Quantifying the total and accessible amount of surface functionalities and ligands on nano-materials: Overview and recommended methods
- Engineered nanoparticles (NPs) with various chemical compositions and surface functionalities are routinely fabricated for industrial applications such as medical diagnostics, drug delivery, sensing, catalysis, energy conversion and storage, opto-electronics, and information storage. NP function, interaction with biological species, and environmental fate are largely determined by surface functionalities. This calls for reliable, reproducible, and standardized surface characterization methods, which are vital for quality control of NPs, and mandatory to meet increasing concerns regarding their safety. Validated and standardized workflows for surface analysis are also increasingly requested by industry, international standardization organizations, regulatory agencies, and policymakers. To establish comparable measurements of surface functionalities across different labs and ease instrument performance validation, reference test materials and reference materials of known surfaceEngineered nanoparticles (NPs) with various chemical compositions and surface functionalities are routinely fabricated for industrial applications such as medical diagnostics, drug delivery, sensing, catalysis, energy conversion and storage, opto-electronics, and information storage. NP function, interaction with biological species, and environmental fate are largely determined by surface functionalities. This calls for reliable, reproducible, and standardized surface characterization methods, which are vital for quality control of NPs, and mandatory to meet increasing concerns regarding their safety. Validated and standardized workflows for surface analysis are also increasingly requested by industry, international standardization organizations, regulatory agencies, and policymakers. To establish comparable measurements of surface functionalities across different labs and ease instrument performance validation, reference test materials and reference materials of known surface chemistry as well as reference data are needed.
In the following, different methods for determining surface functionalities on ligand-stabilized core and core/shell NPs include advanced techniques are presented and discussed regarding method-inherent advantages and limitations. Special emphasis is dedicated to traceable quantitative nuclear magnetic resonance (qNMR), X-ray electron spectroscopy (XPS) and time of flight secondary ion mass spectrometry (ToF-SIMS), and simpler optical and electrochemical methods.…


| Autor*innen: | Ute Resch-GengerORCiD |
|---|---|
| Koautor*innen: | Elina AndresenORCiD, Isabella TavernaroORCiD, Anna MatiushkinaORCiD, P. C. Sander, Lena Scholtz, Christian Homann, Jörg RadnikORCiD, A. Brinkmann, G. Lopinski, L. J. Johnston, Sarah-Luise AbramORCiD |
| Dokumenttyp: | Vortrag |
| Veröffentlichungsform: | Präsentation |
| Sprache: | Englisch |
| Jahr der Erstveröffentlichung: | 2025 |
| Organisationseinheit der BAM: | 1 Analytische Chemie; Referenzmaterialien |
| 1 Analytische Chemie; Referenzmaterialien / 1.2 Biophotonik | |
| 6 Materialchemie | |
| 6 Materialchemie / 6.1 Oberflächen- und Dünnschichtanalyse | |
| DDC-Klassifikation: | Naturwissenschaften und Mathematik / Chemie / Analytische Chemie |
| Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten | |
| Freie Schlagwörter: | Advanced material; Automation; Characterization; Coating; Comparison; Fluorescamine; Fluorescence; Fluram; Functional group; ILC; Method; Nano; Optical assay; Particle; Potentiometry; Quality assurance; Quantification; Reference material; Standardization; Surface; Synthesis; Validation; qNMR |
| Themenfelder/Aktivitätsfelder der BAM: | Chemie und Prozesstechnik |
| Chemie und Prozesstechnik / Chemische Charakterisierung und Spurenanalytik | |
| Material | |
| Material / Advanced Materials | |
| Umwelt | |
| Veranstaltung: | LNE Workshop |
| Veranstaltungsort: | Paris, France |
| Beginndatum der Veranstaltung: | 04.11.2025 |
| Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
| Datum der Freischaltung: | 14.11.2025 |
| Referierte Publikation: | Nein |
| Eingeladener Vortrag (wissenschaftliche Konferenzen): | Ja |

