Multichannel real-time detection of biomarkers with highly miniaturized photonic microchips
- The development of novel photonic integrated microchips (PIC) is a promising approach to allow for the convenient detection of key biomarkers in complex matrices through multichannel real-time analysis in a highly compact package. This study reports the successful development and application of a backside released CMOS chip designed for the multichannel real-time detection of biomarkers. Operating at the C-band at approx. 1550 nm, the microchip features three dedicated detection sensors in addition to a reference sensor, enabling simultaneous analysis of multiple biomarkers. The compact and highly miniaturized design of this microchip, with a footprint of just 1 mm², positions it as promising candidate for point-of-care diagnostics and personalized medicine applications. This technology opens a path to transform biomarker detection across various medical fields, offering rapid, reliable, and cost-effective diagnostic solutions. In conclusion, the presented multichannel photonicThe development of novel photonic integrated microchips (PIC) is a promising approach to allow for the convenient detection of key biomarkers in complex matrices through multichannel real-time analysis in a highly compact package. This study reports the successful development and application of a backside released CMOS chip designed for the multichannel real-time detection of biomarkers. Operating at the C-band at approx. 1550 nm, the microchip features three dedicated detection sensors in addition to a reference sensor, enabling simultaneous analysis of multiple biomarkers. The compact and highly miniaturized design of this microchip, with a footprint of just 1 mm², positions it as promising candidate for point-of-care diagnostics and personalized medicine applications. This technology opens a path to transform biomarker detection across various medical fields, offering rapid, reliable, and cost-effective diagnostic solutions. In conclusion, the presented multichannel photonic microchips signify a substantial leap forward in real-time biomarker detection, providing a highly capable platform for future research and clinical applications.…


| Autor*innen: | Robert Tannenberg, Martin Paul, Tabea Fünning, Christoph Schuhmann, Michael G. WellerORCiD, Patrick Steglich |
|---|---|
| Dokumenttyp: | Beitrag zu einem Tagungsband |
| Veröffentlichungsform: | Verlagsliteratur |
| Sprache: | Englisch |
| Titel des übergeordneten Werkes (Englisch): | SPIE Proceedings |
| Jahr der Erstveröffentlichung: | 2025 |
| Organisationseinheit der BAM: | 1 Analytische Chemie; Referenzmaterialien |
| 1 Analytische Chemie; Referenzmaterialien / 1.5 Proteinanalytik | |
| Verlag: | SPIE |
| Verlagsort: | Prague, Czech Republic |
| Jahrgang/Band: | 13527 |
| Aufsatznummer: | 135270J |
| Erste Seite: | 1 |
| Letzte Seite: | 6 |
| DDC-Klassifikation: | Naturwissenschaften und Mathematik / Chemie / Analytische Chemie |
| Freie Schlagwörter: | Biomarker; C-reactive protein; CMOS; CRP; Multiplexing; Photonic integrated circuit; Real-time detection; Ring resonator; Semiconductor |
| Themenfelder/Aktivitätsfelder der BAM: | Chemie und Prozesstechnik |
| Chemie und Prozesstechnik / Chemische Charakterisierung und Spurenanalytik | |
| Veranstaltung: | SPIE Optics + Optoelectronics 2025 |
| Veranstaltungsort: | Prague, Czech Republic |
| Beginndatum der Veranstaltung: | 07.04.2025 |
| Enddatum der Veranstaltung: | 11.04.2025 |
| DOI: | 10.1117/12.3056453 |
| ISBN: | 978-1-5106-8850-6 |
| Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
| Datum der Freischaltung: | 25.06.2025 |
| Referierte Publikation: | Ja |
| Datum der Eintragung als referierte Publikation: | 11.08.2025 |

