Combination of Monte-Carlo simulations and experimental results to determine the microscopic energy depoit at DNA
- The quantification of radiation induced damage to DNA in aqueous en-
vironment is of fundamental interest for dosimetry and its application
in radiation-therapy and protection. We present a combined experi-
mental and simulational approach to quantify and compare radiation
induced damage to biomolecules in liquid environment for a wide range
of primary radiation sources e. g. photons, electrons or ions and tar-
gets, such as DNA, proteins or cells.[1] To show its viability, we will
apply this method to an experimentally challenging systems, the di-
rect irradiation of plasmid DNA (pUC19) in water with electrons as
primary particles. Here we combine Geant4 electron-scattering simula-
tions with calculations concerning the diffusion and convection induced
movement of the biomolecules, within a coarse-grained model of the
irradiated liquid. Additionally a microscopic target model for the plas-
mid DNA based on the relation of lineal energy and radiation quality
is used toThe quantification of radiation induced damage to DNA in aqueous en-
vironment is of fundamental interest for dosimetry and its application
in radiation-therapy and protection. We present a combined experi-
mental and simulational approach to quantify and compare radiation
induced damage to biomolecules in liquid environment for a wide range
of primary radiation sources e. g. photons, electrons or ions and tar-
gets, such as DNA, proteins or cells.[1] To show its viability, we will
apply this method to an experimentally challenging systems, the di-
rect irradiation of plasmid DNA (pUC19) in water with electrons as
primary particles. Here we combine Geant4 electron-scattering simula-
tions with calculations concerning the diffusion and convection induced
movement of the biomolecules, within a coarse-grained model of the
irradiated liquid. Additionally a microscopic target model for the plas-
mid DNA based on the relation of lineal energy and radiation quality
is used to calculate the effective target volume.…


Metadaten| Autor*innen: | Marc Benjamin HahnORCiD |
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| Koautor*innen: | Tihomir Solomun, Heinz SturmORCiD |
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| Dokumenttyp: | Posterpräsentation |
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| Veröffentlichungsform: | Präsentation |
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| Sprache: | Englisch |
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| Jahr der Erstveröffentlichung: | 2018 |
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| DDC-Klassifikation: | Naturwissenschaften und Mathematik / Chemie / Analytische Chemie |
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| Freie Schlagwörter: | DNA; DNA damage; DNA radiation damage; Dosimetry; Electron scattering; Geant4; Hydroxyl radicals; Low energy electrons; Microdosimetry; Monte-Carlo simulation; Radiation damage; Target volume |
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| Veranstaltung: | DPG-Frühjahrstagung der Sektion Kondensierte Materie gemeinsam mit der EPS |
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| Veranstaltungsort: | Berlin, Germany |
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| Beginndatum der Veranstaltung: | 11.03.2018 |
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| Enddatum der Veranstaltung: | 16.03.2018 |
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| Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
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| Datum der Freischaltung: | 27.03.2018 |
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| Referierte Publikation: | Nein |
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