to form P=N bonds. Fucoidan, a sulfated polysaccharide with intrinsic antiviral activity, and hydrophobic chains are then incorporated to achieve irreversible viral deactivation. The material exhibits strong antiviral inhibition and complete virucidal activity against multiple viruses, including recent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants. It maintains high biocompatibility, remains effective against viral mutations, and is shelf stable for at least five month. The combination of biodegradability, scalable synthesis, and synergistic antiviral and virucidal mechanisms establishes BP-conjugates as a new class of highly efficient antivirals. They offer a broad spectrum antiviral solutions that could bridge the gap between antiviral medicines and general antiseptics.…


| Autor*innen: | Na Xing, Jasmin ErORCiD, Ricardo M. Vidal, Sandhya Khadka, Robert SchusterbauerORCiD, Maik Rosentreter, Ranen Etouki, Rameez Ahmed, Taylor Page, Philip NicklORCiD, Obida Bawadkji, Anja Wiesner, Jörg RadnikORCiD, Vasile-Dan HodoroabaORCiD, Kai Ludwig, Jakob Trimpert, Ievgen DonskyiORCiD |
|---|---|
| Dokumenttyp: | Preprint |
| Veröffentlichungsform: | Graue Literatur |
| Sprache: | Englisch |
| Titel des übergeordneten Werkes (Englisch): | arxiv.org |
| Jahr der Erstveröffentlichung: | 2025 |
| Organisationseinheit der BAM: | 6 Materialchemie |
| 6 Materialchemie / 6.1 Oberflächen- und Dünnschichtanalyse | |
| Veröffentlichende Institution: | Bundesanstalt für Materialforschung und -prüfung (BAM) |
| Verlag: | Cornell University |
| Verlagsort: | Ithaca, NY |
| Aufsatznummer: | arXiv:2510.12854 |
| Erste Seite: | 1 |
| Letzte Seite: | 22 |
| DDC-Klassifikation: | Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten |
| Freie Schlagwörter: | Antiviral materials; Biodegradability; Black phosphorus; Functionalization; Sheets |
| Themenfelder/Aktivitätsfelder der BAM: | Material |
| Material / Advanced Materials | |
| DOI: | 10.48550/arXiv.2510.12854 |
| URN: | urn:nbn:de:kobv:b43-652941 |
| ISSN: | 2331-8422 |
| Verfügbarkeit des Dokuments: | Datei für die Öffentlichkeit verfügbar ("Open Access") |
| Lizenz (Deutsch): | Allgemeines Deutsches Urheberrecht |
| Datum der Freischaltung: | 07.01.2026 |
| Referierte Publikation: | Nein |
| Schriftenreihen ohne Nummerierung: | Preprints der BAM |


