Combining Fluorescent Probes, Functionalized Surfaces, Tailored Particles and Device Embedding for Robust, Reliable and User-friendly Analytical Assays
- Supramolecular chemistry, fluorescence detection, hybrid (nano)materials and device miniaturization are in themselves highly interesting areas of research, yet especially their combination paves the way to (bio)chemical analysis systems that show outstanding performance. The lecture gives an overview of the toolbox of single components developed in BAM’s Chemical and Optical Sensing Division over the years, and how their combination can result in powerful sensors, quick tests and assays. While at the core of a development is the analytical problem, that is, the determination of a certain analyte in a sample of interest with the required sensitivity and selectivity by a specific end user in a given setting, signaling mechanisms, recognition elements, signal transduction modes, materials functionalization, device design and system integration are adequately chosen, tailored and adapted. Examples including molecularly imprinted polymers, hybrid mesoporous nanomaterials, gated indicatorSupramolecular chemistry, fluorescence detection, hybrid (nano)materials and device miniaturization are in themselves highly interesting areas of research, yet especially their combination paves the way to (bio)chemical analysis systems that show outstanding performance. The lecture gives an overview of the toolbox of single components developed in BAM’s Chemical and Optical Sensing Division over the years, and how their combination can result in powerful sensors, quick tests and assays. While at the core of a development is the analytical problem, that is, the determination of a certain analyte in a sample of interest with the required sensitivity and selectivity by a specific end user in a given setting, signaling mechanisms, recognition elements, signal transduction modes, materials functionalization, device design and system integration are adequately chosen, tailored and adapted. Examples including molecularly imprinted polymers, hybrid mesoporous nanomaterials, gated indicator release systems, microfluidic devices, test strips and smartphone-based analysis will be presented.…