Process Monitoring with Compact NMR spectroscopy: Applications from Lab to Field
- The use of compact NMR instruments based on permanent magnets has been increasing in recent years. Their affordability, portability, and ease of operation without the need for trained staff make them particularly interesting for quality control application in industrial production. Recent developments by instrument manufacturers, such as multi-nuclei options or extended interfacing, have made these systems even more versatile. However, the application of NMR spectroscopy as an online PAT tool remains rare, despite its significant potential for process optimization and control. A key challenge in exploiting this potential is the integration of lab instruments into the harsh environment of a chemical plant. Additionally, advancements in automation and data evaluation are key tasks to ensure robust, unattended operation with minimal maintenance requirements.
In this presentation, we showcase examples of using NMR spectroscopy for process monitoring at the lab scale, the development ofThe use of compact NMR instruments based on permanent magnets has been increasing in recent years. Their affordability, portability, and ease of operation without the need for trained staff make them particularly interesting for quality control application in industrial production. Recent developments by instrument manufacturers, such as multi-nuclei options or extended interfacing, have made these systems even more versatile. However, the application of NMR spectroscopy as an online PAT tool remains rare, despite its significant potential for process optimization and control. A key challenge in exploiting this potential is the integration of lab instruments into the harsh environment of a chemical plant. Additionally, advancements in automation and data evaluation are key tasks to ensure robust, unattended operation with minimal maintenance requirements.
In this presentation, we showcase examples of using NMR spectroscopy for process monitoring at the lab scale, the development of open-source software tools for NMR data evaluation (PyIHM, within the Python package KLASSEZ), and a successful example of field integration, running an automated laboratory instrument in the environment of a industrial production plant.…


| Autor*innen: | Klas MeyerORCiD |
|---|---|
| Koautor*innen: | Isabel Thiele, Björn Weiske, Francesco Bruno, Letizia Fiorucci, Enrico Ravera, Matthias Abele, Stefan Falkenstein, Tino Döring, Yannik Friedrich, Michael Maiwald |
| Dokumenttyp: | Vortrag |
| Veröffentlichungsform: | Präsentation |
| Sprache: | Englisch |
| Jahr der Erstveröffentlichung: | 2025 |
| Organisationseinheit der BAM: | 1 Analytische Chemie; Referenzmaterialien |
| 1 Analytische Chemie; Referenzmaterialien / 1.4 Non-Target-Analytik | |
| DDC-Klassifikation: | Naturwissenschaften und Mathematik / Chemie / Analytische Chemie |
| Freie Schlagwörter: | Compact NMR spectroscopy; Downstream processing; Field integration; Indirect Hard Modeling; Process Monitoring |
| Themenfelder/Aktivitätsfelder der BAM: | Chemie und Prozesstechnik |
| Chemie und Prozesstechnik / Anlagensicherheit und Prozesssimulation | |
| Chemie und Prozesstechnik / Chemische Charakterisierung und Spurenanalytik | |
| Veranstaltung: | Quantitative NMR Methods for Reaction and Process Monitoring (NMRPM) |
| Veranstaltungsort: | Kaiserslautern, Germany |
| Beginndatum der Veranstaltung: | 31.03.2025 |
| Enddatum der Veranstaltung: | 02.04.2025 |
| Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
| Datum der Freischaltung: | 03.04.2025 |
| Referierte Publikation: | Nein |
| Eingeladener Vortrag (wissenschaftliche Konferenzen): | Ja |

