Thermomechanochemical Synthesis of Pimelic Acid Cocrystals
- Milling temperature is a critical factor in mechanochemistry, affecting the kinetics and outcomes of reactions. In the context of cocrystallization, the influence of milling temperature on the process has been investigated for cocrystal systems pyrazinamide:pimelic acid (PZA:PA) and 4,4'-bipyridine:pimelic acid (BPY:PA). By means of temperature-controlled milling, stabilization of metastable polymorph of PZA:PA was achieved, thereby decelerating the aging process of the polymorph. This was accomplished through controlled heated milling of PZA and PA. Furthermore, we have successfully synthesized all three BPY:PA polymorphs by mechanochemistry involving controlled cooled and heated milling. In previous studies, only the most stable polymorph was obtained by mechanochemistry.
| Autor*innen: | Anastasia May |
|---|---|
| Koautor*innen: | Franziska EmmerlingORCiD, Lucia CasaliORCiD, Bettina Röder |
| Dokumenttyp: | Posterpräsentation |
| Veröffentlichungsform: | Präsentation |
| Sprache: | Englisch |
| Jahr der Erstveröffentlichung: | 2025 |
| Organisationseinheit der BAM: | 6 Materialchemie |
| 6 Materialchemie / 6.3 Strukturanalytik | |
| DDC-Klassifikation: | Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten |
| Freie Schlagwörter: | Cocrystal; Mechanochemistry |
| Themenfelder/Aktivitätsfelder der BAM: | Material |
| Material / Materialdesign | |
| Veranstaltung: | 10th European Crystallography School |
| Veranstaltungsort: | Ohrid, North Macedonia |
| Beginndatum der Veranstaltung: | 23.06.2025 |
| Enddatum der Veranstaltung: | 27.06.2025 |
| Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
| Datum der Freischaltung: | 28.07.2025 |
| Referierte Publikation: | Nein |

