Evaluating the Normalization Potential of Anthropogenic Markers in Wastewater: Monitoring Influents of German Treatment Plants by ELISA

  • Wastewater-based epidemiology (WBE) has emerged as a vital tool for pandemic preparedness, offering early warning capabilities and supporting public health interventions. In Germany, combined sewer systems are prevalent, leading to fluctuations in wastewater volume and com-position due to rainwater inflow, especially through street drains. This variability complicates the quantitative measurement of pathogens and pollutants in wastewater. While human excretion provides constant inputs, these parameters are often non-specific, lost, or degraded during transport. Pharmaceuticals—such as carbamazepine, diclofenac, and clarithromycin—as well as commonly consumed substances like caffeine, exhibit sufficiently high concentrations and good chemical stability in wastewater and are not subject to seasonal fluctuations. Antibody-based methods, particularly Enzyme-Linked Immunosorbent Assays (ELISA), offer a cost-effective alternative to complex chromatographic techniques for monitoringWastewater-based epidemiology (WBE) has emerged as a vital tool for pandemic preparedness, offering early warning capabilities and supporting public health interventions. In Germany, combined sewer systems are prevalent, leading to fluctuations in wastewater volume and com-position due to rainwater inflow, especially through street drains. This variability complicates the quantitative measurement of pathogens and pollutants in wastewater. While human excretion provides constant inputs, these parameters are often non-specific, lost, or degraded during transport. Pharmaceuticals—such as carbamazepine, diclofenac, and clarithromycin—as well as commonly consumed substances like caffeine, exhibit sufficiently high concentrations and good chemical stability in wastewater and are not subject to seasonal fluctuations. Antibody-based methods, particularly Enzyme-Linked Immunosorbent Assays (ELISA), offer a cost-effective alternative to complex chromatographic techniques for monitoring anthropogenic markers. They demonstrate superior normalization quality compared to the frequently used quantitative PCR-based marker Pepper mild mottle virus (PMMoV).zeige mehrzeige weniger

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Metadaten
Autor*innen:Rudolf J. SchneiderORCiD
Koautor*innen:Zoltán KonthurORCiD, Maximilian Lehnert, Shireen Ewald, Caitlin Hartlage, Doğa İkizoğulları, Thomas Exner, Marcus Lukas, Ulrike BraunORCiD
Dokumenttyp:Posterpräsentation
Veröffentlichungsform:Präsentation
Sprache:Englisch
Jahr der Erstveröffentlichung:2025
Organisationseinheit der BAM:1 Analytische Chemie; Referenzmaterialien
1 Analytische Chemie; Referenzmaterialien / 1.8 Umweltanalytik
DDC-Klassifikation:Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Sanitär- und Kommunaltechnik; Umwelttechnik
Freie Schlagwörter:Carbamazepin; Koffein; Spurenstoffe
Anthropogener Marker Immunoassay
Themenfelder/Aktivitätsfelder der BAM:Umwelt
Veranstaltung:6th International Conference on Risk Assessment of Pharmaceuticals in the Environment - ICRAPHE
Veranstaltungsort:Aveiro, Portugal
Beginndatum der Veranstaltung:20.10.2025
Enddatum der Veranstaltung:21.10.2025
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:22.10.2025
Referierte Publikation:Nein
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