Application of novel tumor cell glycan-specific nanoprobes for detecting and targeting breast and prostate cancer
- Glycosylation is a post-translational modification that is involved in the regulation of many biological processes. The glycosylation pattern in cancer cells differs from that in normal cells. One of the main alterations that has been observed in several cancers is the increase of sialic acids at the end of the glycan. The increase of sialic acids and other alterations affect development and progression of tumors and are found to play an important role in cancer invasiveness and metastasis. Molecularly imprinted polymers (MIPs) are synthetic recognition elements that show high selectivity and affinity for their targets. These polymers show promising applications in detection methods for cancer cells. In this study newly synthesized MIPs, labelled with a nitrobenzoxadiazole (NBD) fluorophore, are investigated for their specificity and utility in the detection of cancer cell-related sialic acids.
Autor*innen: | A. Verhassel |
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Koautor*innen: | S. Shinde, Martha Wamaitha Kimani, I. Guedes, B. Sellegren, Knut Rurack, J. Tuomela, P. Härkönen |
Dokumenttyp: | Posterpräsentation |
Veröffentlichungsform: | Präsentation |
Sprache: | Englisch |
Jahr der Erstveröffentlichung: | 2018 |
Organisationseinheit der BAM: | 1 Analytische Chemie; Referenzmaterialien |
1 Analytische Chemie; Referenzmaterialien / 1.9 Chemische und optische Sensorik | |
DDC-Klassifikation: | Naturwissenschaften und Mathematik / Chemie / Analytische Chemie |
Freie Schlagwörter: | Cancer; MIPs; Nanoparticles |
Themenfelder/Aktivitätsfelder der BAM: | Umwelt |
Umwelt / Sensorik | |
Veranstaltung: | Biomarkers – methods and technologies |
Veranstaltungsort: | Malmö, Sweden |
Beginndatum der Veranstaltung: | 25.10.2018 |
Enddatum der Veranstaltung: | 26.10.2018 |
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
Datum der Freischaltung: | 07.11.2018 |
Referierte Publikation: | Nein |