The physico-chemical basis of DNA radiosensitization: Implications for cancer radiation therapy

  • High-energy radiation is used in combination with radiosensitizing therapeutics to treat cancer. The most common radiosensitizers are halogenatednucleo-sides and cisplatin derivatives, and recently also metal nanoparticles have been suggested as potentialradiosensitizing agents. The radiosensitizingaction of these compounds can at least partly be ascribed to an enhancedreactivity towards secondary low-energy electrons generated along the radiation track of the high-energyprimary radiation, or to an additional emission of secondary reactive electrons close to the tumor tissue. This is referred to as physico-chem ical radiosensitization. In this Conceptarticle we presentcurrent experimental methodsused to study fundamentalprocesses of physico-chemical radiosensitization and discuss the most relevant classes of radiosensitizers. Open questions in the current discussions are identified and future directions outlined, which can lead to optimized treatment protocols or even novelHigh-energy radiation is used in combination with radiosensitizing therapeutics to treat cancer. The most common radiosensitizers are halogenatednucleo-sides and cisplatin derivatives, and recently also metal nanoparticles have been suggested as potentialradiosensitizing agents. The radiosensitizingaction of these compounds can at least partly be ascribed to an enhancedreactivity towards secondary low-energy electrons generated along the radiation track of the high-energyprimary radiation, or to an additional emission of secondary reactive electrons close to the tumor tissue. This is referred to as physico-chem ical radiosensitization. In this Conceptarticle we presentcurrent experimental methodsused to study fundamentalprocesses of physico-chemical radiosensitization and discuss the most relevant classes of radiosensitizers. Open questions in the current discussions are identified and future directions outlined, which can lead to optimized treatment protocols or even novel therapeuticconcepts.zeige mehrzeige weniger

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Metadaten
Autor*innen:Robin Schürmann, Stefanie Vogel, Kenny Ebel, Ilko Bald
Dokumenttyp:Zeitschriftenartikel
Veröffentlichungsform:Verlagsliteratur
Sprache:Englisch
Titel des übergeordneten Werkes (Englisch):Chemistry - A European Journal
Jahr der Erstveröffentlichung:2018
Organisationseinheit der BAM:1 Analytische Chemie; Referenzmaterialien
1 Analytische Chemie; Referenzmaterialien / 1.0 Abteilungsleitung und andere
Verlag:WILEY
Jahrgang/Band:24
Ausgabe/Heft:41
Erste Seite:10271
Letzte Seite:10279
DDC-Klassifikation:Naturwissenschaften und Mathematik / Chemie / Analytische Chemie
Freie Schlagwörter:DNA; Low energy electrons; Radiation damage; Radiosensitization
Themenfelder/Aktivitätsfelder der BAM:Chemie und Prozesstechnik
DOI:10.1002/chem.201800804
ISSN:1521-3765
ISSN:0947-6539
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:21.08.2018
Referierte Publikation:Ja
Datum der Eintragung als referierte Publikation:21.08.2018
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